UniProtKB - A2RUB1 (MEIOC_HUMAN)
Protein
Meiosis-specific coiled-coil domain-containing protein MEIOC
Gene
MEIOC
Organism
Homo sapiens (Human)
Status
Functioni
Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.By similarity
GO - Biological processi
- chromosome organization involved in meiotic cell cycle Source: UniProtKB
- double-strand break repair Source: Ensembl
- female meiosis I Source: GO_Central
- germline cell cycle switching, mitotic to meiotic cell cycle Source: UniProtKB
- male meiosis I Source: GO_Central
- metaphase plate congression Source: Ensembl
- mRNA stabilization Source: GO_Central
- oocyte development Source: UniProtKB
- spermatid development Source: UniProtKB
- synaptonemal complex assembly Source: Ensembl
Keywordsi
Biological process | Meiosis |
Enzyme and pathway databases
PathwayCommonsi | A2RUB1 |
Names & Taxonomyi
Protein namesi | Recommended name: Meiosis-specific coiled-coil domain-containing protein MEIOCCuratedAlternative name(s): Meiosis-specific with coiled-coil domain protein1 PublicationImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180336.17 |
HGNCi | HGNC:26670, MEIOC |
MIMi | 616934, gene |
neXtProti | NX_A2RUB1 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000180336 |
PharmGKBi | PA165431498 |
Miscellaneous databases
Pharosi | A2RUB1, Tdark |
Polymorphism and mutation databases
BioMutai | MEIOC |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000325800 | 1 – 952 | Meiosis-specific coiled-coil domain-containing protein MEIOCAdd BLAST | 952 |
Proteomic databases
EPDi | A2RUB1 |
MassIVEi | A2RUB1 |
MaxQBi | A2RUB1 |
PaxDbi | A2RUB1 |
PeptideAtlasi | A2RUB1 |
PRIDEi | A2RUB1 |
ProteomicsDBi | 503 [A2RUB1-4] 504 [A2RUB1-1] 505 [A2RUB1-2] 506 [A2RUB1-5] |
PTM databases
iPTMneti | A2RUB1 |
PhosphoSitePlusi | A2RUB1 |
Expressioni
Tissue specificityi
Developmental stagei
Expression first detected in wpf (week post-fertilization) 11 and is highest in wpf 22.1 Publication
Gene expression databases
Bgeei | ENSG00000180336, Expressed in testis and 120 other tissues |
ExpressionAtlasi | A2RUB1, baseline and differential |
Genevisiblei | A2RUB1, HS |
Organism-specific databases
HPAi | ENSG00000180336, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with YTHDC2; binds transcript that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally.
By similarityProtein-protein interaction databases
BioGRIDi | 129749, 6 interactors |
IntActi | A2RUB1, 3 interactors |
STRINGi | 9606.ENSP00000386452 |
Miscellaneous databases
RNActi | A2RUB1, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QPMP, Eukaryota |
GeneTreei | ENSGT00390000003267 |
HOGENOMi | CLU_015343_0_0_1 |
InParanoidi | A2RUB1 |
OMAi | GANRCWN |
OrthoDBi | 127098at2759 |
PhylomeDBi | A2RUB1 |
TreeFami | TF313161 |
Family and domain databases
InterProi | View protein in InterPro IPR027963, MEIOC |
PANTHERi | PTHR33861, PTHR33861, 1 hit |
Pfami | View protein in Pfam PF15189, MEIOC, 1 hit |
PROSITEi | View protein in PROSITE PS00012, PHOSPHOPANTETHEINE, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A2RUB1-4) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF
60 70 80 90 100
GSVMLTGSAS FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW
110 120 130 140 150
STYGDDIKQP SNSQISIKNR IQTERNDYGS ETDLYGLVSN ILEEQDKSQP
160 170 180 190 200
YFAEGTCSSN LKSVWPMNTS RFADHHDLLT ETKRPIDTVI SQQAFYSDES
210 220 230 240 250
VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS RSDHSNCHNI
260 270 280 290 300
QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL
310 320 330 340 350
EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS
360 370 380 390 400
KKLANGTPET PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH
410 420 430 440 450
LTEKQFAKEA VFTADFGLTS EYGLKPHTAC PANDFANVTE KQQFAKPDPP
460 470 480 490 500
HSEYFKSVNL LSNSATSSGG INLNRPTWMN VQTKNNTPIP YRNQGNLMKL
510 520 530 540 550
NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP SAFSSFDFSY
560 570 580 590 600
SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII
610 620 630 640 650
ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR
660 670 680 690 700
GGDNSRVNRT QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV
710 720 730 740 750
VPLLDSYDLL SYDDLSHLYP YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP
760 770 780 790 800
ASELHIRLEE CCEQWRALEK ERKKTELALA KNYPGKKVSS TNNTPVPRLT
810 820 830 840 850
SNPSRVDRLI VDELRELARV VTLLGKMERL RSSLLHASIS TALDRHLESI
860 870 880 890 900
HIVQSRRKDE IVNASNRQRQ GVPRCQDDRD VFALASAIKE MCVATRKTRT
910 920 930 940 950
ALWCALQMTL PKTASTADVV KPLQDTVNCE DKVHESINSS NPMNQRGETN
KH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JYK8 | C9JYK8_HUMAN | Meiosis-specific coiled-coil domain... | MEIOC | 163 | Annotation score: | ||
C9J4A2 | C9J4A2_HUMAN | Meiosis-specific coiled-coil domain... | MEIOC | 129 | Annotation score: | ||
K7EPA7 | K7EPA7_HUMAN | Meiosis-specific coiled-coil domain... | MEIOC | 150 | Annotation score: | ||
C9JC06 | C9JC06_HUMAN | Meiosis-specific coiled-coil domain... | MEIOC | 71 | Annotation score: |
Sequence cautioni
The sequence AAH35159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI32823 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI36643 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 496 | N → S in BAG63404 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 552 | G → S in BAC04083 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 920 | V → H in BAG63404 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039917 | 311 | M → L. Corresponds to variant dbSNP:rs8073475Ensembl. | 1 | |
Natural variantiVAR_039918 | 320 | N → T2 PublicationsCorresponds to variant dbSNP:rs9907151Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038971 | 1 – 166 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 166 | |
Alternative sequenceiVSP_038972 | 821 – 825 | VTLLG → SCKNR in isoform 3 and isoform 4. 1 Publication | 5 | |
Alternative sequenceiVSP_038973 | 826 – 952 | Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 127 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091152 Genomic DNA No translation available. BC035159 mRNA Translation: AAH35159.1 Different initiation. BC041481 mRNA Translation: AAH41481.2 BC132822 mRNA Translation: AAI32823.1 Different initiation. BC136642 mRNA Translation: AAI36643.1 Different initiation. AK093167 mRNA Translation: BAC04083.1 AK302001 mRNA Translation: BAG63404.1 |
CCDSi | CCDS45703.2 [A2RUB1-4] |
RefSeqi | NP_001138552.2, NM_001145080.2 [A2RUB1-4] |
Genome annotation databases
Ensembli | ENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4] ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1] |
GeneIDi | 284071 |
KEGGi | hsa:284071 |
UCSCi | uc002igz.4, human [A2RUB1-4] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091152 Genomic DNA No translation available. BC035159 mRNA Translation: AAH35159.1 Different initiation. BC041481 mRNA Translation: AAH41481.2 BC132822 mRNA Translation: AAI32823.1 Different initiation. BC136642 mRNA Translation: AAI36643.1 Different initiation. AK093167 mRNA Translation: BAC04083.1 AK302001 mRNA Translation: BAG63404.1 |
CCDSi | CCDS45703.2 [A2RUB1-4] |
RefSeqi | NP_001138552.2, NM_001145080.2 [A2RUB1-4] |
3D structure databases
SMRi | A2RUB1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129749, 6 interactors |
IntActi | A2RUB1, 3 interactors |
STRINGi | 9606.ENSP00000386452 |
PTM databases
iPTMneti | A2RUB1 |
PhosphoSitePlusi | A2RUB1 |
Polymorphism and mutation databases
BioMutai | MEIOC |
Proteomic databases
EPDi | A2RUB1 |
MassIVEi | A2RUB1 |
MaxQBi | A2RUB1 |
PaxDbi | A2RUB1 |
PeptideAtlasi | A2RUB1 |
PRIDEi | A2RUB1 |
ProteomicsDBi | 503 [A2RUB1-4] 504 [A2RUB1-1] 505 [A2RUB1-2] 506 [A2RUB1-5] |
Protocols and materials databases
Antibodypediai | 17505, 39 antibodies |
DNASUi | 284071 |
Genome annotation databases
Ensembli | ENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4] ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1] |
GeneIDi | 284071 |
KEGGi | hsa:284071 |
UCSCi | uc002igz.4, human [A2RUB1-4] |
Organism-specific databases
CTDi | 284071 |
EuPathDBi | HostDB:ENSG00000180336.17 |
GeneCardsi | MEIOC |
HGNCi | HGNC:26670, MEIOC |
HPAi | ENSG00000180336, Tissue enriched (testis) |
MIMi | 616934, gene |
neXtProti | NX_A2RUB1 |
OpenTargetsi | ENSG00000180336 |
PharmGKBi | PA165431498 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPMP, Eukaryota |
GeneTreei | ENSGT00390000003267 |
HOGENOMi | CLU_015343_0_0_1 |
InParanoidi | A2RUB1 |
OMAi | GANRCWN |
OrthoDBi | 127098at2759 |
PhylomeDBi | A2RUB1 |
TreeFami | TF313161 |
Enzyme and pathway databases
PathwayCommonsi | A2RUB1 |
Miscellaneous databases
BioGRID-ORCSi | 284071, 18 hits in 831 CRISPR screens |
GenomeRNAii | 284071 |
Pharosi | A2RUB1, Tdark |
PROi | PR:A2RUB1 |
RNActi | A2RUB1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180336, Expressed in testis and 120 other tissues |
ExpressionAtlasi | A2RUB1, baseline and differential |
Genevisiblei | A2RUB1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027963, MEIOC |
PANTHERi | PTHR33861, PTHR33861, 1 hit |
Pfami | View protein in Pfam PF15189, MEIOC, 1 hit |
PROSITEi | View protein in PROSITE PS00012, PHOSPHOPANTETHEINE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MEIOC_HUMAN | |
Accessioni | A2RUB1Primary (citable) accession number: A2RUB1 Secondary accession number(s): B4DXJ2 Q8NA45 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | April 20, 2010 | |
Last modified: | December 2, 2020 | |
This is version 101 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations