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Entry version 68 (26 Feb 2020)
Sequence version 1 (06 Mar 2007)
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Protein

1,3-beta-glucan synthase component FKS1

Gene

fksA

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the 1,3-beta-glucan synthase. Synthesizes 1,3-beta-glucan, a major structural component of the cell wall. Involved in cell wall synthesis, maintenance and cell wall remodeling (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT48 Glycosyltransferase Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1,3-beta-glucan synthase component FKS1 (EC:2.4.1.34)
Alternative name(s):
1,3-beta-D-glucan-UDP glucosyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fksA1 Publication
Synonyms:fks1By similarity
ORF Names:An06g01550
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri425011 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006706 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8ER

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Transmembranei655 – 675HelicalSequence analysisAdd BLAST21
Transmembranei707 – 727HelicalSequence analysisAdd BLAST21
Transmembranei728 – 748HelicalSequence analysisAdd BLAST21
Transmembranei1329 – 1349HelicalSequence analysisAdd BLAST21
Transmembranei1386 – 1406HelicalSequence analysisAdd BLAST21
Transmembranei1473 – 1493HelicalSequence analysisAdd BLAST21
Transmembranei1497 – 1517HelicalSequence analysisAdd BLAST21
Transmembranei1588 – 1608HelicalSequence analysisAdd BLAST21
Transmembranei1630 – 1650HelicalSequence analysisAdd BLAST21
Transmembranei1666 – 1686HelicalSequence analysisAdd BLAST21
Transmembranei1701 – 1721HelicalSequence analysisAdd BLAST21
Transmembranei1766 – 1786HelicalSequence analysisAdd BLAST21
Transmembranei1826 – 1846HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00362 Anidulafungin
DB00520 Caspofungin
DB01141 Micafungin

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003225811 – 18971,3-beta-glucan synthase component FKS1Add BLAST1897

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2QLK4

PRoteomics IDEntifications database

More...
PRIDEi
A2QLK4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 1,3-beta-glucan synthase, composed of at least catalytic subunit fksA, and a regulatory subunit.

By similarity

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 78Tyr-richSequence analysisAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 48 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000844_0_1_1

KEGG Orthology (KO)

More...
KOi
K00706

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01205 FKS1_dom1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2QLK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGYPAGHYE DGYGHQEHGG DAYYQDEHGQ AYYDPNDYGD SYYDRGNYYN
60 70 80 90 100
AEGGQAYGQE GGYYDAGHQD DYYGDQYYDQ GNGAPRGRRR GDSEEDSETF
110 120 130 140 150
SDFTMRSETA RAADMDYYGR GDERYNSYAD SQYAGRGYNG YRPPSSQVSY
160 170 180 190 200
GANRSSGAST PVYGMDYGSA LPGGPRSREP YPAWASDGQV PVSKEEIEDI
210 220 230 240 250
FIDLVNKFGF QRDSMRNMYD HLMTQLDSRA SRMTPNQALL SLHADYIGGD
260 270 280 290 300
NANYRRWYFA AHLDLDDAVG FANMKLGKAD RKTRKARKAA KAAAQQNPEN
310 320 330 340 350
VEENLEAMEG DNSLEAAVYR WKSRMNRMSP HDRVRQLALY MLCWGEANQV
360 370 380 390 400
RYMPECICFI FKCADDYYSS PECQSRVEPV EEFTYLNEII TPLYQFCRDQ
410 420 430 440 450
GYEILDGKYV RRERDHEKII GYDDMNQLFW YPEGIERISF EDKTRLVDVP
460 470 480 490 500
PAERWTKLKD VDWKKAFFKT YRETRSWFHM ITNFNRIWVI HLGAFWFFTA
510 520 530 540 550
YNAPTLYTKN YQQQLDNKPA GSKYWSAVGF GGALVGLIQI LATLCEWMYV
560 570 580 590 600
PRRWAGAQHL SKRLMFLIAV FIVNLAPGVV VFGFNNVLSE TICLIIGIVH
610 620 630 640 650
FFIALATFFF FSVMPLGGLF GSYLKKHGRQ YVASQTFTAS YPRLNGNDMW
660 670 680 690 700
MSYGLWICVF GAKLVESYFF LTLSLKDPMR ILSPMRIHQC AGVTYIPNSL
710 720 730 740 750
CHAQPQILLG LMMFMDLTLF FLDSYLWYVI CNTIFSVARS FYLGVSIWSP
760 770 780 790 800
WRNIFSRLPK RIYSKVLATT DMEIKYKPKV LISQVWNAII ISMYREHLLA
810 820 830 840 850
IDHVQKLLYH QVPSEQEGKR TLRAPTFFVS QEDQSFKTEF FPAGSEAERR
860 870 880 890 900
ISFFAQSVAT PMPEPLPVDN MPTFTVLIPH YGEKILLSLR EIIREDEPYS
910 920 930 940 950
RVTLLEYLKQ LHPHEWDCFV KDTKILADET SQLNGEPEKN EKDAQKSKID
960 970 980 990 1000
DLPFYCIGFK SAAPEYTLRT RIWSSLRSQT LYRTISGFMN YSRAIKLLYR
1010 1020 1030 1040 1050
VENPEVVQMF GGNSEKLERE LERMARRKFK ICVSMQRYAK FNKEERENTE
1060 1070 1080 1090 1100
FLLRAYPDLQ IAYLDEEPPA NEGEEPRLYS ALIDGHCELL DNGMRKPKFR
1110 1120 1130 1140 1150
IQLSGNPILG DGKSDNQNHS IIFYRGEYIQ VIDANQDNYL EECLKIRSVL
1160 1170 1180 1190 1200
AEFEELTTDN VSPYTPGIAT EAETPVAILG AREYIFSENV GVLGDVAASK
1210 1220 1230 1240 1250
EQTFGTLFAR TLAQIGGKLH YGHPDFLNGI FMTTRGGISK AQKGLHLNED
1260 1270 1280 1290 1300
IYAGMTALCR GGRIKHCEYF QCGKGRDLGF GSILNFTTKI GTGMGEQMLS
1310 1320 1330 1340 1350
REYYYLGTQL PLDRFLSFYY AHPGFHLNNM FIMLSVQMFM IVLINLGALK
1360 1370 1380 1390 1400
HETITCRYNS NLPITDPLRP TYCADLTPII AWVNRCVVSI FIVFFISFVP
1410 1420 1430 1440 1450
LAVQELTERG LWRMATRLAK HFGSFSFMFE VFVCQIYANA VHQNLSFGGA
1460 1470 1480 1490 1500
RYIGTGRGFA TARIPFGVLY SRFAGPSIYA GSRLLLMLLF ATSTVWTPAL
1510 1520 1530 1540 1550
IWFWVSLLAL CISPFLFNPH QFAWHDFFID YRDYIRWLSR GNSRSHASSW
1560 1570 1580 1590 1600
IAFCRLSRTR LTGYKRKLLG VPSEKGSGDV PRAKFTNIFF SEIIAPLVQV
1610 1620 1630 1640 1650
AVTLVPYLYI NSRTGISNDN ERASNAVVRI AIVAFGPIGV NAGVSGMFFG
1660 1670 1680 1690 1700
MACCMGPIFG MCCKKFGAVL AAIAHAIAVI ILLVIFEVMF FLESWSWPRM
1710 1720 1730 1740 1750
VLGMISAAAI QRFIYKLIIS LALTREFKHD QSNIAWWTGK WYNMGWHSLS
1760 1770 1780 1790 1800
QPGREFLCKI TELGYFSADF VLGHILLFVM LPALCIPYVD KFHSVILFWL
1810 1820 1830 1840 1850
RPSRQIRPPI YSLKQSKLRK RRVVRFAILY FTMLVLFLIL LIAPLVARDE
1860 1870 1880 1890
GISVNLNIMS LMQPLDTDNN DTISSYTGNG LPVGYSAWTP SAASASA
Length:1,897
Mass (Da):216,975
Last modified:March 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i083DB5C85CF51E15
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM270115 Genomic DNA Translation: CAK47999.1
AY533027 Genomic DNA Translation: AAS37661.1

NCBI Reference Sequences

More...
RefSeqi
XP_001390977.1, XM_001390940.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAK47999; CAK47999; An06g01550

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4981154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ang:ANI_1_188054

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270115 Genomic DNA Translation: CAK47999.1
AY533027 Genomic DNA Translation: AAS37661.1
RefSeqiXP_001390977.1, XM_001390940.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Chemistry databases

DrugBankiDB00362 Anidulafungin
DB00520 Caspofungin
DB01141 Micafungin

Protein family/group databases

CAZyiGT48 Glycosyltransferase Family 48

Proteomic databases

PaxDbiA2QLK4
PRIDEiA2QLK4

Genome annotation databases

EnsemblFungiiCAK47999; CAK47999; An06g01550
GeneIDi4981154
KEGGiang:ANI_1_188054

Phylogenomic databases

HOGENOMiCLU_000844_0_1_1
KOiK00706

Family and domain databases

InterProiView protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48
PfamiView protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit
SMARTiView protein in SMART
SM01205 FKS1_dom1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFKS1_ASPNC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2QLK4
Secondary accession number(s): Q5DRK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 6, 2007
Last modified: February 26, 2020
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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