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Protein

Zinc finger protein 320

Gene

ZNF320

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri161 – 183C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 320
Gene namesi
Name:ZNF320
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000182986.12
HGNCiHGNC:13842 ZNF320
MIMi606427 gene
neXtProtiNX_A2RRD8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ZNF320 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with BRWD2/WDR11.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

OpenTargetsiENSG00000182986
ENSG00000204604
PharmGKBiPA37819

Polymorphism and mutation databases

BioMutaiZNF320

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003002631 – 509Zinc finger protein 320Add BLAST509

Proteomic databases

EPDiA2RRD8
MaxQBiA2RRD8
PaxDbiA2RRD8
PRIDEiA2RRD8
ProteomicsDBi462

PTM databases

iPTMnetiA2RRD8
PhosphoSitePlusiA2RRD8

Expressioni

Tissue specificityi

Expressed at high levels in placenta, pancreas, kidney and heart, and at lower levels in liver, skeletal muscle and brain.1 Publication

Gene expression databases

BgeeiENSG00000182986 Expressed in 191 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ZNF320
ExpressionAtlasiA2RRD8 baseline and differential
GenevisibleiA2RRD8 HS

Organism-specific databases

HPAiHPA043696
HPA062474

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi127834, 5 interactors
IntActiA2RRD8, 2 interactors
STRINGi9606.ENSP00000375660

Structurei

3D structure databases

ProteinModelPortaliA2RRD8
SMRiA2RRD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 80KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri161 – 183C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149028
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA2RRD8
KOiK09228
OMAiTFKHDSH
OrthoDBiEOG091G02KC
PhylomeDBiA2RRD8
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A2RRD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMNTLSS TGQGNTEVIH TGTLQRQASY HIGAFCSQEI EKDIHDFVFQ
110 120 130 140 150
WQEDETNDHE APMTEIKKLT SSTDRYDQRH AGNKPIKGQL ESRFHLHLRR
160 170 180 190 200
HRRIHTGEKP YKCEECEKVF SCKSHLEIHR IIHTGEKPYK CKVCDKAFKH
210 220 230 240 250
DSHLAKHTRI HRGDKHYTCN ECGKVFDQKA TLACHHRSHT GEKPYKCNEC
260 270 280 290 300
GKTFSQTSHL VYHHRLHTGE KPYKCNECGK TFARNSVLVI HKAVHTAEKP
310 320 330 340 350
YKCNECGKVF KQRATLAGHR RVHTGEKPYR CEECDKVFSR KSHLERHRRI
360 370 380 390 400
HTGEKPYKCK VCDKAFRSDS RLAEHQRVHT GERPYTCNEC GKVFSTKAYL
410 420 430 440 450
ACHQKLHTGE KLYECEECDK VYIRKSHLER HRRIHTGEKP HKCGDCGKAF
460 470 480 490 500
NSPSHLIRHQ RIHTGQKSYK CHQCGKVFSL RSLLAEHQKI PFGDNCFKCN

EYSKPSSIN
Length:509
Mass (Da):59,326
Last modified:March 6, 2007 - v1
Checksum:i2D221BC43C684B61
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX96M0QX96_HUMAN
Zinc finger protein 320
ZNF320
155Annotation score:
M0R2L4M0R2L4_HUMAN
Zinc finger protein 320
ZNF320
123Annotation score:
M0QZA2M0QZA2_HUMAN
Zinc finger protein 320
ZNF320
86Annotation score:
M0R1K6M0R1K6_HUMAN
Zinc finger protein 320
ZNF320
57Annotation score:
M0R0Z8M0R0Z8_HUMAN
Zinc finger protein 320
ZNF320
25Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131555 mRNA Translation: AAI31556.1
AL831902 mRNA Translation: CAD38570.1
CCDSiCCDS33095.1
RefSeqiNP_997216.2, NM_207333.2
XP_006723122.1, XM_006723059.3
XP_016881882.1, XM_017026393.1
XP_016881883.1, XM_017026394.1
XP_016881884.1, XM_017026395.1
XP_016881885.1, XM_017026396.1
XP_016881886.1, XM_017026397.1
XP_016881887.1, XM_017026398.1
XP_016881888.1, XM_017026399.1
XP_016881889.1, XM_017026400.1
UniGeneiHs.369632
Hs.739250

Genome annotation databases

EnsembliENST00000595635; ENSP00000473091; ENSG00000182986
GeneIDi162967
KEGGihsa:162967
UCSCiuc002qai.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC131555 mRNA Translation: AAI31556.1
AL831902 mRNA Translation: CAD38570.1
CCDSiCCDS33095.1
RefSeqiNP_997216.2, NM_207333.2
XP_006723122.1, XM_006723059.3
XP_016881882.1, XM_017026393.1
XP_016881883.1, XM_017026394.1
XP_016881884.1, XM_017026395.1
XP_016881885.1, XM_017026396.1
XP_016881886.1, XM_017026397.1
XP_016881887.1, XM_017026398.1
XP_016881888.1, XM_017026399.1
XP_016881889.1, XM_017026400.1
UniGeneiHs.369632
Hs.739250

3D structure databases

ProteinModelPortaliA2RRD8
SMRiA2RRD8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127834, 5 interactors
IntActiA2RRD8, 2 interactors
STRINGi9606.ENSP00000375660

PTM databases

iPTMnetiA2RRD8
PhosphoSitePlusiA2RRD8

Polymorphism and mutation databases

BioMutaiZNF320

Proteomic databases

EPDiA2RRD8
MaxQBiA2RRD8
PaxDbiA2RRD8
PRIDEiA2RRD8
ProteomicsDBi462

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000595635; ENSP00000473091; ENSG00000182986
GeneIDi162967
KEGGihsa:162967
UCSCiuc002qai.4 human

Organism-specific databases

CTDi162967
EuPathDBiHostDB:ENSG00000182986.12
GeneCardsiZNF320
HGNCiHGNC:13842 ZNF320
HPAiHPA043696
HPA062474
MIMi606427 gene
neXtProtiNX_A2RRD8
OpenTargetsiENSG00000182986
ENSG00000204604
PharmGKBiPA37819
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149028
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA2RRD8
KOiK09228
OMAiTFKHDSH
OrthoDBiEOG091G02KC
PhylomeDBiA2RRD8
TreeFamiTF341892

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF320 human
GenomeRNAii162967
PROiPR:A2RRD8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182986 Expressed in 191 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ZNF320
ExpressionAtlasiA2RRD8 baseline and differential
GenevisibleiA2RRD8 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN320_HUMAN
AccessioniPrimary (citable) accession number: A2RRD8
Secondary accession number(s): Q8NDR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 6, 2007
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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