UniProtKB - A2SZW8 (REHY_MAIZE)
Protein
1-Cys peroxiredoxin PER1
Gene
PER1
Organism
Zea mays (Maize)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Seems to contribute to the inhibition of germination during stress (By similarity).By similarity
Miscellaneous
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.By similarity
Catalytic activityi
- EC:1.11.1.24By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 46 | Cysteine sulfenic acid (-SOH) intermediateBy similarity | 1 |
GO - Molecular functioni
- peroxidase activity Source: AgBase
- peroxiredoxin activity Source: InterPro
GO - Biological processi
- defense response to fungus Source: AgBase
Keywordsi
Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Protein family/group databases
PeroxiBasei | 4964, Zm1CysPrx |
Names & Taxonomyi
Protein namesi | Recommended name: 1-Cys peroxiredoxin PER1 (EC:1.11.1.24By similarity)Alternative name(s): Rehydrin homolog Thioredoxin peroxidase Thioredoxin-dependent peroxiredoxinCurated |
Gene namesi | Name:PER1 Synonyms:PER-1 |
Organismi | Zea mays (Maize) |
Taxonomic identifieri | 4577 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285101 | 1 – 229 | 1-Cys peroxiredoxin PER1Add BLAST | 229 |
Proteomic databases
PaxDbi | A2SZW8 |
PRIDEi | A2SZW8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 173 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 170 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 205 – 228 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | KOG0854, Eukaryota |
OrthoDBi | 1129256at2759 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A2SZW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGLTIGDTV PNLELDSTHG KIRIHDYVGD GYAIIFSHPA DFTPVCTTEM
60 70 80 90 100
AAMAGYAKEF EKRGVKLLGI SCDDVESHRQ WTKDVEAYGG KQQQQQATTT
110 120 130 140 150
KVTFPILADP ARDAIRQLNM VDPDEKDAAG RSMPSRALHV VGPDKAVKLS
160 170 180 190 200
FLYPATTGRN MDEVLRAVDS LLTAAKHGGK VATPANWKPG ECAVIAPGVS
210 220
DEEARKMFPQ GFETADLPSK KGYLRFTKV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ378060 mRNA Translation: ABD24377.1 |
RefSeqi | NP_001105998.1, NM_001112528.1 |
Genome annotation databases
GeneIDi | 100037830 |
KEGGi | zma:100037830 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ378060 mRNA Translation: ABD24377.1 |
RefSeqi | NP_001105998.1, NM_001112528.1 |
3D structure databases
SMRi | A2SZW8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4577.GRMZM2G129761_P01 |
Protein family/group databases
Allergomei | 9885, Zea m 32 |
PeroxiBasei | 4964, Zm1CysPrx |
Proteomic databases
PaxDbi | A2SZW8 |
PRIDEi | A2SZW8 |
Genome annotation databases
GeneIDi | 100037830 |
KEGGi | zma:100037830 |
Phylogenomic databases
eggNOGi | KOG0854, Eukaryota |
OrthoDBi | 1129256at2759 |
Gene expression databases
ExpressionAtlasi | A2SZW8, baseline and differential |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | REHY_MAIZE | |
Accessioni | A2SZW8Primary (citable) accession number: A2SZW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families