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UniProtKB - A2RTH5 (A2RTH5_MOUSE)
Protein
Leucine carboxyl methyltransferase 1
Gene
Lcmt1
Organism
Mus musculus (Mouse)
Status
Functioni
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
UniRule annotationARBA annotationCatalytic activityi
- [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteineUniRule annotationARBA annotationEC:2.1.1.233UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 71 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 96 | S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 196 | S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation | 1 |
GO - Molecular functioni
- protein C-terminal carboxyl O-methyltransferase activity Source: MGI
- protein C-terminal leucine carboxyl O-methyltransferase activity Source: GO_Central
- protein methyltransferase activity Source: MGI
GO - Biological processi
- C-terminal protein methylation Source: MGI
- negative regulation of protein-containing complex assembly Source: MGI
- protein methylation Source: MGI
- regulation of apoptotic process Source: MGI
- regulation of glucose metabolic process Source: MGI
- regulation of mitotic cell cycle spindle assembly checkpoint Source: MGI
Keywordsi
Molecular function | MethyltransferaseUniRule annotationImported, Transferase |
Ligand | S-adenosyl-L-methionineUniRule annotation |
Enzyme and pathway databases
BRENDAi | 2.1.1.233, 3474 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine carboxyl methyltransferase 1UniRule annotation (EC:2.1.1.233UniRule annotation) |
Gene namesi | Name:Lcmt1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353593, Lcmt1 |
VEuPathDBi | HostDB:ENSMUSG00000030763 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030763, Expressed in pancreas and 292 other tissues |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 169 – 170 | S-adenosyl-L-methionine bindingUniRule annotation | 2 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2918, Eukaryota |
GeneTreei | ENSGT00940000156372 |
HOGENOMi | CLU_031312_0_0_1 |
OMAi | IIYEPIR |
OrthoDBi | 1094856at2759 |
TreeFami | TF315087 |
Family and domain databases
InterProi | View protein in InterPro IPR016651, PPM1 IPR007213, Ppm1/Ppm2/Tcmp IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR13600, PTHR13600, 1 hit |
Pfami | View protein in Pfam PF04072, LCM, 1 hit |
PIRSFi | PIRSF016305, LCM_mtfrase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A2RTH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSSRESSF SSCSSSCDLD DEGVRGTCED ASLCKRFAVS IGYWHDPYIE
60 70 80 90 100
HLVRQSKERK APEINRGYFA RVHGVSQLIK AFLRKTECHC QILNLGAGMD
110 120 130 140 150
TTFWKLKDEG LLPNKYFEVD FPMIVTRKLL TIKSKPLLFR PIMELHPEDT
160 170 180 190 200
LQMDSHMLDS KRYAIIGADL RDLSELEEKL KKCNMNTQLP TLLITECVLV
210 220 230 240 250
YMTPEQSANL LKWAASSFET AMFINYEQVN MDDRFGQIMI ENLRRRSCDL
260 270 280 290 300
AGVETCKSLE SQKERLLLNG WETASAVNMM ELYSGLPRAE VNRIESLEFL
310 320 330
DEMELLEQLM RHYCLCWATR GGQELGLKEI TY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RNF2 | A0A0U1RNF2_MOUSE | Leucine carboxyl methyltransferase ... | Lcmt1 | 332 | Annotation score: | ||
A0A0U1RPZ5 | A0A0U1RPZ5_MOUSE | Leucine carboxyl methyltransferase ... | Lcmt1 | 121 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC132507 mRNA Translation: AAI32508.1 BC132509 mRNA Translation: AAI32510.1 |
RefSeqi | NP_079580.2, NM_025304.3 |
Genome annotation databases
Ensembli | ENSMUST00000033025; ENSMUSP00000033025; ENSMUSG00000030763 |
GeneIDi | 30949 |
UCSCi | uc009jpp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC132507 mRNA Translation: AAI32508.1 BC132509 mRNA Translation: AAI32510.1 |
RefSeqi | NP_079580.2, NM_025304.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033025 |
Proteomic databases
ProteomicsDBi | 343267 |
Protocols and materials databases
Antibodypediai | 26192, 239 antibodies from 20 providers |
DNASUi | 30949 |
Genome annotation databases
Ensembli | ENSMUST00000033025; ENSMUSP00000033025; ENSMUSG00000030763 |
GeneIDi | 30949 |
UCSCi | uc009jpp.1, mouse |
Organism-specific databases
CTDi | 51451 |
MGIi | MGI:1353593, Lcmt1 |
VEuPathDBi | HostDB:ENSMUSG00000030763 |
Phylogenomic databases
eggNOGi | KOG2918, Eukaryota |
GeneTreei | ENSGT00940000156372 |
HOGENOMi | CLU_031312_0_0_1 |
OMAi | IIYEPIR |
OrthoDBi | 1094856at2759 |
TreeFami | TF315087 |
Enzyme and pathway databases
BRENDAi | 2.1.1.233, 3474 |
Miscellaneous databases
BioGRID-ORCSi | 30949, 17 hits in 64 CRISPR screens |
ChiTaRSi | Lcmt1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030763, Expressed in pancreas and 292 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR016651, PPM1 IPR007213, Ppm1/Ppm2/Tcmp IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR13600, PTHR13600, 1 hit |
Pfami | View protein in Pfam PF04072, LCM, 1 hit |
PIRSFi | PIRSF016305, LCM_mtfrase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2RTH5_MOUSE | |
Accessioni | A2RTH5Primary (citable) accession number: A2RTH5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 6, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | January 19, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |