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Entry version 26 (13 Nov 2019)
Sequence version 1 (19 Feb 2014)
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Protein
Submitted name:

TY2B protein

Gene

TY2B

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TY2B proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TY2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (Baker's yeast)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4932 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini696 – 871Integrase catalyticInterPro annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni68 – 126DisorderedSequence analysisAdd BLAST59
Regioni395 – 493DisorderedSequence analysisAdd BLAST99
Regioni956 – 975DisorderedSequence analysisAdd BLAST20
Regioni1045 – 1078DisorderedSequence analysisAdd BLAST34
Regioni1097 – 1245DisorderedSequence analysisAdd BLAST149

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1574 – 1594Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi68 – 107PolarSequence analysisAdd BLAST40
Compositional biasi395 – 480PolarSequence analysisAdd BLAST86
Compositional biasi1100 – 1148PolarSequence analysisAdd BLAST49
Compositional biasi1166 – 1180PolarSequence analysisAdd BLAST15
Compositional biasi1209 – 1227PolarSequence analysisAdd BLAST19
Compositional biasi1228 – 1245PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0017 Eukaryota
COG2801 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025724 GAG-pre-integrase_dom
IPR001584 Integrase_cat-core
IPR015820 Retrotransposon_Ty1A_N
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR013103 RVT_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13976 gag_pre-integrs, 1 hit
PF00665 rve, 1 hit
PF07727 RVT_2, 1 hit
PF01021 TYA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50994 INTEGRASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2P2P7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMIIIFIELY RIADSLLWIP KSSRRTSSIS TYLILLPYKK WNPNNYIKIH
60 70 80 90 100
IFLHGSAYAS VTSKEVPSNQ DPLAVSASNL PEFDRDSTKV NSQQETTPGT
110 120 130 140 150
SAVPENHHHV SPQPASVPPP QNGQYQQHGM MTPNKAMASN WAHYQQPSMM
160 170 180 190 200
TCSHYQTSPA YYQPDPHYPL PRYIPPLSTS SPDPIDLKNQ HSEIPQAKTK
210 220 230 240 250
VGNNVLPPHT LTSEENFSTW VKFYIRFLKN SNLGDIIPND QGEIKRQMTY
260 270 280 290 300
EEHAYIYNTF QAFAPFHLLP TWVKQILEIN YADILTVLCK SVSKMQTNNQ
310 320 330 340 350
ELKDWIALAN LEYDGSTSAD TFEITVSTII QRLKENNINV SDRLACQLIL
360 370 380 390 400
KGLSGDFKYL RNQYRTKTNM KLSQLFAEIQ LIYDENKIMN LNKPSQYKQH
410 420 430 440 450
SEYKNVSRTS PNTTNTKVTT RNYQRTNSSK PRAAKAHNIA TSSKFSRVNN
460 470 480 490 500
DHINESTVSS QYLSDDNELS LGQQQKESKP THTVDSNDEL PDHLLIDSGA
510 520 530 540 550
SQTLVRSAHY LHHATPNSEI NIVDAQKQDI PINAIGNLHF NFQNGTKTSI
560 570 580 590 600
KALHTPNIAY DLLSLSELAN QNITACFTRN TLERSDGTVL APIVKHGDFY
610 620 630 640 650
WLSKKYLIPS HISKLTINNV NKSKSVNKYP YPLIHRMLGH ANFRSIQKSL
660 670 680 690 700
KKNAVTYLKE SDIEWSNAST YQCPDCLIGK STKHRHVKGS RLKYQESYEP
710 720 730 740 750
FQYLHTDIFG PVHHLPKSAP SYFISFTDEK TRFQWVYPLH DRREESILNV
760 770 780 790 800
FTSILAFIKN QFNARVLVIQ MDRGSEYTNK TLHKFFTNRG ITACYTTTAD
810 820 830 840 850
SRAHGVAERL NRTLLNDCRT LLHCSGLPNH LWFSAVEFST IIRNSLVSPK
860 870 880 890 900
NDKSARQHAG LAGLDITTIL PFGQPVIVNN HNPDSKIHPR GIPGYALHPS
910 920 930 940 950
RNSYGYIIYL PSLKKTVDTT NYVILQNKQT KLDQFDYDTL TFDDDLNRLT
960 970 980 990 1000
AHNQSFIEQN ETEQSYDQNT ESDHDYQSEI EINSDPLVND FSSQSINPLQ
1010 1020 1030 1040 1050
LDKEPVQKVR APKEVDADIS EYNILPSTIR SRTPHIINKE STEMVGTVES
1060 1070 1080 1090 1100
DTTSPRHSST FTARNQKRPG SPNDMIDLTS QDRVNYGLEN IKTTRLGGTE
1110 1120 1130 1140 1150
EPYIQRNSDT NIKYRTTNST PSIDDRSSNS ESTTPIISIE TKAVCDNTPS
1160 1170 1180 1190 1200
IDTDPPEYRS SDHATPNIMP DKSSKNVTAD SILDDLPLPD LTHQSPTDTS
1210 1220 1230 1240 1250
DVSKDIPHIH SRQTNSSLGG MDDSNVLTTT KSKKRSLEDN ETEIEVSRDT
1260 1270 1280 1290 1300
WNNKNMRSLE PPRSKKRINL IAAIKGVKSI KPVRTTLRYD EAITYNKDNK
1310 1320 1330 1340 1350
EKDRYVEAYH KEISQLLKMN TWDTNKYYDR NDIDPKKVIN SMFIFNKKRD
1360 1370 1380 1390 1400
GTHKARFVAR GDIQHPDTYD SDMQSNTVHH YALMTSLSIA LDNDYYITQL
1410 1420 1430 1440 1450
DISSAYLYAD IKEELYIRPP PHLGLNDKLL RLRKSLYGLK QSGANWYETI
1460 1470 1480 1490 1500
KSYLINCCDM QEVRGWSCVF KNSQVTICLF VDDMILFSKD LNANKKIITT
1510 1520 1530 1540 1550
LKKQYDTKII NLGESDNDIQ YDILGLEIKY QRSKYMKLGM EKSLTEKLPK
1560 1570 1580 1590 1600
LNVPLNPKGK KLRAPGQPGH YIDQDELEID EDEYKEKVHE MQKLIGLASY
1610 1620 1630 1640 1650
VGYKFRFDLL YYINTLAQHI LFPSRQVLDM TYELIQFMWD TRDKQLIWHK
1660 1670 1680 1690 1700
NKPTKPDNKL VAISDASYGN QPYYKSQIGN IFLLNGKVIG GKSTKASLTC
1710 1720 1730 1740 1750
TSTTEAEIHA VSEAIPLLNN LSHLVQELNK KPIIKGLLTD SRSTISIIKS
1760 1770 1780 1790 1800
TNEEKFRNRF FGTKAMRLRD EVSGNNLYVY YIETKKNIAD VMTKPLPIKT
1810
FKLLTNKWIH
Length:1,810
Mass (Da):206,972
Last modified:February 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2545E508CE22ACEE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z71311 Genomic DNA Translation: CAA95898.1
Z71312 Genomic DNA Translation: CAA95902.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71311 Genomic DNA Translation: CAA95898.1
Z71312 Genomic DNA Translation: CAA95902.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG0017 Eukaryota
COG2801 LUCA

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR025724 GAG-pre-integrase_dom
IPR001584 Integrase_cat-core
IPR015820 Retrotransposon_Ty1A_N
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR013103 RVT_2
PfamiView protein in Pfam
PF13976 gag_pre-integrs, 1 hit
PF00665 rve, 1 hit
PF07727 RVT_2, 1 hit
PF01021 TYA, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2P2P7_YEASX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2P2P7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
Last sequence update: February 19, 2014
Last modified: November 13, 2019
This is version 26 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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