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Entry version 44 (29 Sep 2021)
Sequence version 1 (06 Mar 2007)
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Protein
Submitted name:

TpeL

Gene

tpeL

Organism
Clostridium perfringens
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseARBA annotation, ToxinARBA annotation
Biological processVirulenceARBA annotation
LigandMagnesiumARBA annotation, Metal-bindingARBA annotation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT44, Glycosyltransferase Family 44

Transport Classification Database

More...
TCDBi
1.C.57.1.5, the clostridial cytotoxin (cct) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TpeLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tpeLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridium perfringensImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1502 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaEubacterialesClostridiaceaeClostridium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cell membraneARBA annotation, Host cytoplasmARBA annotation, Host membrane, Membrane, SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Autocatalytic cleavageARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2PYQ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini568 – 772Peptidase C80InterPro annotationAdd BLAST205

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili51 – 71Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11050, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020974, CPD_dom
IPR038383, CPD_dom_sf
IPR029044, Nucleotide-diphossugar_trans
IPR024770, TcdA/TcdB_cat
IPR024772, TcdA/TcdB_N
IPR024769, TcdA/TcdB_pore_forming

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11713, Peptidase_C80, 1 hit
PF12919, TcdA_TcdB, 1 hit
PF12920, TcdA_TcdB_pore, 1 hit
PF12918, TcdB_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448, SSF53448, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51771, CGT_MARTX_CPD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2PYQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLMSKEQLI ILAKNSSPKE GEYKKILELL DEYNLLNNSV EKNSIDLYLK
60 70 80 90 100
LNELSKSIDI YLKKYKNSKR NNALYQLKSD LTKEVIEIKD TNLKPLEKNI
110 120 130 140 150
HFVWVGGMIN NISIDYINQW KDINSDYETI IWYDSEALLV NILKKAIIDS
160 170 180 190 200
SNKEVLTKYE SVLNDNSFDS NKFYRERMEV IFRKQKEFNN YYNTNDNYTK
210 220 230 240 250
SLNDVIKVYL IEKYLKTDEE LEKYINESKE VFKANGAKDI REYDILDDVE
260 270 280 290 300
LKSIYEQELL MRFNLASASD IIRVIVLNKL GGIYLDVDVL PGIKKHIFKD
310 320 330 340 350
INKPTNISEN KWQMIQLETI MKYKQYIKGY TENSFKNLPS DLQEMLQEKV
360 370 380 390 400
VEKNLKSDIF QRLGDIFISE LDTKIAFMFG KIANQVLISK KNSYSLNLII
410 420 430 440 450
NQIKNRYNII NKCLSSAIEK GSNFNNTVDI FIQQLNEFYV NEGFFVSKVM
460 470 480 490 500
GYLGDGYMPD MRATLNISGP GIYTAAYYDL LYFNERSLNP QILQEDLKYF
510 520 530 540 550
EVPQALISQQ TEQEINSSWT FNQVKSQIEY KKLVEKYTNK SLSENDKLNF
560 570 580 590 600
NENKIIDKVE LLNRINSNNL INFDDKEYLR YIIQLQGDKV SYEAAINLFI
610 620 630 640 650
KNPSNSILVQ EINNISYYFN SEYKSIDSIQ FDNIPEILKG KNKIKLTFIG
660 670 680 690 700
HGEEEFNTER FASLTVKEFS KKIYKVLDMI KSNTNVKEIQ IDLLGCNMFS
710 720 730 740 750
YNINVEETYP GKLLKVVLDY VDKIYNADIK PEIKISANQY EVRINKDGKK
760 770 780 790 800
ELLSHSGEWL SKEEAIIKDI ASKEIIYFDT RENTIKAEAK NIMELITFRN
810 820 830 840 850
SLDKKLNDLE SLINNNFIVN EVYEQLTSNN LYRTSFRNSF LDTINFIEDV
860 870 880 890 900
SQELYEIKIK NNINDDYIMA LDEIKQDNNI SEIKFININS GEFRVVRENS
910 920 930 940 950
RLINKFKEDF KFMINNIKRL IKFSDNNKLI TSFELKNIES SSGVSTLNTS
960 970 980 990 1000
FLIQSMIDYK AQNFDFNKLS TSVKVQIYCQ ITNISLSEIQ DASNLVKIIA
1010 1020 1030 1040 1050
EANEIEINLI PTLANAIPLI TTIVDGINLI ANIDELINTK DELLRKELAA
1060 1070 1080 1090 1100
RIGIISSNMT AAISSYILYF TEFGEVFNPL LVPIAGISSG IPTLVNNILI
1110 1120 1130 1140 1150
LEEKSKEITE YFSHISKVES DGLFKVSDNN SILIPLDDIA ISKIDFNKRE
1160 1170 1180 1190 1200
VILDKLDIWA MEGGSGLSGK ETFFSAPYIN ENLPKLSIDN LLKIDINKID
1210 1220 1230 1240 1250
FSIKGMMLPN GVSKTLGYEF NTVANIYELE NDGVNLLNRI RDNYPGQFYW
1260 1270 1280 1290 1300
RYYATLFNYG MVNLKINYHD TDVKINLDNV DRMFIVPTLT IDQAREKLSY
1310 1320 1330 1340 1350
NFNGAGANYY IYLSSQPIKI FINGTKEDNW ILNIDDIVKE VTIVNNSIVR
1360 1370 1380 1390 1400
GKFIENIFKK LTIEDNKIII GNQKIYLKNN KTNIHFSVSI LDGVNLMVEV
1410 1420 1430 1440 1450
DFNNKMYHLS LQGNEKTICN NMNIIQNNIN KLFGSSNIKS IPYFYKNNGL
1460 1470 1480 1490 1500
ENCIGVFSIK NNEFIYMLKY DDKNKIYKYK DNNLVCGFNL FDISYVDIIS
1510 1520 1530 1540 1550
NGDKNYLKGI WNTSVNNSEY KIEFLVELID QNTIEIIKLN LSDGLIKSFL
1560 1570 1580 1590 1600
TILDNLESLD VKISTIYDFL KNILFRDVFL ENESLNFIVS KGFVLTGNNS
1610 1620 1630 1640 1650
KNKYEFICNS ENIQLYITEL YTNGTKFRNW LDNGKILVSS TGESSNNLID

I
Length:1,651
Mass (Da):191,162
Last modified:March 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95BDEE944A2F8D39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB262081 Genomic DNA Translation: BAF46125.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB262081 Genomic DNA Translation: BAF46125.1

3D structure databases

SMRiA2PYQ6
ModBaseiSearch...

Protein family/group databases

CAZyiGT44, Glycosyltransferase Family 44
TCDBi1.C.57.1.5, the clostridial cytotoxin (cct) family

Family and domain databases

Gene3Di3.40.50.11050, 1 hit
InterProiView protein in InterPro
IPR020974, CPD_dom
IPR038383, CPD_dom_sf
IPR029044, Nucleotide-diphossugar_trans
IPR024770, TcdA/TcdB_cat
IPR024772, TcdA/TcdB_N
IPR024769, TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF11713, Peptidase_C80, 1 hit
PF12919, TcdA_TcdB, 1 hit
PF12920, TcdA_TcdB_pore, 1 hit
PF12918, TcdB_N, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51771, CGT_MARTX_CPD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2PYQ6_CLOPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2PYQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2007
Last sequence update: March 6, 2007
Last modified: September 29, 2021
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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