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UniProtKB - A2RU14 (TM218_HUMAN)
Protein
Transmembrane protein 218
Gene
TMEM218
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in ciliary biogenesis or function.
By similarityEnzyme and pathway databases
PathwayCommonsi | A2RU14 |
SignaLinki | A2RU14 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 218 |
Gene namesi | Name:TMEM218 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27344, TMEM218 |
MIMi | 619285, gene |
neXtProti | NX_A2RU14 |
VEuPathDBi | HostDB:ENSG00000150433 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
- cilium By similarity
Note: Localizes at the transition zone, a region between the basal body and the ciliary axoneme.By similarity
Other locations
- cilium Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 5 – 25 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 219854 |
MalaCardsi | TMEM218 |
OpenTargetsi | ENSG00000150433 |
PharmGKBi | PA162406569 |
Miscellaneous databases
Pharosi | A2RU14, Tdark |
Genetic variation databases
BioMutai | TMEM218 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000321836 | 1 – 115 | Transmembrane protein 218Add BLAST | 115 |
Proteomic databases
MassIVEi | A2RU14 |
PaxDbi | A2RU14 |
PeptideAtlasi | A2RU14 |
PRIDEi | A2RU14 |
ProteomicsDBi | 491 |
TopDownProteomicsi | A2RU14 |
Expressioni
Gene expression databases
Bgeei | ENSG00000150433, Expressed in right uterine tube and 204 other tissues |
ExpressionAtlasi | A2RU14, baseline and differential |
Genevisiblei | A2RU14, HS |
Organism-specific databases
HPAi | ENSG00000150433, Low tissue specificity |
Interactioni
Binary interactionsi
A2RU14
Protein-protein interaction databases
BioGRIDi | 128583, 75 interactors |
IntActi | A2RU14, 68 interactors |
STRINGi | 9606.ENSP00000436596 |
Miscellaneous databases
RNActi | A2RU14, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM218 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S2I1, Eukaryota |
GeneTreei | ENSGT00390000016247 |
InParanoidi | A2RU14 |
OMAi | MKIVDTF |
OrthoDBi | 1590037at2759 |
PhylomeDBi | A2RU14 |
TreeFami | TF328597 |
Family and domain databases
InterProi | View protein in InterPro IPR026771, Tmem218 |
PANTHERi | PTHR31622, PTHR31622, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A2RU14-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGTVLGVGA GVFILALLWV AVLLLCVLLS RASGAARFSV IFLFFGAVII
60 70 80 90 100
TSVLLLFPRA GEFPAPEVEV KIVDDFFIGR YVLLAFLSAI FLGGLFLVLI
110
HYVLEPIYAK PLHSY
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PI23 | E9PI23_HUMAN | Transmembrane protein 218 | TMEM218 | 141 | Annotation score: | ||
E9PQM6 | E9PQM6_HUMAN | Transmembrane protein 218 | TMEM218 | 52 | Annotation score: | ||
E9PL96 | E9PL96_HUMAN | Transmembrane protein 218 | TMEM218 | 70 | Annotation score: | ||
B7ZM54 | B7ZM54_HUMAN | TMEM218 protein | TMEM218 | 45 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471065 Genomic DNA Translation: EAW67625.1 BC132716 mRNA Translation: AAI32717.1 BC132718 mRNA Translation: AAI32719.1 BC144270 mRNA Translation: AAI44271.1 BC144277 mRNA Translation: AAI44278.1 |
CCDSi | CCDS31715.1 |
RefSeqi | NP_001074015.1, NM_001080546.2 NP_001245167.1, NM_001258238.1 NP_001245168.1, NM_001258239.1 NP_001245169.1, NM_001258240.1 NP_001245170.1, NM_001258241.1 NP_001245171.1, NM_001258242.1 NP_001245172.1, NM_001258243.1 NP_001245173.1, NM_001258244.1 NP_001245174.1, NM_001258245.1 NP_001245175.1, NM_001258246.1 NP_001245176.1, NM_001258247.1 XP_006718846.1, XM_006718783.3 XP_016872811.1, XM_017017322.1 XP_016872812.1, XM_017017323.1 XP_016872813.1, XM_017017324.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471065 Genomic DNA Translation: EAW67625.1 BC132716 mRNA Translation: AAI32717.1 BC132718 mRNA Translation: AAI32719.1 BC144270 mRNA Translation: AAI44271.1 BC144277 mRNA Translation: AAI44278.1 |
CCDSi | CCDS31715.1 |
RefSeqi | NP_001074015.1, NM_001080546.2 NP_001245167.1, NM_001258238.1 NP_001245168.1, NM_001258239.1 NP_001245169.1, NM_001258240.1 NP_001245170.1, NM_001258241.1 NP_001245171.1, NM_001258242.1 NP_001245172.1, NM_001258243.1 NP_001245173.1, NM_001258244.1 NP_001245174.1, NM_001258245.1 NP_001245175.1, NM_001258246.1 NP_001245176.1, NM_001258247.1 XP_006718846.1, XM_006718783.3 XP_016872811.1, XM_017017322.1 XP_016872812.1, XM_017017323.1 XP_016872813.1, XM_017017324.1 |
3D structure databases
SMRi | A2RU14 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128583, 75 interactors |
IntActi | A2RU14, 68 interactors |
STRINGi | 9606.ENSP00000436596 |
Genetic variation databases
BioMutai | TMEM218 |
Proteomic databases
MassIVEi | A2RU14 |
PaxDbi | A2RU14 |
PeptideAtlasi | A2RU14 |
PRIDEi | A2RU14 |
ProteomicsDBi | 491 |
TopDownProteomicsi | A2RU14 |
Protocols and materials databases
Antibodypediai | 50074, 8 antibodies from 7 providers |
DNASUi | 219854 |
Genome annotation databases
Organism-specific databases
CTDi | 219854 |
DisGeNETi | 219854 |
GeneCardsi | TMEM218 |
HGNCi | HGNC:27344, TMEM218 |
HPAi | ENSG00000150433, Low tissue specificity |
MalaCardsi | TMEM218 |
MIMi | 619285, gene |
neXtProti | NX_A2RU14 |
OpenTargetsi | ENSG00000150433 |
PharmGKBi | PA162406569 |
VEuPathDBi | HostDB:ENSG00000150433 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2I1, Eukaryota |
GeneTreei | ENSGT00390000016247 |
InParanoidi | A2RU14 |
OMAi | MKIVDTF |
OrthoDBi | 1590037at2759 |
PhylomeDBi | A2RU14 |
TreeFami | TF328597 |
Enzyme and pathway databases
PathwayCommonsi | A2RU14 |
SignaLinki | A2RU14 |
Miscellaneous databases
BioGRID-ORCSi | 219854, 5 hits in 1037 CRISPR screens |
ChiTaRSi | TMEM218, human |
GenomeRNAii | 219854 |
Pharosi | A2RU14, Tdark |
PROi | PR:A2RU14 |
RNActi | A2RU14, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000150433, Expressed in right uterine tube and 204 other tissues |
ExpressionAtlasi | A2RU14, baseline and differential |
Genevisiblei | A2RU14, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026771, Tmem218 |
PANTHERi | PTHR31622, PTHR31622, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM218_HUMAN | |
Accessioni | A2RU14Primary (citable) accession number: A2RU14 Secondary accession number(s): B7ZM48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | March 6, 2007 | |
Last modified: | February 23, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families