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Entry version 84 (10 Apr 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Iron only hydrogenase large subunit, C-terminal domain containing protein

Gene

TVAG_483690

Organism
Trichomonas vaginalis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: GO_Central
  • electron transfer activity Source: InterPro
  • FMN binding Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandHemeSAAS annotation, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Iron only hydrogenase large subunit, C-terminal domain containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TVAG_483690Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrichomonas vaginalisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5722 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001542 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
TrichDB:TVAG_483690

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5722.XP_001322682.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A2EA13

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2EA13

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 772Fe-2S ferredoxin-typeInterPro annotationAdd BLAST77
Domaini123 – 1534Fe-4S ferredoxin-typeInterPro annotationAdd BLAST31
Domaini154 – 1834Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30
Domaini553 – 689Flavodoxin-likeInterPro annotationAdd BLAST137
Domaini725 – 953FAD-binding FR-typeInterPro annotationAdd BLAST229

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NARF family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1158 Eukaryota
KOG2439 Eukaryota
COG0369 LUCA
COG1034 LUCA
COG4624 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2EA13

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00207 fer2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.990.10, 1 hit
3.40.50.360, 1 hit
3.40.50.80, 1 hit
4.10.260.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR009016 Fe_hydrogenase
IPR004108 Fe_hydrogenase_lsu_C
IPR003149 Fe_hydrogenase_ssu
IPR036991 Fe_hydrogenase_ssu_sf
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR017938 Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF02906 Fe_hyd_lg_C, 1 hit
PF02256 Fe_hyd_SSU, 1 hit
PF00258 Flavodoxin_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00369 FLAVODOXIN
PR00371 FPNCR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00902 Fe_hyd_SSU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF53920 SSF53920, 1 hit
SSF54292 SSF54292, 1 hit
SSF63380 SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2EA13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSVTINGKQ VSCKKGTFIL QACTDNGIYV PTLCAHPDIP PAGNCGLCVV
60 70 80 90 100
KVNGNSYELA CSTKVTNGMV IETDTPEVKK RSLDALNAFN DMPLMPGSKE
110 120 130 140 150
IEDIYKYLIP KRPIRGRKAE KTNALSFDPE TCVNCGRCVR VCGDMQYIGA
160 170 180 190 200
LDEESHSLND NDCIQCGMCT TVCPTDCLTY NSSISSIIRA MAAGKILVLQ
210 220 230 240 250
IHPSSSVSLG ELFGEKIGVD CTKKIIGAAR EIGFRYVFDV NFGGDINIIE
260 270 280 290 300
TAHELLHKLS LQPDSLPMFT SWCPAWVNFV EKLHPELIPN LSTVKSPHIL
310 320 330 340 350
LSVIIRNYYA HLKEIDLQKL FIVSLLPCTA NKDEIKREQL SETVDCVLTT
360 370 380 390 400
REFGELIKKF DIDWTELHPG EFDEILGESS GSAALYGVSG GALEATARYL
410 420 430 440 450
YENLTGKSLG DVKYHQWRGK DDIREASVDF NGRILNSCVC NGVAAARELI
460 470 480 490 500
ESGNYKKYQF IDVVACPDGC IAGGGQPKLH NKKNALPRTE AIYQMDESKP
510 520 530 540 550
DRPTPHNNKA LLKIYDDFIG NPYDDFAQSL FHTTFAQQNT PILEMKRKVH
560 570 580 590 600
TLPIVAFGSA SGTASRYAGI FAGFIGTVPV QLNMVTIAML EKTSHIVVFC
610 620 630 640 650
STFGDGEFPA NAEKFVRNLS ESKTDLGNLK YSICGLGSHD YPKYCYCGRT
660 670 680 690 700
LDRLFMQHHA QRFMDIAELD SSLPDHGEHI FEAWAPQCVK RLGMKMPDSS
710 720 730 740 750
IGANYTFVPT TSSDESVIKS PMKPVGYEFG TILQTKVITP EGFEPKMRYY
760 770 780 790 800
EIRLPQGMTY EAGDLLAVLP QNDNETVKAV LQELKLNGDD IMDVTTTRPE
810 820 830 840 850
GYNTIPSRLT LWQLFSQYLD LNGVPSRNLI RAYKQFTNDQ FARERYERLL
860 870 880 890 900
DPADPRFYND LAKDMSTREF ILEYTRHGSP PLDVLVSNIT HIRARLYCIA
910 920 930 940 950
SAPCHSSSSV ELIISDNIFG PGNSRRGLCT SFMAREGLTK LAVRTQRGCF
960 970 980 990 1000
SYPKQQKPSI IMAALGCGVA PMLSLLQHRE SLEGEKGDAC LFFGCRVKNS
1010 1020 1030 1040 1050
YPDIDKQLSD YVKSGLLQNC FTSYSREGTT KSFITEDMAE QSDLIWNLWR
1060 1070 1080 1090 1100
DVNCTFAYCG PPRGIPEKIR MNFVRISMEK GGMSREEAEN FCAAHPHFIE

SF
Length:1,102
Mass (Da):122,842
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96E02D711FEE8581
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS113337 Genomic DNA Translation: EAY10459.1

NCBI Reference Sequences

More...
RefSeqi
XP_001322682.1, XM_001322647.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAY10459; EAY10459; TVAG_483690

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4768389

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tva:TVAG_483690

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS113337 Genomic DNA Translation: EAY10459.1
RefSeqiXP_001322682.1, XM_001322647.1

3D structure databases

ProteinModelPortaliA2EA13
SMRiA2EA13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5722.XP_001322682.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAY10459; EAY10459; TVAG_483690
GeneIDi4768389
KEGGitva:TVAG_483690

Organism-specific databases

EuPathDBiTrichDB:TVAG_483690

Phylogenomic databases

eggNOGiKOG1158 Eukaryota
KOG2439 Eukaryota
COG0369 LUCA
COG1034 LUCA
COG4624 LUCA
InParanoidiA2EA13

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.20.990.10, 1 hit
3.40.50.360, 1 hit
3.40.50.80, 1 hit
4.10.260.20, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR009016 Fe_hydrogenase
IPR004108 Fe_hydrogenase_lsu_C
IPR003149 Fe_hydrogenase_ssu
IPR036991 Fe_hydrogenase_ssu_sf
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF02906 Fe_hyd_lg_C, 1 hit
PF02256 Fe_hyd_SSU, 1 hit
PF00258 Flavodoxin_1, 1 hit
PRINTSiPR00369 FLAVODOXIN
PR00371 FPNCR
SMARTiView protein in SMART
SM00902 Fe_hyd_SSU, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF53920 SSF53920, 1 hit
SSF54292 SSF54292, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2EA13_TRIVA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2EA13
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 10, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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