UniProtKB - A2NX49 (A2NX49_HUMAN)
Protein
Submitted name:
Acetyl-CoA carboxylase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
biotinSAAS annotation
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-UniRule
- metal ion binding Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | LigaseSAAS annotationImported |
Ligand | ATP-bindingPROSITE-ProRule annotationSAAS annotation, BiotinSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 117 – 618 | Biotin carboxylationInterPro annotationAdd BLAST | 502 | |
Domaini | 275 – 466 | ATP-graspInterPro annotationAdd BLAST | 192 | |
Domaini | 745 – 819 | Lipoyl-bindingInterPro annotationAdd BLAST | 75 | |
Domaini | 1576 – 1906 | CoA carboxyltransferase N-terminalInterPro annotationAdd BLAST | 331 | |
Domaini | 1910 – 2226 | CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST | 317 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR034733 AcCoA_carboxyl IPR013537 AcCoA_COase_cen IPR011761 ATP-grasp IPR013815 ATP_grasp_subdomain_1 IPR005481 BC-like_N IPR001882 Biotin_BS IPR011764 Biotin_carboxylation_dom IPR005482 Biotin_COase_C IPR000089 Biotin_lipoyl IPR005479 CbamoylP_synth_lsu-like_ATP-bd IPR029045 ClpP/crotonase-like_dom_sf IPR011763 COA_CT_C IPR011762 COA_CT_N IPR016185 PreATP-grasp_dom_sf IPR011054 Rudment_hybrid_motif IPR011053 Single_hybrid_motif |
Pfami | View protein in Pfam PF08326 ACC_central, 1 hit PF02785 Biotin_carb_C, 1 hit PF00289 Biotin_carb_N, 1 hit PF00364 Biotin_lipoyl, 1 hit PF01039 Carboxyl_trans, 1 hit PF02786 CPSase_L_D2, 1 hit |
SMARTi | View protein in SMART SM00878 Biotin_carb_C, 1 hit |
SUPFAMi | SSF51230 SSF51230, 1 hit SSF51246 SSF51246, 1 hit SSF52096 SSF52096, 2 hits SSF52440 SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS50975 ATP_GRASP, 1 hit PS50979 BC, 1 hit PS00188 BIOTIN, 1 hit PS50968 BIOTINYL_LIPOYL, 1 hit PS50989 COA_CT_CTER, 1 hit PS50980 COA_CT_NTER, 1 hit PS00866 CPSASE_1, 1 hit PS00867 CPSASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A2NX49-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEPSPLAQP LELNQHSRFI IGSVSEDNSE DEISNLVKLD LLEEKEGSLS
60 70 80 90 100
PASVGSDTLS DLGISSLQDG LALHIRSSMS GLHLVKQGRD RKKIDSQRDF
110 120 130 140 150
TVASPAEFVT RFGGNKVIEK VLIANNGIAA VKCMRSIRRW SYEMFRNERA
160 170 180 190 200
IRFVVMVTPE DLKANAEYIK MADHYVPVPG GPNNNNYANV ELILDIAKRI
210 220 230 240 250
PVQAVWAGWG HASENPKLPE LLLKNGIAFM GPPSQAMWAL GDKIASSIVA
260 270 280 290 300
QTAGIPTLPW SGSGLRVDWQ ENDFSKRILN VPQELYEKGY VKDVDDGLQA
310 320 330 340 350
AEEVGYPVMI KASEGGGGKG IRKVNNADDF PNLFRQVQAE VPGSPIFVMR
360 370 380 390 400
LAKQSRHLEV QILADQYGNA ISLFGRDCSV QRRHQKIIEE APATIATPAV
410 420 430 440 450
FEHMEQCAVK LAKMVGYVSA GTVEYLYSQD RSFYFLELNP RLQVEHPCTE
460 470 480 490 500
MVADVNLPAA QLQIAMGIPL YRIKDIRMMY GVSPWGDSPI DFEDSAHVPC
510 520 530 540 550
PRGHVIAARI TSENPDEGFK PSSGTVQELN FRSNKNVWGY FSVAAAGGLH
560 570 580 590 600
EFADSQFGHC FSWGESREEA ISNMVVALKE LSIRGDFRTT VEYLIKLLET
610 620 630 640 650
ESFQMNRIDT GWLDRLIAEK VQAERPDTML GVVCGALHVA DVSLRNSVSN
660 670 680 690 700
FLHSLERGQV LPAHTLLNTV DVELIYEGVK YVLKVTRQSP NSYVVIMNGS
710 720 730 740 750
CVEVDVHRLS DGGLLLSYDG SSYTTYMKEE VDRYRITIGN KTCVFEKEND
760 770 780 790 800
PSVMRSPSAG KLIQYIVEDG GHVLAGQCYA EIEVMKMVMT LTAVESGCIH
810 820 830 840 850
YVKRPGAALD PGCVLAKMQL DNPSKVQQAE LHTGSLPRIQ STALRGEKLH
860 870 880 890 900
RVFHYVLDNL VNVMNGYCLP DPFSSSKVKD WVERLMKTLR DPSLPLLELQ
910 920 930 940 950
DIMTSVSGRI PPNVEKSIKK EMAQYASNIT SVLCQFPSQQ IANILDSHAA
960 970 980 990 1000
TLNRKSEREV FFMNTQSIVQ LVQRYRSGIR GHMKAVVMDL LRQYLRVETQ
1010 1020 1030 1040 1050
FQNGHYDKCV FALREENKSD MNTVLNYIFS HAQVTKKNLL VTMLIDQLCG
1060 1070 1080 1090 1100
RDPTLTDELL NILTELTQLS KTTNAKVALR ARQVLIASHL PSYELRHNQV
1110 1120 1130 1140 1150
ESIFLSAIDM YGHQFCIENL QKLILSETSI FDVLPNFFYH SNQVVRMAAL
1160 1170 1180 1190 1200
EVYVRRAYIA YELNSVQHRQ LKDNTCVVEF QFMLPTSHPN RGNIPTLNRM
1210 1220 1230 1240 1250
SFSSNLNHYG MTHVASVSDV LLDNSFTPPC QRMGGMVSFR TFEDFVRIFD
1260 1270 1280 1290 1300
EVMGCFSDSP PQSPTFPEAG HTSLYDEDKV PRDEPIHILN VAIKTDCDIE
1310 1320 1330 1340 1350
DDRLAAMFRE FTQQNKATLV DHGIRRLTFL VAQKDFRKQV NYEVDRRFHR
1360 1370 1380 1390 1400
EFPKFFTFRA RDKFEEDRIY RHLEPALAFQ LELNRMRNFD LTAIPCANHK
1410 1420 1430 1440 1450
MHLYLGAAKV EVGTEVTDYR FFVRAIIRHS DLVTKEASFE YLQNEGERLL
1460 1470 1480 1490 1500
LEAMDELEVA FNNTNVRTDC NHIFLNFVPT VIMDPSKIEE SVRYMVMRYG
1510 1520 1530 1540 1550
SRLWKLRVLQ AEVKINIRQT TTGSAVPIRL FITNESGYYL DISLYKEVTD
1560 1570 1580 1590 1600
SRSGNIMFHS FGNKQGPQHG MLINTPYVTK DLLQAKRFQA QTLGTTYIYD
1610 1620 1630 1640 1650
FPEMFRQALF KLWGSPDKYP KDILTYTELV LDSQGQLVEM NRLPGGNEVG
1660 1670 1680 1690 1700
MVAFKMRFKT QEYPEGRDVI VIGNDITFRI GSFGPGEDLL YLRASEMARA
1710 1720 1730 1740 1750
EAIPKIYVAA NSGARIGMAE EIKHMFHVAW VDPEDPHKGF KYLYLTPQDY
1760 1770 1780 1790 1800
TRISSLNSVH CKHIEEGGES RYMITDIIGK DDGLGVENLR GSGMIAGESS
1810 1820 1830 1840 1850
LAYEEIVTIS LVTCRAIGIG AYLVRLGQRV IQVENSHIIL TGASALNKVL
1860 1870 1880 1890 1900
GREVYTSNNQ LGGVQIMHYN GVSHITVPDD FEGVYTILEW LSYMPKDNHS
1910 1920 1930 1940 1950
PVPIITPTDP IDREIEFLPS RAPYDPRWML AGRPHPTLKG TWQSGFFDHG
1960 1970 1980 1990 2000
SFKEIMAPWA QTVVTGRARL GGIPVGVIAV ETRTVEVAVP ADPANLDSEA
2010 2020 2030 2040 2050
KIIQQAGQVW FPDSAYKTAQ AIKDFNREKL PLMIFANWRG FSGGMKDMYD
2060 2070 2080 2090 2100
QVLKFGAYIV DGLRQYKQPI LIYIRPMREL RGGSWVVIDA TINPLCIEMY
2110 2120 2130 2140 2150
ADKESRGGVL EPEGTVEIKF RKEDLIKSMR RIDPAYKKLM EQLGEPDLSD
2160 2170 2180 2190 2200
KDRKDLEGRL KAREDLLLPI YHQVAVQFAD FHDTPGRMLE KGVISDILEW
2210 2220 2230 2240 2250
KTARTFLYWR LRRLLLEDQV KQEILQASGE LSHVHIQSML RRWFVETEGA
2260 2270 2280 2290 2300
VKAYLWDNNQ VVVQWLEQHW QAGDGPRSTI RENITYLKHD SVLKTIRGLV
2310 2320 2330
EENPEVAVDC VIYLSQHISP AERAQVVHLL STMDSPAST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68968 mRNA Translation: CAA48770.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68968 mRNA Translation: CAA48770.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A2NX49 |
PRIDEi | A2NX49 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR034733 AcCoA_carboxyl IPR013537 AcCoA_COase_cen IPR011761 ATP-grasp IPR013815 ATP_grasp_subdomain_1 IPR005481 BC-like_N IPR001882 Biotin_BS IPR011764 Biotin_carboxylation_dom IPR005482 Biotin_COase_C IPR000089 Biotin_lipoyl IPR005479 CbamoylP_synth_lsu-like_ATP-bd IPR029045 ClpP/crotonase-like_dom_sf IPR011763 COA_CT_C IPR011762 COA_CT_N IPR016185 PreATP-grasp_dom_sf IPR011054 Rudment_hybrid_motif IPR011053 Single_hybrid_motif |
Pfami | View protein in Pfam PF08326 ACC_central, 1 hit PF02785 Biotin_carb_C, 1 hit PF00289 Biotin_carb_N, 1 hit PF00364 Biotin_lipoyl, 1 hit PF01039 Carboxyl_trans, 1 hit PF02786 CPSase_L_D2, 1 hit |
SMARTi | View protein in SMART SM00878 Biotin_carb_C, 1 hit |
SUPFAMi | SSF51230 SSF51230, 1 hit SSF51246 SSF51246, 1 hit SSF52096 SSF52096, 2 hits SSF52440 SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS50975 ATP_GRASP, 1 hit PS50979 BC, 1 hit PS00188 BIOTIN, 1 hit PS50968 BIOTINYL_LIPOYL, 1 hit PS50989 COA_CT_CTER, 1 hit PS50980 COA_CT_NTER, 1 hit PS00866 CPSASE_1, 1 hit PS00867 CPSASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2NX49_HUMAN | |
Accessioni | A2NX49Primary (citable) accession number: A2NX49 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 19, 2014 |
Last sequence update: | February 19, 2014 | |
Last modified: | October 16, 2019 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |