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UniProtKB - A2BHA2 (A2BHA2_DANRE)
Protein
Non-specific serine/threonine protein kinase
Gene
mark4a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- EC:2.7.11.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- tau-protein kinase activity Source: GO_Central
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- microtubule cytoskeleton organization Source: GO_Central
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:mark4aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060531-156, mark4a |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000023914, Expressed in multi-cellular organism and 23 other tissues |
ExpressionAtlasi | A2BHA2, baseline |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 265 | Protein kinaseInterPro annotationAdd BLAST | 252 | |
Domaini | 284 – 323 | UBAInterPro annotationAdd BLAST | 40 | |
Domaini | 648 – 699 | KA1InterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 330 – 443 | DisorderedSequence analysisAdd BLAST | 114 | |
Regioni | 475 – 546 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 571 – 603 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 342 – 372 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 399 – 413 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 423 – 442 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 475 – 520 | Polar residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 571 – 590 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000159555 |
HOGENOMi | CLU_000288_157_5_1 |
OMAi | KDSMSTP |
PhylomeDBi | A2BHA2 |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A2BHA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASYSDELPH IGNYRLLKTI GKGNFAKVKL ARHILTGKEV AIKIIDKTQL
60 70 80 90 100
NPTSLQKLFR EVRIMKTLHH PNIVQLFEVI ETEKTLYLVM EYASGGEVFD
110 120 130 140 150
YLVSHGRMKE IEARAKFRQI VSAVHYCHQK NIVHRDLKAE NLLLDADSNI
160 170 180 190 200
KIADFGFSNE FTLGNKLDTF CGSPPYAAPE LFQGKKYDGP EVDIWSLGVI
210 220 230 240 250
LYTLVSGSLP FDGQNLKELR ERVLRGKYRV PFYMSTDCEG ILRRFLVLNP
260 270 280 290 300
SKRCTLEQVM KDKWMNAGHD GDELKPHIEP TEDYSDANRI EIMVGMGFTT
310 320 330 340 350
EEIKDSLLNQ KYNEVTATYL LLGLKTEDGA ESRVSGSMTL PRVRPSPITN
360 370 380 390 400
GTNKHSSSSS SSSSSHSKTQ RSASTYHRQR RHSDFCGPSM PVMHPKRSPT
410 420 430 440 450
SGGDRELRES RMPPRKASCS VMGSRTLPPS SPMVSTANNP NKAEIPDRRK
460 470 480 490 500
EMTATTNNIP GSTMTRRNTY VCTDRSSTDR HSLLQNGKDN SIVGAGASSS
510 520 530 540 550
SSSGERCRLT RGSTIRSTFH GGQLRDRVPP TYGPPPTSPT LSHDAGALPA
560 570 580 590 600
NARSRATSNL FSKLTSKLTR RVSNESEGVS RSSVTGGHLS GDQKASEPWG
610 620 630 640 650
GGGGWDVRAR LSRPPRAPAE VVLALREAAR GCGCQVRHAG PFLLCCSHGA
660 670 680 690
AGSKVAFQAE VCQLSVGPAE ANGVRYTRLW GAPLAFRHIA SQISKEVEL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1Q5N2 | F1Q5N2_DANRE | Non-specific serine/threonine prote... | mark4a | 736 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX547938 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000146854; ENSDARP00000121243; ENSDARG00000023914 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX547938 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000146854; ENSDARP00000121243; ENSDARG00000023914 |
Organism-specific databases
ZFINi | ZDB-GENE-060531-156, mark4a |
Phylogenomic databases
GeneTreei | ENSGT00940000159555 |
HOGENOMi | CLU_000288_157_5_1 |
OMAi | KDSMSTP |
PhylomeDBi | A2BHA2 |
Gene expression databases
Bgeei | ENSDARG00000023914, Expressed in multi-cellular organism and 23 other tissues |
ExpressionAtlasi | A2BHA2, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2BHA2_DANRE | |
Accessioni | A2BHA2Primary (citable) accession number: A2BHA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |