UniProtKB - A2RUB1 (MEIOC_HUMAN)

BLAST

>sp|A2RUB1|MEIOC_HUMAN Meiosis-specific coiled-coil domain-containing protein MEIOC OS=Homo sapiens OX=9606 GN=MEIOC PE=2 SV=3
MEVRRGDTCPRPHPSGLREEGLEPKVAFPGGANRCWNLGADAGSRLTDVFGSVMLTGSAS
FYDCYTSQSEDNVDLRQTYTPFSSTEYSSSVDSSLFCAPWSTYGDDIKQPSNSQISIKNR
IQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFADHHDLLT
ETKRPIDTVISQQAFYSDESVSAMEKQYLRNSNLTPQQKIDELHHGFTGLDLEEQWMYPS
RSDHSNCHNIQTNDTAKTTFQEYPLIKNCFTPQTGLSDIMKESGVDIYHYGRDRICTKGL
EAPLQQKRAEMFLSQFNRYNENVDYCRYPEYVHPNKAKLNKCSNFSVQDSKKLANGTPET
PTVEADTYTKLFQVKPANQKKMEETIPDQQNFTFPKTTPHLTEKQFAKEAVFTADFGLTS
EYGLKPHTACPANDFANVTEKQQFAKPDPPHSEYFKSVNLLSNSATSSGGINLNRPTWMN
VQTKNNTPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTPNSNLFQKYCQENP
SAFSSFDFSYSGAERIQSVNHIEGLTKPGEENLFKLVTDKKIKQPNGFCDNYSAQKYGII
ENVNKHNFQAKPQSGHYDPEEGPKHLDGLSQNTYQDLLESQGHSNSHRTRGGDNSRVNRT
QVSCFSNNYMMGDLRHNQCFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLLSYDDLSHLYP
YFNMMYGDNSFSGLMPTFGFQRPIKTRSGPASELHIRLEECCEQWRALEKERKKTELALA
KNYPGKKVSSTNNTPVPRLTSNPSRVDRLIVDELRELARVVTLLGKMERLRSSLLHASIS
TALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALASAIKEMCVATRKTRT
ALWCALQMTLPKTASTADVVKPLQDTVNCEDKVHESINSSNPMNQRGETNKH

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History
Entry version 87 (12 Sep 2018)
Sequence version 3 (20 Apr 2010)
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Protein

Meiosis-specific coiled-coil domain-containing protein MEIOC

Gene

MEIOC

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.By similarity

GO - Biological processⁱ

chromosome organization involved in meiotic cell cycle Source: UniProtKB
double-strand break repair Source: Ensembl
female meiosis I Source: Ensembl
germline cell cycle switching, mitotic to meiotic cell cycle Source: UniProtKB
male meiosis I Source: Ensembl
metaphase plate congression Source: Ensembl
mRNA stabilization Source: Ensembl
oocyte development Source: UniProtKB
spermatid development Source: UniProtKB
synaptonemal complex assembly Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Meiosis

Biological process

Meiosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Meiosis-specific coiled-coil domain-containing protein MEIOCCurated Alternative name(s): Meiosis-specific with coiled-coil domain protein1 PublicationImported
Gene namesⁱ	Name:MEIOCImported Synonyms:C17orf104
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180336.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26670 MEIOC
MIMⁱ	616934 gene
neXtProtⁱ	NX_A2RUB1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000180336
PharmGKBⁱ	PA165431498

Polymorphism and mutation databases

BioMutaⁱ	C17orf104

BioMutaⁱ

C17orf104

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000325800	1 – 952	Meiosis-specific coiled-coil domain-containing protein MEIOCAdd BLAST		952

Proteomic databases

EPDⁱ	A2RUB1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2RUB1
PaxDbⁱ	A2RUB1
PRIDEⁱ	A2RUB1
ProteomicsDBⁱ	503 504 [A2RUB1-1] 505 [A2RUB1-2] 506 [A2RUB1-5]

PTM databases

iPTMnetⁱ	A2RUB1
PhosphoSitePlusⁱ	A2RUB1

Expressionⁱ

Tissue specificityⁱ

Expressed in fetal ovaries (PubMed:26742488). Expressed in testis (PubMed:28380054).2 Publications

Developmental stageⁱ

Expression first detected in wpf (week post-fertilization) 11 and is highest in wpf 22.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000180336 Expressed in 98 organ(s), highest expression level in testis
ExpressionAtlasⁱ	A2RUB1 baseline and differential
Genevisibleⁱ	A2RUB1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027266

HPAⁱ

HPA027266

Interactionⁱ

Subunit structureⁱ

Interacts with YTHDC2; binds transcript that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally.By similarity

Protein-protein interaction databases

BioGridⁱ	129749, 3 interactors
STRINGⁱ	9606.ENSP00000386452

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2RUB1
SMRⁱ	A2RUB1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IFNR Eukaryota ENOG41116VZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003267
HOVERGENⁱ	HBG080260
InParanoidⁱ	A2RUB1
OMAⁱ	HTACPAN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BK8
PhylomeDBⁱ	A2RUB1
TreeFamⁱ	TF313161

Family and domain databases

InterProⁱ	View protein in InterPro IPR027963 MEIOC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15189 MEIOC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: A2RUB1-4) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF 
        60         70         80         90        100
GSVMLTGSAS FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW 
       110        120        130        140        150
STYGDDIKQP SNSQISIKNR IQTERNDYGS ETDLYGLVSN ILEEQDKSQP 
       160        170        180        190        200
YFAEGTCSSN LKSVWPMNTS RFADHHDLLT ETKRPIDTVI SQQAFYSDES 
       210        220        230        240        250
VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS RSDHSNCHNI 
       260        270        280        290        300
QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL 
       310        320        330        340        350
EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS 
       360        370        380        390        400
KKLANGTPET PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH 
       410        420        430        440        450
LTEKQFAKEA VFTADFGLTS EYGLKPHTAC PANDFANVTE KQQFAKPDPP 
       460        470        480        490        500
HSEYFKSVNL LSNSATSSGG INLNRPTWMN VQTKNNTPIP YRNQGNLMKL 
       510        520        530        540        550
NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP SAFSSFDFSY 
       560        570        580        590        600
SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII 
       610        620        630        640        650
ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR 
       660        670        680        690        700
GGDNSRVNRT QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV 
       710        720        730        740        750
VPLLDSYDLL SYDDLSHLYP YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP 
       760        770        780        790        800
ASELHIRLEE CCEQWRALEK ERKKTELALA KNYPGKKVSS TNNTPVPRLT 
       810        820        830        840        850
SNPSRVDRLI VDELRELARV VTLLGKMERL RSSLLHASIS TALDRHLESI 
       860        870        880        890        900
HIVQSRRKDE IVNASNRQRQ GVPRCQDDRD VFALASAIKE MCVATRKTRT 
       910        920        930        940        950
ALWCALQMTL PKTASTADVV KPLQDTVNCE DKVHESINSS NPMNQRGETN 

KH

Length:952

Mass (Da):107,559

Last modified:April 20, 2010 - v3

Checksum:ⁱ7455073FCEBEE419

Isoform 2 (identifier: A2RUB1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-166: Missing.

« Hide

        10         20         30         40         50
MNTSRFADHH DLLTETKRPI DTVISQQAFY SDESVSAMEK QYLRNSNLTP 
        60         70         80         90        100
QQKIDELHHG FTGLDLEEQW MYPSRSDHSN CHNIQTNDTA KTTFQEYPLI 
       110        120        130        140        150
KNCFTPQTGL SDIMKESGVD IYHYGRDRIC TKGLEAPLQQ KRAEMFLSQF 
       160        170        180        190        200
NRYNENVDYC RYPEYVHPNK AKLNKCSNFS VQDSKKLANG TPETPTVEAD 
       210        220        230        240        250
TYTKLFQVKP ANQKKMEETI PDQQNFTFPK TTPHLTEKQF AKEAVFTADF 
       260        270        280        290        300
GLTSEYGLKP HTACPANDFA NVTEKQQFAK PDPPHSEYFK SVNLLSNSAT 
       310        320        330        340        350
SSGGINLNRP TWMNVQTKNN TPIPYRNQGN LMKLNSHLSA ASKGSNHSSD 
       360        370        380        390        400
FPQLSSTNLT PNSNLFQKYC QENPSAFSSF DFSYSGAERI QSVNHIEGLT 
       410        420        430        440        450
KPGEENLFKL VTDKKIKQPN GFCDNYSAQK YGIIENVNKH NFQAKPQSGH 
       460        470        480        490        500
YDPEEGPKHL DGLSQNTYQD LLESQGHSNS HRTRGGDNSR VNRTQVSCFS 
       510        520        530        540        550
NNYMMGDLRH NQCFQQLGSN GFPLRSTHPF GHSVVPLLDS YDLLSYDDLS 
       560        570        580        590        600
HLYPYFNMMY GDNSFSGLMP TFGFQRPIKT RSGPASELHI RLEECCEQWR 
       610        620        630        640        650
ALEKERKKTE LALAKNYPGK KVSSTNNTPV PRLTSNPSRV DRLIVDELRE 
       660        670        680        690        700
LARVVTLLGK MERLRSSLLH ASISTALDRH LESIHIVQSR RKDEIVNASN 
       710        720        730        740        750
RQRQGVPRCQ DDRDVFALAS AIKEMCVATR KTRTALWCAL QMTLPKTAST 
       760        770        780 
ADVVKPLQDT VNCEDKVHES INSSNPMNQR GETNKH

Show »

Length:786

Mass (Da):89,223

Checksum:ⁱ9033259D92EB6382

Isoform 3 (identifier: A2RUB1-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     821-825: VTLLG → SCKNR
     826-952: Missing.

« Hide

        10         20         30         40         50
MNTSRFADHH DLLTETKRPI DTVISQQAFY SDESVSAMEK QYLRNSNLTP 
        60         70         80         90        100
QQKIDELHHG FTGLDLEEQW MYPSRSDHSN CHNIQTNDTA KTTFQEYPLI 
       110        120        130        140        150
KNCFTPQTGL SDIMKESGVD IYHYGRDRIC TKGLEAPLQQ KRAEMFLSQF 
       160        170        180        190        200
NRYNENVDYC RYPEYVHPNK AKLNKCSNFS VQDSKKLANG TPETPTVEAD 
       210        220        230        240        250
TYTKLFQVKP ANQKKMEETI PDQQNFTFPK TTPHLTEKQF AKEAVFTADF 
       260        270        280        290        300
GLTSEYGLKP HTACPANDFA NVTEKQQFAK PDPPHSEYFK SVNLLSNSAT 
       310        320        330        340        350
SSGGINLNRP TWMNVQTKNN TPIPYRNQGN LMKLNSHLSA ASKGSNHSSD 
       360        370        380        390        400
FPQLSSTNLT PNSNLFQKYC QENPSAFSSF DFSYSGAERI QSVNHIEGLT 
       410        420        430        440        450
KPGEENLFKL VTDKKIKQPN GFCDNYSAQK YGIIENVNKH NFQAKPQSGH 
       460        470        480        490        500
YDPEEGPKHL DGLSQNTYQD LLESQGHSNS HRTRGGDNSR VNRTQVSCFS 
       510        520        530        540        550
NNYMMGDLRH NQCFQQLGSN GFPLRSTHPF GHSVVPLLDS YDLLSYDDLS 
       560        570        580        590        600
HLYPYFNMMY GDNSFSGLMP TFGFQRPIKT RSGPASELHI RLEECCEQWR 
       610        620        630        640        650
ALEKERKKTE LALAKNYPGK KVSSTNNTPV PRLTSNPSRV DRLIVDELRE 

LARVSCKNR

Show »

Length:659

Mass (Da):75,009

Checksum:ⁱF5EAA6A320FC3562

Isoform 4 (identifier: A2RUB1-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
821-825: VTLLG → SCKNR
826-952: Missing.

« Hide

        10         20         30         40         50
MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF 
        60         70         80         90        100
GSVMLTGSAS FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW 
       110        120        130        140        150
STYGDDIKQP SNSQISIKNR IQTERNDYGS ETDLYGLVSN ILEEQDKSQP 
       160        170        180        190        200
YFAEGTCSSN LKSVWPMNTS RFADHHDLLT ETKRPIDTVI SQQAFYSDES 
       210        220        230        240        250
VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS RSDHSNCHNI 
       260        270        280        290        300
QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL 
       310        320        330        340        350
EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS 
       360        370        380        390        400
KKLANGTPET PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH 
       410        420        430        440        450
LTEKQFAKEA VFTADFGLTS EYGLKPHTAC PANDFANVTE KQQFAKPDPP 
       460        470        480        490        500
HSEYFKSVNL LSNSATSSGG INLNRPTWMN VQTKNNTPIP YRNQGNLMKL 
       510        520        530        540        550
NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP SAFSSFDFSY 
       560        570        580        590        600
SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII 
       610        620        630        640        650
ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR 
       660        670        680        690        700
GGDNSRVNRT QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV 
       710        720        730        740        750
VPLLDSYDLL SYDDLSHLYP YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP 
       760        770        780        790        800
ASELHIRLEE CCEQWRALEK ERKKTELALA KNYPGKKVSS TNNTPVPRLT 
       810        820 
SNPSRVDRLI VDELRELARV SCKNR

Show »

Length:825

Mass (Da):93,345

Checksum:ⁱB45A5332F2733A29

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
K7EPA7	K7EPA7_HUMAN	Meiosis-specific coiled-coil domain... Meiosis-specific coiled-coil domain-containing protein MEIOC	MEIOC	150	Annotation score:
C9JYK8	C9JYK8_HUMAN	Meiosis-specific coiled-coil domain... Meiosis-specific coiled-coil domain-containing protein MEIOC	MEIOC	163	Annotation score:
C9J4A2	C9J4A2_HUMAN	Meiosis-specific coiled-coil domain... Meiosis-specific coiled-coil domain-containing protein MEIOC	MEIOC	129	Annotation score:
C9JC06	C9JC06_HUMAN	Meiosis-specific coiled-coil domain... Meiosis-specific coiled-coil domain-containing protein MEIOC	MEIOC	71	Annotation score:

Sequence cautionⁱ

The sequence AAH35159 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAI32823 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAI36643 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	496	N → S in BAG63404 (PubMed:14702039).Curated	1
Sequence conflictⁱ	552	G → S in BAC04083 (PubMed:14702039).Curated	1
Sequence conflictⁱ	920	V → H in BAG63404 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039917	311	M → L. Corresponds to variant dbSNP:rs8073475Ensembl.		1
Natural variantⁱVAR_039918	320	N → T2 PublicationsCorresponds to variant dbSNP:rs9907151Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_038971	1 – 166	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	166
Alternative sequenceⁱVSP_038972	821 – 825	VTLLG → SCKNR in isoform 3 and isoform 4. 1 Publication	5
Alternative sequenceⁱVSP_038973	826 – 952	Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST	127

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC091152 Genomic DNA No translation available. BC035159 mRNA Translation: AAH35159.1 Different initiation. BC041481 mRNA Translation: AAH41481.2 BC132822 mRNA Translation: AAI32823.1 Different initiation. BC136642 mRNA Translation: AAI36643.1 Different initiation. AK093167 mRNA Translation: BAC04083.1 AK302001 mRNA Translation: BAG63404.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45703.2 [A2RUB1-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001138552.2, NM_001145080.2 [A2RUB1-4]
UniGeneⁱ	Hs.349758

Genome annotation databases

Ensemblⁱ	ENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4] ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1]
GeneIDⁱ	284071
KEGGⁱ	hsa:284071
UCSC genome browser More...UCSCⁱ	uc002igz.4 human [A2RUB1-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC (Fragment)		HUMAN		163	UniRef100_A2RUB1
Meiosis-specific coiled-coil domain-containing protein MEIOC (Fragment)		HUMAN		129
Isoform 2 of Meiosis-specific coiled-coil domain-containing protein MEIOC		HUMAN		786

Protein	Similar proteins		Species	Score	Length	Source
A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC (Fragment)		HUMAN		163	UniRef90_A2RUB1
Meiosis specific with coiled-coil domain		RABIT		1035
meiosis-specific coiled-coil domain-containing protein MEIOC		ERIEU		960
Meiosis specific with coiled-coil domain		PIG		960
Meiosis specific with coiled-coil domain		Cebus capucinus imitator		953
+25
A2RUB1-1	Isoform 4 of Meiosis-specific coiled-coil domain-containing protein MEIOC		HUMAN		825	UniRef90_A2RUB1-5
Uncharacterized protein		AOTNA		955
Meiosis specific with coiled-coil domain		CALJA		954
Uncharacterized protein		AOTNA		946
UPI0006255B00		AOTNA		833
+2
A2RUB1-5	Isoform 3 of Meiosis-specific coiled-coil domain-containing protein MEIOC		HUMAN		659	UniRef90_A2RUB1-5
Uncharacterized protein		AOTNA		955
Meiosis specific with coiled-coil domain		CALJA		954
Uncharacterized protein		AOTNA		946
UPI0006255B00		AOTNA		833
+2

Protein	Similar proteins		Species	Score	Length	Source
A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC		MOUSE		965	UniRef50_A2AG06
uncharacterized protein C17orf104 homolog		MESAU		960
Uncharacterized protein		ANAPL		127
Uncharacterized protein C17orf104 (Fragment)		CALAN		244
Uncharacterized protein		AMAAE		929
+164

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC091152 Genomic DNA No translation available. BC035159 mRNA Translation: AAH35159.1 Different initiation. BC041481 mRNA Translation: AAH41481.2 BC132822 mRNA Translation: AAI32823.1 Different initiation. BC136642 mRNA Translation: AAI36643.1 Different initiation. AK093167 mRNA Translation: BAC04083.1 AK302001 mRNA Translation: BAG63404.1
CCDSⁱ	CCDS45703.2 [A2RUB1-4]
RefSeqⁱ	NP_001138552.2, NM_001145080.2 [A2RUB1-4]
UniGeneⁱ	Hs.349758

3D structure databases

ProteinModelPortalⁱ	A2RUB1
SMRⁱ	A2RUB1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129749, 3 interactors
STRINGⁱ	9606.ENSP00000386452

PTM databases

iPTMnetⁱ	A2RUB1
PhosphoSitePlusⁱ	A2RUB1

Polymorphism and mutation databases

BioMutaⁱ	C17orf104

BioMutaⁱ

C17orf104

Proteomic databases

EPDⁱ	A2RUB1
MaxQBⁱ	A2RUB1
PaxDbⁱ	A2RUB1
PRIDEⁱ	A2RUB1
ProteomicsDBⁱ	503 504 [A2RUB1-1] 505 [A2RUB1-2] 506 [A2RUB1-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	284071
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4] ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1]
GeneIDⁱ	284071
KEGGⁱ	hsa:284071
UCSCⁱ	uc002igz.4 human [A2RUB1-4]

Organism-specific databases

CTDⁱ	284071
EuPathDBⁱ	HostDB:ENSG00000180336.17
GeneCardsⁱ	MEIOC
HGNCⁱ	HGNC:26670 MEIOC
HPAⁱ	HPA027266
MIMⁱ	616934 gene
neXtProtⁱ	NX_A2RUB1
OpenTargetsⁱ	ENSG00000180336
PharmGKBⁱ	PA165431498
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFNR Eukaryota ENOG41116VZ LUCA
GeneTreeⁱ	ENSGT00390000003267
HOVERGENⁱ	HBG080260
InParanoidⁱ	A2RUB1
OMAⁱ	HTACPAN
OrthoDBⁱ	EOG091G0BK8
PhylomeDBⁱ	A2RUB1
TreeFamⁱ	TF313161

Miscellaneous databases

GenomeRNAiⁱ	284071
Protein Ontology More...PROⁱ	PR:A2RUB1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180336 Expressed in 98 organ(s), highest expression level in testis
ExpressionAtlasⁱ	A2RUB1 baseline and differential
Genevisibleⁱ	A2RUB1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027963 MEIOC
Pfamⁱ	View protein in Pfam PF15189 MEIOC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00012 PHOSPHOPANTETHEINE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MEIOC_HUMAN
Accessionⁱ	A2RUB1Primary (citable) accession number: A2RUB1 Secondary accession number(s): B4DXJ2 Q8NA45
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	April 20, 2010
	Last modified:	September 12, 2018
	This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A2RUB1 (MEIOC_HUMAN)

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Meiosis-specific coiled-coil domain-containing protein MEIOC

MEIOC

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Functionⁱ

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Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

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