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UniProtKB - A2RUB1 (MEIOC_HUMAN)

Entry version 101 (02 Dec 2020)
Sequence version 3 (20 Apr 2010)
Previous versions | rss
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Protein

Meiosis-specific coiled-coil domain-containing protein MEIOC

Gene

MEIOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMeiosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A2RUB1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Meiosis-specific coiled-coil domain-containing protein MEIOCCurated
Alternative name(s):
Meiosis-specific with coiled-coil domain protein1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEIOCImported
Synonyms:C17orf104
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000180336.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:26670, MEIOC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616934, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A2RUB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000180336

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165431498

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A2RUB1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MEIOC

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258001 – 952Meiosis-specific coiled-coil domain-containing protein MEIOCAdd BLAST952

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A2RUB1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A2RUB1

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2RUB1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2RUB1

PeptideAtlas

More...PeptideAtlasi		A2RUB1

PRoteomics IDEntifications database

More...PRIDEi		A2RUB1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		503 [A2RUB1-4]
504 [A2RUB1-1]
505 [A2RUB1-2]
506 [A2RUB1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2RUB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2RUB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal ovaries (PubMed:26742488). Expressed in testis (PubMed:28380054).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression first detected in wpf (week post-fertilization) 11 and is highest in wpf 22.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000180336, Expressed in testis and 120 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2RUB1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2RUB1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000180336, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YTHDC2; binds transcript that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129749, 6 interactors

Protein interaction database and analysis system

More...IntActi		A2RUB1, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386452

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2RUB1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2RUB1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPMP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003267

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015343_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2RUB1

Identification of Orthologs from Complete Genome Data

More...OMAi		GANRCWN

Database of Orthologous Groups

More...OrthoDBi		127098at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2RUB1

TreeFam database of animal gene trees

More...TreeFami		TF313161

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027963, MEIOC

The PANTHER Classification System

More...PANTHERi		PTHR33861, PTHR33861, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15189, MEIOC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2RUB1-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF 
        60         70         80         90        100
GSVMLTGSAS FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW 
       110        120        130        140        150
STYGDDIKQP SNSQISIKNR IQTERNDYGS ETDLYGLVSN ILEEQDKSQP 
       160        170        180        190        200
YFAEGTCSSN LKSVWPMNTS RFADHHDLLT ETKRPIDTVI SQQAFYSDES 
       210        220        230        240        250
VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS RSDHSNCHNI 
       260        270        280        290        300
QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL 
       310        320        330        340        350
EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS 
       360        370        380        390        400
KKLANGTPET PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH 
       410        420        430        440        450
LTEKQFAKEA VFTADFGLTS EYGLKPHTAC PANDFANVTE KQQFAKPDPP 
       460        470        480        490        500
HSEYFKSVNL LSNSATSSGG INLNRPTWMN VQTKNNTPIP YRNQGNLMKL 
       510        520        530        540        550
NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP SAFSSFDFSY 
       560        570        580        590        600
SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII 
       610        620        630        640        650
ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR 
       660        670        680        690        700
GGDNSRVNRT QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV 
       710        720        730        740        750
VPLLDSYDLL SYDDLSHLYP YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP 
       760        770        780        790        800
ASELHIRLEE CCEQWRALEK ERKKTELALA KNYPGKKVSS TNNTPVPRLT 
       810        820        830        840        850
SNPSRVDRLI VDELRELARV VTLLGKMERL RSSLLHASIS TALDRHLESI 
       860        870        880        890        900
HIVQSRRKDE IVNASNRQRQ GVPRCQDDRD VFALASAIKE MCVATRKTRT 
       910        920        930        940        950
ALWCALQMTL PKTASTADVV KPLQDTVNCE DKVHESINSS NPMNQRGETN 

KH
Length:952
Mass (Da):107,559
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7455073FCEBEE419
GO
Isoform 2 (identifier: A2RUB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Show »
Length:786
Mass (Da):89,223
Checksum:i9033259D92EB6382
GO
Isoform 3 (identifier: A2RUB1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     821-825: VTLLG → SCKNR
     826-952: Missing.

Show »
Length:659
Mass (Da):75,009
Checksum:iF5EAA6A320FC3562
GO
Isoform 4 (identifier: A2RUB1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     821-825: VTLLG → SCKNR
     826-952: Missing.

Show »
Length:825
Mass (Da):93,345
Checksum:iB45A5332F2733A29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYK8C9JYK8_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4A2C9J4A2_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPA7K7EPA7_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JC06C9JC06_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI32823 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI36643 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti496N → S in BAG63404 (PubMed:14702039).Curated1
Sequence conflicti552G → S in BAC04083 (PubMed:14702039).Curated1
Sequence conflicti920V → H in BAG63404 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039917311M → L. Corresponds to variant dbSNP:rs8073475Ensembl.1
Natural variantiVAR_039918320N → T2 PublicationsCorresponds to variant dbSNP:rs9907151Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0389711 – 166Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST166
Alternative sequenceiVSP_038972821 – 825VTLLG → SCKNR in isoform 3 and isoform 4. 1 Publication5
Alternative sequenceiVSP_038973826 – 952Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC091152 Genomic DNA No translation available.
BC035159 mRNA Translation: AAH35159.1 Different initiation.
BC041481 mRNA Translation: AAH41481.2
BC132822 mRNA Translation: AAI32823.1 Different initiation.
BC136642 mRNA Translation: AAI36643.1 Different initiation.
AK093167 mRNA Translation: BAC04083.1
AK302001 mRNA Translation: BAG63404.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45703.2 [A2RUB1-4]

NCBI Reference Sequences

More...RefSeqi		NP_001138552.2, NM_001145080.2 [A2RUB1-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4]
ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		284071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:284071

UCSC genome browser

More...UCSCi		uc002igz.4, human [A2RUB1-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091152 Genomic DNA No translation available.
BC035159 mRNA Translation: AAH35159.1 Different initiation.
BC041481 mRNA Translation: AAH41481.2
BC132822 mRNA Translation: AAI32823.1 Different initiation.
BC136642 mRNA Translation: AAI36643.1 Different initiation.
AK093167 mRNA Translation: BAC04083.1
AK302001 mRNA Translation: BAG63404.1
CCDSiCCDS45703.2 [A2RUB1-4]
RefSeqiNP_001138552.2, NM_001145080.2 [A2RUB1-4]

3D structure databases

SMRiA2RUB1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129749, 6 interactors
IntActiA2RUB1, 3 interactors
STRINGi9606.ENSP00000386452

PTM databases

iPTMnetiA2RUB1
PhosphoSitePlusiA2RUB1

Polymorphism and mutation databases

BioMutaiMEIOC

Proteomic databases

EPDiA2RUB1
MassIVEiA2RUB1
MaxQBiA2RUB1
PaxDbiA2RUB1
PeptideAtlasiA2RUB1
PRIDEiA2RUB1
ProteomicsDBi503 [A2RUB1-4]
504 [A2RUB1-1]
505 [A2RUB1-2]
506 [A2RUB1-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17505, 39 antibodies

The DNASU plasmid repository

More...DNASUi		284071

Genome annotation databases

EnsembliENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4]
ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1]
GeneIDi284071
KEGGihsa:284071
UCSCiuc002igz.4, human [A2RUB1-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		284071
EuPathDBiHostDB:ENSG00000180336.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		MEIOC
HGNCiHGNC:26670, MEIOC
HPAiENSG00000180336, Tissue enriched (testis)
MIMi616934, gene
neXtProtiNX_A2RUB1
OpenTargetsiENSG00000180336
PharmGKBiPA165431498

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPMP, Eukaryota
GeneTreeiENSGT00390000003267
HOGENOMiCLU_015343_0_0_1
InParanoidiA2RUB1
OMAiGANRCWN
OrthoDBi127098at2759
PhylomeDBiA2RUB1
TreeFamiTF313161

Enzyme and pathway databases

PathwayCommonsiA2RUB1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		284071, 18 hits in 831 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		284071
PharosiA2RUB1, Tdark

Protein Ontology

More...PROi		PR:A2RUB1
RNActiA2RUB1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000180336, Expressed in testis and 120 other tissues
ExpressionAtlasiA2RUB1, baseline and differential
GenevisibleiA2RUB1, HS

Family and domain databases

InterProiView protein in InterPro
IPR027963, MEIOC
PANTHERiPTHR33861, PTHR33861, 1 hit
PfamiView protein in Pfam
PF15189, MEIOC, 1 hit
PROSITEiView protein in PROSITE
PS00012, PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEIOC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RUB1
Secondary accession number(s): B4DXJ2
, B5MD93, B9EGQ6, C4AM97, Q4G0Y1, Q8IVZ7, Q8NA45
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 20, 2010
Last modified: December 2, 2020
This is version 101 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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