mark4a

Functionⁱ

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

establishment of cell polarity Source: InterPro
microtubule cytoskeleton organization Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
Ligand	ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-DRE-5620912 Anchoring of the basal body to the plasma membrane

Reactomeⁱ

R-DRE-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesⁱ	Name:mark4aImported
Organismⁱ	Danio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifierⁱ	7955 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Osteoglossocephalai › Clupeocephala › Otomorpha › Ostariophysi › Otophysi › Cypriniphysae › Cypriniformes › Cyprinoidea › Cyprinidae › Danio
Proteomesⁱ	UP000000437 Componentⁱ: Chromosome 5

Organism-specific databases

ZFINⁱ	ZDB-GENE-060531-156 mark4a

ZFINⁱ

ZDB-GENE-060531-156 mark4a

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSDARG00000023914 Expressed in 15 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasⁱ	A2BHA2 baseline

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2BHA2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	14 – 265	Protein kinaseInterPro annotationAdd BLAST	252
Domainⁱ	284 – 323	UBAInterPro annotationAdd BLAST	40
Domainⁱ	648 – 699	KA1InterPro annotationAdd BLAST	52

Phylogenomic databases

eggNOGⁱ	KOG0586 Eukaryota ENOG410XNQ0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140806
HOGENOMⁱ	HOG000233025
HOVERGENⁱ	HBG052453
OMAⁱ	NEITAMY
PhylomeDBⁱ	A2BHA2

Family and domain databases

InterProⁱ	View protein in InterPro IPR028375 KA1/Ssp2_C IPR001772 KA1_dom IPR011009 Kinase-like_dom_sf IPR033624 MARK/par1 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR015940 UBA
PANTHERⁱ	PTHR24346 PTHR24346, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02149 KA1, 1 hit PF00069 Pkinase, 1 hit PF00627 UBA, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit SM00165 UBA, 1 hit
SUPFAMⁱ	SSF103243 SSF103243, 1 hit SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS50032 KA1, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS50030 UBA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

A2BHA2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASYSDELPH IGNYRLLKTI GKGNFAKVKL ARHILTGKEV AIKIIDKTQL 
        60         70         80         90        100
NPTSLQKLFR EVRIMKTLHH PNIVQLFEVI ETEKTLYLVM EYASGGEVFD 
       110        120        130        140        150
YLVSHGRMKE IEARAKFRQI VSAVHYCHQK NIVHRDLKAE NLLLDADSNI 
       160        170        180        190        200
KIADFGFSNE FTLGNKLDTF CGSPPYAAPE LFQGKKYDGP EVDIWSLGVI 
       210        220        230        240        250
LYTLVSGSLP FDGQNLKELR ERVLRGKYRV PFYMSTDCEG ILRRFLVLNP 
       260        270        280        290        300
SKRCTLEQVM KDKWMNAGHD GDELKPHIEP TEDYSDANRI EIMVGMGFTT 
       310        320        330        340        350
EEIKDSLLNQ KYNEVTATYL LLGLKTEDGA ESRVSGSMTL PRVRPSPITN 
       360        370        380        390        400
GTNKHSSSSS SSSSSHSKTQ RSASTYHRQR RHSDFCGPSM PVMHPKRSPT 
       410        420        430        440        450
SGGDRELRES RMPPRKASCS VMGSRTLPPS SPMVSTANNP NKAEIPDRRK 
       460        470        480        490        500
EMTATTNNIP GSTMTRRNTY VCTDRSSTDR HSLLQNGKDN SIVGAGASSS 
       510        520        530        540        550
SSSGERCRLT RGSTIRSTFH GGQLRDRVPP TYGPPPTSPT LSHDAGALPA 
       560        570        580        590        600
NARSRATSNL FSKLTSKLTR RVSNESEGVS RSSVTGGHLS GDQKASEPWG 
       610        620        630        640        650
GGGGWDVRAR LSRPPRAPAE VVLALREAAR GCGCQVRHAG PFLLCCSHGA 
       660        670        680        690 
AGSKVAFQAE VCQLSVGPAE ANGVRYTRLW GAPLAFRHIA SQISKEVEL

Length:699

Mass (Da):76,947

Last modified:February 20, 2007 - v1

Checksum:ⁱC714FC534F28C665

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F1Q5N2	F1Q5N2_DANRE		Non-specific serine/threonine prote... Non-specific serine/threonine protein kinase, EC 2.7.11.1	mark4a	736	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX547938 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

BX547938 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENSDART00000146854; ENSDARP00000121243; ENSDARG00000023914

Ensemblⁱ

ENSDART00000146854; ENSDARP00000121243; ENSDARG00000023914

Protein	Similar proteins		Species	Score	Length	Source
A2BHA2	Non-specific serine/threonine protein kinase		DANRE		736	UniRef90_F1Q5N2
UPI0007B92B72		Sinocyclocheilus anshuiensis		758
UPI000E4013EB		CARAU		758
UPI0008FAA334		CYPCA		725
UPI0007B933C1		Sinocyclocheilus rhinocerous		695
+9

Protein	Similar proteins		Species	Score	Length	Source
A2BHA2	MAP/microtubule affinity-regulating kinase 4		HUMAN		79	UniRef50_Q96GZ3
MARK4 isoform 12		PONAB		79
MARK4 isoform 12		PANTR		79
Uncharacterized protein		MOUSE		79
MAP/microtubule affinity-regulating kinase 4 (Fragment)		MUSPF		71
+224

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX547938 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

BX547938 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	A2BHA2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSDART00000146854; ENSDARP00000121243; ENSDARG00000023914

Ensemblⁱ

ENSDART00000146854; ENSDARP00000121243; ENSDARG00000023914

Organism-specific databases

ZFINⁱ	ZDB-GENE-060531-156 mark4a

ZFINⁱ

ZDB-GENE-060531-156 mark4a

Phylogenomic databases

eggNOGⁱ	KOG0586 Eukaryota ENOG410XNQ0 LUCA
GeneTreeⁱ	ENSGT00900000140806
HOGENOMⁱ	HOG000233025
HOVERGENⁱ	HBG052453
OMAⁱ	NEITAMY
PhylomeDBⁱ	A2BHA2

Enzyme and pathway databases

Reactomeⁱ	R-DRE-5620912 Anchoring of the basal body to the plasma membrane

Reactomeⁱ

R-DRE-5620912 Anchoring of the basal body to the plasma membrane

Gene expression databases

Bgeeⁱ	ENSDARG00000023914 Expressed in 15 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasⁱ	A2BHA2 baseline

Family and domain databases

InterProⁱ	View protein in InterPro IPR028375 KA1/Ssp2_C IPR001772 KA1_dom IPR011009 Kinase-like_dom_sf IPR033624 MARK/par1 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR015940 UBA
PANTHERⁱ	PTHR24346 PTHR24346, 1 hit
Pfamⁱ	View protein in Pfam PF02149 KA1, 1 hit PF00069 Pkinase, 1 hit PF00627 UBA, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit SM00165 UBA, 1 hit
SUPFAMⁱ	SSF103243 SSF103243, 1 hit SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS50032 KA1, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS50030 UBA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2BHA2_DANRE
Accessionⁱ	A2BHA2Primary (citable) accession number: A2BHA2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	September 12, 2018
	This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - A2BHA2 (A2BHA2_DANRE)

Your basket is currently empty. ⁱ

Non-specific serine/threonine protein kinase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Organism-specific databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence (1+)ⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2BHA2 (A2BHA2_DANRE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Non-specific serine/threonine protein kinase

mark4a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ