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Entry version 69 (10 Apr 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Pyruvate:ferredoxin oxidoreductase BII

Gene

TVAG_242960

Organism
Trichomonas vaginalis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 3 [4Fe-4S] clusters per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi682Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi685Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi688Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi692Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi734Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi737Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi740Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi744Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi800Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi803Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi828Iron-sulfur 3 (4Fe-4S)UniRule annotation1
Metal bindingi1062Iron-sulfur 3 (4Fe-4S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • electron transport chain Source: InterPro
  • response to oxidative stress Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, PyruvateImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pyruvate:ferredoxin oxidoreductase BIIImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TVAG_242960Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrichomonas vaginalisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5722 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001542 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TrichDB:TVAG_242960

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5722.XP_001311861.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2F855

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini673 – 7024Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30
Domaini725 – 7544Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMZJ Eukaryota
COG0674 LUCA
COG1013 LUCA
COG1014 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2F855

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.920, 1 hit
3.40.920.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR033412 PFOR_II
IPR019456 Pyrv-flavodox_OxRtase_EKR
IPR019752 Pyrv/ketoisovalerate_OxRed_cat
IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N
IPR011895 Pyrv_flavodox_OxRed
IPR002869 Pyrv_flavodox_OxRed_cen
IPR029061 THDP-binding
IPR011766 TPP_enzyme-bd_C
IPR009014 Transketo_C/PFOR_II

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10371 EKR, 1 hit
PF12838 Fer4_7, 1 hit
PF17147 PFOR_II, 1 hit
PF01558 POR, 1 hit
PF01855 POR_N, 1 hit
PF02775 TPP_enzyme_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000159 NifJ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00890 EKR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
SSF53323 SSF53323, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02176 pyruv_ox_red, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2F855-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRNFGKRVP GDGNTAATSV AYQLTETSFI YPITPATTMG ELVDAWIAQG
60 70 80 90 100
RKNIWGNKVN MAMMQSEGGA AAAVHGATAV GALCATFTAS QGALLMIPDM
110 120 130 140 150
YKIVGEMCPA VFHISARCIA TSALSIYNDH GDIYACRATG IPILFSNGVQ
160 170 180 190 200
EAHDLAAVAH LTSIHTGLPF IHTFDGFRTS HEINTYEELD NETLWPLIDQ
210 220 230 240 250
QALAAFRARS LNPEHPSERG TICGPEYVWQ MHEKLRKPYQ ALPAEVEKMM
260 270 280 290 300
KALGDKTGRY YKPYQYAGPR DPENVIIMMG SGCDPVEEYI TEHPEYKTGL
310 320 330 340 350
IKIHLYRPFS VEMFNAAIPA SVKRICVLDK VVDPTGPREP LFEDVAASII
360 370 380 390 400
GQRNVKIIGG RYGISSRDFA PVHVEAIVKN LVSQIPKDHF TVGVVNPETA
410 420 430 440 450
LPLGKPFDHL PEGTKQCMFW GLGSDGTVGA NKQAIKLIVS NTKLYGQAYF
460 470 480 490 500
AYDAHKSGGV TTSHLRFGAK PINAPYYVQN ADYIACHNPS YLHKFDMTKQ
510 520 530 540 550
LKQGGVFVIN FPGNLDLNKD LPGSFRRSIA EKDAKLYTID ATQIAIDLKL
560 570 580 590 600
PGRINMLMQT VFFGLANIIP AEECIALLKK SIAKQYARKG KEVIQKNWDM
610 620 630 640 650
VDHALQGLKE FKYNKAEWLN APVEPRPKHE GIRHIIDMSI LQEGESVSVD
660 670 680 690 700
EMVEIGLVPN DTAKFEKRGI AVTVPKWDEK KCIQCNTCAI VCPHAVIRPF
710 720 730 740 750
LLKPEEVQGL TTLKAKGKEI KDYQFRIQIT PLDCTGCGTC VTSCPTKALS
760 770 780 790 800
MTYRNAKIDE EEGKNWERLT AIPNRGHLVP ATNVRNVQFR QPLIEFNGAC
810 820 830 840 850
QGCGETAICK LLTQLYGDQL YLANATGCSL VWGATFPFNP YTTNERGHGP
860 870 880 890 900
AWANSLFEDN AEFGYGMFKA VEARRNITKR LIVDVIESGE VKGELKDLFE
910 920 930 940 950
QLLKVWDQDK ESGDLAEKIK PLLAKVQNPS EKLFDLKSQA DILAKKQVWI
960 970 980 990 1000
VGGDGWAYDI GYGGLDHVLA SGENVKIIIY DTEVYSNTGG QCSKATSRGA
1010 1020 1030 1040 1050
VANFSAAGYT NAKKDLGAIA MTYKNIYVAS TCLLADPNQA LKALQEAKEY
1060 1070 1080 1090 1100
NGPAIIINYS PCINHGIKKG LGSTPKHCKD LLKTGYLNLF RYNPSKDKPL
1110 1120 1130 1140 1150
TVDTKQPNYN LDPLVKGENR FAALKDIYPK EAETKFPLLI NDMKTRYEGY

KKIQQTQ
Length:1,157
Mass (Da):128,046
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4637EAD7937E416
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS113657 Genomic DNA Translation: EAX98931.1

NCBI Reference Sequences

More...
RefSeqi
XP_001311861.1, XM_001311860.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAX98931; EAX98931; TVAG_242960

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4756734

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tva:TVAG_242960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS113657 Genomic DNA Translation: EAX98931.1
RefSeqiXP_001311861.1, XM_001311860.1

3D structure databases

ProteinModelPortaliA2F855
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5722.XP_001311861.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAX98931; EAX98931; TVAG_242960
GeneIDi4756734
KEGGitva:TVAG_242960

Organism-specific databases

EuPathDBiTrichDB:TVAG_242960

Phylogenomic databases

eggNOGiENOG410IMZJ Eukaryota
COG0674 LUCA
COG1013 LUCA
COG1014 LUCA
InParanoidiA2F855

Family and domain databases

Gene3Di3.40.50.920, 1 hit
3.40.920.10, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR033412 PFOR_II
IPR019456 Pyrv-flavodox_OxRtase_EKR
IPR019752 Pyrv/ketoisovalerate_OxRed_cat
IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N
IPR011895 Pyrv_flavodox_OxRed
IPR002869 Pyrv_flavodox_OxRed_cen
IPR029061 THDP-binding
IPR011766 TPP_enzyme-bd_C
IPR009014 Transketo_C/PFOR_II
PfamiView protein in Pfam
PF10371 EKR, 1 hit
PF12838 Fer4_7, 1 hit
PF17147 PFOR_II, 1 hit
PF01558 POR, 1 hit
PF01855 POR_N, 1 hit
PF02775 TPP_enzyme_C, 1 hit
PIRSFiPIRSF000159 NifJ, 1 hit
SMARTiView protein in SMART
SM00890 EKR, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
SSF53323 SSF53323, 1 hit
TIGRFAMsiTIGR02176 pyruv_ox_red, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2F855_TRIVA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2F855
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 10, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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