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Entry version 113 (19 Jan 2022)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Ankyrin 2b, neuronal

Gene

ank2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-8951664, Neddylation
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin 2b, neuronalImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ank2bImported
Synonyms:ank2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041010-165, ank2b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2BIB9

PeptideAtlas

More...
PeptideAtlasi
A2BIB9

PRoteomics IDEntifications database

More...
PRIDEi
A2BIB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000043313, Expressed in retina and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2BIB9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000114785

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati64 – 96ANKPROSITE-ProRule annotationAdd BLAST33
Repeati97 – 129ANKPROSITE-ProRule annotationAdd BLAST33
Repeati130 – 162ANKPROSITE-ProRule annotationAdd BLAST33
Repeati163 – 186ANKPROSITE-ProRule annotationAdd BLAST24
Repeati225 – 257ANKPROSITE-ProRule annotationAdd BLAST33
Repeati258 – 290ANKPROSITE-ProRule annotationAdd BLAST33
Repeati291 – 323ANKPROSITE-ProRule annotationAdd BLAST33
Repeati324 – 356ANKPROSITE-ProRule annotationAdd BLAST33
Repeati357 – 389ANKPROSITE-ProRule annotationAdd BLAST33
Repeati390 – 422ANKPROSITE-ProRule annotationAdd BLAST33
Repeati423 – 455ANKPROSITE-ProRule annotationAdd BLAST33
Repeati456 – 488ANKPROSITE-ProRule annotationAdd BLAST33
Repeati489 – 521ANKPROSITE-ProRule annotationAdd BLAST33
Repeati522 – 554ANKPROSITE-ProRule annotationAdd BLAST33
Repeati555 – 587ANKPROSITE-ProRule annotationAdd BLAST33
Repeati589 – 621ANKPROSITE-ProRule annotationAdd BLAST33
Repeati622 – 654ANKPROSITE-ProRule annotationAdd BLAST33
Repeati655 – 687ANKPROSITE-ProRule annotationAdd BLAST33
Repeati688 – 720ANKPROSITE-ProRule annotationAdd BLAST33
Repeati721 – 753ANKPROSITE-ProRule annotationAdd BLAST33
Repeati754 – 786ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini944 – 1132ZU5InterPro annotationAdd BLAST189
Domaini1134 – 1281ZU5InterPro annotationAdd BLAST148
Domaini3094 – 3178DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni1433 – 1458DisorderedSequence analysisAdd BLAST26
Regioni1648 – 1889DisorderedSequence analysisAdd BLAST242
Regioni1949 – 2015DisorderedSequence analysisAdd BLAST67
Regioni2028 – 2064DisorderedSequence analysisAdd BLAST37
Regioni2078 – 2113DisorderedSequence analysisAdd BLAST36
Regioni2141 – 2279DisorderedSequence analysisAdd BLAST139
Regioni2329 – 2350DisorderedSequence analysisAdd BLAST22
Regioni2393 – 2462DisorderedSequence analysisAdd BLAST70
Regioni2479 – 2498DisorderedSequence analysisAdd BLAST20
Regioni2580 – 2611DisorderedSequence analysisAdd BLAST32
Regioni2631 – 2669DisorderedSequence analysisAdd BLAST39
Regioni2731 – 2998DisorderedSequence analysisAdd BLAST268
Regioni3459 – 3538DisorderedSequence analysisAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3002 – 3022Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 32Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi1441 – 1458Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1649 – 1676Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1677 – 1692Polar residuesSequence analysisAdd BLAST16
Compositional biasi1725 – 1748Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1764 – 1786Polar residuesSequence analysisAdd BLAST23
Compositional biasi1787 – 1801Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1817 – 1836Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1837 – 1858Polar residuesSequence analysisAdd BLAST22
Compositional biasi1859 – 1889Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1977 – 2015Polar residuesSequence analysisAdd BLAST39
Compositional biasi2161 – 2178Polar residuesSequence analysisAdd BLAST18
Compositional biasi2203 – 2225Polar residuesSequence analysisAdd BLAST23
Compositional biasi2244 – 2273Polar residuesSequence analysisAdd BLAST30
Compositional biasi2329 – 2346Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi2414 – 2436Polar residuesSequence analysisAdd BLAST23
Compositional biasi2437 – 2462Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi2638 – 2664Polar residuesSequence analysisAdd BLAST27
Compositional biasi2761 – 2789Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi2792 – 2824Polar residuesSequence analysisAdd BLAST33
Compositional biasi2837 – 2853Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi2870 – 2884Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2893 – 2915Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi2916 – 2934Polar residuesSequence analysisAdd BLAST19
Compositional biasi2935 – 2950Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2951 – 2966Polar residuesSequence analysisAdd BLAST16
Compositional biasi3473 – 3502Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi3521 – 3538Pro residuesSequence analysisAdd BLAST18

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000134_29_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2BIB9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2BIB9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR001969, Aspartic_peptidase_AS
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13637, Ank_4, 2 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 21 hits
PS00141, ASP_PROTEASE, 1 hit
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A2BIB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEDTQSHLR MEASDKLNGL GGRRRRPKKS DSNTSFLRAA RAGNIDKVLE
60 70 80 90 100
YLKGGVDIGT SNQNGLNALH LAAKEGHVDL VQELLGRGSS VDSATKKGNT
110 120 130 140 150
ALHIASLAGQ GDVVKILSKR GANINAQSQN GFTPLYMASQ ENHLDVVRYL
160 170 180 190 200
LENGGNQSIA TEDGFTPLAI ALQQGHNQVV SILLENDTKG KVRLPALHIA
210 220 230 240 250
ARKDDTKSAA LLLQNDHNAD VQSKSGFTPL HIAAHYGNVN VATLLLNRGA
260 270 280 290 300
AVDFTARNGI TPLHVASKRG NTNMVHLLLD RGAQIDAKTR DGLTPLHCAA
310 320 330 340 350
RSGHDTAVEL LLERGAPMLA RTKNGLSPLH MAAQGDHVEC VKHLLQHKAP
360 370 380 390 400
VDDVTLDYLT ALHVAAHCGH YRVTKLLLDK RANPNARALN GFTPLHIACK
410 420 430 440 450
KNRVKVMELL IKYGAFIQAI TESGLTPIHV AAFMGHLNIV LLLLQNGASP
460 470 480 490 500
DVSNIRGETA LHMAARAGQM EVVRCLLRNG AMVDARARED QTPLHIASRL
510 520 530 540 550
GKTEIVQLLL QHMAHPDAAT ANGYTPLHIA AREGHLDVTT VLLEAGAAHS
560 570 580 590 600
LATKKGFTPL HVASKYGSLE VAKLLLQRRA PPDSAGKQNG LTPLHVAAHY
610 620 630 640 650
DNQKVALLLL DKGASPHATA KNGYTPLHIA AKKNQMEIAT TLLQYGAETN
660 670 680 690 700
IQTKQGVMPI HLASQEGHSE MAALLLQRGA QVNVTTKSGL TSLHLAAQED
710 720 730 740 750
KVGVGEILVK QGANLDQQTK LGYTPLIVAC HYGNAKMVNF LLKSGASVND
760 770 780 790 800
KTKNGYTPLH QAAQQGNTHI INVLLQYGAK PNAITNGNTA LAIARRLGYI
810 820 830 840 850
SVVDTLRVVT EEIVTTTTTV TEKHKLNVPE TMTEVLDVSD EEGDDTMTGD
860 870 880 890 900
GGEYLRAEDL RELGDDSLPG QYLDGMNYLR FSLEGGRSDS LDRSYTPTHQ
910 920 930 940 950
SYYSKHYGIM EDVSSLGREN EKDSWETENL DNIALSSSPA HSGFLVSFMV
960 970 980 990 1000
DARGGAMRGC RHNGLRLIIP PRKCSAPTRV TCRLVKRHRL ATMPPMVEGD
1010 1020 1030 1040 1050
GLASRLIEVG PSGAQFLGKL HLPTAPPPLN EGESLVSRIL QLGPPGTKFL
1060 1070 1080 1090 1100
GPVIVEIPHF AALRGKEREL VILRSETGES WKEHHCEYTE EELNQVLNGM
1110 1120 1130 1140 1150
DERLDPPEEL EKKRICRIIT RDFPQYFAVV SRIKQDSNLI GPEGGVLSST
1160 1170 1180 1190 1200
VVPEVQAVFP EGALTKRIRV GLQTQPMSVD VVRNMLGNKA TFSPIVTLEP
1210 1220 1230 1240 1250
RRRKFHKPIT MTIPVPKSSA DPALGSFGGG ETPTLRLLCS ITGGTTPAQW
1260 1270 1280 1290 1300
EDITGTTPLT FTNDCVSFTT NVSARFWLID CRQVQESVNF ATLMYREIIC
1310 1320 1330 1340 1350
VPYMAKFVIF AKTHDPIEAR LRCFCMTDDK MDKTLEQQEN FSEVARSRDV
1360 1370 1380 1390 1400
EVLEGKPIYV DCFGNLVPLT KSGQHHVFSF YAFKENRLAL FIKIRDNTQE
1410 1420 1430 1440 1450
PCGRLSFTKE PRSFRTLSHG AVCNLNISLP AYSKESDSDQ EPDEETSRTL
1460 1470 1480 1490 1500
GKYDDDTETT ETSILKTHLI RDSPALASPD LLSDVSEMKQ DLIKMTAILT
1510 1520 1530 1540 1550
TDSSEKAGPM QGDYLGKGVE EVSAEPFEIM EKVKEDLEKV SEILRSGTCE
1560 1570 1580 1590 1600
KEESAKTEHR RYRKDEEWVL LTESEIEEAK MMAAFESQEA LLKEVRVNRG
1610 1620 1630 1640 1650
SQRPKGARER SGIPIGEVKE YLLDAPASQE TSSQQRFTEV VLRRGGRKIV
1660 1670 1680 1690 1700
PTMAKDTKAH TTEIKKPVRR KGPQGHTDET QSISTKENIA SKSAGKASEE
1710 1720 1730 1740 1750
DAFLPVPGDQ KKSPVSPVVE ETPIGPIKEK VKALQKKVEE EQKGHKKQTS
1760 1770 1780 1790 1800
QKPPFKSTEA KTSVLKDQKT TGLKKTSLPQ KQSSSKSPKT EPERLEETMS
1810 1820 1830 1840 1850
VRELMRAFQT GQDPSKRKSG LFEHKGPSKT EHTTMIKSEA KTTNSQCLPH
1860 1870 1880 1890 1900
SSSREVSLDV SRPVEHHEEK EVFDKDAKEN QKSHVCKQER SGEGLVFGVE
1910 1920 1930 1940 1950
SAGQQSSMTT AIAQNVSKHA SDLLPDNGTE NGTFNDSSDS IKLEALVDSP
1960 1970 1980 1990 2000
SASLAEVEAP LSSEESCKHE GMAETPETSP ESLSLSPQQK ASQSILAKAS
2010 2020 2030 2040 2050
NSTADTHKAK TSKVSVSFSA EMKTKIEQAS EATVHHPALS KAVDEPTKSE
2060 2070 2080 2090 2100
SMCIPHRKKG VNFGGEQTFV DKDIVSISTK SSKSRKLTKR PSETLESFLS
2110 2120 2130 2140 2150
DDESCDGQPT PTFADSLTLR AATQDHGGLV LPLRHQDSET LSPVADDSFN
2160 2170 2180 2190 2200
ISHKDSLEGS PLMEDNSSHK TPDSIEPSPT KESPCCDSLE NSPIEMKSNL
2210 2220 2230 2240 2250
AFPPTVEQPS VTTGPLTSSK APQIPPDSLR NRMLKEQEAN VDDDSCEQAS
2260 2270 2280 2290 2300
LMTSSGKSPL SPDTPSSEEV SYEVNPQPPD PMVLIVPFKA SVIPEETVED
2310 2320 2330 2340 2350
DELKCDLTQR KFTPEEEMFK MAAKIKTFDE MEQDAKDKRD SRKDSEASQT
2360 2370 2380 2390 2400
LVVSDIGQEI ITLFGLVSKH ETSSVDDVGF IESKQASEIA RSVEPIIKVQ
2410 2420 2430 2440 2450
PPSPFPAGIH KSPQTAEDIQ QTMAHSAASS DESAMRRPQS VTEKHTIKPH
2460 2470 2480 2490 2500
PQESHSEKFN QECVKSELAE LNKTASSRSN LAANITDEQK EQSLAKQKIN
2510 2520 2530 2540 2550
ESEEIYSHEM QNQAANFQNV DKLASQEERN VTDEIKGDYM RHAGTSYDDS
2560 2570 2580 2590 2600
CSSSLNIDSM PVIIGQNKET FKPEICIYDD TEEDDGEEEP PKTESRGVTA
2610 2620 2630 2640 2650
KAETDSWNSM REDDEAFAAR VKEEEQKILG LVVDRHSQGA TPDTTPARTP
2660 2670 2680 2690 2700
TEDGTPTSEQ NPFLFQEGKL FEMTRSGAID MTKRSYEEEG FAFYQIEHPI
2710 2720 2730 2740 2750
MEGVAEEGGN ESGGASGDAE KEVGCNLSLQ IKAEEEEDQP KVAADLSVRS
2760 2770 2780 2790 2800
ATAKQSDLSK PKTPIKTDSE KGQGVSEKVE IKSDKVISEG HLISDSGSSD
2810 2820 2830 2840 2850
TVIASIQTAV STVTRSVHSQ QEQESSDSSP EDQHSVIEQP KTPEKKESHG
2860 2870 2880 2890 2900
KLGSKIHTAA SPSTTSKKNM SSSKEEEKPK SRIPVKANSL RSELLEPAKD
2910 2920 2930 2940 2950
KKSKLPIKPQ SRRKSDTDTG PLIPTITKSS KAKSFCESDS SKKPAKKDQN
2960 2970 2980 2990 3000
RPTSTDLSST TKTLPSRLPV RGKPGQPIQT STPAKQKKGR PTHTNKEPVV
3010 3020 3030 3040 3050
FFEEISQEAA KVVESLAQAE KDKQEAAVLS DDESSTIDVS VIENEPFLDM
3060 3070 3080 3090 3100
KMPFPEDPLV IRPRWDNPVE TQMERIPADK VRSQVDPQDE ADRKESRLAV
3110 3120 3130 3140 3150
IANHLGFSWS ELARELEFSD VQINQIRNEN PNSLQDQSHA LIRLWKEREG
3160 3170 3180 3190 3200
KNASENSLMK TLTKINRMDI VHLIETKIIQ SSQDHSSHTY AEIEQTISLD
3210 3220 3230 3240 3250
HSEGFSALQE DMDSPRSGRR ADVSQRRSEL VPVVASIEDL SLNASSLGDS
3260 3270 3280 3290 3300
QKELPDKVTS SVVVGDSTHS FEMVGLRQQF PGTIKQGDDM PEIPPQTVTE
3310 3320 3330 3340 3350
EQYTDEYGNM VVKKITRKVI RKYVSADGVE REEVMLEGPQ QEAVTVDEAD
3360 3370 3380 3390 3400
SFSKVVKRTV VRSGGDQTEV TFSEPLSYAG ATSSKFEEEP VQGRKVSKVV
3410 3420 3430 3440 3450
KTMVVQGDRM EKLIGDPSLS SDLPSAKDDF EKALSYVEGF EKVLLPHLVE
3460 3470 3480 3490 3500
KETVKEDGSV VRRTRMHKTR TQKRTVVKDG EAKQTHLERL EDTAESLRPD
3510 3520 3530
DLQQHLHQLL QRYCTPEPHP PAGQQDKPQP PPAGRPDA
Length:3,538
Mass (Da):388,627
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE4AF0003B19A5FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IYL7A0A0R4IYL7_DANRE
Ankyrin 2b, neuronal
ank2b
1,754Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2BIB8A2BIB8_DANRE
Ankyrin 2b, neuronal
ank2b ank2
312Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2BIC1A2BIC1_DANRE
Ankyrin 2b, neuronal
ank2b
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QI39F1QI39_DANRE
Ankyrin 2b, neuronal
ank2b
467Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1R6Q3F1R6Q3_DANRE
Ankyrin 2b, neuronal
ank2b
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX901910 Genomic DNA No translation available.
CR354563 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSDART00000147287; ENSDARP00000114785; ENSDARG00000043313

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX901910 Genomic DNA No translation available.
CR354563 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000114785

Proteomic databases

PaxDbiA2BIB9
PeptideAtlasiA2BIB9
PRIDEiA2BIB9

Genome annotation databases

EnsembliENSDART00000147287; ENSDARP00000114785; ENSDARG00000043313

Organism-specific databases

ZFINiZDB-GENE-041010-165, ank2b

Phylogenomic databases

eggNOGiKOG4177, Eukaryota
GeneTreeiENSGT00940000155279
HOGENOMiCLU_000134_29_2_1
InParanoidiA2BIB9
PhylomeDBiA2BIB9

Enzyme and pathway databases

ReactomeiR-DRE-8951664, Neddylation
R-DRE-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSDARG00000043313, Expressed in retina and 34 other tissues
ExpressionAtlasiA2BIB9, baseline and differential

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR001969, Aspartic_peptidase_AS
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13637, Ank_4, 2 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 21 hits
PS00141, ASP_PROTEASE, 1 hit
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2BIB9_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BIB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: January 19, 2022
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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