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Protein

Probable cutinase 1

Gene

An14g02170

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle.By similarity

Catalytic activityi

Cutin + H2O = cutin monomers.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138PROSITE-ProRule annotation1
Active sitei193PROSITE-ProRule annotation1
Active sitei206PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERiaspnc-cuti1 Cutinase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cutinase 1 (EC:3.1.1.74)
Alternative name(s):
Cutin hydrolase 1
Gene namesi
ORF Names:An14g02170
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 1R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500022091720 – 262Probable cutinase 1Add BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 196By similarity
Disulfide bondi127 ↔ 189By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA2R2W3

Structurei

3D structure databases

ProteinModelPortaliA2R2W3
SMRiA2R2W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi226 – 257Ser-richAdd BLAST32

Sequence similaritiesi

Belongs to the cutinase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000171425
KOiK08095
OrthoDBiEOG092C4OIR

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000675 Cutinase/axe
IPR011150 Cutinase_monf
PfamiView protein in Pfam
PF01083 Cutinase, 1 hit
PRINTSiPR00129 CUTINASE
SMARTiView protein in SMART
SM01110 Cutinase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00155 CUTINASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2R2W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLKSLLLG ASLATLALST PLATDAENLY ARQFGTGSTA NELEQGSCKD
60 70 80 90 100
VTLIFARGST ELGNMGTVIG PPLCDNLKSK LGSDKVACQG VGGQYSAGLV
110 120 130 140 150
QNALPQNTDP GSISAAKQMF EEANSKCPNT KIVAGGYSQG SAVIDNAVQE
160 170 180 190 200
LSTTVKDQVK GVVLFGFTRN VQDHGQIPNY PKDDVKVYCA VGDLVCDDTL
210 220 230 240 250
VVTAMHLTYG MDAGDAASFL AEKVQSSSSS TTSSSSDAAS SSSAAGTSSS
260
GLSGLSSFFG GL
Length:262
Mass (Da):26,688
Last modified:March 6, 2007 - v1
Checksum:i025B0F0C5E9D86B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270317 Genomic DNA Translation: CAK41954.1
RefSeqiXP_001400843.1, XM_001400806.1

Genome annotation databases

EnsemblFungiiCAK41954; CAK41954; An14g02170
GeneIDi4987073
KEGGiang:ANI_1_330124

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270317 Genomic DNA Translation: CAK41954.1
RefSeqiXP_001400843.1, XM_001400806.1

3D structure databases

ProteinModelPortaliA2R2W3
SMRiA2R2W3
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspnc-cuti1 Cutinase

Proteomic databases

PaxDbiA2R2W3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAK41954; CAK41954; An14g02170
GeneIDi4987073
KEGGiang:ANI_1_330124

Phylogenomic databases

HOGENOMiHOG000171425
KOiK08095
OrthoDBiEOG092C4OIR

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000675 Cutinase/axe
IPR011150 Cutinase_monf
PfamiView protein in Pfam
PF01083 Cutinase, 1 hit
PRINTSiPR00129 CUTINASE
SMARTiView protein in SMART
SM01110 Cutinase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00155 CUTINASE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCUTI1_ASPNC
AccessioniPrimary (citable) accession number: A2R2W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 6, 2007
Last modified: January 31, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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