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Entry version 77 (08 May 2019)
Sequence version 2 (10 Aug 2010)
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Protein

Transmembrane protein 213

Gene

TMEM213

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 213
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM213
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:27220 TMEM213

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2RRL7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 70ExtracellularSequence analysisAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 107CytoplasmicSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
155006

Open Targets

More...
OpenTargetsi
ENSG00000214128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162406494

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033705428 – 107Transmembrane protein 213Add BLAST80

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2RRL7

PRoteomics IDEntifications database

More...
PRIDEi
A2RRL7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
472
473 [A2RRL7-2]
474 [A2RRL7-3]
475 [A2RRL7-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214128 Expressed in 67 organ(s), highest expression level in kidney epithelium

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2RRL7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054059

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127567, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000390407

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J39B Eukaryota
ENOG411196J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014153

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154626

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2RRL7

Identification of Orthologs from Complete Genome Data

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OMAi
CLNVDFC

Database of Orthologous Groups

More...
OrthoDBi
1521865at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2RRL7

TreeFam database of animal gene trees

More...
TreeFami
TF336187

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028121 TMEM213

The PANTHER Classification System

More...
PANTHERi
PTHR36293 PTHR36293, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15192 TMEM213, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2RRL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRLPAATRA TLILSLAFAS LHSACSAEAS SSNSSSLTAH HPDPGTLEQC
60 70 80 90 100
LNVDFCPQAA RCCRTGVDEY GWIAAAVGWS LWFLTLILLC VDKLMKLTPD

EPKDLQA
Note: Gene prediction based on EST data.
Length:107
Mass (Da):11,520
Last modified:August 10, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDE87C507C11E0D3
GO
Isoform 2 (identifier: A2RRL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-52: EASSSNSSSLTAHHPDPGTLEQCLN → D

Note: Gene prediction based on EST data.
Show »
Length:83
Mass (Da):9,071
Checksum:i73B38E1FA5687D74
GO
Isoform 3 (identifier: A2RRL7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: Missing.

Note: No experimental confirmation available.
Show »
Length:106
Mass (Da):11,391
Checksum:i4934C5D10F5165C0
GO
Isoform 4 (identifier: A2RRL7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-107: NVDFCPQAAR...TPDEPKDLQA → RSGYLANLRG...GWRSSVELVG

Note: Gene prediction based on EST data.
Show »
Length:105
Mass (Da):11,555
Checksum:i29AAA003103DD050
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI31698 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03955528 – 52EASSS…EQCLN → D in isoform 2. CuratedAdd BLAST25
Alternative sequenceiVSP_03955628Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_03955752 – 107NVDFC…KDLQA → RSGYLANLRGEADQLWKFCT VLCFWESRRSSSRIALMREA EEWPGWRSSVELVG in isoform 4. CuratedAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC018663 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24042.1
CH471070 Genomic DNA Translation: EAW83898.1
BC131697 mRNA Translation: AAI31698.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47722.1 [A2RRL7-1]

NCBI Reference Sequences

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RefSeqi
NP_001078898.1, NM_001085429.1 [A2RRL7-1]
XP_005250224.1, XM_005250167.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397602; ENSP00000380727; ENSG00000214128 [A2RRL7-3]
ENST00000413208; ENSP00000401570; ENSG00000214128 [A2RRL7-4]
ENST00000442682; ENSP00000390407; ENSG00000214128 [A2RRL7-1]
ENST00000458494; ENSP00000393891; ENSG00000214128 [A2RRL7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
155006

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:155006

UCSC genome browser

More...
UCSCi
uc010lna.5 human [A2RRL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018663 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24042.1
CH471070 Genomic DNA Translation: EAW83898.1
BC131697 mRNA Translation: AAI31698.1 Different initiation.
CCDSiCCDS47722.1 [A2RRL7-1]
RefSeqiNP_001078898.1, NM_001085429.1 [A2RRL7-1]
XP_005250224.1, XM_005250167.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127567, 7 interactors
STRINGi9606.ENSP00000390407

Polymorphism and mutation databases

BioMutaiTMEM213

Proteomic databases

PaxDbiA2RRL7
PRIDEiA2RRL7
ProteomicsDBi472
473 [A2RRL7-2]
474 [A2RRL7-3]
475 [A2RRL7-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397602; ENSP00000380727; ENSG00000214128 [A2RRL7-3]
ENST00000413208; ENSP00000401570; ENSG00000214128 [A2RRL7-4]
ENST00000442682; ENSP00000390407; ENSG00000214128 [A2RRL7-1]
ENST00000458494; ENSP00000393891; ENSG00000214128 [A2RRL7-2]
GeneIDi155006
KEGGihsa:155006
UCSCiuc010lna.5 human [A2RRL7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
155006
DisGeNETi155006

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM213
HGNCiHGNC:27220 TMEM213
HPAiHPA054059
neXtProtiNX_A2RRL7
OpenTargetsiENSG00000214128
PharmGKBiPA162406494

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J39B Eukaryota
ENOG411196J LUCA
GeneTreeiENSGT00390000014153
HOGENOMiHOG000154626
InParanoidiA2RRL7
OMAiCLNVDFC
OrthoDBi1521865at2759
PhylomeDBiA2RRL7
TreeFamiTF336187

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
155006

Protein Ontology

More...
PROi
PR:A2RRL7

Gene expression databases

BgeeiENSG00000214128 Expressed in 67 organ(s), highest expression level in kidney epithelium
GenevisibleiA2RRL7 HS

Family and domain databases

InterProiView protein in InterPro
IPR028121 TMEM213
PANTHERiPTHR36293 PTHR36293, 1 hit
PfamiView protein in Pfam
PF15192 TMEM213, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM213_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RRL7
Secondary accession number(s): A4D1R3
, C9JH49, C9JX41, C9K0P0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 10, 2010
Last modified: May 8, 2019
This is version 77 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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