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UniProtKB - A2I2U6 (A2I2U6_CLOBO)
Protein
Submitted name:
Bont/B
Gene
B
Organism
Clostridium botulinum
Status
Functioni
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
- protein transmembrane transporter activity Source: InterPro
- toxin activity Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- negative regulation of neurotransmitter secretion Source: InterPro
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, NeurotoxinImportedARBA annotation, Protease, Toxin |
Biological process | VirulenceARBA annotation |
Protein family/group databases
MEROPSi | M27.002 |
Names & Taxonomyi
Protein namesi | Submitted name: Bont/BImportedSubmitted name: Botulinum neurotoxin type BImportedSubmitted name: Neurotoxin BImported |
Gene namesi | Name:BImported Synonyms:bontImported ORF Names:EXM69_13415Imported |
Organismi | Clostridium botulinumImported |
Taxonomic identifieri | 1491 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Eubacteriales › Clostridiaceae › Clostridium |
Proteomesi |
|
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 417 | Peptidase_M27InterPro annotationAdd BLAST | 415 | |
Domaini | 536 – 852 | Toxin_transInterPro annotationAdd BLAST | 317 | |
Domaini | 873 – 1066 | Toxin_R_bind_NInterPro annotationAdd BLAST | 194 | |
Domaini | 1075 – 1291 | Toxin_R_bind_CInterPro annotationAdd BLAST | 217 |
Sequence similaritiesi
Belongs to the peptidase M27 family.ARBA annotation
Family and domain databases
Gene3Di | 1.20.1120.10, 1 hit |
InterProi | View protein in InterPro IPR000395, Bot/tetX_LC IPR036248, Clostridium_toxin_transloc IPR013320, ConA-like_dom_sf IPR011065, Kunitz_inhibitor_STI-like_sf IPR013104, Toxin_rcpt-bd_C IPR012928, Toxin_rcpt-bd_N IPR012500, Toxin_trans |
Pfami | View protein in Pfam PF01742, Peptidase_M27, 1 hit PF07951, Toxin_R_bind_C, 1 hit PF07953, Toxin_R_bind_N, 1 hit PF07952, Toxin_trans, 1 hit |
PRINTSi | PR00760, BONTOXILYSIN |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF50386, SSF50386, 1 hit SSF58091, SSF58091, 1 hit |
i Sequence
Sequence statusi: Complete.
A2I2U6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVTINNFNY NDPIDNNNII MMEPPFARGM GRYYKAFKIT DRIWIIPERY
60 70 80 90 100
TFGYKPEDFN KSSGIFNRDV CEYYDPDYLN TNDKKNIFLQ TMIKLFNRIK
110 120 130 140 150
SKPLGEKLLE MIINGIPYLG DRRVPLEEFN TNIASVTVNK LISNPGEVER
160 170 180 190 200
KKGIFANLII FGPGPVLNEN ETIDIGIQNH FASREGFGGI MQMKFCPEYV
210 220 230 240 250
SVFNNVQENK GASIFNRRGY FSDPALILMH ELIHVLHGLY GIKVNDLPIV
260 270 280 290 300
PNEKKFFMQS TDAIQAEELY TFGGQDPSII SPSTDKSIYD KVLQNFRGIV
310 320 330 340 350
DRLNKVLVCI SDPNININIY KNKFKDKYKF VEDSEGKYSI DVESFDKLYK
360 370 380 390 400
SLMFGFTETN IAENYKIKTR ASYFSDSLPP VKIKNLLDNE IYTIEEGFNI
410 420 430 440 450
SDKNMEKEYR GQNKAINKQA YEEISKEHLA VYKIQMCKSV KAPGICIDVD
460 470 480 490 500
NEDLFFIADK NSFSDDLSKN ERIAYNTQNN YIENDFSINE LILDTDLISK
510 520 530 540 550
IELPSENTES LTDFNVYVPV YKKQPAIKKI FTDENTIFQY LYSQTFPLDI
560 570 580 590 600
RDISLTSSFD DALLFSNKVY SFFSMDYIKT ANKVVEAGLF AGWVKQIVDD
610 620 630 640 650
FVIEANKSST MDKIADISLI VPYIGLALNV GNETAKGNFE NAFEIAGASI
660 670 680 690 700
LLEFIPELLI PVVGAFLLES YIDNKNKIIE TINSALTKRD EKWIDMYGLI
710 720 730 740 750
VAQWLSTVNT QFYTIKEGMY KALNYQAQAL EEIIKYKYNI YSEKERSNIN
760 770 780 790 800
IDFNDVNSKL NEGINQAIDN INNFINECSV SYLMKKMIPL AVEKLLDFDN
810 820 830 840 850
TLRKNLLNYI DENKLYLIGS AEYEKSKVDK YLKTSIPFDL STYTNNTILI
860 870 880 890 900
EIFNKYNSDI LNNIILNLRY RDNKLIDLSG YGAKVEVYDG VKLNDKNQFK
910 920 930 940 950
LTSSANSKIR VIQNQNIIFN SMFLDFSVSF WIRIPKYKND GIQNYIHNEY
960 970 980 990 1000
TIINCMKNNS GWKISIRGNM IIWTLIDING KIKSVFFEYS IKEDISEYIN
1010 1020 1030 1040 1050
RWFFVTITNN SDNAKIYING KLESHIDIRD IREVIANDEI IFKLDGNIDR
1060 1070 1080 1090 1100
TQFIWMKYFS IFNTELSQSN IEEIYKIQSY SEYLKDFWGN PLMYNKEYYM
1110 1120 1130 1140 1150
FNAGNKNSYI KLKKDSSVGE ILTRSKYNQN SKYINYRDLY IGEKFIIRRK
1160 1170 1180 1190 1200
SNSQSINDDI VRKEDYIYLD FFNLNQEWRV YMYKYFKKEE EKLFLAPISD
1210 1220 1230 1240 1250
SDEFYNTIQI KEYDEQPTYS CQLLFKKDEE STDEIGLIGI HRFYESGIVF
1260 1270 1280 1290
KEYKDYFCIS KWYLKEVKRK PYNSKLGCNW QFIPKDEGWT E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF033130 Genomic DNA Translation: ABM73986.1 GQ244313 Genomic DNA Translation: ADF42614.1 AB665553 Genomic DNA Translation: BAL63021.1 SGKC01000027 Genomic DNA Translation: NEZ92918.1 |
RefSeqi | WP_012720198.1, NZ_CP031095.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF033130 Genomic DNA Translation: ABM73986.1 GQ244313 Genomic DNA Translation: ADF42614.1 AB665553 Genomic DNA Translation: BAL63021.1 SGKC01000027 Genomic DNA Translation: NEZ92918.1 |
RefSeqi | WP_012720198.1, NZ_CP031095.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M27.002 |
Family and domain databases
Gene3Di | 1.20.1120.10, 1 hit |
InterProi | View protein in InterPro IPR000395, Bot/tetX_LC IPR036248, Clostridium_toxin_transloc IPR013320, ConA-like_dom_sf IPR011065, Kunitz_inhibitor_STI-like_sf IPR013104, Toxin_rcpt-bd_C IPR012928, Toxin_rcpt-bd_N IPR012500, Toxin_trans |
Pfami | View protein in Pfam PF01742, Peptidase_M27, 1 hit PF07951, Toxin_R_bind_C, 1 hit PF07953, Toxin_R_bind_N, 1 hit PF07952, Toxin_trans, 1 hit |
PRINTSi | PR00760, BONTOXILYSIN |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF50386, SSF50386, 1 hit SSF58091, SSF58091, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2I2U6_CLOBO | |
Accessioni | A2I2U6Primary (citable) accession number: A2I2U6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |