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Entry version 68 (16 Jan 2019)
Sequence version 1 (06 Mar 2007)
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Protein
Submitted name:

LOC100037834 protein

Gene

nrip1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-3899300 SUMOylation of transcription cofactors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LOC100037834 proteinImported
Submitted name:
Nuclear receptor-interacting protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nrip1Imported
Synonyms:LOC100037834Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

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Xenbasei
XB-GENE-968871 nrip1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000023130 Expressed in 14 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000050037

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 326NRIP1_repr_1InterPro annotationAdd BLAST300
Domaini407 – 733NRIP1_repr_2InterPro annotationAdd BLAST327
Domaini835 – 1138NRIP1_repr_4InterPro annotationAdd BLAST304

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFW7 Eukaryota
ENOG410XPVS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007999

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236277

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052667

KEGG Orthology (KO)

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KOi
K17965

Identification of Orthologs from Complete Genome Data

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OMAi
RDGLLCH

Database of Orthologous Groups

More...
OrthoDBi
345693at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332210

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026649 NRIP1
IPR031405 NRIP1_RD1
IPR031406 NRIP1_RD2
IPR031407 NRIP1_RD3
IPR031408 NRIP1_RD4

The PANTHER Classification System

More...
PANTHERi
PTHR15088 PTHR15088, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15687 NRIP1_repr_1, 1 hit
PF15688 NRIP1_repr_2, 1 hit
PF15689 NRIP1_repr_3, 1 hit
PF15690 NRIP1_repr_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2RRS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTYGEELSSE MQQDSVVLTY LEGLLMHQAA GGSGTAVDKL SVSRAKSDEN
60 70 80 90 100
FKNSGNIFSN CESNAPIRNN SSPCQGSGML HLKKARLLQS SEDWNAAKRR
110 120 130 140 150
RLSDSVPGVN GKNETFLAGM VANAPKGKQD STLLASLLQS FSSRLQSVAL
160 170 180 190 200
SQQLKQSLEE QGFSLGQETV HEEKNNQCLG LASNHLKTLL NKSRSKEKVT
210 220 230 240 250
DSKMTAKASI QEKSSHSGQS STKAGAAEPI SCAARLQAVA SMVEKRSSPT
260 270 280 290 300
VSPKPSVACS QLALLLSSEA HLQQYSREHA VKAQSASQLA SERLAAMARL
310 320 330 340 350
KETSEKDHGH FPMSTNLPTP LNSPARTTIS NGISNIGNIS PFSSPLSVPH
360 370 380 390 400
SPLKSVGYKT HSEKNHLKPS PNNSLLLHLL KSQNATNMNK CNLQSEKIPV
410 420 430 440 450
FEESATPTTT DDFSDNNPSF TEDETSDDES SHSNCAPIDL SFKNRVDKPE
460 470 480 490 500
VLNTASIDNL TESLLKNWDP KVEGLVINKD NNRDPSLDST LKPHQKVTLL
510 520 530 540 550
QLLLGHKADE NPEKMEDLQG SQKRSDLTKF NLPIQRHGSE NTHVHNSASL
560 570 580 590 600
NTLPINNSLK SDSPVNLSQP FPPKNTFTSY ISNIQSERHV NAASKHLIEL
610 620 630 640 650
TRNKSFHNPT PVVNESAQCN AAFSASKLLQ NLAQCGLQTA APDEQKVQKT
660 670 680 690 700
VSAPNGKTLG LIDRLSSPLI TNQSHAFEED TSFSSPPTPS DSRFPGSEIE
710 720 730 740 750
NLLERRTVLQ LLLGTPNKGK LEKSPNITIK DENQQDRVEK NASEHIVSFK
760 770 780 790 800
IKSEPEDAYS TQHLRDTGIP SPLAMSFHGF SRSTPEGMKS PNLTPQDFSV
810 820 830 840 850
SRNGLLSRLL TQNHNGYEIS DPDFTNRNGE SRQTETKIHC TVPKKRKMHQ
860 870 880 890 900
HEPLESQVKL AKLSPSESGH YYSPPPLSGP MFLQDETYSN KSGMDPRCNL
910 920 930 940 950
TQNSLNEGKH LGWSRESKGF NVLKQLLLSE NCVRDLSQHR NNILVDDMVK
960 970 980 990 1000
GNRSHLAGSS DFVTPPLNVH MGKMSNQTNS LGQMTFQCPS TLKNSPHPPS
1010 1020 1030 1040 1050
DSLIHKTSRT ESGQINMCPV PNDKGPIKWV ITGMEKNDVG KDSPRLTKTN
1060 1070 1080 1090 1100
PILYYMLQKG AHSAGGQELR DRGSWTASLL GNATEMTLKR EMVNCRGTTP
1110 1120 1130
NGSGMMKTTT PVVNKTLHNS SGNKYGLLDI LAIKKEPE
Length:1,138
Mass (Da):124,650
Last modified:March 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC10CAF9D07BF253E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAMC01091601 Genomic DNA No translation available.
AAMC01091602 Genomic DNA No translation available.
AAMC01091603 Genomic DNA No translation available.
AAMC01091604 Genomic DNA No translation available.
BC131832 mRNA Translation: AAI31833.1

NCBI Reference Sequences

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RefSeqi
NP_001090752.1, NM_001097283.1
XP_012811682.1, XM_012956228.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Str.34500

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000050037; ENSXETP00000050037; ENSXETG00000023130

Database of genes from NCBI RefSeq genomes

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GeneIDi
100037834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100037834

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01091601 Genomic DNA No translation available.
AAMC01091602 Genomic DNA No translation available.
AAMC01091603 Genomic DNA No translation available.
AAMC01091604 Genomic DNA No translation available.
BC131832 mRNA Translation: AAI31833.1
RefSeqiNP_001090752.1, NM_001097283.1
XP_012811682.1, XM_012956228.2
UniGeneiStr.34500

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000050037

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000050037; ENSXETP00000050037; ENSXETG00000023130
GeneIDi100037834
KEGGixtr:100037834

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8204
XenbaseiXB-GENE-968871 nrip1

Phylogenomic databases

eggNOGiENOG410IFW7 Eukaryota
ENOG410XPVS LUCA
GeneTreeiENSGT00390000007999
HOGENOMiHOG000236277
HOVERGENiHBG052667
KOiK17965
OMAiRDGLLCH
OrthoDBi345693at2759
TreeFamiTF332210

Enzyme and pathway databases

ReactomeiR-XTR-3899300 SUMOylation of transcription cofactors

Gene expression databases

BgeeiENSXETG00000023130 Expressed in 14 organ(s), highest expression level in embryo

Family and domain databases

InterProiView protein in InterPro
IPR026649 NRIP1
IPR031405 NRIP1_RD1
IPR031406 NRIP1_RD2
IPR031407 NRIP1_RD3
IPR031408 NRIP1_RD4
PANTHERiPTHR15088 PTHR15088, 1 hit
PfamiView protein in Pfam
PF15687 NRIP1_repr_1, 1 hit
PF15688 NRIP1_repr_2, 1 hit
PF15689 NRIP1_repr_3, 1 hit
PF15690 NRIP1_repr_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2RRS6_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RRS6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: January 16, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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