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Entry version 70 (02 Jun 2021)
Sequence version 1 (06 Mar 2007)
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Protein

Probable ATP-dependent DNA helicase HFM1

Gene

hfm1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi172 – 179ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
Biological processMeiosis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ATP-dependent DNA helicase HFM1 (EC:3.6.4.12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hfm1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5894880, hfm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003243941 – 1336Probable ATP-dependent DNA helicase HFM1Add BLAST1336

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A2RUV5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000062751

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2RUV5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini159 – 347Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST189
Domaini388 – 589Helicase C-terminalPROSITE-ProRule annotationAdd BLAST202
Domaini646 – 961SEC63Add BLAST316

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi280 – 283DEAH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0952, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2RUV5

Identification of Orthologs from Complete Genome Data

More...
OMAi
LXLIQAQ

Database of Orthologous Groups

More...
OrthoDBi
154891at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR004179, Sec63-dom
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF02889, Sec63, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00973, Sec63, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2RUV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLPFSWITN DVSQCIDLTQ DEHICSLSPV TDTEENMSAF KKSLFGKYDC
60 70 80 90 100
SLNSEDQCLI VENGSSNFVT SKEAQKEAMK ADSDICPPQQ MAFNLFNETV
110 120 130 140 150
VQKDMLNKEK FSHSASSNIS NKDDAQYGIV TPVTEIPKQF RTVFKEFPYF
160 170 180 190 200
NYIQSKALEH LLYSDRNFVL CAPTGSGKTV IFELAIIRLL MQVPMPWTNV
210 220 230 240 250
KIVYMAPIKA LCGQRYDDWK AKFGPVGLNC KELTGDTEMD DLFEIQHAHI
260 270 280 290 300
IMTTPEKWDS MTRKWKDNTL VQLVRLFLID EVHILKEENR GATLEVVVSR
310 320 330 340 350
MKTIYSLSHL SEDRKAFIPM RFVAVSATIP NVEDIADWLS DENSPGVCMK
360 370 380 390 400
MDESSRPVKL RKVVLGFPCS TKQSEFKFDL TLNYKIANII QTYSDGRPTL
410 420 430 440 450
VFCSTRKGVQ QAASILTKDA KFVMSIEHKQ RLQKCANSIK DSKLRDVLQY
460 470 480 490 500
GVGYHHAGVD ISDRKVIENS FLIGDLPVLF TTSTLAMGVN LPAHLVIVKS
510 520 530 540 550
TMHYVSGMFQ EYSETDILQM IGRAGRPQFD STATAVIMTR LSTKEKYVHM
560 570 580 590 600
LDGADTIESS LHKHLVEHLN AEIALHTITD VKVALEWIRS TFLYIRALKN
610 620 630 640 650
PAYYGFSEGL DKIGIEAKLQ ELCLKNLNDL SSLGLIKMDE EINFKPTETG
660 670 680 690 700
KLMALYYIAF NTAKLFHTIR GTETLAELVS LISSCSEFSD VQLRANERRV
710 720 730 740 750
LNTLNKDKNR VTIRYPMEGK IKTKEMKVNC LIQAHLGCIL VQDFSLTQDI
760 770 780 790 800
SKIFRHGTRL AKCLSEFLAL QENKFSAFLN ALILTKCFKS KLWENSSHIS
810 820 830 840 850
KQLEKIGVTL ANAMVNAGLT TFKKIEDTNA RELELIVNRH PPFGNQIKES
860 870 880 890 900
VAHLPKYEIK FQQLAKYRAT TAEVVLTVLL TNFKQLQKKR TAPDSHFVML
910 920 930 940 950
VIGDDDNQAI FKQKIMDSSL FKTGSWTRKI EIKRASKSTN VCLNLISSEY
960 970 980 990 1000
VGLDIQQSFN ICYLGSDSFN ADLVTQHKSE NIFSQEIYKT STKTKDIADT
1010 1020 1030 1040 1050
NWSMRQTAIK CATRECNHNC KNKDACGHEC CKVGVSEKAE MKTNFYSYLN
1060 1070 1080 1090 1100
DLRTRNSVSS ATPVKRLKMQ MEAETRNVNL QNFVFTPKPS IRSPCLKIPE
1110 1120 1130 1140 1150
NILLQAESSV LTNKYKASHQ EETCCKYEIK GCGEKQTKGM PKKTCERRNL
1160 1170 1180 1190 1200
TDSDKCNSSS SENAAYVTFD LGNDIWDDFD DDNLLDASNI SSLTDQHTSE
1210 1220 1230 1240 1250
FTDVSFSKNQ PVSKSSLSAG HHEEARYNAM SINKDSYRYL NAKSEVFSQE
1260 1270 1280 1290 1300
NTQCIDVVPS NQKLHGKMFS ENTIKHMFTL QEETNYPVTS KMDSPHNGCW
1310 1320 1330
SSNIFFKTPE NKTQERGCYH QEDETNAFIG IFNGIF
Length:1,336
Mass (Da):151,509
Last modified:March 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFA610E5F6C8F1CB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI21499 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC133060 mRNA Translation: AAI33061.1
BC121498 mRNA Translation: AAI21499.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001072383.3, NM_001078915.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
779837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:779837

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133060 mRNA Translation: AAI33061.1
BC121498 mRNA Translation: AAI21499.1 Different initiation.
RefSeqiNP_001072383.3, NM_001078915.2

3D structure databases

SMRiA2RUV5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000062751

Proteomic databases

PRIDEiA2RUV5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
779837

Genome annotation databases

GeneIDi779837
KEGGixtr:779837

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
164045
XenbaseiXB-GENE-5894880, hfm1

Phylogenomic databases

eggNOGiKOG0952, Eukaryota
InParanoidiA2RUV5
OMAiLXLIQAQ
OrthoDBi154891at2759

Family and domain databases

InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR004179, Sec63-dom
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF02889, Sec63, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00973, Sec63, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHFM1_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RUV5
Secondary accession number(s): Q0V9K6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 6, 2007
Last modified: June 2, 2021
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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