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UniProtKB - A2BHM9 (A2BHM9_DANRE)
Protein
Submitted name:
BMP2-inducible kinase
Gene
bmp2k
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- AP-2 adaptor complex binding Source: GO_Central
- ATP binding Source: InterPro
- phosphatase regulator activity Source: GO_Central
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- positive regulation of Notch signaling pathway Source: GO_Central
- protein phosphorylation Source: GO_Central
- regulation of bone mineralization Source: GO_Central
- regulation of clathrin-dependent endocytosis Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: BMP2-inducible kinaseImported |
Gene namesi | Name:bmp2kImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-041212-72, bmp2k |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSDARG00000020009, Expressed in early embryo and 26 other tissues |
ExpressionAtlasi | A2BHM9, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 305 | Protein kinaseInterPro annotationAdd BLAST | 266 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 345 – 374 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 607 – 632 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 346 – 374 | Polar residuesSequence analysisAdd BLAST | 29 |
Phylogenomic databases
GeneTreei | ENSGT00940000157548 |
HOGENOMi | CLU_000288_109_5_1 |
InParanoidi | A2BHM9 |
PhylomeDBi | A2BHM9 |
TreeFami | TF317300 |
Family and domain databases
InterProi | View protein in InterPro IPR026105, BMP-2-ind_kinase IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR22967:SF10, PTHR22967:SF10, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A2BHM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKFSRMPKS ESGSLGGGSG SGTGSSNYIG KVFAVGRYQV TVEELIAEGG
60 70 80 90 100
FSMVFLARTH SGVRCALKRM YVNNVHDLNI FRREITIMKE LSGHKNIVRY
110 120 130 140 150
LDSTTNAVGD SVWEVLILME YCKAGQVVKQ MNQRLHIGFT EAEVLNIFCD
160 170 180 190 200
ACEAVARLHQ CKTPIIHRDL KVENILLNDQ GNYVLCDFGS ATHKVLLPHK
210 220 230 240 250
DGITAVEDEI KKYTTLSYRA PEMINLYQGK AITTKADIWA LGCLLYKLCF
260 270 280 290 300
FTLPFGESQV AICDGTFAVP DGSKFSSKLH GLIRYMLEPD QEKRPDIYQV
310 320 330 340 350
SYFAFRLAGK ECPVPNLFNS PLPTSLPEPF TASDIAAKKS LTKARITDSV
360 370 380 390 400
GPTETSIAPR QRPKAANSNV LPLSSSVTPV KMTVTTASGN GQQSAAQMPN
410 420 430 440 450
SSQQNRVLQQ LQPGDLRLQQ LHHQQQQQQQ HHNIQHQQQI AAQQLQYMQQ
460 470 480 490 500
YHQAMQQSLQ MQQHQHMLQQ QQQQMMMQQQ PIYQSQQQQQ QAHYTALMQQ
510 520 530 540 550
YQQAFVQQQQ CAPVHQVPYI SPLEFQTSVG SYNPAGPSPV ETPFTNISCS
560 570 580 590 600
RNPVSAVDVM SPPPQTVSNP PDMSSWNPFG EDNFSKLTEE ELLNREFDLL
610 620 630 640
RAKKPVERSV SMEASSVDRQ QPVLQPSLPE DPFGSVPFLA NAGKF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4IUS2 | A0A0R4IUS2_DANRE | BMP2-inducible kinase | bmp2k | 1,081 | Annotation score: | ||
A0A2R8PYY6 | A0A2R8PYY6_DANRE | BMP2-inducible kinase | bmp2k | 1,053 | Annotation score: | ||
A0A2R8QBV4 | A0A2R8QBV4_DANRE | BMP2-inducible kinase | bmp2k | 646 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX640536 Genomic DNA No translation available. |
RefSeqi | NP_001008644.2, NM_001008644.2 |
Genome annotation databases
Ensembli | ENSDART00000006079; ENSDARP00000018789; ENSDARG00000020009 |
GeneIDi | 494101 |
KEGGi | dre:494101 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX640536 Genomic DNA No translation available. |
RefSeqi | NP_001008644.2, NM_001008644.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000018789 |
Proteomic databases
PeptideAtlasi | A2BHM9 |
Genome annotation databases
Ensembli | ENSDART00000006079; ENSDARP00000018789; ENSDARG00000020009 |
GeneIDi | 494101 |
KEGGi | dre:494101 |
Organism-specific databases
CTDi | 55589 |
ZFINi | ZDB-GENE-041212-72, bmp2k |
Phylogenomic databases
GeneTreei | ENSGT00940000157548 |
HOGENOMi | CLU_000288_109_5_1 |
InParanoidi | A2BHM9 |
PhylomeDBi | A2BHM9 |
TreeFami | TF317300 |
Gene expression databases
Bgeei | ENSDARG00000020009, Expressed in early embryo and 26 other tissues |
ExpressionAtlasi | A2BHM9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR026105, BMP-2-ind_kinase IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR22967:SF10, PTHR22967:SF10, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2BHM9_DANRE | |
Accessioni | A2BHM9Primary (citable) accession number: A2BHM9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |