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Entry version 54 (05 Jun 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Clan CA, family C2, calpain-like cysteine peptidase

Gene

TVAG_023460

Organism
Trichomonas vaginalis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1108PROSITE-ProRule annotation1
Active sitei1268PROSITE-ProRule annotation1
Active sitei1288PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Clan CA, family C2, calpain-like cysteine peptidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TVAG_023460Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrichomonas vaginalisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5722 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001542 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TrichDB:TVAG_023460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei53 – 80HelicalSequence analysisAdd BLAST28
Transmembranei86 – 107HelicalSequence analysisAdd BLAST22
Transmembranei119 – 143HelicalSequence analysisAdd BLAST25
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei214 – 235HelicalSequence analysisAdd BLAST22
Transmembranei295 – 312HelicalSequence analysisAdd BLAST18
Transmembranei353 – 371HelicalSequence analysisAdd BLAST19
Transmembranei391 – 415HelicalSequence analysisAdd BLAST25
Transmembranei422 – 441HelicalSequence analysisAdd BLAST20
Transmembranei453 – 472HelicalSequence analysisAdd BLAST20
Transmembranei484 – 508HelicalSequence analysisAdd BLAST25
Transmembranei514 – 538HelicalSequence analysisAdd BLAST25
Transmembranei545 – 565HelicalSequence analysisAdd BLAST21
Transmembranei571 – 593HelicalSequence analysisAdd BLAST23
Transmembranei605 – 623HelicalSequence analysisAdd BLAST19
Transmembranei629 – 649HelicalSequence analysisAdd BLAST21
Transmembranei661 – 682HelicalSequence analysisAdd BLAST22
Transmembranei688 – 711HelicalSequence analysisAdd BLAST24
Transmembranei739 – 762HelicalSequence analysisAdd BLAST24
Transmembranei768 – 790HelicalSequence analysisAdd BLAST23
Transmembranei853 – 875HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5722.XP_001309576.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1054 – 1349Calpain catalyticInterPro annotationAdd BLAST296

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni925 – 1005DisorderedSequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi925 – 949PolarSequence analysisAdd BLAST25
Compositional biasi950 – 972PolyampholyteSequence analysisAdd BLAST23
Compositional biasi973 – 1002PolarSequence analysisAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2FEL7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR020846 MFS_dom
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00648 Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2FEL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEEWILILS FCIPYFGFAA LWIFLIKKYF YWRPLVFARF VIANWIKRQI
60 70 80 90 100
GSAVFWICYI LWWIFFSLPI LIPAFFSIYL NKKYESVPIT IVVAITPAVM
110 120 130 140 150
FTLFITYKNY NHNGFKIGYT TKILLGICFA LIFVVNIVTT ILYTPEKNWK
160 170 180 190 200
AYGFFFTAPP ILIYGYCLCY SRRKIKKDAA KSILDNDSSK RSFIYEICNR
210 220 230 240 250
KFDNWFGGSH KLPWYHIIVV VASSVIFNFT FYGLWKDEPT LATAAGSFVI
260 270 280 290 300
DMLILIRQNL IPNQVQTVKF LFVAYLLKVY AIYNSPEYWL YSHSVYFLVF
310 320 330 340 350
GIWFLTRFMI WLSNKSLCPR KKVRLSQSLI DGEVMEQIEK ITPEGIRPTS
360 370 380 390 400
LEAIPSIIVF IIAVILAAVE IKIYGEDVDQ KIFNDNTQKT GYITIIVITI
410 420 430 440 450
AISFILSVII CAYTGRGKIS KLMLLTVISG IIFLHLFLHF YQDLNITPYQ
460 470 480 490 500
NGLFFMIIFM AIDGILFCLS LSGNAFKLTK GTSLFVQTII YMVLLIIISL
510 520 530 540 550
SLIIVPIVCA EKSLIGVIIT LGFLSAVFFF IFSHFFIMPT FKCDWIIYLT
560 570 580 590 600
LFCVFYIGYC LALYFSDYLF VSFVSGGFGI LFIAYGITLI WCYRNQWTLS
610 620 630 640 650
LGPMLISTIT SCIVTGLLTW QFMISEYKLS TAVFAYVFAL IACGSIYIFA
660 670 680 690 700
MQKYRYNHSA LSICAIVFYC VFSVAMLVLI FLQNSTPYFV YTIASIVTAV
710 720 730 740 750
LAVGCAVTYV LMNSKTTVLV LTNFFFPARN YYSGSIHKIP IFTTAYLLLI
760 770 780 790 800
VDLWMWGLFG MISDNTNIVP PIMITAAFTV TSLFGIALLI ELDQKCLSSL
810 820 830 840 850
QYISTEAITH AVGKAMHAAG VSSNLKVPTK VDKSNPQKYL DTERQFNKMN
860 870 880 890 900
SAISYFITAL KAQLFISSQM AFLMAKDKLK TILSSKNIEC NFLDESDFSP
910 920 930 940 950
EERSRVINLY LNLTGQSSVN APTADLKQNI TVKPHTATTT LPSPKTMSDT
960 970 980 990 1000
KQKSDSKPKS KTDTKSKSDK PSKPADTSNA SKAKTTNNTN TNNNNNSSGG
1010 1020 1030 1040 1050
GGWFGKWFNK NSEETHASTK CNYEPPWSHI TEYMKMQDTI RKQIDNIPSN
1060 1070 1080 1090 1100
SNSKYVDNGF HPTKKVTEAN NVLLNGVEWV RAEQLYEKQK FIDTCRPNDL
1110 1120 1130 1140 1150
VQGYFGDCYV VTAMASICRS ISNIKNLFYI PDIAVKNGLC CVVFKAMNKE
1160 1170 1180 1190 1200
MSVNVDTLIP LLNGKPRMVH PATERSPYWF CIVEKAYAKI VGSYSAATGG
1210 1220 1230 1240 1250
TPDEALYRLL GGFPINIDLT DLDVRESITS GELFKQMVEW NKRGSHLIAG
1260 1270 1280 1290 1300
SPEGSHFKKN KDGIVQGHAY NILDVVEFHG VQLLKLRNPW GEQEWKGDWS
1310 1320 1330 1340 1350
AESSMWKKYP AVASKCNFDK DRTQTDGVFW MLFKDFTSNY AQLYCLIVNE
1360 1370 1380 1390 1400
SLPHYRFIIS NTMKPGDTDG AKPVTQSRDA DCLPQYILRV SADCTIKMFL
1410 1420 1430 1440 1450
ERTGPAVPTW VYAVKGKEPI KKIYSGTKYK TEPMPENSAI YSFDWQMESG
1460 1470 1480 1490
EWVIVVCRNK CDKESDYVLK MYSDRRIELT PLINCTQQTI STK
Length:1,493
Mass (Da):169,751
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD521B7B18FEE4D6C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS113749 Genomic DNA Translation: EAX96646.1

NCBI Reference Sequences

More...
RefSeqi
XP_001309576.1, XM_001309575.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAX96646; EAX96646; TVAG_023460

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4754419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tva:TVAG_023460

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS113749 Genomic DNA Translation: EAX96646.1
RefSeqiXP_001309576.1, XM_001309575.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5722.XP_001309576.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAX96646; EAX96646; TVAG_023460
GeneIDi4754419
KEGGitva:TVAG_023460

Organism-specific databases

EuPathDBiTrichDB:TVAG_023460

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
InParanoidiA2FEL7

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR020846 MFS_dom
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2FEL7_TRIVA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2FEL7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 5, 2019
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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