UniProtKB - A2RUC4 (TYW5_HUMAN)

BLAST

>sp|A2RUC4|TYW5_HUMAN tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1
MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKI
HVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVAD
IRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLF
SPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISE
EFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARR
MVLHIQDKAYSKNSE

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History
Entry version 92 (12 Sep 2018)
Sequence version 1 (06 Mar 2007)
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Protein

tRNA wybutosine-synthesizing protein 5

Gene

TYW5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.1 Publication

Catalytic activityⁱ

7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O₂ = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO₂.

Cofactorⁱ

Fe²⁺1 PublicationNote: Binds 1 Fe²⁺ ion per subunit.1 Publication

Pathwayⁱ: wybutosine-tRNA(Phe) biosynthesis

This protein is involved in the pathway wybutosine-tRNA(Phe) biosynthesis, which is part of tRNA modification.2 Publications
View all proteins of this organism that are known to be involved in the pathway wybutosine-tRNA(Phe) biosynthesis and in tRNA modification.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	106	2-oxoglutarate1 Publication	1
Metal bindingⁱ	160	Iron; catalytic	1
Metal bindingⁱ	162	Iron; catalytic	1
Binding siteⁱ	166	2-oxoglutarate1 Publication	1
Binding siteⁱ	175	2-oxoglutarate1 Publication	1
Metal bindingⁱ	235	Iron; catalytic	1

GO - Molecular functionⁱ

iron ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20972222
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Source: UniProtKB
Inferred from direct assayⁱ
- 20739293
- 20972222
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20972222
tRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20972222
tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

tRNA modification Source: Reactome
wybutosine biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20739293
- 20972222

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Dioxygenase, Oxidoreductase
Biological process	tRNA processing
Ligand	Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000162971-MONOMER
BRENDAⁱ	1.14.11.42 2681
Reactomeⁱ	R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe)
UniPathwayⁱ	UPA00375

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: tRNA wybutosine-synthesizing protein 5 (EC:1.14.11.42) Short name: hTYW5 Alternative name(s): tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase
Gene namesⁱ	Name:TYW5 Synonyms:C2orf60
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162971.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26754 TYW5
neXtProtⁱ	NX_A2RUC4

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	108	R → A: Abolishes enzyme activity and ability to bind tRNA. 1 Publication		1
Mutagenesisⁱ	149	R → A: Abolishes enzyme activity and ability to bind tRNA. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000162971
PharmGKBⁱ	PA162379298

Polymorphism and mutation databases

BioMutaⁱ	TYW5

BioMutaⁱ

TYW5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000309274	1 – 315	tRNA wybutosine-synthesizing protein 5Add BLAST		315

Proteomic databases

EPDⁱ	A2RUC4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2RUC4
PaxDbⁱ	A2RUC4
PRIDEⁱ	A2RUC4
ProteomicsDBⁱ	511 512 [A2RUC4-2]

PTM databases

iPTMnetⁱ	A2RUC4
PhosphoSitePlusⁱ	A2RUC4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162971 Expressed in 160 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_C2orf60
ExpressionAtlasⁱ	A2RUC4 baseline and differential
Genevisibleⁱ	A2RUC4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028294 HPA045803

HPAⁱ

HPA028294
HPA045803

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20972222

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	126193, 10 interactors
STRINGⁱ	9606.ENSP00000346627

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	10 – 13	Combined sources	4
Helixⁱ	16 – 22	Combined sources	7
Helixⁱ	24 – 26	Combined sources	3
Beta strandⁱ	30 – 34	Combined sources	5
Helixⁱ	40 – 43	Combined sources	4
Helixⁱ	46 – 53	Combined sources	8
Beta strandⁱ	57 – 66	Combined sources	10
Turnⁱ	70 – 72	Combined sources	3
Beta strandⁱ	76 – 81	Combined sources	6
Helixⁱ	82 – 90	Combined sources	9
Beta strandⁱ	106 – 108	Combined sources	3
Turnⁱ	114 – 116	Combined sources	3
Helixⁱ	121 – 124	Combined sources	4
Helixⁱ	126 – 129	Combined sources	4
Helixⁱ	140 – 142	Combined sources	3
Beta strandⁱ	143 – 151	Combined sources	9
Beta strandⁱ	156 – 160	Combined sources	5
Beta strandⁱ	163 – 170	Combined sources	8
Beta strandⁱ	175 – 180	Combined sources	6
Helixⁱ	182 – 188	Combined sources	7
Beta strandⁱ	194 – 196	Combined sources	3
Beta strandⁱ	200 – 202	Combined sources	3
Turnⁱ	205 – 207	Combined sources	3
Helixⁱ	211 – 213	Combined sources	3
Beta strandⁱ	216 – 221	Combined sources	6
Beta strandⁱ	226 – 229	Combined sources	4
Beta strandⁱ	234 – 241	Combined sources	8
Beta strandⁱ	243 – 250	Combined sources	8
Helixⁱ	255 – 257	Combined sources	3
Beta strandⁱ	263 – 265	Combined sources	3
Helixⁱ	270 – 286	Combined sources	17
Helixⁱ	291 – 308	Combined sources	18

Show more details

3D structure databases

ProteinModelPortalⁱ	A2RUC4
SMRⁱ	A2RUC4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	102 – 267	JmjCPROSITE-ProRule annotationAdd BLAST		166

Sequence similaritiesⁱ

Belongs to the TYW5 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2132 Eukaryota ENOG410XQDR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062914
HOVERGENⁱ	HBG096249
InParanoidⁱ	A2RUC4
KEGG Orthology (KO) More...KOⁱ	K18066
OMAⁱ	PLYDDRP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B98
PhylomeDBⁱ	A2RUC4
TreeFamⁱ	TF332364

Family and domain databases

InterProⁱ	View protein in InterPro IPR003347 JmjC_dom IPR029612 TYW5
PANTHERⁱ	PTHR12461:SF50 PTHR12461:SF50, 1 hit
SMARTⁱ	View protein in SMART SM00558 JmjC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51184 JMJC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: A2RUC4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGQHLPVPR LEGVSREQFM QHLYPQRKPL VLEGIDLGPC TSKWTVDYLS 
        60         70         80         90        100
QVGGKKEVKI HVAAVAQMDF ISKNFVYRTL PFDQLVQRAA EEKHKEFFVS 
       110        120        130        140        150
EDEKYYLRSL GEDPRKDVAD IRKQFPLLKG DIKFPEFFKE EQFFSSVFRI 
       160        170        180        190        200
SSPGLQLWTH YDVMDNLLIQ VTGKKRVVLF SPRDAQYLYL KGTKSEVLNI 
       210        220        230        240        250
DNPDLAKYPL FSKARRYECS LEAGDVLFIP ALWFHNVISE EFGVGVNIFW 
       260        270        280        290        300
KHLPSECYDK TDTYGNKDPT AASRAAQILD RALKTLAELP EEYRDFYARR 
       310 
MVLHIQDKAY SKNSE

Length:315

Mass (Da):36,548

Last modified:March 6, 2007 - v1

Checksum:ⁱF291C48E8CA729FE

Isoform 2 (identifier: A2RUC4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-163: Missing.

« Hide

        10         20         30         40         50
MDNLLIQVTG KKRVVLFSPR DAQYLYLKGT KSEVLNIDNP DLAKYPLFSK 
        60         70         80         90        100
ARRYECSLEA GDVLFIPALW FHNVISEEFG VGVNIFWKHL PSECYDKTDT 
       110        120        130        140        150
YGNKDPTAAS RAAQILDRAL KTLAELPEEY RDFYARRMVL HIQDKAYSKN 

SE

Note: No experimental confirmation available.

Show »

Length:152

Mass (Da):17,526

Checksum:ⁱ3FF012BC9E0CAED4

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A8KAJ9	A8KAJ9_HUMAN		cDNA FLJ78342 cDNA FLJ78342 (tRNA wybutosine-synthesizing protein 5)	TYW5	121	Annotation score:

Sequence cautionⁱ

The sequence AAH63502 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036926	50	S → G. Corresponds to variant dbSNP:rs10497844Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_029106	1 – 163	Missing in isoform 2. 1 PublicationAdd BLAST		163

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK095272 mRNA Translation: BAC04517.1 AK298977 mRNA Translation: BAG61071.1 AC097717 Genomic DNA Translation: AAY24162.1 CH471063 Genomic DNA Translation: EAW70191.1 BC063502 mRNA Translation: AAH63502.1 Different initiation. BC132835 mRNA Translation: AAI32836.1 BC136837 mRNA Translation: AAI36838.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42795.1 [A2RUC4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001034782.1, NM_001039693.2 [A2RUC4-1]
UniGeneⁱ	Hs.204619

Genome annotation databases

Ensemblⁱ	ENST00000354611; ENSP00000346627; ENSG00000162971 [A2RUC4-1]
GeneIDⁱ	129450
KEGGⁱ	hsa:129450
UCSC genome browser More...UCSCⁱ	uc002uvi.5 human [A2RUC4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
A2RUC4	Chromosome 2 open reading frame 60		PANTR		315	UniRef100_A2RUC4
Uncharacterized protein		PANPA		315
Uncharacterized protein		NOMLE		315
UPI0001E9293C		HUMAN		338
UPI0004F08862		PANPA		248
A2RUC4-2	Uncharacterized protein		HUMAN		152	UniRef100_A0A024R403
tRNA-yW synthesizing protein 5		PANTR		152
UPI00075F7A90		MACFA		354

Protein	Similar proteins		Species	Score	Length	Source
A2RUC4	Chromosome 2 open reading frame 60		PANTR		315	UniRef90_A2RUC4
Uncharacterized protein		PANPA		315
Uncharacterized protein		NOMLE		315
Uncharacterized protein		Cebus capucinus imitator		315
TYW5 isoform 2		PONAB		315
+114
A2RUC4-2	Uncharacterized protein		HUMAN		152	UniRef90_A0A024R403
tRNA-yW synthesizing protein 5		PANTR		152
UPI00075F7A90		MACFA		354
UPI000B7B178B		PAPAN		354

Protein	Similar proteins		Species	Score	Length	Source
A2RUC4	tRNA wybutosine-synthesizing protein 5		DANRE		326	UniRef50_A2RUC4
tRNA wybutosine-synthesizing protein 5		CHICK		318
tRNA wybutosine-synthesizing protein 5		MOUSE		315
Chromosome 2 open reading frame 60		PANTR		315
Uncharacterized protein		PANPA		315
+439
A2RUC4-2	Uncharacterized protein		MACMU		331	UniRef50_A0A1D5QIK5
Uncharacterized protein		CERAT		331
Uncharacterized protein		MACFA		331
tRNA wybutosine-synthesizing protein 5		AMAAE		284
tRNA wybutosine-synthesizing protein 5 isoform X1		Florida manatee		337
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK095272 mRNA Translation: BAC04517.1 AK298977 mRNA Translation: BAG61071.1 AC097717 Genomic DNA Translation: AAY24162.1 CH471063 Genomic DNA Translation: EAW70191.1 BC063502 mRNA Translation: AAH63502.1 Different initiation. BC132835 mRNA Translation: AAI32836.1 BC136837 mRNA Translation: AAI36838.1
CCDSⁱ	CCDS42795.1 [A2RUC4-1]
RefSeqⁱ	NP_001034782.1, NM_001039693.2 [A2RUC4-1]
UniGeneⁱ	Hs.204619

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3AL5	X-ray	2.50	A/B/C/D	1-315	[»]
	3AL6	X-ray	2.80	A/B/C/D	1-315	[»]
ProteinModelPortalⁱ	A2RUC4
SMRⁱ	A2RUC4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126193, 10 interactors
STRINGⁱ	9606.ENSP00000346627

PTM databases

iPTMnetⁱ	A2RUC4
PhosphoSitePlusⁱ	A2RUC4

Polymorphism and mutation databases

BioMutaⁱ	TYW5

BioMutaⁱ

TYW5

Proteomic databases

EPDⁱ	A2RUC4
MaxQBⁱ	A2RUC4
PaxDbⁱ	A2RUC4
PRIDEⁱ	A2RUC4
ProteomicsDBⁱ	511 512 [A2RUC4-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	129450
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000354611; ENSP00000346627; ENSG00000162971 [A2RUC4-1]
GeneIDⁱ	129450
KEGGⁱ	hsa:129450
UCSCⁱ	uc002uvi.5 human [A2RUC4-1]

Organism-specific databases

CTDⁱ	129450
EuPathDBⁱ	HostDB:ENSG00000162971.10
GeneCardsⁱ	TYW5
H-InvDBⁱ	HIX0002719
HGNCⁱ	HGNC:26754 TYW5
HPAⁱ	HPA028294 HPA045803
neXtProtⁱ	NX_A2RUC4
OpenTargetsⁱ	ENSG00000162971
PharmGKBⁱ	PA162379298
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2132 Eukaryota ENOG410XQDR LUCA
GeneTreeⁱ	ENSGT00530000062914
HOVERGENⁱ	HBG096249
InParanoidⁱ	A2RUC4
KOⁱ	K18066
OMAⁱ	PLYDDRP
OrthoDBⁱ	EOG091G0B98
PhylomeDBⁱ	A2RUC4
TreeFamⁱ	TF332364

Enzyme and pathway databases

UniPathwayⁱ	UPA00375
BioCycⁱ	MetaCyc:ENSG00000162971-MONOMER
BRENDAⁱ	1.14.11.42 2681
Reactomeⁱ	R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe)

Miscellaneous databases

GenomeRNAiⁱ	129450
Protein Ontology More...PROⁱ	PR:A2RUC4

Gene expression databases

Bgeeⁱ	ENSG00000162971 Expressed in 160 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_C2orf60
ExpressionAtlasⁱ	A2RUC4 baseline and differential
Genevisibleⁱ	A2RUC4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003347 JmjC_dom IPR029612 TYW5
PANTHERⁱ	PTHR12461:SF50 PTHR12461:SF50, 1 hit
SMARTⁱ	View protein in SMART SM00558 JmjC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51184 JMJC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TYW5_HUMAN
Accessionⁱ	A2RUC4Primary (citable) accession number: A2RUC4 Secondary accession number(s): B2RNE3, Q8N1R2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	March 6, 2007
	Last modified:	September 12, 2018
	This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniParc

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UniRef

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Supporting data

UniProtKB - A2RUC4 (TYW5_HUMAN)

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tRNA wybutosine-synthesizing protein 5

TYW5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: wybutosine-tRNA(Phe) biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: wybutosine-tRNA(Phe) biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ