UniProtKB - A2BHM9 (A2BHM9_DANRE)

BLAST

>tr|A2BHM9|A2BHM9_DANRE BMP2-inducible kinase OS=Danio rerio OX=7955 GN=bmp2k PE=1 SV=1
MKKFSRMPKSESGSLGGGSGSGTGSSNYIGKVFAVGRYQVTVEELIAEGGFSMVFLARTH
SGVRCALKRMYVNNVHDLNIFRREITIMKELSGHKNIVRYLDSTTNAVGDSVWEVLILME
YCKAGQVVKQMNQRLHIGFTEAEVLNIFCDACEAVARLHQCKTPIIHRDLKVENILLNDQ
GNYVLCDFGSATHKVLLPHKDGITAVEDEIKKYTTLSYRAPEMINLYQGKAITTKADIWA
LGCLLYKLCFFTLPFGESQVAICDGTFAVPDGSKFSSKLHGLIRYMLEPDQEKRPDIYQV
SYFAFRLAGKECPVPNLFNSPLPTSLPEPFTASDIAAKKSLTKARITDSVGPTETSIAPR
QRPKAANSNVLPLSSSVTPVKMTVTTASGNGQQSAAQMPNSSQQNRVLQQLQPGDLRLQQ
LHHQQQQQQQHHNIQHQQQIAAQQLQYMQQYHQAMQQSLQMQQHQHMLQQQQQQMMMQQQ
PIYQSQQQQQQAHYTALMQQYQQAFVQQQQCAPVHQVPYISPLEFQTSVGSYNPAGPSPV
ETPFTNISCSRNPVSAVDVMSPPPQTVSNPPDMSSWNPFGEDNFSKLTEEELLNREFDLL
RAKKPVERSVSMEASSVDRQQPVLQPSLPEDPFGSVPFLANAGKF

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History
Entry version 75 (07 Nov 2018)
Sequence version 1 (20 Feb 2007)
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Protein

Submitted name:

BMP2-inducible kinase

Gene

bmp2k

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of endocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: BMP2-inducible kinaseImported
Gene namesⁱ	Name:bmp2kImported
Organismⁱ	Danio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifierⁱ	7955 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Osteoglossocephalai › Clupeocephala › Otomorpha › Ostariophysi › Otophysi › Cypriniphysae › Cypriniformes › Cyprinoidea › Cyprinidae › Danio
Proteomesⁱ	UP000000437 Componentⁱ: Chromosome 5

Organism-specific databases

ZFINⁱ	ZDB-GENE-041212-72 bmp2k

ZFINⁱ

ZDB-GENE-041212-72 bmp2k

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	A2BHM9

PeptideAtlasⁱ

A2BHM9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSDARG00000020009 Expressed in 18 organ(s), highest expression level in mature ovarian follicle
ExpressionAtlasⁱ	A2BHM9 baseline

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2BHM9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	40 – 305	Protein kinaseInterPro annotationAdd BLAST		266

Phylogenomic databases

eggNOGⁱ	KOG1989 Eukaryota ENOG410Y515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137958
HOVERGENⁱ	HBG050703
InParanoidⁱ	A2BHM9
KEGG Orthology (KO) More...KOⁱ	K08854
OMAⁱ	TDLNICK
TreeFamⁱ	TF317300

Family and domain databases

InterProⁱ	View protein in InterPro IPR026105 BMP-2-ind_kinase IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
PANTHERⁱ	PTHR22967:SF10 PTHR22967:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

A2BHM9-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKKFSRMPKS ESGSLGGGSG SGTGSSNYIG KVFAVGRYQV TVEELIAEGG 
        60         70         80         90        100
FSMVFLARTH SGVRCALKRM YVNNVHDLNI FRREITIMKE LSGHKNIVRY 
       110        120        130        140        150
LDSTTNAVGD SVWEVLILME YCKAGQVVKQ MNQRLHIGFT EAEVLNIFCD 
       160        170        180        190        200
ACEAVARLHQ CKTPIIHRDL KVENILLNDQ GNYVLCDFGS ATHKVLLPHK 
       210        220        230        240        250
DGITAVEDEI KKYTTLSYRA PEMINLYQGK AITTKADIWA LGCLLYKLCF 
       260        270        280        290        300
FTLPFGESQV AICDGTFAVP DGSKFSSKLH GLIRYMLEPD QEKRPDIYQV 
       310        320        330        340        350
SYFAFRLAGK ECPVPNLFNS PLPTSLPEPF TASDIAAKKS LTKARITDSV 
       360        370        380        390        400
GPTETSIAPR QRPKAANSNV LPLSSSVTPV KMTVTTASGN GQQSAAQMPN 
       410        420        430        440        450
SSQQNRVLQQ LQPGDLRLQQ LHHQQQQQQQ HHNIQHQQQI AAQQLQYMQQ 
       460        470        480        490        500
YHQAMQQSLQ MQQHQHMLQQ QQQQMMMQQQ PIYQSQQQQQ QAHYTALMQQ 
       510        520        530        540        550
YQQAFVQQQQ CAPVHQVPYI SPLEFQTSVG SYNPAGPSPV ETPFTNISCS 
       560        570        580        590        600
RNPVSAVDVM SPPPQTVSNP PDMSSWNPFG EDNFSKLTEE ELLNREFDLL 
       610        620        630        640 
RAKKPVERSV SMEASSVDRQ QPVLQPSLPE DPFGSVPFLA NAGKF

Length:645

Mass (Da):72,198

Last modified:February 20, 2007 - v1

Checksum:ⁱ1B3B1DA9EA62031B

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0R4IUS2	A0A0R4IUS2_DANRE	BMP2-inducible kinase BMP2-inducible kinase	bmp2k	1,081	Annotation score:
A0A2R8PYY6	A0A2R8PYY6_DANRE	BMP2 inducible kinase BMP2 inducible kinase	bmp2k	1,053	Annotation score:
A0A2R8QBV4	A0A2R8QBV4_DANRE	BMP2 inducible kinase BMP2 inducible kinase	bmp2k	646	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX640536 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001008644.2, NM_001008644.2
UniGeneⁱ	Dr.16680

Genome annotation databases

Ensemblⁱ	ENSDART00000006079; ENSDARP00000018789; ENSDARG00000020009
GeneIDⁱ	494101
KEGGⁱ	dre:494101

Protein	Similar proteins		Species	Score	Length	Source
A2BHM9	BMP2 inducible kinase		DANRE		646	UniRef90_A2BHM9
BMP2 inducible kinase		DANRE		646

Protein	Similar proteins		Species	Score	Length	Source
A2BHM9	Isoform 2 of BMP-2-inducible protein kinase		MOUSE		649	UniRef50_Q91Z96-2
BMP-2-inducible protein kinase		Bengalese finch		656
BMP2 inducible kinase		TAKRU		683
BMP2 inducible kinase		DANRE		646
BMP2 inducible kinase		POEFO		662
+20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX640536 Genomic DNA No translation available.
RefSeqⁱ	NP_001008644.2, NM_001008644.2
UniGeneⁱ	Dr.16680

3D structure databases

ProteinModelPortalⁱ	A2BHM9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	A2BHM9

PeptideAtlasⁱ

A2BHM9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSDART00000006079; ENSDARP00000018789; ENSDARG00000020009
GeneIDⁱ	494101
KEGGⁱ	dre:494101

Organism-specific databases

CTDⁱ	55589
ZFINⁱ	ZDB-GENE-041212-72 bmp2k

Phylogenomic databases

eggNOGⁱ	KOG1989 Eukaryota ENOG410Y515 LUCA
GeneTreeⁱ	ENSGT00880000137958
HOVERGENⁱ	HBG050703
InParanoidⁱ	A2BHM9
KOⁱ	K08854
OMAⁱ	TDLNICK
TreeFamⁱ	TF317300

Gene expression databases

Bgeeⁱ	ENSDARG00000020009 Expressed in 18 organ(s), highest expression level in mature ovarian follicle
ExpressionAtlasⁱ	A2BHM9 baseline

Family and domain databases

InterProⁱ	View protein in InterPro IPR026105 BMP-2-ind_kinase IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
PANTHERⁱ	PTHR22967:SF10 PTHR22967:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2BHM9_DANRE
Accessionⁱ	A2BHM9Primary (citable) accession number: A2BHM9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	November 7, 2018
	This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - A2BHM9 (A2BHM9_DANRE)

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BMP2-inducible kinase

bmp2k

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ