UniProtKB - A2RRD8 (ZN320_HUMAN)
Protein
Zinc finger protein 320
Gene
ZNF320
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 161 – 183 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 189 – 211 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 217 – 239 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 245 – 267 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 273 – 295 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 301 – 323 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 329 – 351 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 357 – 379 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 385 – 407 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 413 – 435 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 441 – 463 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 469 – 491 | C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | A2RRD8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 320 |
Gene namesi | Name:ZNF320 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13842, ZNF320 |
MIMi | 606427, gene |
neXtProti | NX_A2RRD8 |
VEuPathDBi | HostDB:ENSG00000182986.12 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving ZNF320 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with BRWD2/WDR11.1 Publication
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
OpenTargetsi | ENSG00000182986 |
PharmGKBi | PA37819 |
Miscellaneous databases
Pharosi | A2RRD8, Tdark |
Genetic variation databases
BioMutai | ZNF320 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000300263 | 1 – 509 | Zinc finger protein 320Add BLAST | 509 |
Proteomic databases
EPDi | A2RRD8 |
jPOSTi | A2RRD8 |
MassIVEi | A2RRD8 |
MaxQBi | A2RRD8 |
PaxDbi | A2RRD8 |
PeptideAtlasi | A2RRD8 |
PRIDEi | A2RRD8 |
ProteomicsDBi | 462 |
PTM databases
iPTMneti | A2RRD8 |
PhosphoSitePlusi | A2RRD8 |
Expressioni
Tissue specificityi
Expressed at high levels in placenta, pancreas, kidney and heart, and at lower levels in liver, skeletal muscle and brain.1 Publication
Gene expression databases
Bgeei | ENSG00000182986, Expressed in buccal mucosa cell and 208 other tissues |
ExpressionAtlasi | A2RRD8, baseline and differential |
Genevisiblei | A2RRD8, HS |
Organism-specific databases
HPAi | ENSG00000182986, Low tissue specificity ENSG00000204604, Tissue enhanced (placenta) |
Interactioni
Binary interactionsi
Hide detailsA2RRD8
With | #Exp. | IntAct |
---|---|---|
KRTAP10-5 [P60370] | 3 | EBI-10173019,EBI-10172150 |
KRTAP10-7 [P60409] | 3 | EBI-10173019,EBI-10172290 |
Protein-protein interaction databases
BioGRIDi | 127834, 7 interactors |
IntActi | A2RRD8, 3 interactors |
STRINGi | 9606.ENSP00000473091 |
Miscellaneous databases
RNActi | A2RRD8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 80 | KRABPROSITE-ProRule annotationAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 161 – 183 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 189 – 211 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 217 – 239 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 245 – 267 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 273 – 295 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 301 – 323 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 329 – 351 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 357 – 379 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 385 – 407 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 413 – 435 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 441 – 463 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 469 – 491 | C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163506 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | A2RRD8 |
OMAi | YHIGALC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A2RRD8 |
TreeFami | TF341892 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
A2RRD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMNTLSS TGQGNTEVIH TGTLQRQASY HIGAFCSQEI EKDIHDFVFQ
110 120 130 140 150
WQEDETNDHE APMTEIKKLT SSTDRYDQRH AGNKPIKGQL ESRFHLHLRR
160 170 180 190 200
HRRIHTGEKP YKCEECEKVF SCKSHLEIHR IIHTGEKPYK CKVCDKAFKH
210 220 230 240 250
DSHLAKHTRI HRGDKHYTCN ECGKVFDQKA TLACHHRSHT GEKPYKCNEC
260 270 280 290 300
GKTFSQTSHL VYHHRLHTGE KPYKCNECGK TFARNSVLVI HKAVHTAEKP
310 320 330 340 350
YKCNECGKVF KQRATLAGHR RVHTGEKPYR CEECDKVFSR KSHLERHRRI
360 370 380 390 400
HTGEKPYKCK VCDKAFRSDS RLAEHQRVHT GERPYTCNEC GKVFSTKAYL
410 420 430 440 450
ACHQKLHTGE KLYECEECDK VYIRKSHLER HRRIHTGEKP HKCGDCGKAF
460 470 480 490 500
NSPSHLIRHQ RIHTGQKSYK CHQCGKVFSL RSLLAEHQKI PFGDNCFKCN
EYSKPSSIN
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QX96 | M0QX96_HUMAN | Zinc finger protein 320 | ZNF320 | 155 | Annotation score: | ||
M0QZA2 | M0QZA2_HUMAN | Zinc finger protein 320 | ZNF320 | 86 | Annotation score: | ||
M0R1K6 | M0R1K6_HUMAN | Zinc finger protein 320 | ZNF320 | 57 | Annotation score: | ||
M0R2L4 | M0R2L4_HUMAN | Zinc finger protein 320 | ZNF320 | 123 | Annotation score: | ||
M0R0Z8 | M0R0Z8_HUMAN | Zinc finger protein 320 | ZNF320 | 25 | Annotation score: | ||
A0A669KBJ2 | A0A669KBJ2_HUMAN | Zinc finger protein 320 | ZNF320 | 117 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC131555 mRNA Translation: AAI31556.1 AL831902 mRNA Translation: CAD38570.1 |
CCDSi | CCDS33095.1 |
RefSeqi | NP_997216.2, NM_207333.2 XP_006723122.1, XM_006723059.3 XP_016881882.1, XM_017026393.1 XP_016881883.1, XM_017026394.1 XP_016881884.1, XM_017026395.1 XP_016881885.1, XM_017026396.1 XP_016881886.1, XM_017026397.1 XP_016881887.1, XM_017026398.1 XP_016881888.1, XM_017026399.1 XP_016881889.1, XM_017026400.1 |
Genome annotation databases
Ensembli | ENST00000391781; ENSP00000375660; ENSG00000182986 ENST00000595635; ENSP00000473091; ENSG00000182986 |
GeneIDi | 162967 |
KEGGi | hsa:162967 |
UCSCi | uc002qai.4, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC131555 mRNA Translation: AAI31556.1 AL831902 mRNA Translation: CAD38570.1 |
CCDSi | CCDS33095.1 |
RefSeqi | NP_997216.2, NM_207333.2 XP_006723122.1, XM_006723059.3 XP_016881882.1, XM_017026393.1 XP_016881883.1, XM_017026394.1 XP_016881884.1, XM_017026395.1 XP_016881885.1, XM_017026396.1 XP_016881886.1, XM_017026397.1 XP_016881887.1, XM_017026398.1 XP_016881888.1, XM_017026399.1 XP_016881889.1, XM_017026400.1 |
3D structure databases
SMRi | A2RRD8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127834, 7 interactors |
IntActi | A2RRD8, 3 interactors |
STRINGi | 9606.ENSP00000473091 |
PTM databases
iPTMneti | A2RRD8 |
PhosphoSitePlusi | A2RRD8 |
Genetic variation databases
BioMutai | ZNF320 |
Proteomic databases
EPDi | A2RRD8 |
jPOSTi | A2RRD8 |
MassIVEi | A2RRD8 |
MaxQBi | A2RRD8 |
PaxDbi | A2RRD8 |
PeptideAtlasi | A2RRD8 |
PRIDEi | A2RRD8 |
ProteomicsDBi | 462 |
Protocols and materials databases
Antibodypediai | 46227, 41 antibodies |
Genome annotation databases
Ensembli | ENST00000391781; ENSP00000375660; ENSG00000182986 ENST00000595635; ENSP00000473091; ENSG00000182986 |
GeneIDi | 162967 |
KEGGi | hsa:162967 |
UCSCi | uc002qai.4, human |
Organism-specific databases
CTDi | 162967 |
GeneCardsi | ZNF320 |
HGNCi | HGNC:13842, ZNF320 |
HPAi | ENSG00000182986, Low tissue specificity ENSG00000204604, Tissue enhanced (placenta) |
MIMi | 606427, gene |
neXtProti | NX_A2RRD8 |
OpenTargetsi | ENSG00000182986 |
PharmGKBi | PA37819 |
VEuPathDBi | HostDB:ENSG00000182986.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163506 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | A2RRD8 |
OMAi | YHIGALC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A2RRD8 |
TreeFami | TF341892 |
Enzyme and pathway databases
PathwayCommonsi | A2RRD8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 162967, 39 hits in 981 CRISPR screens |
ChiTaRSi | ZNF320, human |
GenomeRNAii | 162967 |
Pharosi | A2RRD8, Tdark |
PROi | PR:A2RRD8 |
RNActi | A2RRD8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182986, Expressed in buccal mucosa cell and 208 other tissues |
ExpressionAtlasi | A2RRD8, baseline and differential |
Genevisiblei | A2RRD8, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN320_HUMAN | |
Accessioni | A2RRD8Primary (citable) accession number: A2RRD8 Secondary accession number(s): Q8NDR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | April 7, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families