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Protein

Homeobox protein HMX2

Gene

HMX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi149 – 208HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein HMX2
Alternative name(s):
Homeobox protein H6 family member 2
Gene namesi
Name:HMX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000188816.3
HGNCiHGNC:5018 HMX2
MIMi600647 gene
neXtProtiNX_A2RU54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188816
PharmGKBiPA29345

Polymorphism and mutation databases

BioMutaiHMX2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943661 – 273Homeobox protein HMX2Add BLAST273

Proteomic databases

EPDiA2RU54
PaxDbiA2RU54
PRIDEiA2RU54
ProteomicsDBi500
TopDownProteomicsiA2RU54

PTM databases

iPTMnetiA2RU54
PhosphoSitePlusiA2RU54

Expressioni

Gene expression databases

BgeeiENSG00000188816
CleanExiHS_HMX2
GenevisibleiA2RU54 HS

Organism-specific databases

HPAiHPA043379

Interactioni

Protein-protein interaction databases

IntActiA2RU54, 2 interactors
STRINGi9606.ENSP00000341108

Structurei

3D structure databases

ProteinModelPortaliA2RU54
SMRiA2RU54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0485 Eukaryota
ENOG4111R8D LUCA
GeneTreeiENSGT00910000144003
HOGENOMiHOG000231923
HOVERGENiHBG045543
InParanoidiA2RU54
KOiK09349
OMAiPFPCLGT
OrthoDBiEOG091G0RNV
PhylomeDBiA2RU54
TreeFamiTF320562

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2RU54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS
60 70 80 90 100
SEEEEPDDGW KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP
110 120 130 140 150
GGLERTPFLS PSHSDFKEEK ERLLPAGSPS PGSERPRDGG AERQAGAAKK
160 170 180 190 200
KTRTVFSRSQ VYQLESTFDM KRYLSSSERA CLASSLQLTE TQVKTWFQNR
210 220 230 240 250
RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV PVPRSLAFPA
260 270
PLYYPGSNLS ALPLYNLYNK LDY
Length:273
Mass (Da):29,598
Last modified:March 6, 2007 - v1
Checksum:i1100C836F8D131F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471066 Genomic DNA Translation: EAW49288.1
BC132758 mRNA Translation: AAI32759.1
BC137139 mRNA Translation: AAI37140.1
CCDSiCCDS31305.1
RefSeqiNP_005510.1, NM_005519.1
XP_005269800.1, XM_005269743.3
UniGeneiHs.444756

Genome annotation databases

EnsembliENST00000339992; ENSP00000341108; ENSG00000188816
GeneIDi3167
KEGGihsa:3167
UCSCiuc001lhc.1 human

Similar proteinsi

Entry informationi

Entry nameiHMX2_HUMAN
AccessioniPrimary (citable) accession number: A2RU54
Secondary accession number(s): B2RNV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 6, 2007
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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