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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Burkholderia mallei (strain NCTC 10229)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Activity regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei855-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei1105-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei200Uracil; via amide nitrogenUniRule annotation1
Binding sitei2065-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:BMA10229_A0790
OrganismiBurkholderia mallei (strain NCTC 10229)
Taxonomic identifieri412022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002283 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000536851 – 216Uracil phosphoribosyltransferaseAdd BLAST216

Structurei

3D structure databases

ProteinModelPortaliA2S4B1
SMRiA2S4B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 1435-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation9
Regioni205 – 207Uracil bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262754
KOiK00761
OMAiRICGYEI

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit

Sequencei

Sequence statusi: Complete.

A2S4B1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQDSRFPNL FILDHPLIQH KLTHMRDKDT STRTFRELLR EITLLMGYEI
60 70 80 90 100
TRNLPITTKR VETPLVEIDA PVIAGKKLAI VPVLRAGVGM SDGLLELIPS
110 120 130 140 150
ARVGHIGVYR ADDHRPVEYL VRLPDLEDRI FILCDPMVAT GYSAAHAIDV
160 170 180 190 200
LKRRGVPGER LMFLALVAAP EGVQVFQDAH PDVKLYVASL DSHLDDHAYI
210
VPGLGDAGDR LFGTKN
Length:216
Mass (Da):24,075
Last modified:March 6, 2007 - v1
Checksum:iDA8F1B3A2ECFB56B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000546 Genomic DNA Translation: ABN01817.1
RefSeqiWP_004186446.1, NC_008836.1

Genome annotation databases

EnsemblBacteriaiABN01817; ABN01817; BMA10229_A0790
KEGGibml:BMA10229_A0790

Similar proteinsi

Entry informationi

Entry nameiUPP_BURM9
AccessioniPrimary (citable) accession number: A2S4B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: September 12, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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