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Entry version 79 (13 Feb 2019)
Sequence version 1 (06 Mar 2007)
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Protein

Single-pass membrane and coiled-coil domain-containing protein 3

Gene

SMCO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Single-pass membrane and coiled-coil domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMCO3
Synonyms:C12orf69
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000179256.2

Human Gene Nomenclature Database

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HGNCi
HGNC:34401 SMCO3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2RU48

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei155 – 175HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000179256

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162378005

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMCO3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003369881 – 225Single-pass membrane and coiled-coil domain-containing protein 3Add BLAST225

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2RU48

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2RU48

PRoteomics IDEntifications database

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PRIDEi
A2RU48

ProteomicsDB human proteome resource

More...
ProteomicsDBi
496

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2RU48

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A2RU48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179256 Expressed in 82 organ(s), highest expression level in tibial nerve

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2RU48 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040574
HPA047804

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
136283, 5 interactors

Protein interaction database and analysis system

More...
IntActi
A2RU48, 4 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2RU48

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili62 – 92Sequence analysisAdd BLAST31
Coiled coili183 – 207Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IPT6 Eukaryota
ENOG411198U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013440

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111771

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095374

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2RU48

Identification of Orthologs from Complete Genome Data

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OMAi
CDIIIQA

Database of Orthologous Groups

More...
OrthoDBi
1399012at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2RU48

TreeFam database of animal gene trees

More...
TreeFami
TF335698

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027895 DUF4533
IPR040004 SMCO3

The PANTHER Classification System

More...
PANTHERi
PTHR35972 PTHR35972, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15047 DUF4533, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2RU48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQSDFLYPE NPKRREEVNR LHQQLLDCLS DSFDVTNKLT EVLNMHLGCR
60 70 80 90 100
LASIEMKRDG TIKENCDLII QAIMKIQKEL QKVDEALKDK LEPTLYRKLQ
110 120 130 140 150
DIKEKETDKI AIVQKVISVI LGEATSAASA VAVKLVGSNV TTGIINKLVT
160 170 180 190 200
VLAQIGASLL GSIGVAVLGL GIDMIVRAIL GAVEKTQLQA AIKSYEKHLV
210 220
EFKSASEKYN HAITEVINTV KHQMK
Length:225
Mass (Da):24,877
Last modified:March 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B80F5E0FF66CD20
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03930 differs from that shown. Reason: Frameshift at position 219.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04355849C → R. Corresponds to variant dbSNP:rs11609202Ensembl.1
Natural variantiVAR_04355975K → R. Corresponds to variant dbSNP:rs2241221Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK092637 mRNA Translation: BAC03930.1 Frameshift.
AC007655 Genomic DNA No translation available.
BC132752 mRNA Translation: AAI32753.1
BC132754 mRNA Translation: AAI32755.1
CH471094 Genomic DNA Translation: EAW96331.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41759.1

NCBI Reference Sequences

More...
RefSeqi
NP_001013720.2, NM_001013698.2
XP_016874801.1, XM_017019312.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.220931

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316048; ENSP00000381895; ENSG00000179256

Database of genes from NCBI RefSeq genomes

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GeneIDi
440087

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:440087

UCSC genome browser

More...
UCSCi
uc001rck.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092637 mRNA Translation: BAC03930.1 Frameshift.
AC007655 Genomic DNA No translation available.
BC132752 mRNA Translation: AAI32753.1
BC132754 mRNA Translation: AAI32755.1
CH471094 Genomic DNA Translation: EAW96331.1
CCDSiCCDS41759.1
RefSeqiNP_001013720.2, NM_001013698.2
XP_016874801.1, XM_017019312.1
UniGeneiHs.220931

3D structure databases

ProteinModelPortaliA2RU48
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136283, 5 interactors
IntActiA2RU48, 4 interactors

PTM databases

iPTMnetiA2RU48
PhosphoSitePlusiA2RU48

Polymorphism and mutation databases

BioMutaiSMCO3

Proteomic databases

EPDiA2RU48
PaxDbiA2RU48
PRIDEiA2RU48
ProteomicsDBi496

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
440087
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316048; ENSP00000381895; ENSG00000179256
GeneIDi440087
KEGGihsa:440087
UCSCiuc001rck.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
440087
EuPathDBiHostDB:ENSG00000179256.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SMCO3
HGNCiHGNC:34401 SMCO3
HPAiHPA040574
HPA047804
neXtProtiNX_A2RU48
OpenTargetsiENSG00000179256
PharmGKBiPA162378005

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPT6 Eukaryota
ENOG411198U LUCA
GeneTreeiENSGT00390000013440
HOGENOMiHOG000111771
HOVERGENiHBG095374
InParanoidiA2RU48
OMAiCDIIIQA
OrthoDBi1399012at2759
PhylomeDBiA2RU48
TreeFamiTF335698

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
440087

Protein Ontology

More...
PROi
PR:A2RU48

Gene expression databases

BgeeiENSG00000179256 Expressed in 82 organ(s), highest expression level in tibial nerve
GenevisibleiA2RU48 HS

Family and domain databases

InterProiView protein in InterPro
IPR027895 DUF4533
IPR040004 SMCO3
PANTHERiPTHR35972 PTHR35972, 1 hit
PfamiView protein in Pfam
PF15047 DUF4533, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMCO3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RU48
Secondary accession number(s): Q8NAI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 6, 2007
Last modified: February 13, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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