Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PR domain zinc finger protein 10

Gene

prdm10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri319 – 341C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 608C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri613 – 635C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 664C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri696 – 719C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri741 – 764C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri803 – 826C2H2-type 10PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 10 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 10
Gene namesi
Name:prdm10
ORF Names:si:ch211-151h10.3, si:dkey-11k4.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050419-74 prdm10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003639651 – 1121PR domain zinc finger protein 10Add BLAST1121

Proteomic databases

PRIDEiA2BID7

Structurei

3D structure databases

SMRiA2BID7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 290SETPROSITE-ProRule annotationAdd BLAST118

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi888 – 1011Gln-richAdd BLAST124
Compositional biasi1105 – 1108Poly-Thr4

Domaini

The SET domain is degenerated, suggesting that it has lost methyltransferase activity.

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri319 – 341C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 608C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri613 – 635C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 664C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri696 – 719C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri741 – 764C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri803 – 826C2H2-type 10PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG053664
InParanoidiA2BID7
PhylomeDBiA2BID7

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

A2BID7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKQESSTV WSTASNNDTG NTPQVHFEAG AVAQIVYSGD QSDRTQQQVV
60 70 80 90 100
YAADGSSYTS VESAEHTLVY IHPADGTQSQ LAVTNAALPT LTEASSSPLG
110 120 130 140 150
ATDSTVDSED EEEDNDSEDS EMDDWEPRAL QPFTPQNLWC EDCNNANPAA
160 170 180 190 200
CIKHGPLHPI LNRPVMSKAR ASLPLVLYID RFLGGVFTKR RIPKRTQFGP
210 220 230 240 250
LEGPLVRQSE LLDTHIHLKL YMLDPEKEGE RAQDLWFDLS DEERCNWMMF
260 270 280 290 300
VRPAQNHLEQ NLVAYQYGSD IFYTSIKNIQ PKQELKVWYA ASYAEFVNQK
310 320 330 340 350
VHDVTEEERK VLREQEKNWP CYECNRRFMS SEQLQQHLNM HDDKLNLIQR
360 370 380 390 400
PKSRGRGRGR KRFGGARRPG RRTKFLCPQT PVESADKTQE LLASVDKLQF
410 420 430 440 450
EERTDGALNG LKVVEMAAES METETEDALD PPPIHTESLQ DEEDSVTPPP
460 470 480 490 500
VTEIPESAKD DLSHTSPIDP HLTPQDMRRA RRIRNAALKH LFIRKSFRPF
510 520 530 540 550
KCPQCGKAFR DKEKLEQHMR FHGRDGCRHV CHQCGKGFLS STSLEDHLVL
560 570 580 590 600
HSDQRNYSCL FCAESYDRLE LLKVHVGIHM VNGCFLCPSC KKSFTDFIQV
610 620 630 640 650
KKHVRSFHSE KVFQCSECDK AFCRPDKLRL HMLRHSDRKD FLCSTCGKQF
660 670 680 690 700
KRKDKLREHM QRMHNPEREA KKADRIHRTK ALKQKEPTTD FESFMFKCRL
710 720 730 740 750
CMMGFRRRGM LVNHLSKRHP EMRLEEVPEL TLPIIKPNRD YYCQYCDKVY
760 770 780 790 800
KSASKRKAHI LKNHPGAELP PSIRKLRPAG PGEPDPMLST HTQLTGTIAT
810 820 830 840 850
APVCCPHCAK QYSSKTKMVQ HIRKKHPEYQ YNSSSNIQAP LAATVISSTP
860 870 880 890 900
AVITTDGTTA EAVVTTDLLT QAMTELSQTL TTDYRTAQGD FQRIQYIPVS
910 920 930 940 950
QAGGGLSQPQ HIQLQVVQVA PASSPHSQHS TVDVSQLHDP HSYSQHSIQV
960 970 980 990 1000
QHIQVAEPTA AVQANAQVSG QPLSPSSQQA AQELSTAQLT PVTLAQQTLQ
1010 1020 1030 1040 1050
TSSNQTQGAT QHAYLPSNWN YRSYPSEIQM MALPHTQYVI AEASTPVTAA
1060 1070 1080 1090 1100
VNSSQVKTTH YVISDGQTEL DGKQVSVPST ATQGHPDPLE QPAGGQQATT
1110 1120
QYIITTTTNG AGASEVHITK P
Length:1,121
Mass (Da):126,179
Last modified:February 10, 2009 - v2
Checksum:i13D642EEA8FD6C2B
GO

Sequence cautioni

The sequence CAM13007 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401E → D in CAK04147 (PubMed:23594743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908391 Genomic DNA Translation: CAK04147.1
BX908399 Genomic DNA Translation: CAM13007.1 Sequence problems.

Similar proteinsi

Entry informationi

Entry nameiPRD10_DANRE
AccessioniPrimary (citable) accession number: A2BID7
Secondary accession number(s): Q1LV64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health