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UniProtKB - A2RU14 (TM218_HUMAN)

Entry version 86 (08 May 2019)
Sequence version 1 (06 Mar 2007)
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Protein

Transmembrane protein 218

Gene

TMEM218

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in ciliary biogenesis or function.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 218
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM218
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27344 TMEM218

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A2RU14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		219854

Open Targets

More...OpenTargetsi		ENSG00000150433

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162406569

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM218

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003218361 – 115Transmembrane protein 218Add BLAST115

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2RU14

PRoteomics IDEntifications database

More...PRIDEi		A2RU14

ProteomicsDB human proteome resource

More...ProteomicsDBi		491

Consortium for Top Down Proteomics

More...TopDownProteomicsi		A2RU14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000150433 Expressed in 189 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2RU14 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2RU14 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA038489

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		128583, 4 interactors

Protein interaction database and analysis system

More...IntActi		A2RU14, 62 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000436596

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM218 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J07M Eukaryota
ENOG4112157 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016247

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000082500

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2RU14

Database of Orthologous Groups

More...OrthoDBi		1590037at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2RU14

TreeFam database of animal gene trees

More...TreeFami		TF328597

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026771 Tmem218

The PANTHER Classification System

More...PANTHERi		PTHR31622 PTHR31622, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A2RU14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGTVLGVGA GVFILALLWV AVLLLCVLLS RASGAARFSV IFLFFGAVII 
        60         70         80         90        100
TSVLLLFPRA GEFPAPEVEV KIVDDFFIGR YVLLAFLSAI FLGGLFLVLI 
       110 
HYVLEPIYAK PLHSY
Length:115
Mass (Da):12,459
Last modified:March 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82641C83F92E2337
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PI23E9PI23_HUMAN
Transmembrane protein 218
TMEM218
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQM6E9PQM6_HUMAN
Transmembrane protein 218
TMEM218
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL96E9PL96_HUMAN
Transmembrane protein 218
TMEM218
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZM54B7ZM54_HUMAN
TMEM218 protein
TMEM218
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471065 Genomic DNA Translation: EAW67625.1
BC132716 mRNA Translation: AAI32717.1
BC132718 mRNA Translation: AAI32719.1
BC144270 mRNA Translation: AAI44271.1
BC144277 mRNA Translation: AAI44278.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31715.1

NCBI Reference Sequences

More...RefSeqi		NP_001074015.1, NM_001080546.2
NP_001245167.1, NM_001258238.1
NP_001245168.1, NM_001258239.1
NP_001245169.1, NM_001258240.1
NP_001245170.1, NM_001258241.1
NP_001245171.1, NM_001258242.1
NP_001245172.1, NM_001258243.1
NP_001245173.1, NM_001258244.1
NP_001245174.1, NM_001258245.1
NP_001245175.1, NM_001258246.1
NP_001245176.1, NM_001258247.1
XP_006718846.1, XM_006718783.3
XP_016872811.1, XM_017017322.1
XP_016872812.1, XM_017017323.1
XP_016872813.1, XM_017017324.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000279968; ENSP00000279968; ENSG00000150433
ENST00000526175; ENSP00000436177; ENSG00000150433
ENST00000527271; ENSP00000436162; ENSG00000150433
ENST00000527766; ENSP00000435526; ENSG00000150433
ENST00000529583; ENSP00000433374; ENSG00000150433
ENST00000531909; ENSP00000436596; ENSG00000150433
ENST00000532407; ENSP00000434597; ENSG00000150433

Database of genes from NCBI RefSeq genomes

More...GeneIDi		219854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:219854

UCSC genome browser

More...UCSCi		uc010sax.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471065 Genomic DNA Translation: EAW67625.1
BC132716 mRNA Translation: AAI32717.1
BC132718 mRNA Translation: AAI32719.1
BC144270 mRNA Translation: AAI44271.1
BC144277 mRNA Translation: AAI44278.1
CCDSiCCDS31715.1
RefSeqiNP_001074015.1, NM_001080546.2
NP_001245167.1, NM_001258238.1
NP_001245168.1, NM_001258239.1
NP_001245169.1, NM_001258240.1
NP_001245170.1, NM_001258241.1
NP_001245171.1, NM_001258242.1
NP_001245172.1, NM_001258243.1
NP_001245173.1, NM_001258244.1
NP_001245174.1, NM_001258245.1
NP_001245175.1, NM_001258246.1
NP_001245176.1, NM_001258247.1
XP_006718846.1, XM_006718783.3
XP_016872811.1, XM_017017322.1
XP_016872812.1, XM_017017323.1
XP_016872813.1, XM_017017324.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi128583, 4 interactors
IntActiA2RU14, 62 interactors
STRINGi9606.ENSP00000436596

Polymorphism and mutation databases

BioMutaiTMEM218

Proteomic databases

PaxDbiA2RU14
PRIDEiA2RU14
ProteomicsDBi491
TopDownProteomicsiA2RU14

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		219854
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279968; ENSP00000279968; ENSG00000150433
ENST00000526175; ENSP00000436177; ENSG00000150433
ENST00000527271; ENSP00000436162; ENSG00000150433
ENST00000527766; ENSP00000435526; ENSG00000150433
ENST00000529583; ENSP00000433374; ENSG00000150433
ENST00000531909; ENSP00000436596; ENSG00000150433
ENST00000532407; ENSP00000434597; ENSG00000150433
GeneIDi219854
KEGGihsa:219854
UCSCiuc010sax.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		219854
DisGeNETi219854

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM218
HGNCiHGNC:27344 TMEM218
HPAiHPA038489
neXtProtiNX_A2RU14
OpenTargetsiENSG00000150433
PharmGKBiPA162406569

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J07M Eukaryota
ENOG4112157 LUCA
GeneTreeiENSGT00390000016247
HOGENOMiHOG000082500
InParanoidiA2RU14
OrthoDBi1590037at2759
PhylomeDBiA2RU14
TreeFamiTF328597

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM218 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		219854

Protein Ontology

More...PROi		PR:A2RU14

Gene expression databases

BgeeiENSG00000150433 Expressed in 189 organ(s), highest expression level in right uterine tube
ExpressionAtlasiA2RU14 baseline and differential
GenevisibleiA2RU14 HS

Family and domain databases

InterProiView protein in InterPro
IPR026771 Tmem218
PANTHERiPTHR31622 PTHR31622, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM218_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RU14
Secondary accession number(s): B7ZM48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 6, 2007
Last modified: May 8, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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