UniProtKB - A2T7F2 (PEG3_PANTR)
Protein
Paternally-expressed gene 3 protein
Gene
PEG3
Organism
Pan troglodytes (Chimpanzee)
Status
Functioni
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 454 – 476 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 507 – 529 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 627 – 649 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 969 – 991 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1107 – 1129 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1163 – 1185 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1225 – 1247 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1282 – 1304 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1332 – 1354 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1505 – 1527 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1564 – 1586 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Paternally-expressed gene 3 protein |
Gene namesi | Name:PEG3 |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285534 | 1 – 1588 | Paternally-expressed gene 3 proteinAdd BLAST | 1588 |
Proteomic databases
PaxDbi | A2T7F2 |
Interactioni
Subunit structurei
Homodimer.
Interacts with SIAH1A and SIAH2.
Interacts with TRAF2 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9598.ENSPTRP00000055316 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 128 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Repeati | 1397 – 1403 | 2-1 | 7 | |
Repeati | 1404 – 1410 | 2-2 | 7 | |
Repeati | 1411 – 1417 | 2-3 | 7 | |
Repeati | 1418 – 1422 | 1-1 | 5 | |
Repeati | 1425 – 1429 | 1-2 | 5 | |
Repeati | 1432 – 1436 | 1-3 | 5 | |
Repeati | 1439 – 1443 | 1-4 | 5 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1397 – 1417 | 3 X 7 AA repeat of P-E-V-E-A-A-EAdd BLAST | 21 | |
Regioni | 1418 – 1443 | 4 X 5 AA repeat of P-X-G-E-AAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1352 – 1512 | Glu-richAdd BLAST | 161 |
Domaini
The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.By similarity
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 454 – 476 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 507 – 529 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 627 – 649 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 969 – 991 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1107 – 1129 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1163 – 1185 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1225 – 1247 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1282 – 1304 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1332 – 1354 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1505 – 1527 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1564 – 1586 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | A2T7F2 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
i Sequence
Sequence statusi: Complete.
A2T7F2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPPKHLSAT KPKKSWAPNL YELDSDLTKE PDVIIGEGPT DSEFFHQRFR
60 70 80 90 100
NLIYVEFVGP RKTLIKLRNL CLDWLQPETH TKEEIIELLV LEQYLTIIPE
110 120 130 140 150
KLKPWVRAKK PENCEKLVTL LENYKEMYQP EDDNNSDVTS DDDMTRNRRE
160 170 180 190 200
SSPPHSVHSF SGDRDWDRRG RSRDMEPRDR WSHTRNPRSR MPQRDLSLPV
210 220 230 240 250
VAKTSFEMDR DDDRDSRAYE SRSQDAESYQ NVVDLAEDRK PHNTIQDNME
260 270 280 290 300
NYRKLLSLGV QLAEDDGHSH MTQGHSSRSK RSAYPSTSRG LKTMPEAKKS
310 320 330 340 350
THRRGICEDE SSHGVIMEKF IKDVSRSSKS GRARESSDRS QRFPRMSDDN
360 370 380 390 400
WKDISLNKRE SVIQQRVYEG NAFRGGFRFN STLVSRKRVL ERKRRYHFDT
410 420 430 440 450
DGKGSIHDQK ACPRKKPFEC GSEMRKAMSM SSLSSLSSPS FTESQPIDFG
460 470 480 490 500
AMPYVCDECG RSFSVISEFV EHQIMHTREN LYEYGESFIH SVAVSEVQKS
510 520 530 540 550
QVGGKRFECK DCGETFNKSA ALAEHRKIHA RGYLVECKNQ ECEEAFMPSP
560 570 580 590 600
TFSELQKIYG KDKFYECRVC KETFLHSSAL IEHQKIHFGD DKDNEREHER
610 620 630 640 650
ERERGETFRP SPALNEFQKM YGKEKMYECK VCGETFLHSS SLKEHQKIHT
660 670 680 690 700
RGNPFENKGK VCEETFIPGQ SLKKRQKTYN KEKLYDFTDG RDAFMQSSEL
710 720 730 740 750
SEHQKIHSRK NLFEGRGYEK SVIHSGPFTE SQKSHTITRP LESDEDEKAF
760 770 780 790 800
TISSNPYENQ KIPTKENVYE AKSYERSVIH SLASVEAQKS HSVAGPSKPK
810 820 830 840 850
VMAESTIQSF DAINHQRVRA GGNTSEGREY SRSVIHSLVA SKPPRSHNGN
860 870 880 890 900
ELVESNEKGE SSIYISDLND KRQKIPAREN PCEGGSKNRN YEDSVIQSVS
910 920 930 940 950
RAKPQKSVPG EGSGEFKKDG EFSVPSSNVR EYQKARAKKK YIEHRSNETS
960 970 980 990 1000
VIHSLPFGEQ TFRPRGMLYE CQECGECFAH SSDLTEHQKI HEREKPSGSR
1010 1020 1030 1040 1050
NYEWSVIRSL APTDPQTSYA QEQYAKEQAW NKCKEFRQFF ATSEDLNTNQ
1060 1070 1080 1090 1100
KIYDQEKSHG EESQGENTDG EETHSEETHG QETIEDPVIQ GSDMEDPQKD
1110 1120 1130 1140 1150
DPDDKIYECE DCGLGFVDLT DLTDHQKVHS RKCLVDSREY THSVIHTHSI
1160 1170 1180 1190 1200
SEYQRDYTGE QLYECPKCGE SFIHSSFLFE HQRIHEQDQL YSMKGCDDGF
1210 1220 1230 1240 1250
IALLPMKPRR NRAAERNPAL AGSAIRCLLC GQGFIHSSAL NEHMRLHRED
1260 1270 1280 1290 1300
DLLEQSQMAE EAIIPGLALT EFQRSQTEER LFECAVCGES FINPAELADH
1310 1320 1330 1340 1350
VTVHKNEPYE YGSSYTHTSF LTEPLKGAIP FYECKDCGKS FIHSTVLTKH
1360 1370 1380 1390 1400
KELHLEEEEE DEAAAAAAAA AQEVEANVHV PQVVLRIQGS NVEAAEPEVE
1410 1420 1430 1440 1450
AAEPEVEAAE PEVEAAEPNG EAEGPDGEAA EPIGEAGQPN GEAEQPNGDA
1460 1470 1480 1490 1500
DEPDGAGIED PEERAEEPEG KAEEPEGDAD EPDGVGIEDP EEGEDQEIQV
1510 1520 1530 1540 1550
EEPYYDCHEC TETFTSSTAF GEHLKTHASM IIFEPANAFG ECSGYIERAS
1560 1570 1580
TSTGGANQAD EKYFKCDVCG QLFNDRLSLA RHQNTHTG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ977436 Genomic DNA Translation: ABM92107.1 |
RefSeqi | NP_001129091.1, NM_001135619.1 |
Genome annotation databases
GeneIDi | 469030 |
KEGGi | ptr:469030 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ977436 Genomic DNA Translation: ABM92107.1 |
RefSeqi | NP_001129091.1, NM_001135619.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000055316 |
Proteomic databases
PaxDbi | A2T7F2 |
Genome annotation databases
GeneIDi | 469030 |
KEGGi | ptr:469030 |
Organism-specific databases
CTDi | 5178 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | A2T7F2 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PEG3_PANTR | |
Accessioni | A2T7F2Primary (citable) accession number: A2T7F2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families