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Entry version 90 (16 Jan 2019)
Sequence version 3 (20 Apr 2010)
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Protein

Meiosis-specific coiled-coil domain-containing protein MEIOC

Gene

MEIOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMeiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Meiosis-specific coiled-coil domain-containing protein MEIOCCurated
Alternative name(s):
Meiosis-specific with coiled-coil domain protein1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEIOCImported
Synonyms:C17orf104
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180336.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26670 MEIOC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616934 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2RUB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000180336

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165431498

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MEIOC

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258001 – 952Meiosis-specific coiled-coil domain-containing protein MEIOCAdd BLAST952

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2RUB1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2RUB1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2RUB1

PRoteomics IDEntifications database

More...
PRIDEi
A2RUB1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
503
504 [A2RUB1-1]
505 [A2RUB1-2]
506 [A2RUB1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2RUB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2RUB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal ovaries (PubMed:26742488). Expressed in testis (PubMed:28380054).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression first detected in wpf (week post-fertilization) 11 and is highest in wpf 22.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180336 Expressed in 98 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2RUB1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2RUB1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027266

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YTHDC2; binds transcript that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129749, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2RUB1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2RUB1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFNR Eukaryota
ENOG41116VZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003267

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080260

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2RUB1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTACPAN

Database of Orthologous Groups

More...
OrthoDBi
127098at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2RUB1

TreeFam database of animal gene trees

More...
TreeFami
TF313161

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027963 MEIOC

The PANTHER Classification System

More...
PANTHERi
PTHR33861 PTHR33861, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15189 MEIOC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2RUB1-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVRRGDTCP RPHPSGLREE GLEPKVAFPG GANRCWNLGA DAGSRLTDVF
60 70 80 90 100
GSVMLTGSAS FYDCYTSQSE DNVDLRQTYT PFSSTEYSSS VDSSLFCAPW
110 120 130 140 150
STYGDDIKQP SNSQISIKNR IQTERNDYGS ETDLYGLVSN ILEEQDKSQP
160 170 180 190 200
YFAEGTCSSN LKSVWPMNTS RFADHHDLLT ETKRPIDTVI SQQAFYSDES
210 220 230 240 250
VSAMEKQYLR NSNLTPQQKI DELHHGFTGL DLEEQWMYPS RSDHSNCHNI
260 270 280 290 300
QTNDTAKTTF QEYPLIKNCF TPQTGLSDIM KESGVDIYHY GRDRICTKGL
310 320 330 340 350
EAPLQQKRAE MFLSQFNRYN ENVDYCRYPE YVHPNKAKLN KCSNFSVQDS
360 370 380 390 400
KKLANGTPET PTVEADTYTK LFQVKPANQK KMEETIPDQQ NFTFPKTTPH
410 420 430 440 450
LTEKQFAKEA VFTADFGLTS EYGLKPHTAC PANDFANVTE KQQFAKPDPP
460 470 480 490 500
HSEYFKSVNL LSNSATSSGG INLNRPTWMN VQTKNNTPIP YRNQGNLMKL
510 520 530 540 550
NSHLSAASKG SNHSSDFPQL SSTNLTPNSN LFQKYCQENP SAFSSFDFSY
560 570 580 590 600
SGAERIQSVN HIEGLTKPGE ENLFKLVTDK KIKQPNGFCD NYSAQKYGII
610 620 630 640 650
ENVNKHNFQA KPQSGHYDPE EGPKHLDGLS QNTYQDLLES QGHSNSHRTR
660 670 680 690 700
GGDNSRVNRT QVSCFSNNYM MGDLRHNQCF QQLGSNGFPL RSTHPFGHSV
710 720 730 740 750
VPLLDSYDLL SYDDLSHLYP YFNMMYGDNS FSGLMPTFGF QRPIKTRSGP
760 770 780 790 800
ASELHIRLEE CCEQWRALEK ERKKTELALA KNYPGKKVSS TNNTPVPRLT
810 820 830 840 850
SNPSRVDRLI VDELRELARV VTLLGKMERL RSSLLHASIS TALDRHLESI
860 870 880 890 900
HIVQSRRKDE IVNASNRQRQ GVPRCQDDRD VFALASAIKE MCVATRKTRT
910 920 930 940 950
ALWCALQMTL PKTASTADVV KPLQDTVNCE DKVHESINSS NPMNQRGETN

KH
Length:952
Mass (Da):107,559
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7455073FCEBEE419
GO
Isoform 2 (identifier: A2RUB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Show »
Length:786
Mass (Da):89,223
Checksum:i9033259D92EB6382
GO
Isoform 3 (identifier: A2RUB1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     821-825: VTLLG → SCKNR
     826-952: Missing.

Show »
Length:659
Mass (Da):75,009
Checksum:iF5EAA6A320FC3562
GO
Isoform 4 (identifier: A2RUB1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     821-825: VTLLG → SCKNR
     826-952: Missing.

Show »
Length:825
Mass (Da):93,345
Checksum:iB45A5332F2733A29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYK8C9JYK8_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4A2C9J4A2_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPA7K7EPA7_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JC06C9JC06_HUMAN
Meiosis-specific coiled-coil domain...
MEIOC
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI32823 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI36643 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti496N → S in BAG63404 (PubMed:14702039).Curated1
Sequence conflicti552G → S in BAC04083 (PubMed:14702039).Curated1
Sequence conflicti920V → H in BAG63404 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039917311M → L. Corresponds to variant dbSNP:rs8073475Ensembl.1
Natural variantiVAR_039918320N → T2 PublicationsCorresponds to variant dbSNP:rs9907151Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0389711 – 166Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST166
Alternative sequenceiVSP_038972821 – 825VTLLG → SCKNR in isoform 3 and isoform 4. 1 Publication5
Alternative sequenceiVSP_038973826 – 952Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC091152 Genomic DNA No translation available.
BC035159 mRNA Translation: AAH35159.1 Different initiation.
BC041481 mRNA Translation: AAH41481.2
BC132822 mRNA Translation: AAI32823.1 Different initiation.
BC136642 mRNA Translation: AAI36643.1 Different initiation.
AK093167 mRNA Translation: BAC04083.1
AK302001 mRNA Translation: BAG63404.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45703.2 [A2RUB1-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001138552.2, NM_001145080.2 [A2RUB1-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.349758

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4]
ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
284071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:284071

UCSC genome browser

More...
UCSCi
uc002igz.4 human [A2RUB1-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091152 Genomic DNA No translation available.
BC035159 mRNA Translation: AAH35159.1 Different initiation.
BC041481 mRNA Translation: AAH41481.2
BC132822 mRNA Translation: AAI32823.1 Different initiation.
BC136642 mRNA Translation: AAI36643.1 Different initiation.
AK093167 mRNA Translation: BAC04083.1
AK302001 mRNA Translation: BAG63404.1
CCDSiCCDS45703.2 [A2RUB1-4]
RefSeqiNP_001138552.2, NM_001145080.2 [A2RUB1-4]
UniGeneiHs.349758

3D structure databases

ProteinModelPortaliA2RUB1
SMRiA2RUB1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129749, 3 interactors
STRINGi9606.ENSP00000386452

PTM databases

iPTMnetiA2RUB1
PhosphoSitePlusiA2RUB1

Polymorphism and mutation databases

BioMutaiMEIOC

Proteomic databases

EPDiA2RUB1
MaxQBiA2RUB1
PaxDbiA2RUB1
PRIDEiA2RUB1
ProteomicsDBi503
504 [A2RUB1-1]
505 [A2RUB1-2]
506 [A2RUB1-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
284071
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409122; ENSP00000386452; ENSG00000180336 [A2RUB1-4]
ENST00000409464; ENSP00000386586; ENSG00000180336 [A2RUB1-1]
GeneIDi284071
KEGGihsa:284071
UCSCiuc002igz.4 human [A2RUB1-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284071
EuPathDBiHostDB:ENSG00000180336.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MEIOC
HGNCiHGNC:26670 MEIOC
HPAiHPA027266
MIMi616934 gene
neXtProtiNX_A2RUB1
OpenTargetsiENSG00000180336
PharmGKBiPA165431498

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFNR Eukaryota
ENOG41116VZ LUCA
GeneTreeiENSGT00390000003267
HOVERGENiHBG080260
InParanoidiA2RUB1
OMAiHTACPAN
OrthoDBi127098at2759
PhylomeDBiA2RUB1
TreeFamiTF313161

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284071

Protein Ontology

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PROi
PR:A2RUB1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000180336 Expressed in 98 organ(s), highest expression level in testis
ExpressionAtlasiA2RUB1 baseline and differential
GenevisibleiA2RUB1 HS

Family and domain databases

InterProiView protein in InterPro
IPR027963 MEIOC
PANTHERiPTHR33861 PTHR33861, 1 hit
PfamiView protein in Pfam
PF15189 MEIOC, 1 hit
PROSITEiView protein in PROSITE
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEIOC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RUB1
Secondary accession number(s): B4DXJ2
, B5MD93, B9EGQ6, C4AM97, Q4G0Y1, Q8IVZ7, Q8NA45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 20, 2010
Last modified: January 16, 2019
This is version 90 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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