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Entry version 85 (07 Oct 2020)
Sequence version 2 (02 Oct 2007)
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Protein

Dicer-like protein 1

Gene

dcl1

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1283Magnesium or manganeseBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1376Important for activityBy similarity1
Metal bindingi1380Magnesium or manganeseBy similarity1
Metal bindingi1383Magnesium or manganeseBy similarity1
Metal bindingi1440ZincBy similarity1
Metal bindingi1467Zinc; via tele nitrogenBy similarity1
Metal bindingi1508ZincBy similarity1
Metal bindingi1510ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi137 – 144ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntiviral protein, Helicase, Hydrolase, RNA-binding
Biological processAntiviral defense
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dicer-like protein 1
Including the following 2 domains:
Endoribonuclease dcl1 (EC:3.1.26.-)
ATP-dependent helicase dcl1 (EC:3.6.4.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dcl1
ORF Names:An18g02950
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri425011 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Circumdati
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006706 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003067751 – 1525Dicer-like protein 1Add BLAST1525

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2RAF3

PRoteomics IDEntifications database

More...
PRIDEi
A2RAF3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini124 – 305Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST182
Domaini439 – 605Helicase C-terminalPROSITE-ProRule annotationAdd BLAST167
Domaini641 – 731Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd BLAST91
Domaini1032 – 1192RNase III 1PROSITE-ProRule annotationAdd BLAST161
Domaini1243 – 1394RNase III 2PROSITE-ProRule annotationAdd BLAST152
Domaini1428 – 1496DRBMAdd BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi250 – 253DEAH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00593, RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 2 hits
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248, Dicer_dimer_sf
IPR005034, Dicer_dimerisation_dom
IPR006935, Helicase/UvrB_N
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000999, RNase_III_dom
IPR036389, RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271, Helicase_C, 1 hit
PF04851, ResIII, 1 hit
PF00636, Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00535, RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF69065, SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327, DICER_DSRBF, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS00517, RNASE_3_1, 1 hit
PS50142, RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2RAF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSAHAFDMR ITSDIYKPDQ HLPMETMKVC AVTMTEDLQE DDGSSDESDN
60 70 80 90 100
DEREDHSKTG VSQQRITQNA KFKALLAQRA DTGPIHDVSV THDLPDAQLS
110 120 130 140 150
TAHLVAKQDL GIGTLDPREY QLELFERAKV QNTIAVLDTG SGKTLIAVLL
160 170 180 190 200
LKHTLEKELN DRMEGKPHRI AFFLVDSVTL AYQQAAVLRN NLDQSVGHFF
210 220 230 240 250
GAMGTDLWSK SVWDQHFQKN MVIVCTAEIL NQCLLNSYIK MSQINILIFD
260 270 280 290 300
EAHHTKKDHP YARIIRDSYL EEVYSKRPRI FGMTASPIDT KGDIVDEATR
310 320 330 340 350
LEKLLDSRIA TTSNMSLLRQ VARRPVERVW SFNKLEQPFA TSLYKHLEDR
360 370 380 390 400
FGDMACLEGI FRFAWQASSE LGRWCSDRAW ARALADDVLP KLEGSVRKTA
410 420 430 440 450
NSETSSNVPE SAYKEILRIT EASEIVKSYA FSSPETFGQL SPKVQVLREE
460 470 480 490 500
LARYFGRQTE TKCIVFTQKR YTALILAELF QTLNIPFLRP GVLIGVRSGD
510 520 530 540 550
LAGMNITFRQ QFISLVKFRT GEINCLFATS VAEEGLDIPD CNLVVRFDLY
560 570 580 590 600
QTLIQYVQSR GRARHFNSTY ASMVERGNLE HEQRLLEVQD AEMMQSFCRT
610 620 630 640 650
LPEDRLLYGF DHDLDTVLQK DEGNRTFRIK STGAKLTYHS ATAILARYAS
660 670 680 690 700
SLQYEKEFSA QVTYVVLPIN GAFVCEVILP EKSPIRGLTG SPAMKKSIAK
710 720 730 740 750
RSAAFDTCLL LRKNKLLDDH FNSIYHRRLP AMRNAKLAIT SKRTSQYDMI
760 770 780 790 800
SKPSLWGRKQ GMPPKELHGT FITFLPSMQL SHEPAPLLLF TRERLPHFPE
810 820 830 840 850
FPIFLDDDVE TTIITTPLEK QLLLSEKEVD ALTVFTLRVF RDVFHKTYDK
860 870 880 890 900
EPEKMAYWLA PAKVQSSYLP SYDPRQILDW ESLTYVRDND SIPFSTNADP
910 920 930 940 950
ESWVDLFVFD AWDGRCRFFT VGVEHSLTPS SPPPPFVARR RHMNDVMNYC
960 970 980 990 1000
LSLSKNSRAK FLSTCHWDQP VLRAELVRLR RNLLDKMTDT ERDVETRCFI
1010 1020 1030 1040 1050
CIEPLKVSAI PASTAFSCLA FPAIISRIDA YLISLQGCES LNFTVKLDLA
1060 1070 1080 1090 1100
LEAFTKDSDN TDEHRAQQIH VQRGMGRNYE RLEFLGDCFL KMATSIALFT
1110 1120 1130 1140 1150
QNPDDDEFDY HVNRMCLICN KNLFNAAVDK EIYKYIRSRG FSRHTWYPEG
1160 1170 1180 1190 1200
LKLLQGKDHS RKATTESKHA LAEKTIADVC EALIGAALLS GGPDHRFDMA
1210 1220 1230 1240 1250
VKAVTTLVNS PSHKAERWKD YISFYTIPKY QRRAADGAEL YLSRKIEEKL
1260 1270 1280 1290 1300
SYRFRYPTLL GSAFTHPSYP SAWAKVPCYQ RLEFLGDSLI DMVCVEDLFA
1310 1320 1330 1340 1350
RFPDRDPQWL TEHKMAMVSN KFLGALAVKL GLHTHLKYFS APLQSQITQY
1360 1370 1380 1390 1400
AEEIQTAEGE SEGAVDYWTV TKDPPKCLPD MVEAYVGAVF VDSDFNFEVI
1410 1420 1430 1440 1450
ERFFRDYIKP FFEDMAIYDT FANKHPTTFL HNRLTNEFGC VNYCLKAGEM
1460 1470 1480 1490 1500
PSIDGAPAGV LAAVIVHDVV IAEGTATSGR YAKVKASEKA LAVLDEISSA
1510 1520
EFQRKFRCDC RESGDSARLD IGTAI
Length:1,525
Mass (Da):173,497
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A8FB7B056844A69
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAK48679 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM270401 Genomic DNA Translation: CAK48679.1 Sequence problems.

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAK48679; CAK48679; An18g02950

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270401 Genomic DNA Translation: CAK48679.1 Sequence problems.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiA2RAF3
PRIDEiA2RAF3

Genome annotation databases

EnsemblFungiiCAK48679; CAK48679; An18g02950

Family and domain databases

CDDicd00593, RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248, Dicer_dimer_sf
IPR005034, Dicer_dimerisation_dom
IPR006935, Helicase/UvrB_N
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000999, RNase_III_dom
IPR036389, RNase_III_sf
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF04851, ResIII, 1 hit
PF00636, Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00535, RIBOc, 2 hits
SUPFAMiSSF52540, SSF52540, 1 hit
SSF69065, SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327, DICER_DSRBF, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS00517, RNASE_3_1, 1 hit
PS50142, RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCL1_ASPNC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2RAF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 7, 2020
This is version 85 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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