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Protein

AT-rich interactive domain-containing protein 4B

Gene

Arid4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A (PubMed:17043311). Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (PubMed:18728284).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214815 HDACs deacetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4B
Short name:
ARID domain-containing protein 4B
Alternative name(s):
180 kDa Sin3-associated polypeptide
Short name:
Sin3-associated polypeptide p180
Histone deacetylase complex subunit SAP180
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arid4b
Synonyms:Sap180
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2137512 Arid4b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal. Lethality occurs between embryonic day E3.5 and E7.5 (PubMed:17043311). Heterozygous males are fully fertile (PubMed:23487765). Double knockouts of ARID4B heterozygotes with ARID4A homozygotes show various hematological abnormalities, which are more severe than the ARID4A phenotype alone. Hematopoietic stem cell (HSC) and common myeloid progenitor (CMP) counts in bone marrow and spleen are increased. Lymphocyte numbers in spleen are significantly reduced. In peripheral blood, red blood cell counts and lymphocyte counts are reduced. Approximately 83% of animals develop acute myeloid leukemia (AML) and/or myeloid sarcoma. In bone marrow cells, expression of FOXP3 is significantly reduced (PubMed:18728284). Expression of HOXB3, HOXB5, HOXB6, HOXB8 and PITX2 in bone marrow cells is reduced (PubMed:17043311). Males show progressive reduction in fertility from 2 months of age onwards, with reduced testis size and variable defects in seminal vesicle formation. Spermatogenesis is partially blocked from the meiosis II stage onwards leading to reduced numbers of mature spermatozoa. Expression in testis of CLDN3, an androgen receptor-regulated gene, is significantly reduced. Expression of PTGDS is also reduced, whereas expression of INHA and EMB is moderately increased (PubMed:23487765).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002828641 – 1314AT-rich interactive domain-containing protein 4BAdd BLAST1314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei276PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki428Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei482PhosphoserineBy similarity1
Modified residuei666PhosphoserineBy similarity1
Modified residuei668PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei717PhosphoserineBy similarity1
Cross-linki751Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei778PhosphoserineBy similarity1
Modified residuei790PhosphoserineCombined sources1
Modified residuei793PhosphothreonineCombined sources1
Modified residuei1016PhosphoserineBy similarity1
Modified residuei1028PhosphothreonineBy similarity1
Modified residuei1031PhosphoserineBy similarity1
Modified residuei1152PhosphothreonineBy similarity1
Modified residuei1154PhosphoserineBy similarity1
Modified residuei1155PhosphoserineBy similarity1
Modified residuei1157PhosphoserineBy similarity1
Modified residuei1161PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A2CG63

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2CG63

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2CG63

PeptideAtlas

More...
PeptideAtlasi
A2CG63

PRoteomics IDEntifications database

More...
PRIDEi
A2CG63

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2CG63

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2CG63

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in Sertoli cells of the testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000039219 Expressed in 270 organ(s), highest expression level in supraoptic nucleus

CleanEx database of gene expression profiles

More...
CleanExi
MM_ARID4B

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2CG63 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2CG63 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2 (By similarity). Interacts with ARID4A (PubMed:17043311). Interacts with AR (PubMed:23487765).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Stra8P702784EBI-6394082,EBI-6394115

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
220492, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443 SIN3A histone deacetylase complex
CPX-3444 SIN3B histone deacetylase complex

Protein interaction database and analysis system

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IntActi
A2CG63, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000106163

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2CG63

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2CG63

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini306 – 398ARIDPROSITE-ProRule annotationAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1227 – 1272Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 159Poly-Ser6
Compositional biasi268 – 567Glu-richAdd BLAST300
Compositional biasi1097 – 1103Poly-Ser7
Compositional biasi1273 – 1305Ser-richAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus mediates interaction with mSin3A corepressor complex.By similarity
The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.By similarity
The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2744 Eukaryota
KOG3001 Eukaryota
ENOG410Y2AP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158149

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG058247

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2CG63

KEGG Orthology (KO)

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KOi
K19195

Identification of Orthologs from Complete Genome Data

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OMAi
THTRNDL

Database of Orthologous Groups

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OrthoDBi
EOG091G0EG4

Database for complete collections of gene phylogenies

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PhylomeDBi
A2CG63

TreeFam database of animal gene trees

More...
TreeFami
TF106427

Family and domain databases

Conserved Domains Database

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CDDi
cd00024 CHROMO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028853 ARID4B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR012603 RBB1NT
IPR002999 Tudor
IPR025995 Tudor-knot

The PANTHER Classification System

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PANTHERi
PTHR13964:SF24 PTHR13964:SF24, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF08169 RBB1NT, 1 hit
PF11717 Tudor-knot, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit
SM00333 TUDOR, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46774 SSF46774, 1 hit
SSF54160 SSF54160, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2CG63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE
60 70 80 90 100
VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT
110 120 130 140 150
LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP
160 170 180 190 200
EEESSSSSSD DDEEERKQTD ELLGKVVCVD YVSLEKKKAM WFPALVVCPD
210 220 230 240 250
CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTVPK PDAVLKQAFD
260 270 280 290 300
QALEFHKSRA IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE
310 320 330 340 350
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL
360 370 380 390 400
GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA
410 420 430 440 450
NIDFQMALPE KVLNKPCKDC ENKEVKVKEE SETEIKEVNV EDSKNVMPKE
460 470 480 490 500
ETPAEDESER KENIKPSLGS KKSLLECIPA QSDEEKEAHI TKLEENENLE
510 520 530 540 550
DKDGGRARTE EAFSTEVDGE EEQARSGDET NKEEDEDDEE IEEEEEEDEE
560 570 580 590 600
EDEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG
610 620 630 640 650
EALYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD
660 670 680 690 700
RDEKYSPKNC KLRRLSKSPF QSNPSPEMVS KLDLADAKNS DTAHIKSIEI
710 720 730 740 750
TSILNGLQAS ESSAEDSEQE DERCTQDVDN IGKDESKVEH STHSRNELIS
760 770 780 790 800
KEEQSSPSLL EENKVHTDLV IAKTVSKSPE RLRKDMEAIS EDTDFEEEDE
810 820 830 840 850
ITKKRKDVKK DTTDKALKPQ TKRGKRRYCS ADECLQTGSP GKKEDRTKSK
860 870 880 890 900
EPLCTENSSN SSSDEDEEEK SKAKMTPTKK YNGLEEKRKS LRTTSFYSGF
910 920 930 940 950
SEVAEKRIKL LNNSDERLQN NRAKDRKDVW SSIQGQWPKK TLKELFSDSD
960 970 980 990 1000
TEAAASPPHP APDEGAVEES LQTVAEEESC SPIMELEKPL PASVDNKPIE
1010 1020 1030 1040 1050
EKPLEVSDRK TEFPSSGSNS VLNTPPTTPE SPSSVTITEA SQQQSSVTVS
1060 1070 1080 1090 1100
VPLPPNQEEV RSIKSETDST IEVDSVVGEL QDLQSEGNSS PAGFDASVSS
1110 1120 1130 1140 1150
SSSNQPEPDN PEKACTGQKR VKDTQGVGSS SKKQKRSHKA TVVNNKKKGK
1160 1170 1180 1190 1200
GTNSSDSEEL SAGESVTKTQ TIKSVPTGMK THNSKSPARV QSPGKGGRNG
1210 1220 1230 1240 1250
DKDPDLKEPS NRLPKVYKWS FQTSDLENMT SAERISILQE KLQEIRKHYL
1260 1270 1280 1290 1300
SLKSEVASID RRRKRLKKKE RESAATSSSS SSPSSSSITA AVMLTLAEPS
1310
MSSASQNGMS VECR
Length:1,314
Mass (Da):147,643
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE5E69DAA208A200
GO
Isoform 2 (identifier: A2CG63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-614: Missing.

Show »
Length:1,227
Mass (Da):137,325
Checksum:i28B18F3DB2D6884D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YL44Z4YL44_MOUSE
AT-rich interactive domain-containi...
Arid4b
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YMH1Z4YMH1_MOUSE
AT-rich interactive domain-containi...
Arid4b
540Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VIX3A0A1Y7VIX3_MOUSE
AT rich interactive domain 4B (Rbp1...
Arid4b mCG_18829
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VKA9A0A1Y7VKA9_MOUSE
AT-rich interactive domain-containi...
Arid4b
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM21242 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024236528 – 614Missing in isoform 2. CuratedAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CT025604 Genomic DNA Translation: CAM21242.1 Sequence problems.
CT025604 Genomic DNA Translation: CAM21243.1
CT025604 Genomic DNA Translation: CAM21244.1
CT025604 Genomic DNA Translation: CAM21245.1
BC137783 mRNA Translation: AAI37784.1
AK031062 mRNA Translation: BAC27233.1
AK041414 mRNA Translation: BAC30936.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS36599.1 [A2CG63-1]
CCDS36600.1 [A2CG63-2]

NCBI Reference Sequences

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RefSeqi
NP_919238.1, NM_194262.2 [A2CG63-1]
NP_937755.1, NM_198122.2 [A2CG63-2]
XP_006516869.1, XM_006516806.2 [A2CG63-1]
XP_006516870.1, XM_006516807.2 [A2CG63-1]
XP_017171137.1, XM_017315648.1 [A2CG63-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.439784

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000039538; ENSMUSP00000043889; ENSMUSG00000039219 [A2CG63-2]
ENSMUST00000110534; ENSMUSP00000106163; ENSMUSG00000039219 [A2CG63-1]
ENSMUST00000110536; ENSMUSP00000106165; ENSMUSG00000039219 [A2CG63-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
94246

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:94246

UCSC genome browser

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UCSCi
uc007pmz.2 mouse [A2CG63-1]
uc007pna.2 mouse [A2CG63-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025604 Genomic DNA Translation: CAM21242.1 Sequence problems.
CT025604 Genomic DNA Translation: CAM21243.1
CT025604 Genomic DNA Translation: CAM21244.1
CT025604 Genomic DNA Translation: CAM21245.1
BC137783 mRNA Translation: AAI37784.1
AK031062 mRNA Translation: BAC27233.1
AK041414 mRNA Translation: BAC30936.1
CCDSiCCDS36599.1 [A2CG63-1]
CCDS36600.1 [A2CG63-2]
RefSeqiNP_919238.1, NM_194262.2 [A2CG63-1]
NP_937755.1, NM_198122.2 [A2CG63-2]
XP_006516869.1, XM_006516806.2 [A2CG63-1]
XP_006516870.1, XM_006516807.2 [A2CG63-1]
XP_017171137.1, XM_017315648.1 [A2CG63-1]
UniGeneiMm.439784

3D structure databases

ProteinModelPortaliA2CG63
SMRiA2CG63
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220492, 3 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443 SIN3A histone deacetylase complex
CPX-3444 SIN3B histone deacetylase complex
IntActiA2CG63, 1 interactor
STRINGi10090.ENSMUSP00000106163

PTM databases

iPTMnetiA2CG63
PhosphoSitePlusiA2CG63

Proteomic databases

EPDiA2CG63
MaxQBiA2CG63
PaxDbiA2CG63
PeptideAtlasiA2CG63
PRIDEiA2CG63

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039538; ENSMUSP00000043889; ENSMUSG00000039219 [A2CG63-2]
ENSMUST00000110534; ENSMUSP00000106163; ENSMUSG00000039219 [A2CG63-1]
ENSMUST00000110536; ENSMUSP00000106165; ENSMUSG00000039219 [A2CG63-2]
GeneIDi94246
KEGGimmu:94246
UCSCiuc007pmz.2 mouse [A2CG63-1]
uc007pna.2 mouse [A2CG63-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51742
MGIiMGI:2137512 Arid4b

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
KOG3001 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00940000158149
HOVERGENiHBG058247
InParanoidiA2CG63
KOiK19195
OMAiTHTRNDL
OrthoDBiEOG091G0EG4
PhylomeDBiA2CG63
TreeFamiTF106427

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Arid4b mouse

Protein Ontology

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PROi
PR:A2CG63

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039219 Expressed in 270 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_ARID4B
ExpressionAtlasiA2CG63 baseline and differential
GenevisibleiA2CG63 MM

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR028853 ARID4B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR012603 RBB1NT
IPR002999 Tudor
IPR025995 Tudor-knot
PANTHERiPTHR13964:SF24 PTHR13964:SF24, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF08169 RBB1NT, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SM00333 TUDOR, 2 hits
SUPFAMiSSF46774 SSF46774, 1 hit
SSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI4B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2CG63
Secondary accession number(s): A2CG61
, A2CG62, A2CG64, B2RQ67, Q8BMI8, Q8BYA5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 20, 2007
Last modified: December 5, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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