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UniProtKB - A2CEF0 (A2CEF0_DANRE)

Entry version 86 (19 Jan 2022)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Si:ch211-244o22.2

Gene

si:ch211-244o22.2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycleARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:ch211-244o22.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:si:ch211-244o22.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-3271, si:ch211-244o22.2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation, Ubl conjugationARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2CEF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000068759, Expressed in blastula and 35 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000090340

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini248 – 310PP1-bindingInterPro annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni46 – 74DisorderedSequence analysisAdd BLAST29
Regioni123 – 237DisorderedSequence analysisAdd BLAST115
Regioni258 – 320DisorderedSequence analysisAdd BLAST63
Regioni384 – 487DisorderedSequence analysisAdd BLAST104
Regioni506 – 539DisorderedSequence analysisAdd BLAST34
Regioni568 – 692DisorderedSequence analysisAdd BLAST125
Regioni776 – 807DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi123 – 141Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi142 – 158Polar residuesSequence analysisAdd BLAST17
Compositional biasi188 – 215Polar residuesSequence analysisAdd BLAST28
Compositional biasi277 – 292Polar residuesSequence analysisAdd BLAST16
Compositional biasi302 – 320Polar residuesSequence analysisAdd BLAST19
Compositional biasi431 – 452Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi470 – 486Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi573 – 595Basic and acidic residuesSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S079, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_349141_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2CEF0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033064, CDCA2
IPR029334, PP1-bd

The PANTHER Classification System

More...PANTHERi		PTHR21603:SF16, PTHR21603:SF16, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15276, PP1_bind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2CEF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVTEAMDSR PALADLSPSQ QNTEAADVDF SKLTSLQFGI STDSFLPSSK 
        60         70         80         90        100
SKDKSRVAQL KARRRSTIGL RGSPETNSLI CFRARQAAKT PPRTPQLLQG 
       110        120        130        140        150
SPFLSRCDSL KKKMAAFQCL MEDDEEKDEW KKNEENESAK STLAKDSQNG 
       160        170        180        190        200
KENTPTTPSP PISMTPPASK KRCWAPPGEC EDKITKTPLP NPTATTQQDQ 
       210        220        230        240        250
GVKCTGSQSQ RPLSDVDSDA KNELLSLPML SKPDIKPADE NVVSSVCKKK 
       260        270        280        290        300
RVRFGAPLSP EFFDKALPPS TPLQKGGTPR CPPSSTGPKR SLLKTPQRCE 
       310        320        330        340        350
PSLPQPDFNS PQSNGASPVL VIDRRSTGLL YSDEVFEEIE KISFPIMEEE 
       360        370        380        390        400
SPSNQLPGKW KDALFAEDTW KPQAEETEVM NAAFQEEEDV PANVQTGDER 
       410        420        430        440        450
PCTTDDQPLA LSVEAAISEK TLSSNSSTEA TRSRGRKRKQ PAESEPEKRR 
       460        470        480        490        500
SSRTAAVSAS GKMKKTTGAK RKFGNKEVDR SLYGKRDYAS KNPLLSPIFE 
       510        520        530        540        550
TASTSFNLTP TQNQSGKITD GDQNGIQKPS VPQSKTLRPV VGLGTASTWT 
       560        570        580        590        600
NESPSSIMTD SDINVTCLEH QDLAERQNSR SKTSKTKRDS GRPVRQRRSS 
       610        620        630        640        650
GAAKIKKLDN PTIDSTTESD AETVEQDTES QKSAESAGMS SMYHHECSEK 
       660        670        680        690        700
RETEELMSCE EAIEDSVSTE RLEQKTPSNK RPGQGQKVQK SPHVMIDVVK 
       710        720        730        740        750
VDEMALSEGI ALESNTGPAE SDLAPWQQAD FNIDDILKPV GKSRGSVRRS 
       760        770        780        790        800
LRNRRSMDLQ AVGLAWVDHT SPELVKASRR RTRGRLSGVS EPFIPQPSEE 

LTTNLGE
Length:807
Mass (Da):88,573
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i453CA93247E28960
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286Y9L2A0A286Y9L2_DANRE
Si:ch211-244o22.2
si:ch211-244o22.2
808Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR392037 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001076292.1, NM_001082823.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000099566; ENSDARP00000090340; ENSDARG00000068759
ENSDART00000180742; ENSDARP00000148561; ENSDARG00000068759

Database of genes from NCBI RefSeq genomes

More...GeneIDi		561487

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:561487

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR392037 Genomic DNA No translation available.
RefSeqiNP_001076292.1, NM_001082823.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090340

Proteomic databases

PaxDbiA2CEF0

Genome annotation databases

EnsembliENSDART00000099566; ENSDARP00000090340; ENSDARG00000068759
ENSDART00000180742; ENSDARP00000148561; ENSDARG00000068759
GeneIDi561487
KEGGidre:561487

Organism-specific databases

ZFINiZDB-GENE-030131-3271, si:ch211-244o22.2

Phylogenomic databases

eggNOGiENOG502S079, Eukaryota
GeneTreeiENSGT00940000154352
HOGENOMiCLU_349141_0_0_1
InParanoidiA2CEF0

Gene expression databases

BgeeiENSDARG00000068759, Expressed in blastula and 35 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR033064, CDCA2
IPR029334, PP1-bd
PANTHERiPTHR21603:SF16, PTHR21603:SF16, 2 hits
PfamiView protein in Pfam
PF15276, PP1_bind, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2CEF0_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2CEF0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: January 19, 2022
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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