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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63SubstrateUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Binding sitei202SubstrateUniRule annotation1
Binding sitei232SubstrateUniRule annotation1
Binding sitei236SubstrateUniRule annotation1
Binding sitei237NADUniRule annotation1
Binding sitei289NADUniRule annotation1
Binding sitei324NADUniRule annotation1
Binding sitei390NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 205NADUniRule annotation3
Nucleotide bindingi266 – 271NADUniRule annotation6
Nucleotide bindingi345 – 347NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciMPET420662:G1G81-3346-MONOMER
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Mpe_A3286
OrganismiMethylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Taxonomic identifieri420662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesMethylibium
Proteomesi
  • UP000000366 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002120561 – 477AdenosylhomocysteinaseAdd BLAST477

Proteomic databases

PRIDEiA2SL00

Interactioni

Protein-protein interaction databases

STRINGi420662.Mpe_A3286

Structurei

3D structure databases

ProteinModelPortaliA2SL00
SMRiA2SL00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA
HOGENOMiHOG000227986
KOiK01251
OMAiTGNRDII
OrthoDBiPOG091H00W2

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2SL00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVLKPTPT HDHHVADLSL ADWGRKEIKI AETEMPGLMA IRQEFAASQP
60 70 80 90 100
LKGARITGSL HMTIQTAVLV ETLQALGAQV RWASCNIFST QDHAAAALVA
110 120 130 140 150
AGTPVFAYKG ETLTDYWDYT HRIFDFGAKG TDGEGPNMIL DDGGDATLLM
160 170 180 190 200
HLGQKAEKDP SVISKPTSEE ETCLFAAIKA KLAQDPTWYT RKSAQIIGVT
210 220 230 240 250
EETTTGVHRL NEMSAKGTLL FRAINVNDSV TKSKFDNLYG CRESLVDSIK
260 270 280 290 300
RATDVMIAGK VACVAGYGDV GKGSAQALRA LSAQVWVTEI DPINALQAAM
310 320 330 340 350
EGYKVVTMEY AADKADIFVS ATGNKNVIRY EHMAAMKDEA IVCNIGHFDN
360 370 380 390 400
EIDVASLEKL KWDEIKPQVD HVVFPDGKKI TLLAKGRLVN LGCATGHPSF
410 420 430 440 450
VMSSSFANQT IAQIELFTKS ADYQVGKVYV LPKHLDEKVA RLHLKKVGAM
460 470
LTELTDEQAA YIGVSKSGPY KADTYRY
Length:477
Mass (Da):51,937
Last modified:March 6, 2007 - v1
Checksum:i3A8BE09B0DA93386
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000555 Genomic DNA Translation: ABM96239.1
RefSeqiWP_011830862.1, NC_008825.1

Genome annotation databases

EnsemblBacteriaiABM96239; ABM96239; Mpe_A3286
KEGGimpt:Mpe_A3286

Similar proteinsi

Entry informationi

Entry nameiSAHH_METPP
AccessioniPrimary (citable) accession number: A2SL00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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