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Protein

Ventricular zone-expressed PH domain-containing protein

Gene

veph

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • brain development Source: ZFIN
  • ear morphogenesis Source: ZFIN

Names & Taxonomyi

Protein namesi
Recommended name:
Ventricular zone-expressed PH domain-containing protein
Alternative name(s):
Protein melted homolog
Gene namesi
Name:veph
ORF Names:si:ch211-283j23.5
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041014-375 veph1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979581 – 813Ventricular zone-expressed PH domain-containing proteinAdd BLAST813

Proteomic databases

PaxDbiA2BID5
PRIDEiA2BID5

Expressioni

Tissue specificityi

Expressed at high levels in kidney, and at low levels in eye, brain, gill and heart.1 Publication

Developmental stagei

Expressed in diencephalon, mesencephalon, anterior hindbrain and otic vesicles at 24 hpf.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000048984

Structurei

3D structure databases

ProteinModelPortaliA2BID5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini696 – 799PHPROSITE-ProRule annotationAdd BLAST104

Domaini

The PH domain is required for membrane targeting.By similarity

Sequence similaritiesi

Belongs to the MELT/VEPH family.Curated

Phylogenomic databases

eggNOGiKOG3723 Eukaryota
ENOG410XQXD LUCA
HOGENOMiHOG000113559
HOVERGENiHBG097059
InParanoidiA2BID5
PhylomeDBiA2BID5
TreeFamiTF314736

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A2BID5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHQLFRLVLG QRDLSRAGDL FSLDDSEIED CLSQALEEIK VISCSPDYLT
60 70 80 90 100
NDNDQAVVEI CITRITTAIR ETGSIERHGA ALVSLWESCL EHNLQPQGKD
110 120 130 140 150
EDTPHAKIAS DITSCILQNY NRPPVMALAV PVAVRFLQQG NQELSRNMSS
160 170 180 190 200
YLSLAAIAKA ELLAQHTEAI TCSVLAGNTM LLRVLPSVYP RQPEPIHQHV
210 220 230 240 250
RELTAMMPRL DQTGRQHLLR LLQMISDLHP LVLSSLVPLL IGFLGDSDLG
260 270 280 290 300
DSALGVLVNV AQSSPVSLAP FLSTLRNVGQ KNPWLLGHIA KIHRAVGLTS
310 320 330 340 350
EIQARGALQY LVSLLASMEH SAHHTLLLEI RCLTDRYTSI LGGGGKDIYR
360 370 380 390 400
MSNSFSAIAR LLGRKLEADG AVSRGEEKVQ DLPRPHEAES GSEMFAENLH
410 420 430 440 450
LQVKIQAFEE KIGDEEVESE VDGASPGPQR RHSLGQAARD ERREMRFNRS
460 470 480 490 500
KSLALHAVRT RSINSDSSPE GEGLDLNAEL NVCEAETSSV SSTPHNHTEL
510 520 530 540 550
TETQPDTSPN TEGAKVEDGD PRERDRLWIH LRDNMEEIKS FCAEMIKQIP
560 570 580 590 600
VPEHCVIEDS HRGCVAKLSF SCPLKGHYCL YGKSSFSLCS SQPHLWIQIM
610 620 630 640 650
LLALQSKESE ALCCRDECVL QLRKLWEKTQ LTGAHSFELA MTQTTVPHKK
660 670 680 690 700
DVDSLQMYLE EVRFFDLFSY SEDKGGWLCF MCSNPEKATV VNQDGQPLIE
710 720 730 740 750
GKLKEKQVRW KFIKRWKTRY FTLAGNQLLF RRGKSKDELD NNTIELSKVQ
760 770 780 790 800
SVKVVAKKRR DRGLPRAFEI FTDSKTYVLK AQDEKHAEEW LQCINVAVAQ
810
AKERENREAT TYL
Length:813
Mass (Da):91,209
Last modified:February 20, 2007 - v1
Checksum:i6591DE92600CD08D
GO
Isoform 2 (identifier: A2BID5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-451: SK → WD
     452-813: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,849
Checksum:i4D76EC18851E78F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti399L → Q in BAC02921 (PubMed:15388229).Curated1
Sequence conflicti399L → Q in AAI34891 (Ref. 3) Curated1
Sequence conflicti608E → A in BAC02921 (PubMed:15388229).Curated1
Sequence conflicti615R → Q in BAC02921 (PubMed:15388229).Curated1
Sequence conflicti661E → D in BAC02921 (PubMed:15388229).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027435450 – 451SK → WD in isoform 2. 1 Publication2
Alternative sequenceiVSP_027436452 – 813Missing in isoform 2. 1 PublicationAdd BLAST362

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085188 mRNA Translation: BAC02921.1
BX901975, BX255879 Genomic DNA Translation: CAM14213.1
BX255879, BX901975 Genomic DNA Translation: CAM56445.1
BX255887, CR936375, CU076107 Genomic DNA Translation: CAN88285.1
CU076107, BX255887, CR936375 Genomic DNA Translation: CAN88557.1
CR936375, BX255887, CU076107 Genomic DNA Translation: CAN88666.1
BC134890 mRNA Translation: AAI34891.1
RefSeqiNP_997996.1, NM_212831.1
UniGeneiDr.134017

Genome annotation databases

GeneIDi405756
KEGGidre:405756

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMELT_DANRE
AccessioniPrimary (citable) accession number: A2BID5
Secondary accession number(s): A4IG20, Q8JIG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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