Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 126 (03 Jul 2019)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Kalirin

Gene

Kalrn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2685ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2775Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2662 – 2670ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-416476 G alpha (q) signalling events
R-MMU-5687128 MAPK6/MAPK4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KalirinBy similarity (EC:2.7.11.1)
Alternative name(s):
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KalrnImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685385 Kalrn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003081731 – 2964KalirinAdd BLAST2964

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1722PhosphoserineCombined sources1
Modified residuei1725PhosphoserineBy similarity1
Modified residuei1771PhosphoserineCombined sources1
Modified residuei1784PhosphothreonineBy similarity1
Modified residuei1789PhosphoserineCombined sources1
Modified residuei1881PhosphothreonineCombined sources1
Modified residuei1884PhosphothreonineCombined sources1
Modified residuei2233PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2464 ↔ 2520PROSITE-ProRule annotationBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2CG49

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2CG49

PeptideAtlas

More...
PeptideAtlasi
A2CG49

PRoteomics IDEntifications database

More...
PRIDEi
A2CG49

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2CG49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2CG49

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2CG49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000061751 Expressed in 251 organ(s), highest expression level in cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2CG49 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2CG49 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1).

Interacts with FASLG (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
244011, 57 interactors

Protein interaction database and analysis system

More...
IntActi
A2CG49, 60 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000110611

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12964
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2CG49

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A2CG49

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 162CRAL-TRIOPROSITE-ProRule annotationAdd BLAST146
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati149 – 290Spectrin 1Sequence analysisAdd BLAST142
Repeati292 – 399Spectrin 2Sequence analysisAdd BLAST108
Repeati400 – 517Spectrin 3Sequence analysisAdd BLAST118
Repeati518 – 621Spectrin 4Sequence analysisAdd BLAST104
Repeati622 – 752Spectrin 5Sequence analysisAdd BLAST131
Repeati753 – 870Spectrin 6Sequence analysisAdd BLAST118
Repeati871 – 977Spectrin 7Sequence analysisAdd BLAST107
Repeati978 – 1101Spectrin 8Sequence analysisAdd BLAST124
Repeati1102 – 1207Spectrin 9Sequence analysisAdd BLAST106
Domaini1254 – 1429DH 1PROSITE-ProRule annotationAdd BLAST176
Domaini1441 – 1553PH 1PROSITE-ProRule annotationAdd BLAST113
Domaini1619 – 1684SH3 1PROSITE-ProRule annotationAdd BLAST66
Domaini1900 – 2075DH 2PROSITE-ProRule annotationAdd BLAST176
Domaini2087 – 2197PH 2PROSITE-ProRule annotationAdd BLAST111
Domaini2292 – 2357SH3 2PROSITE-ProRule annotationAdd BLAST66
Domaini2443 – 2536Ig-like C2-typeSequence analysisAdd BLAST94
Domaini2543 – 2637Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95
Domaini2656 – 2910Protein kinasePROSITE-ProRule annotationAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi664 – 669Poly-GlnSequence analysis6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4240 Eukaryota
ENOG410XPCA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000081798

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2CG49

KEGG Orthology (KO)

More...
KOi
K15048

Database of Orthologous Groups

More...
OrthoDBi
5761at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2CG49

TreeFam database of animal gene trees

More...
TreeFami
TF318080

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit
cd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 2 hits
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR028569 Kalirin
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR22826:SF49 PTHR22826:SF49, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 2 hits
SSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 10 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2CG49-1) [UniParc]FASTAAdd to basket
Also known as: Kalirin-12ABy similarity

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLSGSFRND GLKASDVLPI LKEKVAFVSG GRDKRGGPIL TFPARSNHDR
60 70 80 90 100
IRQEDLRKLV TYLASVPSED VCKRGFTVII DMRGSKWDLI KPLLKTLQEA
110 120 130 140 150
FPAEIHVALI IKPDNFWQKQ KTNFGSSKFI FETSMVSVEG LTKLVDPSQL
160 170 180 190 200
TEEFDGSLDY NHEEWIELRL SLEEFFNSAV HLLSRLEDLQ EMLARKEFPV
210 220 230 240 250
DVEGSRRLID EHTQLKKKVL KAPVEELDRE GQRLLQCIRC SDGFSGRNCI
260 270 280 290 300
PGSADFQSLV PKITSLLDKL HSTRQHLHQM WHVRKLKLDQ CFQLRLFEQD
310 320 330 340 350
AEKMFDWISH NKELFLQSHT EIGVSYQHAL DLQTQHNHFA MNSMNAYVNI
360 370 380 390 400
NRIMSVASRL SEAGHYASQQ IKQISTQLDQ EWKSFAAALD ERSTILAMSA
410 420 430 440 450
VFHQKAEQFL SGVDAWCKMC SEGGLPSEMQ DLELAIHHHQ SLYEQVTQAY
460 470 480 490 500
TEVSQDGKAL LDVLQRPLSP GNSESLTATA NYSKAVHQVL DVVHEVLHHQ
510 520 530 540 550
RRLESIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA FLSKHTGVGK
560 570 580 590 600
SLHRARALQK RHDDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYKA
610 620 630 640 650
ARHLEVRIQD FVRRVEQRKL LLDMSVSFHT HTKELWTWME DLQKEVLEDV
660 670 680 690 700
CADSVDAVQE LIKQFQQQQT ATLDATLNVI KEGEDLIQQL RSAPPSLGEP
710 720 730 740 750
TEARDSAMSN NKTPHSSSIS HIESVLQQLD DAQVQMEELF HERKIKLDIF
760 770 780 790 800
LQLRIFEQYT IEVTAELDAW NEDLLRQMND FNTEDLTLAE QRLQRHTERK
810 820 830 840 850
LAMNNMTFEV IQQGQDLHQY IMEVQASGIE LICEKDLDLA AQVQELLEFL
860 870 880 890 900
HEKQHELELN AEQTHKRLEQ CLQLRHLQAE VKQVLGWIRN GESMLNASLV
910 920 930 940 950
NASSLSEAEQ LQREHEQFQL AIEKTHQSAL QVQQKAEALL QAGHYDADAI
960 970 980 990 1000
RECAEKVALH WQQLMLKMED RLKLVNASVA FYKTSEQVCS VLESLEQEYR
1010 1020 1030 1040 1050
RDEDWCGGRD KLGPAAEMDH VIPLLSKHLE QKEAFLKACT LARRNAEVFL
1060 1070 1080 1090 1100
KYIHRNNVSM PSVASHTRGP EQQVKAILSE LLQRENRVLH FWTLKKRRLD
1110 1120 1130 1140 1150
QCQQYVVFER SAKQALDWIQ ETGEYYLSTH TSTGETTEET QELLKEYGEF
1160 1170 1180 1190 1200
RVPAKQTKEK VKLLIQLADS FVEKGHIHAT EIRKWVTTVD KHYRDFSLRM
1210 1220 1230 1240 1250
GKYRYSLEKA LGVNTEDNKD LELDIIPASL SDREVKLRDA NHEINEEKRK
1260 1270 1280 1290 1300
SARKKEFIMA ELLQTEKAYV RDLHECLETY LWEMTSGVEE IPPGILNKEH
1310 1320 1330 1340 1350
IIFGNIQEIY DFHNNIFLKE LEKYEQLPED VGHCFVTWAD KFQMYVTYCK
1360 1370 1380 1390 1400
NKPDSNQLIL EHAGTFFDEI QQRHGLANSI SSYLIKPVQR VTKYQLLLKE
1410 1420 1430 1440 1450
LLTCCEEGKG ELKDGLEVML SVPKKANDAM HVSMLEGFDE NLDVQGELIL
1460 1470 1480 1490 1500
QDAFQVWDPK SLIRKGRERH LFLFEISLVF SKEIKDSSGH TKYVYKNKLL
1510 1520 1530 1540 1550
TSELGVTEHV EGDPCKFALW SGRTPSSDNK TVLKASNIET KQEWIKNIRE
1560 1570 1580 1590 1600
VIQERIIHLK GALKEPIQLP KTPAKLRNNS KRDGVEDGDS QGDGSSQPDT
1610 1620 1630 1640 1650
ISIASRTSQN TVESDKLSGG CELTVVLQDF SAGHSSELSI QVGQTVELLE
1660 1670 1680 1690 1700
RPSERPGWCL VRTTERSPPQ EGLVPSSALC ISHSRSSVEM DCFFPLKDSY
1710 1720 1730 1740 1750
SHSSSENGGK SESVAHLQSQ PSLNSIHSSP GPKRSTNTLK KWLTSPVRRL
1760 1770 1780 1790 1800
NSGKADGNIK KQKKVRDGRK SFDLGSPKPG DETTPQGDSA DEKSKKGWGE
1810 1820 1830 1840 1850
DEPDEESHTP LPPPMKIFDN DPTQDEMSSL LAARQAPPDV PTAADLVSAI
1860 1870 1880 1890 1900
EKLVKNKLTL EGGSYRGSLK DPTGCLNEGM TPPTPPRNLE EEQKAKALRG
1910 1920 1930 1940 1950
RMFVLNELVQ TEKDYVKDLG IVVEGFMKRI EEKGVPEDMR GKEKIVFGNI
1960 1970 1980 1990 2000
HQIYDWHKDF FLAELEKCIQ EQDRLAQLFI KHERKLHIYV WYCQNKPRSE
2010 2020 2030 2040 2050
YIVAEYDAYF EEVKQEINQR LTLSDFLIKP IQRITKYQLL LKDFLRYSEK
2060 2070 2080 2090 2100
AGLECSDIEK AVELMCLVPK RCNDMMNLGR LQGFEGTLTA QGKLLQQDTF
2110 2120 2130 2140 2150
YVIELDAGMQ SRTKERRVFL FEQIVIFSEL LRKGSLTPGY MFKRSIKMNY
2160 2170 2180 2190 2200
LVLEDNVDGD PCKFALMNRE TSERVILQAA NSDIQQAWVQ DINQVLETQR
2210 2220 2230 2240 2250
DFLNALQSPI EYQRKERSTA VIRSQPPRVP QASPRPYSSG PVGSEKPPKG
2260 2270 2280 2290 2300
SSYNPPLPPL KISTSNGSPG FDYHQPGDKF DASKQNDLGG CNGTSTMTVI
2310 2320 2330 2340 2350
KDYYALKENE ICVSQGEVVQ VLAVNQQNMC LVYQPASDHS PAAEGWVPGS
2360 2370 2380 2390 2400
ILAPLAKATA AAESSDGSIK KSCSWHTLRM RKRADVENSG KNEATGPRKP
2410 2420 2430 2440 2450
KDILGNKVSV KETNSSEESE CDDLDPNTSM EILNPNFIQE VAPEFLVPLV
2460 2470 2480 2490 2500
DVTCLLGDTV LLQCKACGRP KPSITWKGPD QNILDTDNSS ATYTISSCDS
2510 2520 2530 2540 2550
GESTLKICNL MPQDSGIYTC IAANDHGTAS TSATVKVQGV PAAPNRPIAQ
2560 2570 2580 2590 2600
ERSCTSVILR WLPPASTGNC TISGYTVEYR EEGSQVWQQS VASTLDTYLV
2610 2620 2630 2640 2650
IEDLSPGCPY QFRVSASNPW GISLPSEPSE FVRLPEYDAA ADGATISWKE
2660 2670 2680 2690 2700
NFDSAYTELN EIGRGRFSIV KKCIHKATRK DVAVKFVSKK MKKKEQAAHE
2710 2720 2730 2740 2750
AALLQHLQHP QYVTLHDTYE SPTSYILILE LMDDGRLLDY LMNHDELMEE
2760 2770 2780 2790 2800
KVAFYIRDIM EALQYLHNCR VAHLDIKPEN LLIDLRIPVP RVKLIDLEDA
2810 2820 2830 2840 2850
VQISGHFHIH HLLGNPEFAA PEVIQGIPVS LGTDIWSIGV LTYVMLSGVS
2860 2870 2880 2890 2900
PFLDESKEET CINVCRVDFS FPHEYFCGVS NAARDFINVI LQEDFRRRPT
2910 2920 2930 2940 2950
AATCLQHPWL QPHNGSYSKI PLDTSRLACF IERRKHQNDV RPIPNVKSYI
2960
VNRVNQGTSL SHNP
Note: Produced by alternative splicing.Curated
Length:2,964
Mass (Da):337,000
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76064FE06AA2BD9C
GO
Isoform 2 (identifier: A2CG49-2) [UniParc]FASTAAdd to basket
Also known as: Kalirin-9ABy similarity

The sequence of this isoform differs from the canonical sequence as follows:
     2371-2375: KSCSW → TLLKP
     2376-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:2,375
Mass (Da):271,141
Checksum:i56F56B5B2D7DF990
GO
Isoform 31 Publication (identifier: A2CG49-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2731: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:233
Mass (Da):26,709
Checksum:i97FE34463CE6BF04
GO
Isoform 41 Publication (identifier: A2CG49-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1669: Missing.
     1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
     1828-1858: Missing.
     2285-2285: Missing.
     2372-2374: SCS → EPY
     2375-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:673
Mass (Da):75,717
Checksum:i1534A65BEB4A2EC6
GO
Isoform 51 Publication (identifier: A2CG49-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     923-923: E → ESLFHATSLQ
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative initiation at Met-624 of isoform 1. Inferred by similarity.Curated
Show »
Length:1,022
Mass (Da):117,971
Checksum:iFDA70F10D8DAA1DC
GO
Isoform 61 Publication (identifier: A2CG49-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1669: Missing.
     1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
     2285-2285: Missing.
     2357-2364: KATAAAES → QSQSRGRK
     2365-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:694
Mass (Da):78,009
Checksum:iE610DD0659D34AC6
GO
Isoform 71 Publication (identifier: A2CG49-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MNPPEGASEEGGAADSDVDAFFRT
     1859-1898: TLEGGSYRGS...LEEEQKAKAL → VSGHAGGSSE...HPNFTNRNCI

Note: Produced by alternative splicing.Curated
Show »
Length:2,984
Mass (Da):338,885
Checksum:i012852FBADE5C66B
GO
Isoform 81 Publication (identifier: A2CG49-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
     923-923: E → ESLFHATSLQ
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:1,663
Mass (Da):192,182
Checksum:i409352E757B550F5
GO
Isoform 91 Publication (identifier: A2CG49-9) [UniParc]FASTAAdd to basket
Also known as: Kalirin-7cBy similarity

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:1,654
Mass (Da):191,197
Checksum:i5EE5FD961CE9AB09
GO
Isoform 10 (identifier: A2CG49-10) [UniParc]FASTAAdd to basket
Also known as: Delta Kalirin-7By similarity

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Show »
Length:1,013
Mass (Da):116,985
Checksum:iB2F1DCB9A1E85B90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z4R2D3Z4R2_MOUSE
Kalirin
Kalrn
1,295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1A7B1B1A7_MOUSE
Kalirin
Kalrn
1,403Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QYT9F6QYT9_MOUSE
Kalirin
Kalrn
2,371Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z532D3Z532_MOUSE
Kalirin
Kalrn
705Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z534D3Z534_MOUSE
Kalirin
Kalrn
674Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z535D3Z535_MOUSE
Kalirin
Kalrn
739Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z560D3Z560_MOUSE
Kalirin
Kalrn
823Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1824Q → H in BAC40535 (PubMed:16141072).Curated1
Sequence conflicti2316G → S in BAB25925 (PubMed:16141072).Curated1
Sequence conflicti2344E → K in BAB25925 (PubMed:16141072).Curated1
Sequence conflicti2355L → F in BAB25925 (PubMed:16141072).Curated1
Isoform 51 Publication (identifier: A2CG49-5)
Sequence conflicti711E → K in BAE34776 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0525621 – 2731Missing in isoform 3. 1 PublicationAdd BLAST2731
Alternative sequenceiVSP_0525631 – 1669Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST1669
Alternative sequenceiVSP_0525641 – 623Missing in isoform 5 and isoform 10. 1 PublicationAdd BLAST623
Alternative sequenceiVSP_0525651 – 4MVLS → MNPPEGASEEGGAADSDVDA FFRT in isoform 7. 1 Publication4
Alternative sequenceiVSP_0525661 – 4MVLS → MTDRFWDQWYLWYLRLLRLL DR in isoform 8 and isoform 9. 2 Publications4
Alternative sequenceiVSP_052567923E → ESLFHATSLQ in isoform 5 and isoform 8. 1 Publication1
Alternative sequenceiVSP_0525681617 – 1636LSGGC…AGHSS → DGNLVPRWHLGPGDPFSTYV in isoform 5, isoform 8, isoform 9 and isoform 10. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_0525691637 – 2964Missing in isoform 5, isoform 8, isoform 9 and isoform 10. 2 PublicationsAdd BLAST1328
Alternative sequenceiVSP_0525701670 – 1697QEGLV…FFPLK → MKGGDQAYTRGPSLGWLFAK CCCCFPCR in isoform 4 and isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0525711828 – 1858Missing in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0525721859 – 1898TLEGG…KAKAL → VSGHAGGSSELPLTSVWLPG PQPGPRTGLPHPNFTNRNCI in isoform 7. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0525732285Missing in isoform 4 and isoform 6. 1 Publication1
Alternative sequenceiVSP_0525742357 – 2364KATAAAES → QSQSRGRK in isoform 6. 1 Publication8
Alternative sequenceiVSP_0525752365 – 2964Missing in isoform 6. 1 PublicationAdd BLAST600
Alternative sequenceiVSP_0525762371 – 2375KSCSW → TLLKP in isoform 2. 1 Publication5
Alternative sequenceiVSP_0525772372 – 2374SCS → EPY in isoform 4. 1 Publication3
Alternative sequenceiVSP_0525782375 – 2964Missing in isoform 4. 1 PublicationAdd BLAST590
Alternative sequenceiVSP_0525792376 – 2964Missing in isoform 2. 1 PublicationAdd BLAST589

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK008844 mRNA Translation: BAB25925.1
AK081504 mRNA Translation: BAC38239.1
AK088732 mRNA Translation: BAC40535.1
AK139581 mRNA Translation: BAE24075.1
AK158544 mRNA Translation: BAE34552.1
AK159031 mRNA Translation: BAE34776.1
CT010573
, AC154524, AC155257, AC165079 Genomic DNA Translation: CAM18305.1
CT010573, AC154524, AC165079 Genomic DNA Translation: CAM18306.1
CT010573, AC154524, AC154588 Genomic DNA Translation: CAM18307.1
CT010573, AC154524, AC154588 Genomic DNA Translation: CAM18308.1
CT010573, AC154524, AC154588 Genomic DNA Translation: CAM18309.1
BC157950 mRNA Translation: AAI57951.1
BC172101 mRNA Translation: AAI72101.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49836.1 [A2CG49-9]

NCBI Reference Sequences

More...
RefSeqi
NP_001157740.1, NM_001164268.1 [A2CG49-9]
XP_006522445.1, XM_006522382.3 [A2CG49-8]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000076810; ENSMUSP00000076088; ENSMUSG00000061751 [A2CG49-1]
ENSMUST00000089655; ENSMUSP00000087084; ENSMUSG00000061751 [A2CG49-8]
ENSMUST00000114949; ENSMUSP00000110599; ENSMUSG00000061751 [A2CG49-10]
ENSMUST00000114953; ENSMUSP00000110603; ENSMUSG00000061751 [A2CG49-5]
ENSMUST00000114954; ENSMUSP00000110604; ENSMUSG00000061751 [A2CG49-5]
ENSMUST00000114960; ENSMUSP00000110611; ENSMUSG00000061751 [A2CG49-9]
ENSMUST00000232157; ENSMUSP00000156147; ENSMUSG00000061751 [A2CG49-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
545156

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:545156

UCSC genome browser

More...
UCSCi
uc007zar.2 mouse [A2CG49-3]
uc007zas.1 mouse [A2CG49-6]
uc007zat.1 mouse [A2CG49-4]
uc007zav.1 mouse [A2CG49-5]
uc007zax.2 mouse [A2CG49-9]
uc012aew.1 mouse [A2CG49-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008844 mRNA Translation: BAB25925.1
AK081504 mRNA Translation: BAC38239.1
AK088732 mRNA Translation: BAC40535.1
AK139581 mRNA Translation: BAE24075.1
AK158544 mRNA Translation: BAE34552.1
AK159031 mRNA Translation: BAE34776.1
CT010573
, AC154524, AC155257, AC165079 Genomic DNA Translation: CAM18305.1
CT010573, AC154524, AC165079 Genomic DNA Translation: CAM18306.1
CT010573, AC154524, AC154588 Genomic DNA Translation: CAM18307.1
CT010573, AC154524, AC154588 Genomic DNA Translation: CAM18308.1
CT010573, AC154524, AC154588 Genomic DNA Translation: CAM18309.1
BC157950 mRNA Translation: AAI57951.1
BC172101 mRNA Translation: AAI72101.1
CCDSiCCDS49836.1 [A2CG49-9]
RefSeqiNP_001157740.1, NM_001164268.1 [A2CG49-9]
XP_006522445.1, XM_006522382.3 [A2CG49-8]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFWNMR-A2295-2354[»]
SMRiA2CG49
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi244011, 57 interactors
IntActiA2CG49, 60 interactors
STRINGi10090.ENSMUSP00000110611

PTM databases

iPTMnetiA2CG49
PhosphoSitePlusiA2CG49
SwissPalmiA2CG49

Proteomic databases

MaxQBiA2CG49
PaxDbiA2CG49
PeptideAtlasiA2CG49
PRIDEiA2CG49

Genome annotation databases

EnsembliENSMUST00000076810; ENSMUSP00000076088; ENSMUSG00000061751 [A2CG49-1]
ENSMUST00000089655; ENSMUSP00000087084; ENSMUSG00000061751 [A2CG49-8]
ENSMUST00000114949; ENSMUSP00000110599; ENSMUSG00000061751 [A2CG49-10]
ENSMUST00000114953; ENSMUSP00000110603; ENSMUSG00000061751 [A2CG49-5]
ENSMUST00000114954; ENSMUSP00000110604; ENSMUSG00000061751 [A2CG49-5]
ENSMUST00000114960; ENSMUSP00000110611; ENSMUSG00000061751 [A2CG49-9]
ENSMUST00000232157; ENSMUSP00000156147; ENSMUSG00000061751 [A2CG49-4]
GeneIDi545156
KEGGimmu:545156
UCSCiuc007zar.2 mouse [A2CG49-3]
uc007zas.1 mouse [A2CG49-6]
uc007zat.1 mouse [A2CG49-4]
uc007zav.1 mouse [A2CG49-5]
uc007zax.2 mouse [A2CG49-9]
uc012aew.1 mouse [A2CG49-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8997
MGIiMGI:2685385 Kalrn

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00940000155248
HOGENOMiHOG000081798
InParanoidiA2CG49
KOiK15048
OrthoDBi5761at2759
PhylomeDBiA2CG49
TreeFamiTF318080

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-416476 G alpha (q) signalling events
R-MMU-5687128 MAPK6/MAPK4 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Kalrn mouse
EvolutionaryTraceiA2CG49

Protein Ontology

More...
PROi
PR:A2CG49

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000061751 Expressed in 251 organ(s), highest expression level in cingulate cortex
ExpressionAtlasiA2CG49 baseline and differential
GenevisibleiA2CG49 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
cd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 2 hits
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR028569 Kalirin
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR22826:SF49 PTHR22826:SF49, 3 hits
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits
SUPFAMiSSF48065 SSF48065, 2 hits
SSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKALRN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2CG49
Secondary accession number(s): A2CG50
, A2CG51, A2CG52, A2CG53, B2RXR5, D3Z559, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: July 3, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again