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UniProtKB - A2RSY7 (A2RSY7_MOUSE)
Protein
Submitted name:
Perforin 1 (Pore forming protein)
Gene
Prf1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
- identical protein binding Source: Ensembl
- wide pore channel activity Source: Ensembl
GO - Biological processi
- cytolysis Source: UniProtKB-KW
- immunological synapse formation Source: Ensembl
- positive regulation of killing of cells of other organism Source: Ensembl
- protein homooligomerization Source: Ensembl
Keywordsi
Biological process | CytolysisARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Perforin 1 (Pore forming protein)Imported |
Gene namesi | Name:Prf1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97551, Prf1 |
VEuPathDBi | HostDB:ENSMUSG00000037202 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Lysosome
- cytolytic granule Source: Ensembl
Other locations
- integral component of membrane Source: Ensembl
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5014296814 | 21 – 554 | Sequence analysisAdd BLAST | 534 |
Keywords - PTMi
Disulfide bondARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000037202, Expressed in decidua and 67 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 374 | MACPFInterPro annotationAdd BLAST | 349 | |
Domaini | 395 – 513 | C2InterPro annotationAdd BLAST | 119 |
Sequence similaritiesi
Belongs to the complement C6/C7/C8/C9 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_039516_2_0_1 |
OMAi | LCKNALQ |
OrthoDBi | 360042at2759 |
Family and domain databases
CDDi | cd04032, C2_Perforin, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR020864, MACPF IPR020863, MACPF_CS IPR037300, Perforin-1_C2 |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF01823, MACPF, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00457, MACPF, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00279, MACPF_1, 1 hit PS51412, MACPF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A2RSY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATCLFLLGL FLLLPRPVPA PCYTATRSEC KQKHKFVPGV WMAGEGMDVT
60 70 80 90 100
TLRRSGSFPV NTQRFLRPDR TCTLCKNSLM RDATQRLPVA ITHWRPHSSH
110 120 130 140 150
CQRNVAAAKV HSTEGVAREA AANINNDWRV GLDVNPRPEA NMRASVAGSH
160 170 180 190 200
SKVANFAAEK TYQDQYNFNS DTVECRMYSF RLVQKPPLHL DFKKALRALP
210 220 230 240 250
RNFNSSTEHA YHRLISSYGT HFITAVDLGG RISVLTALRT CQLTLNGLTA
260 270 280 290 300
DEVGDCLNVE AQVSIGAQAS VSSEYKACEE KKKQHKMATS FHQTYRERHV
310 320 330 340 350
EVLGGPLDST HDLLFGNQAT PEQFSTWTAS LPSNPGLVDY SLEPLHTLLE
360 370 380 390 400
EQNPKREALR QAISHYIMSR ARWQNCSRPC RSGQHKSSHD SCQCECQDSK
410 420 430 440 450
VTNQDCCPRQ RGLAHLVVSN FRAEHLWGDY TTATDAYLKV FFGGQEFRTG
460 470 480 490 500
VVWNNNNPRW TDKMDFENVL LSTGGPLRVQ VWDADYGWDD DLLGSCDRSP
510 520 530 540 550
HSGFHEVTCE LNHGRVKFSY HAKCLPHLTG GTCLEYAPQG LLGDPPGNRS
GAVW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC132300 mRNA Translation: AAI32301.1 BC137962 mRNA Translation: AAI37963.1 |
RefSeqi | NP_035203.3, NM_011073.3 XP_006513433.1, XM_006513370.3 |
Genome annotation databases
GeneIDi | 18646 |
KEGGi | mmu:18646 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC132300 mRNA Translation: AAI32301.1 BC137962 mRNA Translation: AAI37963.1 |
RefSeqi | NP_035203.3, NM_011073.3 XP_006513433.1, XM_006513370.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3723, 592 antibodies from 44 providers |
DNASUi | 18646 |
Genome annotation databases
GeneIDi | 18646 |
KEGGi | mmu:18646 |
Organism-specific databases
CTDi | 5551 |
MGIi | MGI:97551, Prf1 |
VEuPathDBi | HostDB:ENSMUSG00000037202 |
Phylogenomic databases
HOGENOMi | CLU_039516_2_0_1 |
OMAi | LCKNALQ |
OrthoDBi | 360042at2759 |
Miscellaneous databases
BioGRID-ORCSi | 18646, 1 hit in 63 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037202, Expressed in decidua and 67 other tissues |
Family and domain databases
CDDi | cd04032, C2_Perforin, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR020864, MACPF IPR020863, MACPF_CS IPR037300, Perforin-1_C2 |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF01823, MACPF, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00457, MACPF, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00279, MACPF_1, 1 hit PS51412, MACPF_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2RSY7_MOUSE | |
Accessioni | A2RSY7Primary (citable) accession number: A2RSY7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 6, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | January 19, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |