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Entry version 80 (10 Apr 2019)
Sequence version 2 (11 May 2016)
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Protein
Submitted name:

Zinc finger, ZZ-type with EF hand domain 1

Gene

zzef1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger, ZZ-type with EF hand domain 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:zzef1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041222-2 zzef1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2CES1

PeptideAtlas

More...
PeptideAtlasi
A2CES1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000094380 Expressed in 20 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2CES1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000114487

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini145 – 180EF-handInterPro annotationAdd BLAST36
Domaini254 – 432DOCInterPro annotationAdd BLAST179
Domaini1822 – 1872ZZ-typeInterPro annotationAdd BLAST51
Domaini1871 – 1917ZZ-typeInterPro annotationAdd BLAST47

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II3P Eukaryota
ENOG410XS5C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155045

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2CES1

TreeFam database of animal gene trees

More...
TreeFami
TF331572

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR008979 Galactose-bd-like_sf
IPR000433 Znf_ZZ
IPR040099 ZZEF1

The PANTHER Classification System

More...
PANTHERi
PTHR22772:SF4 PTHR22772:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03256 ANAPC10, 1 hit
PF00569 ZZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337 APC10, 1 hit
SM00291 ZnF_ZZ, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF49785 SSF49785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51284 DOC, 1 hit
PS50222 EF_HAND_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2CES1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNAESGCGA GSGDEEDVET ESPVFAEGSP ASAATGTRAG SGGGGGGGGA
60 70 80 90 100
GGAAAAGSAG PGRSGRGSAN PPAPSHGLPT PEALLEQVKL REAAARMSDS
110 120 130 140 150
WVAISESVLA RNESALVRWL EERLSRGEES VTLEQFCEML ESRDAARDEC
160 170 180 190 200
EEAFGQFDAE GDGIVDVENM LMALRNSNGA NLQGELSHVI RQLQACSLTP
210 220 230 240 250
GFVDIFSKSK DRLKAHASKI LKFLHRNRIP SNVIPFPVLD GYNSICTMRT
260 270 280 290 300
SVVQDFLDYL LQKEKDLDIQ YRAELNHDPD VDKVKVVTQC FSFIEASSNN
310 320 330 340 350
TDVNKLTNGE TVSFWQLKMK PDIVLRRLAI AVASNDHSYM PQLVSIAVGK
360 370 380 390 400
NRRSLQEIRD VRIPSNITGY VPLLENANIS HPYIQINIKR CLSDGCDTRI
410 420 430 440 450
HGLKTMGYQI TKSKEVSVSD ASAIWYLSLL TSLVTASMET NPVLAQTVLQ
460 470 480 490 500
STQKALQHMP PLSLTPSSTE FPKFFSANIL EEVDGFLLRI ANCCVSPEAE
510 520 530 540 550
LTLLAFALAR GSVAKVLISL SGICGHLDSE YRASSLLASM SSVRLRLLHR
560 570 580 590 600
NGKPLQLHLM ACDVKSKEEK SGPENMLTEP NTGDGFLTEN GKRKASVILS
610 620 630 640 650
TENQSCFQVT QIKIKVRKGA IGAKCGLVFA YNDCEVFDAD KHFKRFKKYD
660 670 680 690 700
SWDYKDYKEF VQDSTRITES SEEEPIGWFE VEEDWNDVDI KLQQCRVSKF
710 720 730 740 750
LMVKFLCARQ DTAERLGVQQ LIFSGYLCPD SERMEDVEDL SAQAEGSDSG
760 770 780 790 800
LVTGLALMKK TLYFIQQLTR DMDVSLSKQK TLLDFSDLNL LLFWDFYRKL
810 820 830 840 850
RSIEGEEAIK TRVLLLQLLQ NCFPMLPSPT ESQPSDLSAS ASASPSGSSD
860 870 880 890 900
VDPAEAVGEL CRHLCQVVDG PEGETAAEKA LRKEAVKAIL NGAAIFYPDK
910 920 930 940 950
QSRRDKLFHM MKNITEENQP ESVKLTFESL CSYFSDQDPK GLLMLPPKGA
960 970 980 990 1000
PSDFDISPVL SVMDTLLIVA SRECEVLMSE SSGGSIWRVL LSLFWALQGS
1010 1020 1030 1040 1050
LLSWCFLQLK GGTATSSDLA REILLKYVEQ FLSGTRDILI PLTKSFSGAD
1060 1070 1080 1090 1100
IMKKLSGSIL AMATRQLTIF LLELCALDIP HCVLLKRFYP ISDLLKNMSS
1110 1120 1130 1140 1150
DTDDIFSKVD LEGCQQPQQP VVLRTWQMES PHNYENSRHE TTVFVCPGAT
1160 1170 1180 1190 1200
SFEVEFDARC ETEKRYDYLE FTDARGGKVR YDMKVGTEKW PKKVTFKAGP
1210 1220 1230 1240 1250
QLQFLFHSDS SNNEWGYKFT VTAYGLPDVT VSWTSDLQLL VSRLMGRLAS
1260 1270 1280 1290 1300
RTMALKSPYE IRGVKELPAT LMNHILSCPL WKPVFRHGLS GLPGEQKLAL
1310 1320 1330 1340 1350
ASPEASQEDP APLGDELVEF LKEFARWDPS QDSSDGRTEL MRTLLVNCKK
1360 1370 1380 1390 1400
QLIRNEIASG LKVDQAVNAI WAAMVYHTPA LHPCLKSFVA KNGQSGLSED
1410 1420 1430 1440 1450
LVQVYTLADG IRTWMLEMKQ RYLMGKMNGV EEKDEGQNEV TMESLAEVCI
1460 1470 1480 1490 1500
SRSLFLFQFS PSGGTSAPQD QETSRPEDIA CAAPLLRSIS TSEGDFQPSP
1510 1520 1530 1540 1550
SLSISQTPHG AEAVTSPVSA SRERTQDQSF SASGDAGASG SISSQGATGS
1560 1570 1580 1590 1600
SESLQSQTGE PLSPSVFPRK APFSRGRLRL LSLRSMEEPR MAPPVKERFP
1610 1620 1630 1640 1650
ILKHILSFMK DMVINESSVL QTLALKKAQA VSVCEVLELV QQCILTLGKP
1660 1670 1680 1690 1700
HLFQAPCILF LQELLACQKD FTNYFSQLVG SGQEMRERVR HSYHQLVLML
1710 1720 1730 1740 1750
VEAVQGFSAL NEKVLLPALS CVQTCLLHLL DMSWEAEDLS LFLDIKLPDL
1760 1770 1780 1790 1800
LLAMSQENIS VHDIAISQWT EEDEIADYER NCEWMDECLD GMFEKWFDKI
1810 1820 1830 1840 1850
SQASVEDKRK MHMFIARYCD LLNVEISCDG CERIAPWHRY RCLQCTDMDL
1860 1870 1880 1890 1900
CKTCFLSGAK PEGHEDDHEM VNMEYACDHC QGLIVGSRIN CNVCEDFDLC
1910 1920 1930 1940 1950
FGCYNAKKYP DSHLPTHRIT VYPMVTIRIS DRHRLIQPYI HNYSWLLFAA
1960 1970 1980 1990 2000
LALFTSELIS EKAQDGESLD DVTLGNASAL QTQCFDIIKE CLLKGQTGKG
2010 2020 2030 2040 2050
LRASALLSLL SSNESATVSE LCPATAGSSQ DISSTDTSSL PSSTTAICSP
2060 2070 2080 2090 2100
PLPRDRGGGE GDEKRRRKLV SQDTSDSSCA SQTPSVSSED TLSPGVRGSE
2110 2120 2130 2140 2150
SSGDTITSPT SENLDAYKEQ EEKTARGPLQ EHVFAECSRE RILGLLAAML
2160 2170 2180 2190 2200
PATKPGSPLS LSSLSPILPL LFRVVISNAG CLNETYHLTL GLLGQLLLRI
2210 2220 2230 2240 2250
CPAEADAAVT EALTDKFELL NLGDGAALDV AGWKTTQLLF SLGAVCLDSR
2260 2270 2280 2290 2300
IGLDWACSVA DILRNLNVSS QWCTVLASFT DHCILQLPQH LKRTNLFTLL
2310 2320 2330 2340 2350
VLVGFPEVLC MGTQAVFIDN ANEQHNMILL KHFTEKNRAA VVDVKTRKRR
2360 2370 2380 2390 2400
TVKDYQLVQA HESSSRNDSE SHEGQAVSPN SAHLSHYLKN FTSIVSFLLQ
2410 2420 2430 2440 2450
TGVESSAQDA VEATWVLSLA LKGLYNTLKK HGVDQAQEAL QGSGLMQLLV
2460 2470 2480 2490 2500
RKCSKGTGFS KMWLLRDLEI LSIMLYSSKR EIHSMAEDAD TETDGEKERE
2510 2520 2530 2540 2550
KEQDSDHSSC CADDADPNRP DPLEGLDEET KICFQITHDA LNAPLHILRA
2560 2570 2580 2590 2600
MYELQMKRTD SFFLEVQKRF DGDAIKTDET IRTLAQKWQP SKRPRSDERS
2610 2620 2630 2640 2650
TKAVDTDIII VPCVSKPTRC ERATEETNVV TQKLITNTES DLQLSYAKQR
2660 2670 2680 2690 2700
RTKSSALLHK ELDARSNKAV RQYLFKVNEA IAILYARHVL ATLLADWPSD
2710 2720 2730 2740 2750
TPIREEDLEL SGASHMAYIL DMLMQLEERP MWEKILQKVL RGCSQSMLGN
2760 2770 2780 2790 2800
LSLTACQFME EPGMAVQVRE SKHPYDNNTN FEDKVHIPGA IFLSVKFDSR
2810 2820 2830 2840 2850
CHTEEGCDEL LMASSSDFLQ DLHTFSGSHQ KWTDFEIPGD TLYFRFISDM
2860 2870 2880 2890 2900
SNTEWGYKFT VTGGHRGRFQ TGFEILKQML ADEQALTHLP LPDIWEWQVG
2910 2920 2930 2940 2950
VACRQTGNQR LKAVHLLLRL LQCPSQWACD LTLLRPLWQL FTTMESGLCQ
2960 2970 2980 2990 3000
DPTSITVLLP LHRALTELFF IAEAKAMEQN VLQEYLLALT TNEQLVVRTA
3010 3020
QALKNIAAIS LAINYPNKST KQLNLSP
Length:3,027
Mass (Da):336,085
Last modified:May 11, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43E7BCF951C14563
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IX34A0A0R4IX34_DANRE
Zinc finger, ZZ-type with EF hand d...
zzef1
3,038Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LGR5A0A140LGR5_DANRE
Zinc finger, ZZ-type with EF hand d...
zzef1
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR753844 Genomic DNA No translation available.
CR812798 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000141463; ENSDARP00000114487; ENSDARG00000094380

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR753844 Genomic DNA No translation available.
CR812798 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000114487

Proteomic databases

PaxDbiA2CES1
PeptideAtlasiA2CES1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000141463; ENSDARP00000114487; ENSDARG00000094380

Organism-specific databases

ZFINiZDB-GENE-041222-2 zzef1

Phylogenomic databases

eggNOGiENOG410II3P Eukaryota
ENOG410XS5C LUCA
GeneTreeiENSGT00940000155045
InParanoidiA2CES1
TreeFamiTF331572

Gene expression databases

BgeeiENSDARG00000094380 Expressed in 20 organ(s), highest expression level in intestine
ExpressionAtlasiA2CES1 baseline and differential

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR008979 Galactose-bd-like_sf
IPR000433 Znf_ZZ
IPR040099 ZZEF1
PANTHERiPTHR22772:SF4 PTHR22772:SF4, 1 hit
PfamiView protein in Pfam
PF03256 ANAPC10, 1 hit
PF00569 ZZ, 2 hits
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM00291 ZnF_ZZ, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF49785 SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS51284 DOC, 1 hit
PS50222 EF_HAND_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2CES1_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2CES1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: May 11, 2016
Last modified: April 10, 2019
This is version 80 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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