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UniProtKB - A2QGA1 (M2DH_ASPNC)
Protein
Mannitol 2-dehydrogenase
Gene
An03g02430
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Functioni
Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.
By similarityCatalytic activityi
- EC:1.1.1.67
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 37 – 48 | NADBy similarityAdd BLAST | 12 |
GO - Molecular functioni
- mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:An03g02430 |
Organismi | Aspergillus niger (strain CBS 513.88 / FGSC A1513) |
Taxonomic identifieri | 425011 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Circumdati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:An03g02430 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371541 | 1 – 488 | Mannitol 2-dehydrogenaseAdd BLAST | 488 |
Proteomic databases
PaxDbi | A2QGA1 |
Interactioni
Subunit structurei
Monomer.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the mannitol dehydrogenase family.Curated
Phylogenomic databases
HOGENOMi | CLU_027324_0_1_1 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
A2QGA1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPLKLNTAN LSQIVAAGAG RVKVPTYRRG PALKEGIVHV GVGGFHRAHL
60 70 80 90 100
AVYVDQLMQN HGVTDYAICG VGLQPFDSAM RDALSSQDNL YTVIERSAKG
110 120 130 140 150
SFANVIGSIN SYLFAPDDRE AVIAKMAHPD TRIVSLTITE SGYYYNENTH
160 170 180 190 200
ELQSEHPDIQ FDLDPANEKT PRTTFGFLYA ALARRHQQEE WFHHPSHARV
210 220 230 240 250
FRPSPHPEVA QWITDKGAFP NAMVDRITPQ TSPADKESLA NTMGIEDSWP
260 270 280 290 300
VVTEPFMQWV IEDQFSDGRP PFEKVGVQVV KDVHAVEEFE KHKLRLLNGS
310 320 330 340 350
HSAIGYPGQM AGFNYVHEVL ENPDFNKFVW QMMQEEVKPS LPEIPGVDID
360 370 380 390 400
QYCKTLMERF SNPTIMDQLP RICLNASGKI PQFIMPSIAE AIWVKGPLRR
410 420 430 440 450
LCFVAAAWFR YINGVDDQGN TFTVDDPMRE ELQAKARAGG TKPSELLSIT
460 470 480
SLFGDDLRND KRFMQEITNA MEDIARDGIL KTLPKYID
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM270048 Genomic DNA Translation: CAK38211.1 |
Genome annotation databases
EnsemblFungii | CAK38211; CAK38211; An03g02430 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM270048 Genomic DNA Translation: CAK38211.1 |
3D structure databases
SMRi | A2QGA1 |
ModBasei | Search... |
Proteomic databases
PaxDbi | A2QGA1 |
Genome annotation databases
EnsemblFungii | CAK38211; CAK38211; An03g02430 |
Organism-specific databases
VEuPathDBi | FungiDB:An03g02430 |
Phylogenomic databases
HOGENOMi | CLU_027324_0_1_1 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M2DH_ASPNC | |
Accessioni | A2QGA1Primary (citable) accession number: A2QGA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | March 6, 2007 | |
Last modified: | September 29, 2021 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families