UniProtKB - A2CEA2 (A2CEA2_DANRE)
Protein
Methylcytosine dioxygenase TET
Gene
tet3
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.UniRule annotation
Catalytic activityi
- 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinateUniRule annotationEC:1.14.11.n2UniRule annotation
GO - Molecular functioni
- methylcytosine dioxygenase activity Source: GO_Central
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- 5-methylcytosine catabolic process Source: UniProtKB-UniRule
- cellular response to lipopolysaccharide Source: ZFIN
- DNA demethylation Source: GO_Central
- endothelial to hematopoietic transition Source: ZFIN
- hemopoiesis Source: ZFIN
- oxidative demethylation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of interleukin-13 production Source: ZFIN
Keywordsi
Molecular function | DioxygenaseUniRule annotation, Oxidoreductase |
Ligand | IronUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tet3Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060526-109, tet3 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000062646, Expressed in retina and 27 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 310 – 1001 | Tet_JBPInterPro annotationAdd BLAST | 692 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 666 – 846 | DisorderedSequence analysisAdd BLAST | 181 | |
Regioni | 888 – 947 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 1049 – 1068 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 486 – 506 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 29 – 49 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 666 – 704 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 725 – 742 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 761 – 775 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 784 – 803 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 804 – 845 | Pro-richSequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | ENOG502QURD, Eukaryota |
GeneTreei | ENSGT00940000157631 |
HOGENOMi | CLU_001618_0_0_1 |
OMAi | PRQEKPW |
TreeFami | TF342373 |
Family and domain databases
InterProi | View protein in InterPro IPR024779, 2OGFeDO_noxygenase_dom IPR040175, TET1/2/3 |
PANTHERi | PTHR23358, PTHR23358, 2 hits |
Pfami | View protein in Pfam PF12851, Tet_JBP, 1 hit |
SMARTi | View protein in SMART SM01333, Tet_JBP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A2CEA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIGSHERLE EGLLNQELSN GLSKHASNEE NVCDNEDRDA TKEQHQHNFH
60 70 80 90 100
EGAGSISQTP GWVLEHTGKL SNPESQQGVW SGQNASTTVN DVDMEDAQTL
110 120 130 140 150
VAFSVGSLPP YTNHQPSPSL KGFLESPLRY LDTPTKNLLD TPGKDVQPDF
160 170 180 190 200
PICDCVDQVL EKDEGPYYNH LGSGRDIPSV RQLMEDRYGE KGEAVRIEKV
210 220 230 240 250
VYTGREGKSS QGCPIAKWVL RRSSEKEKVL CVVKQRPGHH CANTVIVVVI
260 270 280 290 300
LAWEGVPRAL GDKLYREVTE TITKYGNPTS RRCGLNEDRT CACQGKDPET
310 320 330 340 350
CGASFSFGCS WSMYFNGCKY ARSKVPRKFR LQGEHPKEED NLRDNFQALA
360 370 380 390 400
THVAPLYKKL APQAYSNQCL HEDVASDCRL GLKEGRPFSG ITACMDFCAH
410 420 430 440 450
AHKDQHNLHN GCTVVCTLTK EDNRTVGTIP EDEQLHVLPL YKLATTDEFG
460 470 480 490 500
SEENQRLKMQ TGAIQVLANF RREVRKLPEP AKSCRQRRLE AKKAASEKKN
510 520 530 540 550
RKLQLAETPE KTVKMEIRHA ESPHIQQGNK AIPKQEVKPT IKKEPVDHFQ
560 570 580 590 600
PFNGAIHGYQ ALGNGKTNPD PHNMNSSFSY PGNYARGRIP GNSHPPAQNP
610 620 630 640 650
INGFHPNLQD IRYGYYNYPS SALFSPELLR YDKGAWPKNG EPSAQAFEQK
660 670 680 690 700
PDVQCLQANL AQAYPTHHGQ SQAQMADASI QGYPQPSDIS QCRTPSMSLE
710 720 730 740 750
QTHRSKPIVK QEPMDVPLYE ARSDGQAQSC PTTPSTTPTP EGWHGHKPNG
760 770 780 790 800
SLVPKGWDGN IRAASNNSPF TPDKQRLHQQ HQHEHPQYPQ QQQWNSYSCP
810 820 830 840 850
NTPMASPAPS PSPSLKAGLS PAPSPHPSTP RQWGSPAPSP QPKAWGPYGP
860 870 880 890 900
MGYGAGVIRQ GNPAGAYPDN MLSQAGVNCG SAPLGLQEKA WKSGGGSAAG
910 920 930 940 950
STPSPAPEGR LFPDALQRSD GQACWDSGAE TQSERDPEED EVWSDSEHNF
960 970 980 990 1000
LDPNIGGVAV APAHGCVLIE CARRELHATT PLKKPDRTHP SRISLVFYQH
1010 1020 1030 1040 1050
KNLNQPCHGL ALWESKMKIL AERARQRQQE AALLGLSQEE IKAYGKKRKW
1060 1070 1080 1090 1100
AAGSASPSPG QTKDKREGVV TRMAPTQHST TIVTVSPYPS THLTGPYSRF
V
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Q4R6 | A0A2R8Q4R6_DANRE | Methylcytosine dioxygenase TET | tet3 | 2,052 | Annotation score: | ||
A0A2R8Q5Y7 | A0A2R8Q5Y7_DANRE | Methylcytosine dioxygenase TET | tet3 | 1,895 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR388049 Genomic DNA No translation available. CT009570 Genomic DNA No translation available. KC690001 mRNA Translation: AHE93331.1 |
Genome annotation databases
Ensembli | ENSDART00000137355; ENSDARP00000115297; ENSDARG00000062646 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR388049 Genomic DNA No translation available. CT009570 Genomic DNA No translation available. KC690001 mRNA Translation: AHE93331.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000115297 |
Proteomic databases
PRIDEi | A2CEA2 |
Genome annotation databases
Ensembli | ENSDART00000137355; ENSDARP00000115297; ENSDARG00000062646 |
Organism-specific databases
ZFINi | ZDB-GENE-060526-109, tet3 |
Phylogenomic databases
eggNOGi | ENOG502QURD, Eukaryota |
GeneTreei | ENSGT00940000157631 |
HOGENOMi | CLU_001618_0_0_1 |
OMAi | PRQEKPW |
TreeFami | TF342373 |
Gene expression databases
Bgeei | ENSDARG00000062646, Expressed in retina and 27 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR024779, 2OGFeDO_noxygenase_dom IPR040175, TET1/2/3 |
PANTHERi | PTHR23358, PTHR23358, 2 hits |
Pfami | View protein in Pfam PF12851, Tet_JBP, 1 hit |
SMARTi | View protein in SMART SM01333, Tet_JBP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2CEA2_DANRE | |
Accessioni | A2CEA2Primary (citable) accession number: A2CEA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |