UniProtKB - A2RRH5 (WDR27_HUMAN)
Protein
WD repeat-containing protein 27
Gene
WDR27
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 27 |
Gene namesi | Name:WDR27 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21248, WDR27 |
neXtProti | NX_A2RRH5 |
VEuPathDBi | HostDB:ENSG00000184465.15 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 253769 |
OpenTargetsi | ENSG00000184465 |
PharmGKBi | PA134875091 |
Miscellaneous databases
Pharosi | A2RRH5, Tdark |
Genetic variation databases
BioMutai | WDR27 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306831 | 1 – 827 | WD repeat-containing protein 27Add BLAST | 827 |
Proteomic databases
MassIVEi | A2RRH5 |
PaxDbi | A2RRH5 |
PeptideAtlasi | A2RRH5 |
PRIDEi | A2RRH5 |
ProteomicsDBi | 10146 468 [A2RRH5-1] 469 [A2RRH5-2] 470 [A2RRH5-3] 471 [A2RRH5-4] |
TopDownProteomicsi | A2RRH5-2 [A2RRH5-2] |
PTM databases
iPTMneti | A2RRH5 |
PhosphoSitePlusi | A2RRH5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184465, Expressed in right uterine tube and 191 other tissues |
ExpressionAtlasi | A2RRH5, baseline and differential |
Genevisiblei | A2RRH5, HS |
Organism-specific databases
HPAi | ENSG00000184465, Low tissue specificity |
Interactioni
Binary interactionsi
A2RRH5
With | #Exp. | IntAct |
---|---|---|
ASNS [P08243] | 3 | EBI-9476803,EBI-722989 |
Protein-protein interaction databases
BioGRIDi | 128986, 5 interactors |
IntActi | A2RRH5, 2 interactors |
STRINGi | 9606.ENSP00000416289 |
Miscellaneous databases
RNActi | A2RRH5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 3 – 57 | WD 1Add BLAST | 55 | |
Repeati | 62 – 101 | WD 2Add BLAST | 40 | |
Repeati | 112 – 151 | WD 3Add BLAST | 40 | |
Repeati | 155 – 194 | WD 4Add BLAST | 40 | |
Repeati | 201 – 237 | WD 5Add BLAST | 37 | |
Repeati | 292 – 337 | WD 6Add BLAST | 46 | |
Repeati | 344 – 387 | WD 7Add BLAST | 44 | |
Repeati | 502 – 542 | WD 8Add BLAST | 41 | |
Repeati | 546 – 584 | WD 9Add BLAST | 39 | |
Repeati | 590 – 629 | WD 10Add BLAST | 40 | |
Repeati | 646 – 687 | WD 11Add BLAST | 42 | |
Repeati | 698 – 740 | WD 12Add BLAST | 43 | |
Repeati | 746 – 784 | WD 13Add BLAST | 39 | |
Repeati | 788 – 826 | WD 14Add BLAST | 39 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0266, Eukaryota |
GeneTreei | ENSGT00390000012017 |
HOGENOMi | CLU_018295_0_0_1 |
InParanoidi | A2RRH5 |
OMAi | AEFCPWQ |
OrthoDBi | 698548at2759 |
PhylomeDBi | A2RRH5 |
TreeFami | TF351563 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR011047, Quinoprotein_ADH-like_supfam IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR042411, WDR27 |
PANTHERi | PTHR44525, PTHR44525, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
SMARTi | View protein in SMART SM00320, WD40, 10 hits |
SUPFAMi | SSF50998, SSF50998, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A2RRH5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENPQDIFSS NGGCLSDIVI EKYLVESKES VSHVQLACSM QDCAFPLDGT
60 70 80 90 100
ELCIWNTKDP SHQLLILRGH HQPITAMAFG NKVNPLLICS ASLDYVIMWN
110 120 130 140 150
LDECREKVLQ GLVPRGTVMG SLLGKVLCLQ LSLDDHVVAV CAGNKIFMLD
160 170 180 190 200
IETQAVRAEL QGHLGPVTAV EFCPWRAGTL ISASEDRGFK VWDHCTGSLI
210 220 230 240 250
YSSSVLSAYP LLSLFIDAES RQLVTGCADG QLWIFSLMDG HHYRRVARVD
260 270 280 290 300
LRKKTETFST RRVKSGLCSQ PEESQLPSTS ALGKGEQVEV TFPVLRLAPC
310 320 330 340 350
DLSLIPNSAC GCLSSENTRC VWIGSSVGLF VFNLANLEVE AALYYKDFQS
360 370 380 390 400
LSILLAGSCA LRNRTADQKV LCLLASLFGG KIAVLEINPA ALVRAQQCPS
410 420 430 440 450
MGQSLSVPAS SCVLPTSPLY LGIAKEKSTK AASEQRRAAR NVMKDQRLVF
460 470 480 490 500
HSKVRSSGYA SAPHVTMFSP KTNIKSEGKG SSRSRSSCAR EAYPVECAVP
510 520 530 540 550
TKPGPQVAAA PTCTRVCCIQ YSGDGQWLAC GLANHLLLVF DASLTGTPAV
560 570 580 590 600
FSGHDGAVNA VCWSQDRRWL LSAARDGTLR MWSARGAELA LLLGKDMFSK
610 620 630 640 650
PIQSAQFYYI DAFILLSSGP EFQLLRYHID TCKDEIKRYK QKSKSKLICR
660 670 680 690 700
LSTTGAVDMT SLSAVNDFYS HIVLAAGRNR TVEVFDLNAG CSAAVIAEAH
710 720 730 740 750
SRPVHQICQN KGSSFTTQQP QAYNLFLTTA IGDGMRLWDL RTLRCERHFE
760 770 780 790 800
GHPTRGYPCG IAFSPCGRFA ACGAEDRHAY VYEMGSSTFS HRLAGHTDTV
810 820
TGVAFNPSAP QLATATLDGK LQLFLAE
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C3H5 | H7C3H5_HUMAN | WD repeat-containing protein 27 | WDR27 | 195 | Annotation score: | ||
A0A3B3IS64 | A0A3B3IS64_HUMAN | WD repeat-containing protein 27 | WDR27 | 338 | Annotation score: | ||
F8VUY7 | F8VUY7_HUMAN | WD repeat-containing protein 27 | WDR27 | 88 | Annotation score: | ||
A0A3B3ITF5 | A0A3B3ITF5_HUMAN | WD repeat-containing protein 27 | WDR27 | 437 | Annotation score: | ||
B4DDD4 | B4DDD4_HUMAN | WD repeat-containing protein 27 | WDR27 | 181 | Annotation score: | ||
A0A3B3IT90 | A0A3B3IT90_HUMAN | WD repeat-containing protein 27 | WDR27 | 177 | Annotation score: | ||
A0A3B3IRT0 | A0A3B3IRT0_HUMAN | WD repeat-containing protein 27 | WDR27 | 128 | Annotation score: | ||
A0A3B3ISN9 | A0A3B3ISN9_HUMAN | WD repeat-containing protein 27 | WDR27 | 163 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 153 | T → A in BC040606 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 512 | T → S in AAI31634 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 512 | T → S in AAI42983 (PubMed:15489334).Curated | 1 | ||
Isoform 4 (identifier: A2RRH5-4) | |||||
Sequence conflicti | 845 | R → C in BC040606 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 875 | L → F in BC040606 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035317 | 133 | L → P1 PublicationCorresponds to variant dbSNP:rs4236176Ensembl. | 1 | |
Natural variantiVAR_035318 | 393 | V → L. Corresponds to variant dbSNP:rs35895089Ensembl. | 1 | |
Natural variantiVAR_035319 | 437 | R → H1 PublicationCorresponds to variant dbSNP:rs3800544Ensembl. | 1 | |
Natural variantiVAR_035320 | 470 | P → L. Corresponds to variant dbSNP:rs34313252Ensembl. | 1 | |
Natural variantiVAR_035321 | 697 | A → V. Corresponds to variant dbSNP:rs9396946Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028510 | 111 – 207 | Missing in isoform 2. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_028511 | 111 – 112 | GL → GK in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_028512 | 113 – 827 | Missing in isoform 3. 1 PublicationAdd BLAST | 715 | |
Alternative sequenceiVSP_040796 | 152 | E → EQRFSVTYIERPDVNNRHKV PPPTFLHTFSQ in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_040797 | 812 – 827 | LATAT…LFLAE → MESRSVAHAGVQWHDLGSLQ PPPSRFKQFFCLSLPSSWDY SLPQLPWMVNSSSF in isoform 4. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031315 Genomic DNA No translation available. AL135910 Genomic DNA No translation available. AL441927 Genomic DNA No translation available. AL513547 Genomic DNA No translation available. BC040606 mRNA No translation available. BC131633 mRNA Translation: AAI31634.1 BC142982 mRNA Translation: AAI42983.1 |
CCDSi | CCDS47520.2 [A2RRH5-4] CCDS56459.1 [A2RRH5-2] |
RefSeqi | NP_001189479.1, NM_001202550.1 [A2RRH5-2] NP_872358.4, NM_182552.4 [A2RRH5-4] |
Genome annotation databases
Ensembli | ENST00000423258; ENSP00000397869; ENSG00000184465 [A2RRH5-2] ENST00000448612; ENSP00000416289; ENSG00000184465 [A2RRH5-4] |
GeneIDi | 253769 |
KEGGi | hsa:253769 |
UCSCi | uc003qwx.4, human [A2RRH5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031315 Genomic DNA No translation available. AL135910 Genomic DNA No translation available. AL441927 Genomic DNA No translation available. AL513547 Genomic DNA No translation available. BC040606 mRNA No translation available. BC131633 mRNA Translation: AAI31634.1 BC142982 mRNA Translation: AAI42983.1 |
CCDSi | CCDS47520.2 [A2RRH5-4] CCDS56459.1 [A2RRH5-2] |
RefSeqi | NP_001189479.1, NM_001202550.1 [A2RRH5-2] NP_872358.4, NM_182552.4 [A2RRH5-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128986, 5 interactors |
IntActi | A2RRH5, 2 interactors |
STRINGi | 9606.ENSP00000416289 |
PTM databases
iPTMneti | A2RRH5 |
PhosphoSitePlusi | A2RRH5 |
Genetic variation databases
BioMutai | WDR27 |
Proteomic databases
MassIVEi | A2RRH5 |
PaxDbi | A2RRH5 |
PeptideAtlasi | A2RRH5 |
PRIDEi | A2RRH5 |
ProteomicsDBi | 10146 468 [A2RRH5-1] 469 [A2RRH5-2] 470 [A2RRH5-3] 471 [A2RRH5-4] |
TopDownProteomicsi | A2RRH5-2 [A2RRH5-2] |
Protocols and materials databases
Antibodypediai | 49469, 98 antibodies |
Genome annotation databases
Ensembli | ENST00000423258; ENSP00000397869; ENSG00000184465 [A2RRH5-2] ENST00000448612; ENSP00000416289; ENSG00000184465 [A2RRH5-4] |
GeneIDi | 253769 |
KEGGi | hsa:253769 |
UCSCi | uc003qwx.4, human [A2RRH5-1] |
Organism-specific databases
CTDi | 253769 |
DisGeNETi | 253769 |
GeneCardsi | WDR27 |
HGNCi | HGNC:21248, WDR27 |
HPAi | ENSG00000184465, Low tissue specificity |
neXtProti | NX_A2RRH5 |
OpenTargetsi | ENSG00000184465 |
PharmGKBi | PA134875091 |
VEuPathDBi | HostDB:ENSG00000184465.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0266, Eukaryota |
GeneTreei | ENSGT00390000012017 |
HOGENOMi | CLU_018295_0_0_1 |
InParanoidi | A2RRH5 |
OMAi | AEFCPWQ |
OrthoDBi | 698548at2759 |
PhylomeDBi | A2RRH5 |
TreeFami | TF351563 |
Enzyme and pathway databases
PathwayCommonsi | A2RRH5 |
SignaLinki | A2RRH5 |
Miscellaneous databases
BioGRID-ORCSi | 253769, 2 hits in 1001 CRISPR screens |
ChiTaRSi | WDR27, human |
GenomeRNAii | 253769 |
Pharosi | A2RRH5, Tdark |
PROi | PR:A2RRH5 |
RNActi | A2RRH5, protein |
Gene expression databases
Bgeei | ENSG00000184465, Expressed in right uterine tube and 191 other tissues |
ExpressionAtlasi | A2RRH5, baseline and differential |
Genevisiblei | A2RRH5, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR011047, Quinoprotein_ADH-like_supfam IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR042411, WDR27 |
PANTHERi | PTHR44525, PTHR44525, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
SMARTi | View protein in SMART SM00320, WD40, 10 hits |
SUPFAMi | SSF50998, SSF50998, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR27_HUMAN | |
Accessioni | A2RRH5Primary (citable) accession number: A2RRH5 Secondary accession number(s): A5PLM8, C9JGV0, Q5T066 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | April 5, 2011 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports