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Protein
Submitted name:

Rho guanine nucleotide exchange factor (GEF) 1

Gene

arhgef1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingSAAS annotation, ZincSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-193648 NRAGE signals death through JNK
R-DRE-194840 Rho GTPase cycle
R-DRE-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 1Imported
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 1aImported
Gene namesi
Name:arhgef1aImported
Synonyms:arhgef1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-030722-5 arhgef1a

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSDARG00000040380 Expressed in 40 organ(s), highest expression level in midbrain tegmentum

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000098827

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 92Phorbol-ester/DAG-typeInterPro annotationAdd BLAST48
Domaini241 – 438DHInterPro annotationAdd BLAST198
Domaini478 – 579PHInterPro annotationAdd BLAST102

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili7 – 41Sequence analysisAdd BLAST35
Coiled coili598 – 618Sequence analysisAdd BLAST21
Coiled coili792 – 812Sequence analysisAdd BLAST21
Coiled coili816 – 836Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IR0Y Eukaryota
ENOG410XT68 LUCA
GeneTreeiENSGT00760000119193
HOGENOMiHOG000236361
HOVERGENiHBG050566
KOiK12791
OMAiRCRDTLP
OrthoDBiEOG091G00G7
TreeFamiTF325887

Family and domain databases

CDDicd00029 C1, 1 hit
cd13393 PH_ARHGEF2, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037806 ARHGEF2_PH
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2RUX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRVADLSKL RQERMREISQ RNKEKERMRE REREAREREA RYSNGHLFNC
60 70 80 90 100
LTVSGTTLCS ACNKSITAKE ALSCPTCNVT IHNRCRDTLP NCVKMKQKQQ
110 120 130 140 150
KMALMRNNSA YQNVTLRNKA HLKERPSSAI YPSDSLRQSL LGSRRGRSSL
160 170 180 190 200
LLSKSVSTNN IAGTLNDDSP LGLRRILSQS TDSLNFRSRT MSMESLNDEG
210 220 230 240 250
ECYVSSLLED LDCEGPEFEA DSWSMAVDSS YLQTHRKDVI KRQDVIYELI
260 270 280 290 300
QTELHHVRTL RIMDCVFRRG MLEEVQLEPG VVHALFPCLE RLLSIHTHFL
310 320 330 340 350
TQLLARRAHS LQPGSTNNFT ITQISDVLIK QFSGQFADDM LKAYSEFCSR
360 370 380 390 400
HMKAVKLYKE LLARDKRLQL FIRRVSRGPL LRRHGFQECI LLVTQRITKY
410 420 430 440 450
PVLLQRIHDN TKDNLEEAAG LSQALACLRE LLCSVDQQVL ELERTHRLQE
460 470 480 490 500
IRSRVDPRAE AKLRSGALFR PAELLRRQLI HEGTLLWKTP SSRLKDVQVL
510 520 530 540 550
LMTDILVFLQ EKDQRFIFAS LDKSAVVSLQ SLLVRDIANQ ERGLFLISSE
560 570 580 590 600
SSPPEMYELY AASKDDRNTW LRLIQQTIGS CPSREEFPLI ETEDKALLRR
610 620 630 640 650
LKADIQQKDS EVLELLQERV TLFSDLAEVM GGYEVMLPAC SRNLFRAESP
660 670 680 690 700
QAPRGEQLLT QAITEVDRLT ELLLGSGLEV PLPCNSNGHH NPPGSLVING
710 720 730 740 750
QEVLVNGSQE NQAAQDGNGN QMEDKTPSEE VSQRLVNLSA QLHALQGVVI
760 770 780 790 800
RQDTILELCL RESPVSQTPS GARTVRSLSR DGASDMGSVG ELALLQRQHS
810 820 830 840 850
LLQEELVRLR GADGKLRDSE RVRAHLEKQL RDMKTNSAAL GDRGGTAGSQ
860 870 880 890 900
APSNRRESDT DPNTDTPLAS QESMDQSDGL QECSDVEVDV ISDDDDDDEV
910 920 930
DSRVSPRSES PRDLQDIPEE SETATDPRER DASHC
Length:935
Mass (Da):105,624
Last modified:March 6, 2007 - v1
Checksum:i750830B5218E4F51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573147 Genomic DNA No translation available.
BC133079 mRNA Translation: AAI33080.1
RefSeqiNP_001075100.1, NM_001081631.2
UniGeneiDr.34449

Genome annotation databases

EnsembliENSDART00000059102; ENSDARP00000059101; ENSDARG00000040380
GeneIDi368266
KEGGidre:368266

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573147 Genomic DNA No translation available.
BC133079 mRNA Translation: AAI33080.1
RefSeqiNP_001075100.1, NM_001081631.2
UniGeneiDr.34449

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000098827

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000059102; ENSDARP00000059101; ENSDARG00000040380
GeneIDi368266
KEGGidre:368266

Organism-specific databases

CTDi368266
ZFINiZDB-GENE-030722-5 arhgef1a

Phylogenomic databases

eggNOGiENOG410IR0Y Eukaryota
ENOG410XT68 LUCA
GeneTreeiENSGT00760000119193
HOGENOMiHOG000236361
HOVERGENiHBG050566
KOiK12791
OMAiRCRDTLP
OrthoDBiEOG091G00G7
TreeFamiTF325887

Enzyme and pathway databases

ReactomeiR-DRE-193648 NRAGE signals death through JNK
R-DRE-194840 Rho GTPase cycle
R-DRE-416482 G alpha (12/13) signalling events

Gene expression databases

BgeeiENSDARG00000040380 Expressed in 40 organ(s), highest expression level in midbrain tegmentum

Family and domain databases

CDDicd00029 C1, 1 hit
cd13393 PH_ARHGEF2, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037806 ARHGEF2_PH
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2RUX1_DANRE
AccessioniPrimary (citable) accession number: A2RUX1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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