Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Xaa-Pro dipeptidyl-peptidase

Gene

pepX

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.UniRule annotation

Catalytic activityi

Hydrolyzes Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-p-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei348Charge relay systemUniRule annotation1
Active sitei468Charge relay systemUniRule annotation1
Active sitei498Charge relay systemUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERilacla-pepx Lactobacillus_peptidase

Names & Taxonomyi

Protein namesi
Recommended name:
Xaa-Pro dipeptidyl-peptidaseUniRule annotation (EC:3.4.14.11UniRule annotation)
Alternative name(s):
X-Pro dipeptidyl-peptidaseUniRule annotation
X-prolyl-dipeptidyl aminopeptidaseUniRule annotation
Short name:
X-PDAPUniRule annotation
Gene namesi
Name:pepXUniRule annotation
Ordered Locus Names:llmg_2328
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000000364 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000454821 – 763Xaa-Pro dipeptidyl-peptidaseAdd BLAST763

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi416870.llmg_2328

Structurei

3D structure databases

ProteinModelPortaliA2RNK1
SMRiA2RNK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S15 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105GYP Bacteria
ENOG410XPUZ LUCA
HOGENOMiHOG000267430
KOiK01281
OMAiNRWFTRY

Family and domain databases

Gene3Di2.60.120.260, 3 hits
3.40.50.1820, 4 hits
HAMAPiMF_00698 Aminopeptidase_S15, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR008979 Galactose-bd-like_sf
IPR008252 Pept_S15_Xpro
IPR015251 PepX_N_dom
IPR036313 PepX_N_dom_sf
IPR000383 Xaa-Pro-like_dom
IPR013736 Xaa-Pro_dipept_C
PfamiView protein in Pfam
PF02129 Peptidase_S15, 1 hit
PF08530 PepX_C, 1 hit
PF09168 PepX_N, 1 hit
PRINTSiPR00923 LACTOPTASE
SMARTiView protein in SMART
SM00939 PepX_C, 1 hit
SM00940 PepX_N, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF53474 SSF53474, 1 hit
SSF81761 SSF81761, 1 hit

Sequencei

Sequence statusi: Complete.

A2RNK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFNHFSIVD KNFDEQLAEL DQLGFRWSVF WDEKKILKDF LIQSPSDMTA
60 70 80 90 100
LQATAELDVI EFLKSSIELD WEIFWNIALQ LLDFVPNFDF EIGKAFEYAK
110 120 130 140 150
NSNLPQIEAE MTTENIISAF YYLLCTRRKT GMILVEHWVS EGLLPLDNHY
160 170 180 190 200
HFFNDKSLAT FDSSLLEREV LWVESPVDSE QRGENDLIKI QIIRPKSTEK
210 220 230 240 250
LPVVMTASPY HLGINDKAND LALHDMNVEL EEKTSHEIHV EQKLPQKLSA
260 270 280 290 300
KAKELPIVDK APYRFTHGWT YSLNDYFLTR GFASIYVAGV GTRSSDGFQT
310 320 330 340 350
SGDYQQIYSM TAVIDWLNGR ARAYTSRKKT HEIKASWANG KVAMTGKSYL
360 370 380 390 400
GTMAYGAATT GVEGLELILA EAGISSWYNY YRENGLVRSP GGFPGEDLDV
410 420 430 440 450
LAALTYSRNL DGADFLKGNA EYEKRLAEMT AALDRKSGDY NQFWHDRNYL
460 470 480 490 500
INTDKVKADV LIVHGLQDWN VTPEQAYNFW KALPEGHAKH AFLHRGAHIY
510 520 530 540 550
MNSWQSIDFS ETINAYFVAK LLDRDLNLNL PPVILQENSK DQVWTMMNDF
560 570 580 590 600
GANTQIKLPL GKTAVSFAQF DNNYDDETFK KYSKDFNVFK KDLFENKANE
610 620 630 640 650
AVIDLELPSM LTINGPVELE LRLKLNDTKG FLSAQILDFG QKKRLEDKVR
660 670 680 690 700
VKDFKVLDRG RNFMLDDLVE LPLVESPYQL VTKGFTNLQN QSLLTVSDLK
710 720 730 740 750
ADEWFTIKFE LQPTIYHLEK ADKLRVILYS TDFEHTVRDN RKVTYEIDLS
760
QSKLIIPIES VKN
Length:763
Mass (Da):87,697
Last modified:March 6, 2007 - v1
Checksum:iF89D81F88BDD7BEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406671 Genomic DNA Translation: CAL98891.1
RefSeqiWP_011835997.1, NC_009004.1

Genome annotation databases

EnsemblBacteriaiCAL98891; CAL98891; llmg_2328
KEGGillm:llmg_2328

Similar proteinsi

Entry informationi

Entry nameiPEPX_LACLM
AccessioniPrimary (citable) accession number: A2RNK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 6, 2007
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health