Zxdb

Functionⁱ

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	340 – 364	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	373 – 397	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	403 – 427	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	433 – 455	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	462 – 486	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	493 – 517	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	523 – 547	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	553 – 577	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	583 – 607	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	616 – 641	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	26

GO - Molecular functionⁱ

C2H2 zinc finger domain binding Source: UniProtKB
DNA-binding transcription factor activity Source: UniProtKB
metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription, DNA-templated Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger X-linked protein ZXDB
Gene namesⁱ	Name:Zxdb
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:3694898 Zxdb

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000292802	1 – 873	Zinc finger X-linked protein ZXDBAdd BLAST		873

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	89	Omega-N-methylarginineCombined sources		1

Keywords - PTMⁱ

Methylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2CE44
PaxDbⁱ	A2CE44
PeptideAtlas More...PeptideAtlasⁱ	A2CE44
PRIDEⁱ	A2CE44

PTM databases

iPTMnetⁱ	A2CE44
PhosphoSitePlusⁱ	A2CE44

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000073062 Expressed in 228 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	MM_ZXDB
Genevisibleⁱ	A2CE44 MM

Interactionⁱ

Subunit structureⁱ

Self-associates. Interacts with ZXDC and CIITA (By similarity).By similarity

GO - Molecular functionⁱ

C2H2 zinc finger domain binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000100524

STRINGⁱ

10090.ENSMUSP00000100524

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2CE44
SMRⁱ	A2CE44
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	340 – 646	Required for interaction with ZXDCBy similarityAdd BLAST		307
Regionⁱ	645 – 776	Required for transcriptional activationBy similarityAdd BLAST		132

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	11 – 122	Gly-richAdd BLAST		112
Compositional biasⁱ	183 – 322	Ala-richAdd BLAST		140

Sequence similaritiesⁱ

Belongs to the ZXD family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	340 – 364	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	373 – 397	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	403 – 427	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	433 – 455	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	462 – 486	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	493 – 517	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	523 – 547	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	553 – 577	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	583 – 607	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	616 – 641	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	26

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000013019
HOVERGENⁱ	HBG002277
InParanoidⁱ	A2CE44
OMAⁱ	DWNVHPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0K27
PhylomeDBⁱ	A2CE44
TreeFamⁱ	TF330996

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 10 hits PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

A2CE44-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEIPRLLPAR GTPQGAGGGG CPAGGGGVHR APASLACQAP TRRLLLLRGA 
        60         70         80         90        100
QDGGPGPRSA EAQRASRGLG PSLNRLAPRP DHRSSGGGRG GGAGGGGGGS 
       110        120        130        140        150
GGGGGGGGGG GGGGGGGGSR GGSDDFFLLL LDPVGGDVET VGTEQAGAPV 
       160        170        180        190        200
RREEAGAGPR PERRQSAGPP AGRPEPGPRC LSAVPAASPL PAAGPGPAAA 
       210        220        230        240        250
AAAAAAAAFA GTITIHNQDL LLRFENGVLT LTTPPLPAWE PGVAPFPQPQ 
       260        270        280        290        300
PPPQPGALIA PQAAAAGFPP AAAAAAAAAA AGAQLGDCPE LPPDLLLAEP 
       310        320        330        340        350
AEPAACPAPP EEEAEAPAAA AAQSPRGPAG PGPGPGVVLY LCPEAQCGQT 
       360        370        380        390        400
FAKKHQLKVH LLTHSSSQGQ RPFKCPLSGC GWTFTTSYKL KRHLQSHDKL 
       410        420        430        440        450
RPFGCPVQGC GKSFTTVYNL KAHMKGHEQE NSFKCEVCEE SFPTQAKLST 
       460        470        480        490        500
HQRSHFEPER PYQCAFSGCK KTFITVSALF SHNRAHFREQ ELFACSFPGC 
       510        520        530        540        550
SKQYDKACRL KIHLRSHTGE RPFLCDFDGC GWNFTSMSKL LRHKRKHEDD 
       560        570        580        590        600
RRFTCPVEGC GKSFTRAEHL KGHSITHLGT KPFVCPVEGC CARFSARSSL 
       610        620        630        640        650
YIHSKKHLQD VGAWKSRCPV PTCNKLFTSK HSMKTHMTKR HNLSQDLLAQ 
       660        670        680        690        700
LEAANSLTPS SELTSPGQSD LSGAELVSLF SDVPGHGSAA VLDTALVNSG 
       710        720        730        740        750
ILTIDVASVN SSLAGSLPAD NNSNNHSLGQ AAEPRALRGA PSDLPQSLDT 
       760        770        780        790        800
SLFFGTSVAG YQHSPLDMDD VSAGNVGLFG SLALKNSSLE PQALTPSNKL 
       810        820        830        840        850
TVDTEALTPS STLCENSVSE LLTPAKAEWN VHPESDFFGH EEETQFGFSH 
       860        870 
PTGSHGSQKD TDLITVTGTP FLV

Length:873

Mass (Da):90,376

Last modified:February 20, 2007 - v1

Checksum:ⁱ77E31C72C7098264

GO

Sequence cautionⁱ

The sequence BAC25496 differs from that shown. Reason: Frameshift at positions 616 and 649.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	271 – 280	AAAAAAAAAA → VAGGVVFFVG in BAE21123 (PubMed:16141072).Curated	10
Sequence conflictⁱ	300	P → R in BAC25496 (PubMed:16141072).Curated	1
Sequence conflictⁱ	631	H → P in BAC25496 (PubMed:16141072).Curated	1
Sequence conflictⁱ	643	L → F in BAC25496 (PubMed:16141072).Curated	1
Sequence conflictⁱ	651	L → I in BAC25496 (PubMed:16141072).Curated	1
Sequence conflictⁱ	689	A → T in BAC25496 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR293526 Genomic DNA No translation available. AK016708 mRNA Translation: BAC25496.1 Frameshift. AK132358 mRNA Translation: BAE21123.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41065.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001074942.1, NM_001081473.1
UniGeneⁱ	Mm.426145

Genome annotation databases

Ensemblⁱ	ENSMUST00000101388; ENSMUSP00000100524; ENSMUSG00000073062
GeneIDⁱ	668166
KEGGⁱ	mmu:668166
UCSC genome browser More...UCSCⁱ	uc009ttq.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A2CE44	Zinc finger X-linked protein ZXDA		MACFA		802	UniRef50_A2CE44
Zinc finger X-linked protein ZXDB (Fragment)		TUPCH		623
Uncharacterized protein		RABIT		788
Uncharacterized protein		NOMLE		756
Uncharacterized protein		OTOGA		800
+102

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR293526 Genomic DNA No translation available. AK016708 mRNA Translation: BAC25496.1 Frameshift. AK132358 mRNA Translation: BAE21123.1
CCDSⁱ	CCDS41065.1
RefSeqⁱ	NP_001074942.1, NM_001081473.1
UniGeneⁱ	Mm.426145

3D structure databases

ProteinModelPortalⁱ	A2CE44
SMRⁱ	A2CE44
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000100524

STRINGⁱ

10090.ENSMUSP00000100524

PTM databases

iPTMnetⁱ	A2CE44
PhosphoSitePlusⁱ	A2CE44

Proteomic databases

MaxQBⁱ	A2CE44
PaxDbⁱ	A2CE44
PeptideAtlasⁱ	A2CE44
PRIDEⁱ	A2CE44

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000101388; ENSMUSP00000100524; ENSMUSG00000073062
GeneIDⁱ	668166
KEGGⁱ	mmu:668166
UCSCⁱ	uc009ttq.1 mouse

Organism-specific databases

CTDⁱ	158586
MGIⁱ	MGI:3694898 Zxdb

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000013019
HOVERGENⁱ	HBG002277
InParanoidⁱ	A2CE44
OMAⁱ	DWNVHPD
OrthoDBⁱ	EOG091G0K27
PhylomeDBⁱ	A2CE44
TreeFamⁱ	TF330996

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:A2CE44
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000073062 Expressed in 228 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	MM_ZXDB
Genevisibleⁱ	A2CE44 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 10 hits PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZXDB_MOUSE
Accessionⁱ	A2CE44Primary (citable) accession number: A2CE44 Secondary accession number(s): Q3V1M7, Q8CEQ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	February 20, 2007
	Last modified:	November 7, 2018
	This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2CE44 (ZXDB_MOUSE)

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Zinc finger X-linked protein ZXDB

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ