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Entry version 112 (13 Feb 2019)
Sequence version 2 (11 Sep 2007)
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Protein

DENN domain-containing protein 3

Gene

DENND3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
A2RUS2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND3
Synonyms:KIAA0870
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000105339.10

Human Gene Nomenclature Database

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HGNCi
HGNC:29134 DENND3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617503 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2RUS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22898

Open Targets

More...
OpenTargetsi
ENSG00000105339

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671987

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DENND3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003046721 – 1198DENN domain-containing protein 3Add BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei472Phosphoserine; by ULK1By similarity1
Modified residuei490Phosphoserine; by ULK1By similarity1
Modified residuei858PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2RUS2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2RUS2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2RUS2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2RUS2

PRoteomics IDEntifications database

More...
PRIDEi
A2RUS2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
519
520 [A2RUS2-2]
521 [A2RUS2-3]
522 [A2RUS2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2RUS2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2RUS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105339 Expressed in 190 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2RUS2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A2RUS2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024491
HPA041668

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms oligomers. Interacts with 6 of the 7 known isoforms of 14-3-3 proteins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116562, 1 interactor

Protein interaction database and analysis system

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IntActi
A2RUS2, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262585

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2RUS2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2RUS2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 163uDENNPROSITE-ProRule annotationAdd BLAST163
Domaini186 – 318cDENNPROSITE-ProRule annotationAdd BLAST133
Domaini320 – 424dDENNPROSITE-ProRule annotationAdd BLAST105
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati893 – 931WD 1Sequence analysisAdd BLAST39
Repeati937 – 973WD 2Sequence analysisAdd BLAST37
Repeati977 – 1018WD 3Sequence analysisAdd BLAST42
Repeati1022 – 1059WD 4Sequence analysisAdd BLAST38
Repeati1065 – 1105WD 5Sequence analysisAdd BLAST41
Repeati1110 – 1152WD 6Sequence analysisAdd BLAST43
Repeati1158 – 1197WD 7Sequence analysisAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni438 – 888LinkerCuratedAdd BLAST451

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Inactive DENND3 is found in a closed conformation, in which the linker region interacts with the DENN domain. Phosphorylation of Tyr-858 in the linker region intereferes with this interaction leading to an open conformation and enhances the GEF activity of the protein towards RAB12.By similarity

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQM8 Eukaryota
ENOG410XTT7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060114

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG095574

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2RUS2

KEGG Orthology (KO)

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KOi
K20162

Database of Orthologous Groups

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OrthoDBi
521943at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A2RUS2

TreeFam database of animal gene trees

More...
TreeFami
TF331814

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR037516 Tripartite_DENN
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141 DENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00320 WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2RUS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSLRKKREK PRPEQWKGLP GPPRAPEPED VAVPGGVDLL TLPQLCFPGG
60 70 80 90 100
VCVATEPKED CVHFLVLTDV CGNRTYGVVA QYYRPLHDEY CFYNGKTHRE
110 120 130 140 150
CPGCFVPFAV CVVSRFPYYN SLKDCLSCLL ALLKPCKDFE VDSHIKDFAA
160 170 180 190 200
KLSLIPSPPP GPLHLVFNMK SLQIVLPARA DPESPILDLD LHLPLLCFRP
210 220 230 240 250
EKVLQILTCI LTEQRIVFFS SDWALLTLVT ECFMAYLYPL QWQHPFVPIL
260 270 280 290 300
SDQMLDFVMA PTSFLMGCHL DHFEEVSKEA DGLVLINIDH GSITYSKSTD
310 320 330 340 350
DNVDIPDVPL LAAQTFIQRV QSLQLHHELH AAHLLSSTDL KEGRAHRRSW
360 370 380 390 400
QQKLNCQIQQ TTLQLLVSIF RDVKNHLNYE HRVFNSEEFL KTRAPGDHQF
410 420 430 440 450
YKQVLDTYMF HSFLKARLNR RMDAFAQMDL DTQSEEDRIN GMLLSPRRPT
460 470 480 490 500
VEKRASRKSS HLHVTHRRMV VSMPNLQDIA MPELAPRNSS LRLTDTAGCR
510 520 530 540 550
GSSAVLNVTP KSPYTFKIPE IHFPLESKCV QAYHAHFVSM LSEAMCFLAP
560 570 580 590 600
DNSLLLARYL YLRGLVYLMQ GQLLNALLDF QNLYKTDIRI FPTDLVKRTV
610 620 630 640 650
ESMSAPEWEG AEQAPELMRL ISEILDKPHE ASKLDDHVKK FKLPKKHMQL
660 670 680 690 700
GDFMKRVQES GIVKDASIIH RLFEALTVGQ EKQIDPETFK DFYNCWKETE
710 720 730 740 750
AEAQEVSLPW LVMEHLDKNE CVCKLSSSVK TNLGVGKIAM TQKRLFLLTE
760 770 780 790 800
GRPGYLEIST FRNIEEVRRT TTTFLLRRIP TLKIRVASKK EVFEANLKTE
810 820 830 840 850
CDLWHLMVKE MWAGKKLADD HKDPHYVQQA LTNVLLMDAV VGTLQSPGAI
860 870 880 890 900
YAASKLSYFD KMSNEMPMTL PETTLETLKH KINPSAGEAF PQAVDVLLYT
910 920 930 940 950
PGHLDPAEKV EDAHPKLWCA LSEGKVTVFN ASSWTIHQHS FKVGTAKVNC
960 970 980 990 1000
MVMADQNQVW VGSEDSVIYI INVHSMSCNK QLTAHCSSVT DLIVQDGQEA
1010 1020 1030 1040 1050
PSNVYSCSMD GMVLVWNVST LQVTSRFQLP RGGLTSIRLH GGRLWCCTGN
1060 1070 1080 1090 1100
SIMVMKMNGS LHQELKIEEN FKDTSTSFLA FQLLPEEEQL WAACAGRSEV
1110 1120 1130 1140 1150
YIWSLKDLAQ PPQRVPLEDC SEINCMIRVK KQVWVGSRGL GQGTPKGKIY
1160 1170 1180 1190
VIDAERKTVE KELVAHMDTV RTLCSAEDRY VLSGSGREEG KVAIWKGE
Length:1,198
Mass (Da):135,890
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52D51635DDD88A4E
GO
Isoform 2 (identifier: A2RUS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-370: Missing.

Note: No experimental confirmation available.
Show »
Length:1,146
Mass (Da):129,809
Checksum:iB8D7B60A600DDD0C
GO
Isoform 3 (identifier: A2RUS2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-950: Missing.
     1133-1198: VWVGSRGLGQ...EGKVAIWKGE → VGWRARHPQH...PNWMASNDRT

Note: No experimental confirmation available.
Show »
Length:266
Mass (Da):29,486
Checksum:iB5D62298848A4332
GO
Isoform 4 (identifier: A2RUS2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-128: C → W
     129-1198: Missing.

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):14,509
Checksum:iB5E0DB642AC3F733
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PF32E9PF32_HUMAN
DENN domain-containing protein 3
DENND3
1,278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAY3H0YAY3_HUMAN
DENN domain-containing protein 3
DENND3
1,203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KRG7B3KRG7_HUMAN
DENN domain-containing protein 3
DENND3 hCG_20740
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIR7E5RIR7_HUMAN
DENN domain-containing protein 3
DENND3
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHH2E5RHH2_HUMAN
DENN domain-containing protein 3
DENND3
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI43E5RI43_HUMAN
DENN domain-containing protein 3
DENND3
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ42E5RJ42_HUMAN
DENN domain-containing protein 3
DENND3
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBH5H0YBH5_HUMAN
DENN domain-containing protein 3
DENND3
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAW2H0YAW2_HUMAN
DENN domain-containing protein 3
DENND3
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBK9H0YBK9_HUMAN
DENN domain-containing protein 3
DENND3
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035053143S → N. Corresponds to variant dbSNP:rs307761Ensembl.1
Natural variantiVAR_035054364Q → R. Corresponds to variant dbSNP:rs11997191Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0280751 – 950Missing in isoform 3. 1 PublicationAdd BLAST950
Alternative sequenceiVSP_028077128C → W in isoform 4. 1 Publication1
Alternative sequenceiVSP_028078129 – 1198Missing in isoform 4. 1 PublicationAdd BLAST1070
Alternative sequenceiVSP_028080319 – 370Missing in isoform 2. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_0280811133 – 1198VWVGS…IWKGE → VGWRARHPQHPRQVSLALAA SPCSREPAARPRALLPSPLR VPLLTGTCRVGANGPTGHHV LVSWCGPSTPQRIPPNWMAS NDRT in isoform 3. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK058001 mRNA Translation: BAB71630.1
AK131505 mRNA Translation: BAD18649.1
AC040970 Genomic DNA No translation available.
BC133023 mRNA Translation: AAI33024.1
BC144226 mRNA Translation: AAI44227.1
AB020677 mRNA Translation: BAA74893.2

NCBI Reference Sequences

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RefSeqi
NP_055772.2, NM_014957.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.18166
Hs.714882

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262585; ENSP00000262585; ENSG00000105339 [A2RUS2-1]
ENST00000424248; ENSP00000410594; ENSG00000105339 [A2RUS2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22898

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22898

UCSC genome browser

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UCSCi
uc003yvy.4 human [A2RUS2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058001 mRNA Translation: BAB71630.1
AK131505 mRNA Translation: BAD18649.1
AC040970 Genomic DNA No translation available.
BC133023 mRNA Translation: AAI33024.1
BC144226 mRNA Translation: AAI44227.1
AB020677 mRNA Translation: BAA74893.2
RefSeqiNP_055772.2, NM_014957.2
UniGeneiHs.18166
Hs.714882

3D structure databases

ProteinModelPortaliA2RUS2
SMRiA2RUS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116562, 1 interactor
IntActiA2RUS2, 8 interactors
STRINGi9606.ENSP00000262585

PTM databases

iPTMnetiA2RUS2
PhosphoSitePlusiA2RUS2

Polymorphism and mutation databases

BioMutaiDENND3

Proteomic databases

EPDiA2RUS2
jPOSTiA2RUS2
MaxQBiA2RUS2
PaxDbiA2RUS2
PRIDEiA2RUS2
ProteomicsDBi519
520 [A2RUS2-2]
521 [A2RUS2-3]
522 [A2RUS2-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262585; ENSP00000262585; ENSG00000105339 [A2RUS2-1]
ENST00000424248; ENSP00000410594; ENSG00000105339 [A2RUS2-2]
GeneIDi22898
KEGGihsa:22898
UCSCiuc003yvy.4 human [A2RUS2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22898
DisGeNETi22898
EuPathDBiHostDB:ENSG00000105339.10

GeneCards: human genes, protein and diseases

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GeneCardsi
DENND3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0007822
HGNCiHGNC:29134 DENND3
HPAiHPA024491
HPA041668
MIMi617503 gene
neXtProtiNX_A2RUS2
OpenTargetsiENSG00000105339
PharmGKBiPA142671987

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQM8 Eukaryota
ENOG410XTT7 LUCA
GeneTreeiENSGT00940000155784
HOGENOMiHOG000060114
HOVERGENiHBG095574
InParanoidiA2RUS2
KOiK20162
OrthoDBi521943at2759
PhylomeDBiA2RUS2
TreeFamiTF331814

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkiA2RUS2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DENND3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22898

Protein Ontology

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PROi
PR:A2RUS2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105339 Expressed in 190 organ(s), highest expression level in right lung
ExpressionAtlasiA2RUS2 baseline and differential
GenevisibleiA2RUS2 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR037516 Tripartite_DENN
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02141 DENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEND3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RUS2
Secondary accession number(s): B7ZM28
, O94947, Q2TAM7, Q6ZMS6, Q96DK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: February 13, 2019
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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