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Protein

Zinc finger X-linked protein ZXDB

Gene

Zxdb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri340 – 364C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri373 – 397C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri403 – 427C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri433 – 455C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 486C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri493 – 517C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri523 – 547C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri553 – 577C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri583 – 607C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri616 – 641C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger X-linked protein ZXDB
Gene namesi
Name:Zxdb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3694898 Zxdb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002928021 – 873Zinc finger X-linked protein ZXDBAdd BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiA2CE44
PaxDbiA2CE44
PeptideAtlasiA2CE44
PRIDEiA2CE44

PTM databases

iPTMnetiA2CE44
PhosphoSitePlusiA2CE44

Expressioni

Gene expression databases

BgeeiENSMUSG00000073062 Expressed in 228 organ(s), highest expression level in islet of Langerhans
CleanExiMM_ZXDB
GenevisibleiA2CE44 MM

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDC and CIITA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100524

Structurei

3D structure databases

ProteinModelPortaliA2CE44
SMRiA2CE44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni340 – 646Required for interaction with ZXDCBy similarityAdd BLAST307
Regioni645 – 776Required for transcriptional activationBy similarityAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 122Gly-richAdd BLAST112
Compositional biasi183 – 322Ala-richAdd BLAST140

Sequence similaritiesi

Belongs to the ZXD family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri340 – 364C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri373 – 397C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri403 – 427C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri433 – 455C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 486C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri493 – 517C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri523 – 547C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri553 – 577C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri583 – 607C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri616 – 641C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000013019
HOVERGENiHBG002277
InParanoidiA2CE44
OMAiDWNVHPD
OrthoDBiEOG091G0K27
PhylomeDBiA2CE44
TreeFamiTF330996

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

A2CE44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIPRLLPAR GTPQGAGGGG CPAGGGGVHR APASLACQAP TRRLLLLRGA
60 70 80 90 100
QDGGPGPRSA EAQRASRGLG PSLNRLAPRP DHRSSGGGRG GGAGGGGGGS
110 120 130 140 150
GGGGGGGGGG GGGGGGGGSR GGSDDFFLLL LDPVGGDVET VGTEQAGAPV
160 170 180 190 200
RREEAGAGPR PERRQSAGPP AGRPEPGPRC LSAVPAASPL PAAGPGPAAA
210 220 230 240 250
AAAAAAAAFA GTITIHNQDL LLRFENGVLT LTTPPLPAWE PGVAPFPQPQ
260 270 280 290 300
PPPQPGALIA PQAAAAGFPP AAAAAAAAAA AGAQLGDCPE LPPDLLLAEP
310 320 330 340 350
AEPAACPAPP EEEAEAPAAA AAQSPRGPAG PGPGPGVVLY LCPEAQCGQT
360 370 380 390 400
FAKKHQLKVH LLTHSSSQGQ RPFKCPLSGC GWTFTTSYKL KRHLQSHDKL
410 420 430 440 450
RPFGCPVQGC GKSFTTVYNL KAHMKGHEQE NSFKCEVCEE SFPTQAKLST
460 470 480 490 500
HQRSHFEPER PYQCAFSGCK KTFITVSALF SHNRAHFREQ ELFACSFPGC
510 520 530 540 550
SKQYDKACRL KIHLRSHTGE RPFLCDFDGC GWNFTSMSKL LRHKRKHEDD
560 570 580 590 600
RRFTCPVEGC GKSFTRAEHL KGHSITHLGT KPFVCPVEGC CARFSARSSL
610 620 630 640 650
YIHSKKHLQD VGAWKSRCPV PTCNKLFTSK HSMKTHMTKR HNLSQDLLAQ
660 670 680 690 700
LEAANSLTPS SELTSPGQSD LSGAELVSLF SDVPGHGSAA VLDTALVNSG
710 720 730 740 750
ILTIDVASVN SSLAGSLPAD NNSNNHSLGQ AAEPRALRGA PSDLPQSLDT
760 770 780 790 800
SLFFGTSVAG YQHSPLDMDD VSAGNVGLFG SLALKNSSLE PQALTPSNKL
810 820 830 840 850
TVDTEALTPS STLCENSVSE LLTPAKAEWN VHPESDFFGH EEETQFGFSH
860 870
PTGSHGSQKD TDLITVTGTP FLV
Length:873
Mass (Da):90,376
Last modified:February 20, 2007 - v1
Checksum:i77E31C72C7098264
GO

Sequence cautioni

The sequence BAC25496 differs from that shown. Reason: Frameshift at positions 616 and 649.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271 – 280AAAAAAAAAA → VAGGVVFFVG in BAE21123 (PubMed:16141072).Curated10
Sequence conflicti300P → R in BAC25496 (PubMed:16141072).Curated1
Sequence conflicti631H → P in BAC25496 (PubMed:16141072).Curated1
Sequence conflicti643L → F in BAC25496 (PubMed:16141072).Curated1
Sequence conflicti651L → I in BAC25496 (PubMed:16141072).Curated1
Sequence conflicti689A → T in BAC25496 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR293526 Genomic DNA No translation available.
AK016708 mRNA Translation: BAC25496.1 Frameshift.
AK132358 mRNA Translation: BAE21123.1
CCDSiCCDS41065.1
RefSeqiNP_001074942.1, NM_001081473.1
UniGeneiMm.426145

Genome annotation databases

EnsembliENSMUST00000101388; ENSMUSP00000100524; ENSMUSG00000073062
GeneIDi668166
KEGGimmu:668166
UCSCiuc009ttq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR293526 Genomic DNA No translation available.
AK016708 mRNA Translation: BAC25496.1 Frameshift.
AK132358 mRNA Translation: BAE21123.1
CCDSiCCDS41065.1
RefSeqiNP_001074942.1, NM_001081473.1
UniGeneiMm.426145

3D structure databases

ProteinModelPortaliA2CE44
SMRiA2CE44
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100524

PTM databases

iPTMnetiA2CE44
PhosphoSitePlusiA2CE44

Proteomic databases

MaxQBiA2CE44
PaxDbiA2CE44
PeptideAtlasiA2CE44
PRIDEiA2CE44

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101388; ENSMUSP00000100524; ENSMUSG00000073062
GeneIDi668166
KEGGimmu:668166
UCSCiuc009ttq.1 mouse

Organism-specific databases

CTDi158586
MGIiMGI:3694898 Zxdb

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000013019
HOVERGENiHBG002277
InParanoidiA2CE44
OMAiDWNVHPD
OrthoDBiEOG091G0K27
PhylomeDBiA2CE44
TreeFamiTF330996

Miscellaneous databases

PROiPR:A2CE44
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073062 Expressed in 228 organ(s), highest expression level in islet of Langerhans
CleanExiMM_ZXDB
GenevisibleiA2CE44 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZXDB_MOUSE
AccessioniPrimary (citable) accession number: A2CE44
Secondary accession number(s): Q3V1M7, Q8CEQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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