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Protein

Leucine carboxyl methyltransferase 1

Gene

Lcmt1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71S-adenosyl-L-methionineUniRule annotation1
Binding sitei96S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei196S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

  • protein C-terminal carboxyl O-methyltransferase activity Source: MGI
  • protein C-terminal leucine carboxyl O-methyltransferase activity Source: GO_Central
  • protein methyltransferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotationImported, Transferase
LigandS-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine carboxyl methyltransferase 1UniRule annotation (EC:2.1.1.233UniRule annotation)
Gene namesi
Name:Lcmt1Imported
ORF Names:mCG_20988Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1353593 Lcmt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000030763 Expressed in 270 organ(s), highest expression level in pancreas

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033025

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 170S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methyltransferase superfamily. LCMT family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2918 Eukaryota
ENOG410YB9K LUCA
GeneTreeiENSGT00530000063793
HOGENOMiHOG000205368
HOVERGENiHBG052313
OMAiCKRFATS
OrthoDBiEOG091G0CW2
TreeFamiTF315087

Family and domain databases

InterProiView protein in InterPro
IPR016651 Leu_CO_MeTrfase_LCMT1
IPR007213 Ppm1/Ppm2/Tcmp
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF04072 LCM, 1 hit
PIRSFiPIRSF016305 LCM_mtfrase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2RTH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSRESSF SSCSSSCDLD DEGVRGTCED ASLCKRFAVS IGYWHDPYIE
60 70 80 90 100
HLVRQSKERK APEINRGYFA RVHGVSQLIK AFLRKTECHC QILNLGAGMD
110 120 130 140 150
TTFWKLKDEG LLPNKYFEVD FPMIVTRKLL TIKSKPLLFR PIMELHPEDT
160 170 180 190 200
LQMDSHMLDS KRYAIIGADL RDLSELEEKL KKCNMNTQLP TLLITECVLV
210 220 230 240 250
YMTPEQSANL LKWAASSFET AMFINYEQVN MDDRFGQIMI ENLRRRSCDL
260 270 280 290 300
AGVETCKSLE SQKERLLLNG WETASAVNMM ELYSGLPRAE VNRIESLEFL
310 320 330
DEMELLEQLM RHYCLCWATR GGQELGLKEI TY
Length:332
Mass (Da):38,192
Last modified:March 6, 2007 - v1
Checksum:iD638E98A47ECCED0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNF2A0A0U1RNF2_MOUSE
Leucine carboxyl methyltransferase ...
Lcmt1
332Annotation score:
A0A0U1RPZ5A0A0U1RPZ5_MOUSE
Leucine carboxyl methyltransferase ...
Lcmt1
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121956 Genomic DNA No translation available.
BC132507 mRNA Translation: AAI32508.1
BC132509 mRNA Translation: AAI32510.1
CH466531 Genomic DNA Translation: EDL17309.1
RefSeqiNP_079580.2, NM_025304.3
UniGeneiMm.260527

Genome annotation databases

EnsembliENSMUST00000033025; ENSMUSP00000033025; ENSMUSG00000030763
GeneIDi30949
UCSCiuc009jpp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121956 Genomic DNA No translation available.
BC132507 mRNA Translation: AAI32508.1
BC132509 mRNA Translation: AAI32510.1
CH466531 Genomic DNA Translation: EDL17309.1
RefSeqiNP_079580.2, NM_025304.3
UniGeneiMm.260527

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033025; ENSMUSP00000033025; ENSMUSG00000030763
GeneIDi30949
UCSCiuc009jpp.1 mouse

Organism-specific databases

CTDi51451
MGIiMGI:1353593 Lcmt1

Phylogenomic databases

eggNOGiKOG2918 Eukaryota
ENOG410YB9K LUCA
GeneTreeiENSGT00530000063793
HOGENOMiHOG000205368
HOVERGENiHBG052313
OMAiCKRFATS
OrthoDBiEOG091G0CW2
TreeFamiTF315087

Enzyme and pathway databases

ReactomeiR-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition

Miscellaneous databases

ChiTaRSiLcmt1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030763 Expressed in 270 organ(s), highest expression level in pancreas

Family and domain databases

InterProiView protein in InterPro
IPR016651 Leu_CO_MeTrfase_LCMT1
IPR007213 Ppm1/Ppm2/Tcmp
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF04072 LCM, 1 hit
PIRSFiPIRSF016305 LCM_mtfrase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2RTH5_MOUSE
AccessioniPrimary (citable) accession number: A2RTH5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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