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Entry version 94 (02 Dec 2020)
Sequence version 2 (10 Jul 2007)
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Protein
Submitted name:

Ataxin 2

Gene

atxn2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ataxin 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atxn2Imported
Synonyms:si:dkey-165i4.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060526-217, atxn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2CF31

PRoteomics IDEntifications database

More...
PRIDEi
A2CF31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000052897, Expressed in heart and 25 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000078091

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini204 – 272LsmADInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni301 – 748DisorderedSequence analysisAdd BLAST448
Regioni800 – 822DisorderedSequence analysisAdd BLAST23
Regioni906 – 984DisorderedSequence analysisAdd BLAST79
Regioni1002 – 1023DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi307 – 325PolarSequence analysisAdd BLAST19
Compositional biasi350 – 366PolarSequence analysisAdd BLAST17
Compositional biasi367 – 385Pro-richSequence analysisAdd BLAST19
Compositional biasi387 – 402PolarSequence analysisAdd BLAST16
Compositional biasi442 – 521PolarSequence analysisAdd BLAST80
Compositional biasi607 – 621PolyampholyteSequence analysisAdd BLAST15
Compositional biasi627 – 689PolarSequence analysisAdd BLAST63
Compositional biasi690 – 706PolyampholyteSequence analysisAdd BLAST17
Compositional biasi906 – 931PolarSequence analysisAdd BLAST26
Compositional biasi932 – 948Pro-richSequence analysisAdd BLAST17
Compositional biasi949 – 978PolarSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ataxin-2 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2375, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156812

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003766_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2CF31

Identification of Orthologs from Complete Genome Data

More...
OMAi
APMMMHQ

Database of Orthologous Groups

More...
OrthoDBi
282700at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2CF31

TreeFam database of animal gene trees

More...
TreeFami
TF326591

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009818, Ataxin-2_C
IPR033093, ATXN2
IPR009604, LsmAD_domain
IPR025852, SM_dom_ATX

The PANTHER Classification System

More...
PANTHERi
PTHR12854:SF11, PTHR12854:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06741, LsmAD, 1 hit
PF07145, PAM2, 1 hit
PF14438, SM-ATX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01272, LsmAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A2CF31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMKPQAGGN RKPGGSNSGA AAASGTGGAG GGVGRQNMGR GRNNAKGPST
60 70 80 90 100
AVAFNGVYAN MRMVHVLTSV VGTKCELKVK NGLIYEGVFK TYGPECDIVL
110 120 130 140 150
DAAHRKSVEP NAGPRREDIV ESIIFKSSDV VVVHFKDVDL NYAKKDNFTD
160 170 180 190 200
SAVSARVNGE HKEKDLEPWD GGEQHISGSM ESLDTDLSNG WDPDEMFKYN
210 220 230 240 250
EETYGVKSTY DSSLSSYTVP LERDNSEEFL KREARASQLA EEIEASATYK
260 270 280 290 300
ARVALENDDR SEEEKYTAVV RGERELHSLN RENKYIPPSQ RNREAGMSWG
310 320 330 340 350
AGRQVSPRLV QCSSGPPTPR SGPHDYNTID QRVVNGGAQP WPSRCPSPSS
360 370 380 390 400
RPPSRYQSGP TNSLPPRAAT PTRPPSRPPS RPSRPLSHPS AHGTSGPLSN
410 420 430 440 450
MPKRLSSEGP PRMSPKSQRT PRPHRVASCR GGGPPPSDYM SQGASVEVSA
460 470 480 490 500
PPPTRNSPSG GTWSSVVSGA HRPRSPRQNS IGGEAPNSSC LSSPQAGTVP
510 520 530 540 550
VDSVTASTTA TSPTAANPAT NLEASPIEEA KESRVLETRQ NSPNANKENV
560 570 580 590 600
KPIEASPGIA RSIGKGSPSM ASDHRKQIDN LKKFSAAFRL QPSSSSDPGF
610 620 630 640 650
EAMGTKPPRD LGEKPKDQAA EKGSVDSTGL KASTESSISE ETSSPVSVTS
660 670 680 690 700
AGSKAGTPSL SPSSAVPEQK RGPDVTSQGV QTTSPLANAV TKDKDEKEDK
710 720 730 740 750
NDPVAESVRK STLNPNAKEF NPRVFCSPPK PATTPTLTRP QGQPSPSIVV
760 770 780 790 800
QQPPTVYGQT MFQMYPLTPV SPGVQPPAMY HVQVPHMTMS QTKSYRSGKV
810 820 830 840 850
QNMPQQRPDQ HHPPGTSTMM HSATAAGPPI VAPSPAYSTQ YFTCSPQQFA
860 870 880 890 900
SQPLVQQMPH YQSQAQHVFS PVIQGSARMI TPPTHAQPSL VSSSTTQYGE
910 920 930 940 950
QTHTMYGKNF PSTMTKLNKP TYSTPIPQQF PHPSSTLHPH PQHPQPSATP
960 970 980 990 1000
TGQPQQGTQH GGSHPAPSPV QHQQHQAAAA AAAQAIHLGN PQQQQMYSAL
1010 1020 1030 1040 1050
AATPPSMTPG PNPQSPQASF PSAQQAVYIH PQHGYNPNHM AHVQQAHMQS
1060 1070 1080 1090 1100
GMVPPHHGNP SHPPTMMLMA TQAPAGPQPA LPQGTLNPIP VSSGTHFYST
1110
LTPVQAHHQQ QL
Length:1,112
Mass (Da):118,689
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75351AD1887DFFC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8PWZ8A0A2R8PWZ8_DANRE
Ataxin 2
atxn2
1,060Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QB57A0A2R8QB57_DANRE
Ataxin 2
atxn2
1,022Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QG13A0A2R8QG13_DANRE
Ataxin 2
atxn2
939Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RND2A0A2R8RND2_DANRE
Ataxin 2
atxn2
1,027Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8S0C3A0A2R8S0C3_DANRE
Ataxin 2
atxn2
593Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR753867 Genomic DNA No translation available.
CR854992 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001121821.1, NM_001128349.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000083656; ENSDARP00000078091; ENSDARG00000052897

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
569210

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:569210

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR753867 Genomic DNA No translation available.
CR854992 Genomic DNA No translation available.
RefSeqiNP_001121821.1, NM_001128349.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000078091

Proteomic databases

PaxDbiA2CF31
PRIDEiA2CF31

Genome annotation databases

EnsembliENSDART00000083656; ENSDARP00000078091; ENSDARG00000052897
GeneIDi569210
KEGGidre:569210

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6311
ZFINiZDB-GENE-060526-217, atxn2

Phylogenomic databases

eggNOGiKOG2375, Eukaryota
GeneTreeiENSGT00940000156812
HOGENOMiCLU_003766_2_0_1
InParanoidiA2CF31
OMAiAPMMMHQ
OrthoDBi282700at2759
PhylomeDBiA2CF31
TreeFamiTF326591

Gene expression databases

BgeeiENSDARG00000052897, Expressed in heart and 25 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR009818, Ataxin-2_C
IPR033093, ATXN2
IPR009604, LsmAD_domain
IPR025852, SM_dom_ATX
PANTHERiPTHR12854:SF11, PTHR12854:SF11, 1 hit
PfamiView protein in Pfam
PF06741, LsmAD, 1 hit
PF07145, PAM2, 1 hit
PF14438, SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272, LsmAD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2CF31_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2CF31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: July 10, 2007
Last modified: December 2, 2020
This is version 94 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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