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Entry version 87 (02 Dec 2020)
Sequence version 1 (20 Feb 2007)
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Protein

Nucleoporin 88

Gene

nup88

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-159227, Transport of the SLBP independent Mature mRNA
R-DRE-159230, Transport of the SLBP Dependant Mature mRNA
R-DRE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DRE-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859, snRNP Assembly
R-DRE-3108214, SUMOylation of DNA damage response and repair proteins
R-DRE-3232142, SUMOylation of ubiquitinylation proteins
R-DRE-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453, Regulation of HSF1-mediated heat shock response
R-DRE-4085377, SUMOylation of SUMOylation proteins
R-DRE-4551638, SUMOylation of chromatin organization proteins
R-DRE-4570464, SUMOylation of RNA binding proteins
R-DRE-4615885, SUMOylation of DNA replication proteins
R-DRE-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin 88Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nup88Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050522-297, nup88

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi244 – 720Missing in sa2206; homozygous mutant fishes have reduced head and eye size, dysmorphic jaw, lack of pharyngeal arches, flat head without protruding mouth, downward curvature of the anterior-posterior axis, aplastic swim bladder, impaired locomotor behavior and neuromuscular junction defects. 1 PublicationAdd BLAST477
Mutagenesisi414D → Y: Does not rescue developmental defects in sa2206 mutants. 1 Publication1
Mutagenesisi490 – 720Missing : Does not rescue developmental defects in sa2206 mutants. 1 PublicationAdd BLAST231
Mutagenesisi613Missing : Does not rescue developmental defects in sa2206 mutants. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004480551 – 720Nucleoporin 88Add BLAST720

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2CEI4

PeptideAtlas

More...
PeptideAtlasi
A2CEI4

PRoteomics IDEntifications database

More...
PRIDEi
A2CEI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Higher levels of expression are detected in highly proliferative frontal regions of the embryo, e.g. brain, eye and anterior trunk.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000003235, Expressed in presomitic mesoderm and 40 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000025718

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2CEI4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili584 – 611Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4460, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017144_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2CEI4

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCSIMCL

Database of Orthologous Groups

More...
OrthoDBi
1149034at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2CEI4

TreeFam database of animal gene trees

More...
TreeFami
TF105307

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019321, Nucleoporin_Nup88
IPR037700, NUP88/NUP82

The PANTHER Classification System

More...
PANTHERi
PTHR13257, PTHR13257, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10168, Nup88, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2CEI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLAGDRWR EALKNHDIFN NLQERLHLEP QGTSKRIAKN LTFCLNGDLF
60 70 80 90 100
IWDSVESVFY TTNLRQLNSD GEPDTSRYQT LLCINPPLFE VCQVLVSPSQ
110 120 130 140 150
YHVALIGQRG ATVLELPQRW GKKSEFEGGR IQINCKTIPV AERFFTSSAS
160 170 180 190 200
VTLRQAVWYP SETEEPHLVL LTSDNTIRFY NLKEPQSPAR VLSVSQMDDD
210 220 230 240 250
SSVHTRSRSY AASLGETAVA FDFGPLADSP HLSSLRMKAE LVVYPLYILY
260 270 280 290 300
GNGETFLNYI SLSHSVGSLG KPMGPLPMYP AAEDNYGYDA CAVLCLPCVP
310 320 330 340 350
NILVIATESG MLYHCVVLEA EEEEDGGAVE RWSRGSETAP SLYVFECVEL
360 370 380 390 400
ELTLKLPAGE EEEITESDFT CPIRLHRDPL CQHRYHCTHE AGVHSVGLTW
410 420 430 440 450
FKKLHKFLES DEEDKDSLQE LAAEQRCIVE HILCTRPLAN SLPAPVRGFW
460 470 480 490 500
IVSDLSLGAT MICITSTYEC LLLPLLSSIR PASPPLLCSH PGAGSDSSPL
510 520 530 540 550
RGLAEDSFEQ HIRNILARSS TNPLMLRSGD KDSSPPPSEC LQLLSRATQV
560 570 580 590 600
FREEYILKLG LAHEEMQRRV KLLSGQKNKQ LEDLALCRED RKSLTEAAER
610 620 630 640 650
LADKYEDAKY RQEAIMNRVK RVLGSLRSQL PVLSDSEKDM RKELQTINDQ
660 670 680 690 700
LRHLDNGIKQ VNMKKDYQKK QMNAGASPAH SSLTLNAHQR KCLQGVLKEQ
710 720
GEHIAGMMKQ IKDIKNHFSF
Length:720
Mass (Da):80,861
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59A73F2A1185D832
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93Q → L in AAH95815 (Ref. 2) Curated1
Sequence conflicti140V → L in BX957294 (PubMed:23594743).Curated1
Sequence conflicti190R → K in AAH95815 (Ref. 2) Curated1
Sequence conflicti197M → L in BX957294 (PubMed:23594743).Curated1
Sequence conflicti197M → L in AAH95815 (Ref. 2) Curated1
Sequence conflicti704I → T in AAH95815 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR450697 Genomic DNA No translation available.
BX957294 Genomic DNA No translation available.
BC095815 mRNA Translation: AAH95815.1

NCBI Reference Sequences

More...
RefSeqi
NP_001018302.1, NM_001020466.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000023123; ENSDARP00000025718; ENSDARG00000003235

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
321744

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:321744

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450697 Genomic DNA No translation available.
BX957294 Genomic DNA No translation available.
BC095815 mRNA Translation: AAH95815.1
RefSeqiNP_001018302.1, NM_001020466.1

3D structure databases

SMRiA2CEI4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025718

Proteomic databases

PaxDbiA2CEI4
PeptideAtlasiA2CEI4
PRIDEiA2CEI4

Genome annotation databases

EnsembliENSDART00000023123; ENSDARP00000025718; ENSDARG00000003235
GeneIDi321744
KEGGidre:321744

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4927
ZFINiZDB-GENE-050522-297, nup88

Phylogenomic databases

eggNOGiKOG4460, Eukaryota
GeneTreeiENSGT00390000015063
HOGENOMiCLU_017144_0_0_1
InParanoidiA2CEI4
OMAiSCSIMCL
OrthoDBi1149034at2759
PhylomeDBiA2CEI4
TreeFamiTF105307

Enzyme and pathway databases

ReactomeiR-DRE-159227, Transport of the SLBP independent Mature mRNA
R-DRE-159230, Transport of the SLBP Dependant Mature mRNA
R-DRE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DRE-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859, snRNP Assembly
R-DRE-3108214, SUMOylation of DNA damage response and repair proteins
R-DRE-3232142, SUMOylation of ubiquitinylation proteins
R-DRE-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453, Regulation of HSF1-mediated heat shock response
R-DRE-4085377, SUMOylation of SUMOylation proteins
R-DRE-4551638, SUMOylation of chromatin organization proteins
R-DRE-4570464, SUMOylation of RNA binding proteins
R-DRE-4615885, SUMOylation of DNA replication proteins
R-DRE-5578749, Transcriptional regulation by small RNAs

Gene expression databases

BgeeiENSDARG00000003235, Expressed in presomitic mesoderm and 40 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR019321, Nucleoporin_Nup88
IPR037700, NUP88/NUP82
PANTHERiPTHR13257, PTHR13257, 1 hit
PfamiView protein in Pfam
PF10168, Nup88, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP88_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2CEI4
Secondary accession number(s): A0A2R8QUY6, Q501Y6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2019
Last sequence update: February 20, 2007
Last modified: December 2, 2020
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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