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Protein

Meiosis-specific coiled-coil domain-containing protein MEIOC

Gene

MEIOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.By similarity

GO - Biological processi

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis-specific coiled-coil domain-containing protein MEIOCCurated
Alternative name(s):
Meiosis-specific with coiled-coil domain protein1 PublicationImported
Gene namesi
Name:MEIOCImported
Synonyms:C17orf104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000180336.17
HGNCiHGNC:26670 MEIOC
MIMi616934 gene
neXtProtiNX_A2RUB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180336
PharmGKBiPA165431498

Polymorphism and mutation databases

BioMutaiC17orf104

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258001 – 952Meiosis-specific coiled-coil domain-containing protein MEIOCAdd BLAST952

Proteomic databases

EPDiA2RUB1
MaxQBiA2RUB1
PaxDbiA2RUB1
PRIDEiA2RUB1
ProteomicsDBi503
504 [A2RUB1-1]
505 [A2RUB1-2]
506 [A2RUB1-5]

PTM databases

iPTMnetiA2RUB1
PhosphoSitePlusiA2RUB1

Expressioni

Tissue specificityi

Expressed in fetal ovaries (PubMed:26742488). Expressed in testis (PubMed:28380054).2 Publications

Developmental stagei

Expression first detected in wpf (week post-fertilization) 11 and is highest in wpf 22.1 Publication

Gene expression databases

BgeeiENSG00000180336 Expressed in 98 organ(s), highest expression level in testis
ExpressionAtlasiA2RUB1 baseline and differential
GenevisibleiA2RUB1 HS

Organism-specific databases

HPAiHPA027266

Interactioni

Subunit structurei

Interacts with YTHDC2; binds transcript that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally.By similarity

Protein-protein interaction databases

BioGridi129749, 3 interactors
STRINGi9606.ENSP00000386452

Structurei

3D structure databases

ProteinModelPortaliA2RUB1
SMRiA2RUB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFNR Eukaryota
ENOG41116VZ LUCA
GeneTreeiENSGT00390000003267
HOVERGENiHBG080260
InParanoidiA2RUB1
OMAiHTACPAN
OrthoDBiEOG091G0BK8
PhylomeDBiA2RUB1
TreeFamiTF313161

Family and domain databases

InterProiView protein in InterPro
IPR027963 MEIOC
PfamiView protein in Pfam
PF15189 MEIOC, 1 hit
PROSITEiView protein in PROSITE
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: A2RUB1-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF
60 70 80 90 100
GSVMLTGSAS FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW
110 120 130 140 150
STYGDDIKQP SNSQISIKNR IQTERNDYGS ETDLYGLVSN ILEEQDKSQP
160 170 180 190 200
YFAEGTCSSN LKSVWPMNTS RFADHHDLLT ETKRPIDTVI SQQAFYSDES
210 220 230 240 250
VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS RSDHSNCHNI
260 270 280 290 300
QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL
310 320 330 340 350
EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS
360 370 380 390 400
KKLANGTPET PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH
410 420 430 440 450
LTEKQFAKEA VFTADFGLTS EYGLKPHTAC PANDFANVTE KQQFAKPDPP
460 470 480 490 500
HSEYFKSVNL LSNSATSSGG INLNRPTWMN VQTKNNTPIP YRNQGNLMKL
510 520 530 540 550
NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP SAFSSFDFSY
560 570 580 590 600
SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII
610 620 630 640 650
ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR
660 670 680 690 700
GGDNSRVNRT QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV
710 720 730 740 750
VPLLDSYDLL SYDDLSHLYP YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP
760 770 780 790 800
ASELHIRLEE CCEQWRALEK ERKKTELALA KNYPGKKVSS TNNTPVPRLT
810 820 830 840 850
SNPSRVDRLI VDELRELARV VTLLGKMERL RSSLLHASIS TALDRHLESI
860 870 880 890 900
HIVQSRRKDE IVNASNRQRQ GVPRCQDDRD VFALASAIKE MCVATRKTRT
910 920 930 940 950
ALWCALQMTL PKTASTADVV KPLQDTVNCE DKVHESINSS NPMNQRGETN

KH
Length:952
Mass (Da):107,559
Last modified:April 20, 2010 - v3
Checksum:i7455073FCEBEE419
GO
Isoform 2 (identifier: A2RUB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Show »
Length:786
Mass (Da):89,223
Checksum:i9033259D92EB6382
GO
Isoform 3 (identifier: A2RUB1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     821-825: VTLLG → SCKNR
     826-952: Missing.

Show »
Length:659
Mass (Da):75,009
Checksum:iF5EAA6A320FC3562
GO
Isoform 4 (identifier: A2RUB1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     821-825: VTLLG → SCKNR
     826-952: Missing.

Show »
Length:825
Mass (Da):93,345
Checksum:iB45A5332F2733A29
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPA7K7EPA7_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
150Annotation score:
C9JYK8C9JYK8_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
163Annotation score:
C9J4A2C9J4A2_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
129Annotation score:
C9JC06C9JC06_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
71Annotation score:

Sequence cautioni

The sequence AAH35159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI32823 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI36643 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti496N → S in BAG63404 (PubMed:14702039).Curated1
Sequence conflicti552G → S in BAC04083 (PubMed:14702039).Curated1
Sequence conflicti920V → H in BAG63404 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039917311M → L. Corresponds to variant dbSNP:rs8073475Ensembl.1
Natural variantiVAR_039918320N → T2 PublicationsCorresponds to variant dbSNP:rs9907151Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0389711 – 166Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST166
Alternative sequenceiVSP_038972821 – 825VTLLG → SCKNR in isoform 3 and isoform 4. 1 Publication5
Alternative sequenceiVSP_038973826 – 952Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091152 Genomic DNA No translation available.
BC035159 mRNA Translation: AAH35159.1 Different initiation.
BC041481 mRNA Translation: AAH41481.2
BC132822 mRNA Translation: AAI32823.1 Different initiation.
BC136642 mRNA Translation: AAI36643.1 Different initiation.
AK093167 mRNA Translation: BAC04083.1
AK302001 mRNA Translation: BAG63404.1
CCDSiCCDS45703.2 [A2RUB1-4]
RefSeqiNP_001138552.2, NM_001145080.2 [A2RUB1-4]
UniGeneiHs.349758

Genome annotation databases

EnsembliENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4]
ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1]
GeneIDi284071
KEGGihsa:284071
UCSCiuc002igz.4 human [A2RUB1-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091152 Genomic DNA No translation available.
BC035159 mRNA Translation: AAH35159.1 Different initiation.
BC041481 mRNA Translation: AAH41481.2
BC132822 mRNA Translation: AAI32823.1 Different initiation.
BC136642 mRNA Translation: AAI36643.1 Different initiation.
AK093167 mRNA Translation: BAC04083.1
AK302001 mRNA Translation: BAG63404.1
CCDSiCCDS45703.2 [A2RUB1-4]
RefSeqiNP_001138552.2, NM_001145080.2 [A2RUB1-4]
UniGeneiHs.349758

3D structure databases

ProteinModelPortaliA2RUB1
SMRiA2RUB1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129749, 3 interactors
STRINGi9606.ENSP00000386452

PTM databases

iPTMnetiA2RUB1
PhosphoSitePlusiA2RUB1

Polymorphism and mutation databases

BioMutaiC17orf104

Proteomic databases

EPDiA2RUB1
MaxQBiA2RUB1
PaxDbiA2RUB1
PRIDEiA2RUB1
ProteomicsDBi503
504 [A2RUB1-1]
505 [A2RUB1-2]
506 [A2RUB1-5]

Protocols and materials databases

DNASUi284071
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4]
ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1]
GeneIDi284071
KEGGihsa:284071
UCSCiuc002igz.4 human [A2RUB1-4]

Organism-specific databases

CTDi284071
EuPathDBiHostDB:ENSG00000180336.17
GeneCardsiMEIOC
HGNCiHGNC:26670 MEIOC
HPAiHPA027266
MIMi616934 gene
neXtProtiNX_A2RUB1
OpenTargetsiENSG00000180336
PharmGKBiPA165431498
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFNR Eukaryota
ENOG41116VZ LUCA
GeneTreeiENSGT00390000003267
HOVERGENiHBG080260
InParanoidiA2RUB1
OMAiHTACPAN
OrthoDBiEOG091G0BK8
PhylomeDBiA2RUB1
TreeFamiTF313161

Miscellaneous databases

GenomeRNAii284071
PROiPR:A2RUB1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180336 Expressed in 98 organ(s), highest expression level in testis
ExpressionAtlasiA2RUB1 baseline and differential
GenevisibleiA2RUB1 HS

Family and domain databases

InterProiView protein in InterPro
IPR027963 MEIOC
PfamiView protein in Pfam
PF15189 MEIOC, 1 hit
PROSITEiView protein in PROSITE
PS00012 PHOSPHOPANTETHEINE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEIOC_HUMAN
AccessioniPrimary (citable) accession number: A2RUB1
Secondary accession number(s): B4DXJ2
, B5MD93, B9EGQ6, C4AM97, Q4G0Y1, Q8IVZ7, Q8NA45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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