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UniProtKB - A2CE44 (ZXDB_MOUSE)
Protein
Zinc finger X-linked protein ZXDB
Gene
Zxdb
Organism
Mus musculus (Mouse)
Status
Functioni
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 340 – 364 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 373 – 397 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 403 – 427 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 433 – 455 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 462 – 486 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 493 – 517 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 523 – 547 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 553 – 577 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 583 – 607 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 616 – 641 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- transcription coactivator activity Source: UniProtKB
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger X-linked protein ZXDB |
Gene namesi | Name:Zxdb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3694898, Zxdb |
VEuPathDBi | HostDB:ENSMUSG00000073062 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292802 | 1 – 873 | Zinc finger X-linked protein ZXDBAdd BLAST | 873 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 89 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
MethylationProteomic databases
MaxQBi | A2CE44 |
PaxDbi | A2CE44 |
PeptideAtlasi | A2CE44 |
PRIDEi | A2CE44 |
ProteomicsDBi | 275249 |
PTM databases
iPTMneti | A2CE44 |
PhosphoSitePlusi | A2CE44 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000073062, Expressed in islet of Langerhans and 254 other tissues |
Genevisiblei | A2CE44, MM |
Interactioni
Subunit structurei
Self-associates.
Interacts with ZXDC and CIITA (By similarity).
By similarityGO - Molecular functioni
- C2H2 zinc finger domain binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000100524 |
Miscellaneous databases
RNActi | A2CE44, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 48 – 120 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 138 – 184 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 240 – 259 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 301 – 330 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 340 – 646 | Required for interaction with ZXDCBy similarityAdd BLAST | 307 | |
Regioni | 645 – 776 | Required for transcriptional activationBy similarityAdd BLAST | 132 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 240 – 258 | Pro residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the ZXD family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 340 – 364 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 373 – 397 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 403 – 427 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 433 – 455 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 462 – 486 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 493 – 517 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 523 – 547 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 553 – 577 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 583 – 607 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 616 – 641 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162988 |
HOGENOMi | CLU_007312_0_0_1 |
InParanoidi | A2CE44 |
OMAi | KVEWNVH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A2CE44 |
TreeFami | TF330996 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
i Sequence
Sequence statusi: Complete.
A2CE44-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIPRLLPAR GTPQGAGGGG CPAGGGGVHR APASLACQAP TRRLLLLRGA
60 70 80 90 100
QDGGPGPRSA EAQRASRGLG PSLNRLAPRP DHRSSGGGRG GGAGGGGGGS
110 120 130 140 150
GGGGGGGGGG GGGGGGGGSR GGSDDFFLLL LDPVGGDVET VGTEQAGAPV
160 170 180 190 200
RREEAGAGPR PERRQSAGPP AGRPEPGPRC LSAVPAASPL PAAGPGPAAA
210 220 230 240 250
AAAAAAAAFA GTITIHNQDL LLRFENGVLT LTTPPLPAWE PGVAPFPQPQ
260 270 280 290 300
PPPQPGALIA PQAAAAGFPP AAAAAAAAAA AGAQLGDCPE LPPDLLLAEP
310 320 330 340 350
AEPAACPAPP EEEAEAPAAA AAQSPRGPAG PGPGPGVVLY LCPEAQCGQT
360 370 380 390 400
FAKKHQLKVH LLTHSSSQGQ RPFKCPLSGC GWTFTTSYKL KRHLQSHDKL
410 420 430 440 450
RPFGCPVQGC GKSFTTVYNL KAHMKGHEQE NSFKCEVCEE SFPTQAKLST
460 470 480 490 500
HQRSHFEPER PYQCAFSGCK KTFITVSALF SHNRAHFREQ ELFACSFPGC
510 520 530 540 550
SKQYDKACRL KIHLRSHTGE RPFLCDFDGC GWNFTSMSKL LRHKRKHEDD
560 570 580 590 600
RRFTCPVEGC GKSFTRAEHL KGHSITHLGT KPFVCPVEGC CARFSARSSL
610 620 630 640 650
YIHSKKHLQD VGAWKSRCPV PTCNKLFTSK HSMKTHMTKR HNLSQDLLAQ
660 670 680 690 700
LEAANSLTPS SELTSPGQSD LSGAELVSLF SDVPGHGSAA VLDTALVNSG
710 720 730 740 750
ILTIDVASVN SSLAGSLPAD NNSNNHSLGQ AAEPRALRGA PSDLPQSLDT
760 770 780 790 800
SLFFGTSVAG YQHSPLDMDD VSAGNVGLFG SLALKNSSLE PQALTPSNKL
810 820 830 840 850
TVDTEALTPS STLCENSVSE LLTPAKAEWN VHPESDFFGH EEETQFGFSH
860 870
PTGSHGSQKD TDLITVTGTP FLV
Sequence cautioni
The sequence BAC25496 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 271 – 280 | AAAAAAAAAA → VAGGVVFFVG in BAE21123 (PubMed:16141072).Curated | 10 | |
Sequence conflicti | 300 | P → R in BAC25496 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 631 | H → P in BAC25496 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 643 | L → F in BAC25496 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 651 | L → I in BAC25496 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 689 | A → T in BAC25496 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR293526 Genomic DNA No translation available. AK016708 mRNA Translation: BAC25496.1 Frameshift. AK132358 mRNA Translation: BAE21123.1 |
CCDSi | CCDS41065.1 |
RefSeqi | NP_001074942.1, NM_001081473.1 |
Genome annotation databases
Ensembli | ENSMUST00000101388; ENSMUSP00000100524; ENSMUSG00000073062 |
GeneIDi | 668166 |
KEGGi | mmu:668166 |
UCSCi | uc009ttq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR293526 Genomic DNA No translation available. AK016708 mRNA Translation: BAC25496.1 Frameshift. AK132358 mRNA Translation: BAE21123.1 |
CCDSi | CCDS41065.1 |
RefSeqi | NP_001074942.1, NM_001081473.1 |
3D structure databases
AlphaFoldDBi | A2CE44 |
SMRi | A2CE44 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000100524 |
PTM databases
iPTMneti | A2CE44 |
PhosphoSitePlusi | A2CE44 |
Proteomic databases
MaxQBi | A2CE44 |
PaxDbi | A2CE44 |
PeptideAtlasi | A2CE44 |
PRIDEi | A2CE44 |
ProteomicsDBi | 275249 |
Genome annotation databases
Ensembli | ENSMUST00000101388; ENSMUSP00000100524; ENSMUSG00000073062 |
GeneIDi | 668166 |
KEGGi | mmu:668166 |
UCSCi | uc009ttq.1, mouse |
Organism-specific databases
CTDi | 158586 |
MGIi | MGI:3694898, Zxdb |
VEuPathDBi | HostDB:ENSMUSG00000073062 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162988 |
HOGENOMi | CLU_007312_0_0_1 |
InParanoidi | A2CE44 |
OMAi | KVEWNVH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A2CE44 |
TreeFami | TF330996 |
Miscellaneous databases
BioGRID-ORCSi | 668166, 5 hits in 69 CRISPR screens |
PROi | PR:A2CE44 |
RNActi | A2CE44, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000073062, Expressed in islet of Langerhans and 254 other tissues |
Genevisiblei | A2CE44, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZXDB_MOUSE | |
Accessioni | A2CE44Primary (citable) accession number: A2CE44 Secondary accession number(s): Q3V1M7, Q8CEQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families