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Protein

Protein TESPA1

Gene

TESPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release and mitochondrial Ca2+ uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TESPA1
Alternative name(s):
Thymocyte-expressed positive selection-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TESPA1
Synonyms:KIAA0748
ORF Names:HSPC257
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000135426.14

Human Gene Nomenclature Database

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HGNCi
HGNC:29109 TESPA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615664 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_A2RU30

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Signalosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi185F → A: Loss of ITPR1-binding. 1 Publication1
Mutagenesisi186F → A: Strong decrease in ITPR1-binding. Complete loss of ITPR1-binding; when associated with A-185. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9840

Open Targets

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OpenTargetsi
ENSG00000135426

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA128394561

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TESPA1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003152191 – 521Protein TESPA1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei311PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated in response to store-operated Ca(+2) entry.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A2RU30

PRoteomics IDEntifications database

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PRIDEi
A2RU30

ProteomicsDB human proteome resource

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ProteomicsDBi
492
493 [A2RU30-2]
494 [A2RU30-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
A2RU30

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A2RU30

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135426 Expressed in 135 organ(s), highest expression level in dorsolateral prefrontal cortex

CleanEx database of gene expression profiles

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CleanExi
HS_KIAA0748

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2RU30 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A2RU30 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA058823

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PLCG1 and GRB2; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome. Interacts with ITPR1. Also interacts with ITPR3 (By similarity). Interacts with HSPA9.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115176, 13 interactors

Protein interaction database and analysis system

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IntActi
A2RU30, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000312679

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A2RU30

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IH77 Eukaryota
ENOG410YGJ1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160763

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108022

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2RU30

Identification of Orthologs from Complete Genome Data

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OMAi
EPHSPRD

Database of Orthologous Groups

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OrthoDBi
417705at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2RU30

TreeFam database of animal gene trees

More...
TreeFami
TF331566

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029325 ITPR-bd
IPR026647 TESPA1

The PANTHER Classification System

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PANTHERi
PTHR17469:SF1 PTHR17469:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14722 KRAP_IP3R_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01257 KRAP_IP3R_bind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2RU30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASVLSPTS WEKRRAWLRQ SRNWQTQVLE EEAAAALQDV PDPEPSSLDD
60 70 80 90 100
VFQEGNPINK IEDWLQDCGY SEEGFSEEAG QFIYNGFCSH GTSFEDDLTL
110 120 130 140 150
GAEATLLAAN GKLFSRSFLE TARPCQLLDL GCSLASSSMT GGTNKTSSSI
160 170 180 190 200
SEILDKVQED AEDVLFSLGF GQEDHKDTSR IPARFFTTPS QAKGIDFQLF
210 220 230 240 250
LKSQVRRIEM EDPCLMLASR FKQVQTLAVT ADAFFCLYSY VSKTPVQKFT
260 270 280 290 300
PSHMFWNCNH PTDVPSIRIL SREPEPQSPR DRLRKAISKM CLYTCPRDRP
310 320 330 340 350
PPPHNTPKRN SLDQVVLEVM DKVKEEKQFL QQDSDLGQFS QEDPVPPAEG
360 370 380 390 400
KKLPTSPYPC VFCCEEETQQ RMSTVLAPSQ TLDSNPKVPC CTHSLPIEDP
410 420 430 440 450
QWSTDPAQIR RELCSLPATN TETHPAKDET FWKRKSRARK SLFQKNLMGR
460 470 480 490 500
KVKSLDLSIT QQKWKQSVDR PELRRSLSQQ PQDTFDLEEV QSNSEEEQSQ
510 520
SRWPSRPRHP HHHQTFAGKD S
Length:521
Mass (Da):59,213
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE10A8FC0056909F3
GO
Isoform 2 (identifier: A2RU30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:383
Mass (Da):43,975
Checksum:i6927EFC7FFCEB3E6
GO
Isoform 3 (identifier: A2RU30-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     520-521: DS → FVKLSPPPQQHVV

Show »
Length:394
Mass (Da):45,230
Checksum:i09B886FD97D657F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM24E9PM24_HUMAN
Protein TESPA1
TESPA1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPW8E9PPW8_HUMAN
Protein TESPA1
TESPA1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIN8E9PIN8_HUMAN
Protein TESPA1
TESPA1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN46E9PN46_HUMAN
Protein TESPA1
TESPA1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHY9E9PHY9_HUMAN
Protein TESPA1
TESPA1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEX3H0YEX3_HUMAN
Protein TESPA1
TESPA1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIT9E9PIT9_HUMAN
Protein TESPA1
TESPA1
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDP3H0YDP3_HUMAN
Protein TESPA1
TESPA1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28935 differs from that shown. Reason: Frameshift at position 511.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti475R → Q in AAH44578 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049513496E → K1 PublicationCorresponds to variant dbSNP:rs997173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0304881 – 138Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST138
Alternative sequenceiVSP_030489520 – 521DS → FVKLSPPPQQHVV in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018291 mRNA Translation: BAA34468.2
AK298405 mRNA Translation: BAG60635.1
AK303223 mRNA Translation: BAG64310.1
AK315972 mRNA Translation: BAH14343.1
AC079842 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96796.1
CH471054 Genomic DNA Translation: EAW96799.1
BC044578 mRNA Translation: AAH44578.1
BC132732 mRNA Translation: AAI32733.2
BC132734 mRNA Translation: AAI32735.2
AF161375 mRNA Translation: AAF28935.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44913.1 [A2RU30-1]
CCDS58240.1 [A2RU30-2]

NCBI Reference Sequences

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RefSeqi
NP_001092285.1, NM_001098815.2 [A2RU30-1]
NP_001129502.1, NM_001136030.2 [A2RU30-1]
NP_001248773.1, NM_001261844.1 [A2RU30-2]
NP_055611.1, NM_014796.2 [A2RU30-2]
XP_005269304.1, XM_005269247.2 [A2RU30-2]
XP_006719778.1, XM_006719715.3 [A2RU30-1]
XP_011537337.1, XM_011539035.2 [A2RU30-1]
XP_011537338.1, XM_011539036.1
XP_011537339.1, XM_011539037.2 [A2RU30-1]
XP_016875751.1, XM_017020262.1 [A2RU30-1]
XP_016875752.1, XM_017020263.1 [A2RU30-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.33187

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316577; ENSP00000312679; ENSG00000135426 [A2RU30-1]
ENST00000449076; ENSP00000400892; ENSG00000135426 [A2RU30-1]
ENST00000524622; ENSP00000435622; ENSG00000135426 [A2RU30-2]
ENST00000531122; ENSP00000433098; ENSG00000135426 [A2RU30-2]
ENST00000532804; ENSP00000432030; ENSG00000135426 [A2RU30-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9840

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9840

UCSC genome browser

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UCSCi
uc001sgl.5 human [A2RU30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018291 mRNA Translation: BAA34468.2
AK298405 mRNA Translation: BAG60635.1
AK303223 mRNA Translation: BAG64310.1
AK315972 mRNA Translation: BAH14343.1
AC079842 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96796.1
CH471054 Genomic DNA Translation: EAW96799.1
BC044578 mRNA Translation: AAH44578.1
BC132732 mRNA Translation: AAI32733.2
BC132734 mRNA Translation: AAI32735.2
AF161375 mRNA Translation: AAF28935.1 Frameshift.
CCDSiCCDS44913.1 [A2RU30-1]
CCDS58240.1 [A2RU30-2]
RefSeqiNP_001092285.1, NM_001098815.2 [A2RU30-1]
NP_001129502.1, NM_001136030.2 [A2RU30-1]
NP_001248773.1, NM_001261844.1 [A2RU30-2]
NP_055611.1, NM_014796.2 [A2RU30-2]
XP_005269304.1, XM_005269247.2 [A2RU30-2]
XP_006719778.1, XM_006719715.3 [A2RU30-1]
XP_011537337.1, XM_011539035.2 [A2RU30-1]
XP_011537338.1, XM_011539036.1
XP_011537339.1, XM_011539037.2 [A2RU30-1]
XP_016875751.1, XM_017020262.1 [A2RU30-1]
XP_016875752.1, XM_017020263.1 [A2RU30-1]
UniGeneiHs.33187

3D structure databases

ProteinModelPortaliA2RU30
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115176, 13 interactors
IntActiA2RU30, 3 interactors
STRINGi9606.ENSP00000312679

PTM databases

iPTMnetiA2RU30
PhosphoSitePlusiA2RU30

Polymorphism and mutation databases

BioMutaiTESPA1

Proteomic databases

PaxDbiA2RU30
PRIDEiA2RU30
ProteomicsDBi492
493 [A2RU30-2]
494 [A2RU30-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316577; ENSP00000312679; ENSG00000135426 [A2RU30-1]
ENST00000449076; ENSP00000400892; ENSG00000135426 [A2RU30-1]
ENST00000524622; ENSP00000435622; ENSG00000135426 [A2RU30-2]
ENST00000531122; ENSP00000433098; ENSG00000135426 [A2RU30-2]
ENST00000532804; ENSP00000432030; ENSG00000135426 [A2RU30-2]
GeneIDi9840
KEGGihsa:9840
UCSCiuc001sgl.5 human [A2RU30-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9840
DisGeNETi9840
EuPathDBiHostDB:ENSG00000135426.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TESPA1
HGNCiHGNC:29109 TESPA1
HPAiHPA058823
MIMi615664 gene
neXtProtiNX_A2RU30
OpenTargetsiENSG00000135426
PharmGKBiPA128394561

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH77 Eukaryota
ENOG410YGJ1 LUCA
GeneTreeiENSGT00940000160763
HOVERGENiHBG108022
InParanoidiA2RU30
OMAiEPHSPRD
OrthoDBi417705at2759
PhylomeDBiA2RU30
TreeFamiTF331566

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TESPA1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9840

Protein Ontology

More...
PROi
PR:A2RU30

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135426 Expressed in 135 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_KIAA0748
ExpressionAtlasiA2RU30 baseline and differential
GenevisibleiA2RU30 HS

Family and domain databases

InterProiView protein in InterPro
IPR029325 ITPR-bd
IPR026647 TESPA1
PANTHERiPTHR17469:SF1 PTHR17469:SF1, 1 hit
PfamiView protein in Pfam
PF14722 KRAP_IP3R_bind, 1 hit
SMARTiView protein in SMART
SM01257 KRAP_IP3R_bind, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTESP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RU30
Secondary accession number(s): B4DPM3
, B4E048, B7Z9K7, O94849, Q4G0P2, Q9P0C4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 16, 2019
This is version 92 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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