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Protein
Submitted name:

Protocadherin 7

Gene

Pcdh7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin 7Imported
Submitted name:
Protocadherin 7, isoform CRA_dImported
Gene namesi
Name:Pcdh7Imported
ORF Names:mCG_9825Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1860487 Pcdh7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei878 – 901HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_501508606831 – 1069Sequence analysisAdd BLAST1039

Expressioni

Gene expression databases

BgeeiENSMUSG00000029108 Expressed in 262 organ(s), highest expression level in aorta

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 141CAInterPro annotationAdd BLAST94
Domaini165 – 306CAInterPro annotationAdd BLAST142
Domaini330 – 413CAInterPro annotationAdd BLAST84
Domaini445 – 533CAInterPro annotationAdd BLAST89
Domaini557 – 637CAInterPro annotationAdd BLAST81
Domaini661 – 740CAInterPro annotationAdd BLAST80
Domaini766 – 847CAInterPro annotationAdd BLAST82

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II7Q Eukaryota
ENOG410XPHP LUCA
GeneTreeiENSGT00920000148958
HOGENOMiHOG000234535
HOVERGENiHBG053523

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR013585 Protocadherin
PfamiView protein in Pfam
PF00028 Cadherin, 6 hits
PF08266 Cadherin_2, 1 hit
PF08374 Protocadherin, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 7 hits
SUPFAMiSSF49313 SSF49313, 8 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A2RS43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRMRTTGWA RGWCLGCCLL LPLCFSLAAA KQLLRYRLAE EGPADVRIGN
60 70 80 90 100
VASDLGIVTG SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ
110 120 130 140 150
MIFDENECFL DFEVSVIGPS QSWVDLFEGR VIVLDINDNT PTFPSPVLTL
160 170 180 190 200
TVEENRPVGT LYLLPTATDR DFGRNGIERY ELLQEPGGGG GSGEGRRLGP
210 220 230 240 250
ADSAPYPGGG GNSASGGGSG GSKRRLDAPE GGGGTSPSGR SSVFELQVAD
260 270 280 290 300
TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD
310 320 330 340 350
VNDNSPRFEK SVYEADLAEN SAPGTPILQL RATDLDVGVN GQIEYVFGAA
360 370 380 390 400
TESVRRLLRL DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT
410 420 430 440 450
VVLNIKDEND NVPSIEIRKI GRIPLKDGVA NVAEDVLVDT PIALVQVSDR
460 470 480 490 500
DQGENGVVTC TVVGDVPFQL KPASDTEGDQ NKKKYFLHTS APLDYETTRE
510 520 530 540 550
FNVVIVAVDS GSPSLSSNNS LVVKVGDTND NPPVFGQSVV EVYFPENNIP
560 570 580 590 600
GERVATVLAT DADSGKNAEI AYSLDSSVMG TFAIDPDSGD ILVNTVLDRE
610 620 630 640 650
QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE
660 670 680 690 700
NLQPNSPVGM VTVMDADKGR NAEMSLYIEE NSNIFSIEND TGTIYSTMSF
710 720 730 740 750
DREHQTTYTF RVKAVDGGDP PRSATATVSL FVMDENDNAP TVTLPRNISY
760 770 780 790 800
TLLPPSSNVR TVVATVLATD SDDGINADLN YSIVGGNPFK LFEIDSTSGV
810 820 830 840 850
VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN ESVSNATVID
860 870 880 890 900
SQIVRSLHTP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVMM
910 920 930 940 950
ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS
960 970 980 990 1000
IVTVEASKPN GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS
1010 1020 1030 1040 1050
PLPTVQLHPQ SPTAGKKHQA VQDLPPANTF VGAGDNISIG SDHCSEYSCQ
1060
TSNKYSKQMR VHPYITVFG
Length:1,069
Mass (Da):116,258
Last modified:March 6, 2007 - v1
Checksum:i299E221B3498B6A9
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YY83A0A0A6YY83_MOUSE
Protocadherin 7
Pcdh7
1,255Annotation score:
E9Q2S0E9Q2S0_MOUSE
Protocadherin 7
Pcdh7 mCG_9825
1,247Annotation score:
A0A0A6YY48A0A0A6YY48_MOUSE
Protocadherin 7
Pcdh7
802Annotation score:
A0A0A6YW34A0A0A6YW34_MOUSE
Protocadherin 7
Pcdh7
379Annotation score:
A0A0G2JG16A0A0G2JG16_MOUSE
Protocadherin 7
Pcdh7
171Annotation score:
A0A0A6YWD5A0A0A6YWD5_MOUSE
Protocadherin 7
Pcdh7
125Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119244 Genomic DNA No translation available.
AC125025 Genomic DNA No translation available.
AC131036 Genomic DNA No translation available.
AC163275 Genomic DNA No translation available.
BC131967 mRNA Translation: AAI31968.1
CH466524 Genomic DNA Translation: EDL37692.1
RefSeqiNP_061234.2, NM_018764.3
UniGeneiMm.332387
Mm.397491

Genome annotation databases

EnsembliENSMUST00000068110; ENSMUSP00000066306; ENSMUSG00000029108
GeneIDi54216
UCSCiuc008xlt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119244 Genomic DNA No translation available.
AC125025 Genomic DNA No translation available.
AC131036 Genomic DNA No translation available.
AC163275 Genomic DNA No translation available.
BC131967 mRNA Translation: AAI31968.1
CH466524 Genomic DNA Translation: EDL37692.1
RefSeqiNP_061234.2, NM_018764.3
UniGeneiMm.332387
Mm.397491

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068110; ENSMUSP00000066306; ENSMUSG00000029108
GeneIDi54216
UCSCiuc008xlt.2 mouse

Organism-specific databases

CTDi5099
MGIiMGI:1860487 Pcdh7

Phylogenomic databases

eggNOGiENOG410II7Q Eukaryota
ENOG410XPHP LUCA
GeneTreeiENSGT00920000148958
HOGENOMiHOG000234535
HOVERGENiHBG053523

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSiPcdh7 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029108 Expressed in 262 organ(s), highest expression level in aorta

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR013585 Protocadherin
PfamiView protein in Pfam
PF00028 Cadherin, 6 hits
PF08266 Cadherin_2, 1 hit
PF08374 Protocadherin, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 7 hits
SUPFAMiSSF49313 SSF49313, 8 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA2RS43_MOUSE
AccessioniPrimary (citable) accession number: A2RS43
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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