Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein TESPA1

Gene

TESPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release and mitochondrial Ca2+ uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TESPA1
Alternative name(s):
Thymocyte-expressed positive selection-associated protein 1
Gene namesi
Name:TESPA1
Synonyms:KIAA0748
ORF Names:HSPC257
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135426.14
HGNCiHGNC:29109 TESPA1
MIMi615664 gene
neXtProtiNX_A2RU30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Signalosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi185F → A: Loss of ITPR1-binding. 1 Publication1
Mutagenesisi186F → A: Strong decrease in ITPR1-binding. Complete loss of ITPR1-binding; when associated with A-185. 1 Publication1

Organism-specific databases

DisGeNETi9840
OpenTargetsiENSG00000135426
PharmGKBiPA128394561

Polymorphism and mutation databases

BioMutaiTESPA1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152191 – 521Protein TESPA1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei311PhosphoserineCombined sources1

Post-translational modificationi

May be phosphorylated in response to store-operated Ca(+2) entry.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA2RU30
PRIDEiA2RU30
ProteomicsDBi492
493 [A2RU30-2]
494 [A2RU30-3]

PTM databases

iPTMnetiA2RU30
PhosphoSitePlusiA2RU30

Expressioni

Gene expression databases

BgeeiENSG00000135426 Expressed in 135 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_KIAA0748
ExpressionAtlasiA2RU30 baseline and differential
GenevisibleiA2RU30 HS

Organism-specific databases

HPAiHPA058823

Interactioni

Subunit structurei

Interacts with PLCG1 and GRB2; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome. Interacts with ITPR1. Also interacts with ITPR3 (By similarity). Interacts with HSPA9.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115176, 13 interactors
IntActiA2RU30, 3 interactors
STRINGi9606.ENSP00000312679

Structurei

3D structure databases

ProteinModelPortaliA2RU30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH77 Eukaryota
ENOG410YGJ1 LUCA
GeneTreeiENSGT00530000063345
HOVERGENiHBG108022
InParanoidiA2RU30
OMAiEPHSPRD
OrthoDBiEOG091G011N
PhylomeDBiA2RU30
TreeFamiTF331566

Family and domain databases

InterProiView protein in InterPro
IPR029325 ITPR-bd
IPR026647 TESPA1
PANTHERiPTHR17469:SF1 PTHR17469:SF1, 1 hit
PfamiView protein in Pfam
PF14722 KRAP_IP3R_bind, 1 hit
SMARTiView protein in SMART
SM01257 KRAP_IP3R_bind, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2RU30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASVLSPTS WEKRRAWLRQ SRNWQTQVLE EEAAAALQDV PDPEPSSLDD
60 70 80 90 100
VFQEGNPINK IEDWLQDCGY SEEGFSEEAG QFIYNGFCSH GTSFEDDLTL
110 120 130 140 150
GAEATLLAAN GKLFSRSFLE TARPCQLLDL GCSLASSSMT GGTNKTSSSI
160 170 180 190 200
SEILDKVQED AEDVLFSLGF GQEDHKDTSR IPARFFTTPS QAKGIDFQLF
210 220 230 240 250
LKSQVRRIEM EDPCLMLASR FKQVQTLAVT ADAFFCLYSY VSKTPVQKFT
260 270 280 290 300
PSHMFWNCNH PTDVPSIRIL SREPEPQSPR DRLRKAISKM CLYTCPRDRP
310 320 330 340 350
PPPHNTPKRN SLDQVVLEVM DKVKEEKQFL QQDSDLGQFS QEDPVPPAEG
360 370 380 390 400
KKLPTSPYPC VFCCEEETQQ RMSTVLAPSQ TLDSNPKVPC CTHSLPIEDP
410 420 430 440 450
QWSTDPAQIR RELCSLPATN TETHPAKDET FWKRKSRARK SLFQKNLMGR
460 470 480 490 500
KVKSLDLSIT QQKWKQSVDR PELRRSLSQQ PQDTFDLEEV QSNSEEEQSQ
510 520
SRWPSRPRHP HHHQTFAGKD S
Length:521
Mass (Da):59,213
Last modified:January 15, 2008 - v2
Checksum:iE10A8FC0056909F3
GO
Isoform 2 (identifier: A2RU30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:383
Mass (Da):43,975
Checksum:i6927EFC7FFCEB3E6
GO
Isoform 3 (identifier: A2RU30-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     520-521: DS → FVKLSPPPQQHVV

Show »
Length:394
Mass (Da):45,230
Checksum:i09B886FD97D657F7
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIN8E9PIN8_HUMAN
Protein TESPA1
TESPA1
60Annotation score:
E9PM24E9PM24_HUMAN
Protein TESPA1
TESPA1
80Annotation score:
E9PPW8E9PPW8_HUMAN
Protein TESPA1
TESPA1
100Annotation score:
E9PN46E9PN46_HUMAN
Protein TESPA1
TESPA1
67Annotation score:
H0YEX3H0YEX3_HUMAN
Protein TESPA1
TESPA1
149Annotation score:
E9PIT9E9PIT9_HUMAN
Protein TESPA1
TESPA1
47Annotation score:
E9PHY9E9PHY9_HUMAN
Protein TESPA1
TESPA1
82Annotation score:
H0YDP3H0YDP3_HUMAN
Protein TESPA1
TESPA1
80Annotation score:

Sequence cautioni

The sequence AAF28935 differs from that shown. Reason: Frameshift at position 511.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti475R → Q in AAH44578 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049513496E → K1 PublicationCorresponds to variant dbSNP:rs997173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0304881 – 138Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST138
Alternative sequenceiVSP_030489520 – 521DS → FVKLSPPPQQHVV in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018291 mRNA Translation: BAA34468.2
AK298405 mRNA Translation: BAG60635.1
AK303223 mRNA Translation: BAG64310.1
AK315972 mRNA Translation: BAH14343.1
AC079842 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96796.1
CH471054 Genomic DNA Translation: EAW96799.1
BC044578 mRNA Translation: AAH44578.1
BC132732 mRNA Translation: AAI32733.2
BC132734 mRNA Translation: AAI32735.2
AF161375 mRNA Translation: AAF28935.1 Frameshift.
CCDSiCCDS44913.1 [A2RU30-1]
CCDS58240.1 [A2RU30-2]
RefSeqiNP_001092285.1, NM_001098815.2 [A2RU30-1]
NP_001129502.1, NM_001136030.2 [A2RU30-1]
NP_001248773.1, NM_001261844.1 [A2RU30-2]
NP_055611.1, NM_014796.2 [A2RU30-2]
XP_005269304.1, XM_005269247.2 [A2RU30-2]
XP_006719778.1, XM_006719715.3 [A2RU30-1]
XP_011537337.1, XM_011539035.2 [A2RU30-1]
XP_011537338.1, XM_011539036.1
XP_011537339.1, XM_011539037.2 [A2RU30-1]
XP_016875751.1, XM_017020262.1 [A2RU30-1]
XP_016875752.1, XM_017020263.1 [A2RU30-1]
UniGeneiHs.33187

Genome annotation databases

EnsembliENST00000316577; ENSP00000312679; ENSG00000135426 [A2RU30-1]
ENST00000449076; ENSP00000400892; ENSG00000135426 [A2RU30-1]
ENST00000524622; ENSP00000435622; ENSG00000135426 [A2RU30-2]
ENST00000531122; ENSP00000433098; ENSG00000135426 [A2RU30-2]
ENST00000532804; ENSP00000432030; ENSG00000135426 [A2RU30-2]
GeneIDi9840
KEGGihsa:9840
UCSCiuc001sgl.5 human [A2RU30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018291 mRNA Translation: BAA34468.2
AK298405 mRNA Translation: BAG60635.1
AK303223 mRNA Translation: BAG64310.1
AK315972 mRNA Translation: BAH14343.1
AC079842 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96796.1
CH471054 Genomic DNA Translation: EAW96799.1
BC044578 mRNA Translation: AAH44578.1
BC132732 mRNA Translation: AAI32733.2
BC132734 mRNA Translation: AAI32735.2
AF161375 mRNA Translation: AAF28935.1 Frameshift.
CCDSiCCDS44913.1 [A2RU30-1]
CCDS58240.1 [A2RU30-2]
RefSeqiNP_001092285.1, NM_001098815.2 [A2RU30-1]
NP_001129502.1, NM_001136030.2 [A2RU30-1]
NP_001248773.1, NM_001261844.1 [A2RU30-2]
NP_055611.1, NM_014796.2 [A2RU30-2]
XP_005269304.1, XM_005269247.2 [A2RU30-2]
XP_006719778.1, XM_006719715.3 [A2RU30-1]
XP_011537337.1, XM_011539035.2 [A2RU30-1]
XP_011537338.1, XM_011539036.1
XP_011537339.1, XM_011539037.2 [A2RU30-1]
XP_016875751.1, XM_017020262.1 [A2RU30-1]
XP_016875752.1, XM_017020263.1 [A2RU30-1]
UniGeneiHs.33187

3D structure databases

ProteinModelPortaliA2RU30
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115176, 13 interactors
IntActiA2RU30, 3 interactors
STRINGi9606.ENSP00000312679

PTM databases

iPTMnetiA2RU30
PhosphoSitePlusiA2RU30

Polymorphism and mutation databases

BioMutaiTESPA1

Proteomic databases

PaxDbiA2RU30
PRIDEiA2RU30
ProteomicsDBi492
493 [A2RU30-2]
494 [A2RU30-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316577; ENSP00000312679; ENSG00000135426 [A2RU30-1]
ENST00000449076; ENSP00000400892; ENSG00000135426 [A2RU30-1]
ENST00000524622; ENSP00000435622; ENSG00000135426 [A2RU30-2]
ENST00000531122; ENSP00000433098; ENSG00000135426 [A2RU30-2]
ENST00000532804; ENSP00000432030; ENSG00000135426 [A2RU30-2]
GeneIDi9840
KEGGihsa:9840
UCSCiuc001sgl.5 human [A2RU30-1]

Organism-specific databases

CTDi9840
DisGeNETi9840
EuPathDBiHostDB:ENSG00000135426.14
GeneCardsiTESPA1
HGNCiHGNC:29109 TESPA1
HPAiHPA058823
MIMi615664 gene
neXtProtiNX_A2RU30
OpenTargetsiENSG00000135426
PharmGKBiPA128394561
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH77 Eukaryota
ENOG410YGJ1 LUCA
GeneTreeiENSGT00530000063345
HOVERGENiHBG108022
InParanoidiA2RU30
OMAiEPHSPRD
OrthoDBiEOG091G011N
PhylomeDBiA2RU30
TreeFamiTF331566

Miscellaneous databases

ChiTaRSiTESPA1 human
GenomeRNAii9840
PROiPR:A2RU30
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135426 Expressed in 135 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_KIAA0748
ExpressionAtlasiA2RU30 baseline and differential
GenevisibleiA2RU30 HS

Family and domain databases

InterProiView protein in InterPro
IPR029325 ITPR-bd
IPR026647 TESPA1
PANTHERiPTHR17469:SF1 PTHR17469:SF1, 1 hit
PfamiView protein in Pfam
PF14722 KRAP_IP3R_bind, 1 hit
SMARTiView protein in SMART
SM01257 KRAP_IP3R_bind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTESP1_HUMAN
AccessioniPrimary (citable) accession number: A2RU30
Secondary accession number(s): B4DPM3
, B4E048, B7Z9K7, O94849, Q4G0P2, Q9P0C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again