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Protein

AT-rich interactive domain-containing protein 1A

Gene

Arid1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523).2 PublicationsBy similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 1A
Short name:
ARID domain-containing protein 1A
Alternative name(s):
BRG1-associated factor 250
Short name:
BAF250
BRG1-associated factor 250a
Short name:
BAF250A
Osa homolog 1
SWI-like protein
SWI/SNF complex protein p270
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arid1a
Synonyms:Baf250, Baf250a, Osa1, Smarcf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1935147 Arid1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003916192 – 2283AT-rich interactive domain-containing protein 1AAdd BLAST2282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei287PhosphothreonineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei365PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei431Asymmetric dimethylarginineCombined sources1
Modified residuei605PhosphoserineBy similarity1
Modified residuei697PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1
Modified residuei731PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Modified residuei773PhosphoserineCombined sources1
Modified residuei1185PhosphoserineBy similarity1
Modified residuei1236PhosphoserineBy similarity1
Modified residuei1277Omega-N-methylarginineCombined sources1
Modified residuei1605PhosphoserineBy similarity1
Modified residuei1613N6-acetyllysineBy similarity1
Modified residuei1874PhosphothreonineCombined sources1
Modified residuei1886PhosphothreonineBy similarity1
Modified residuei1903N6-acetyllysineBy similarity1
Modified residuei1927PhosphoserineBy similarity1
Modified residuei1942PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A2BH40

MaxQB - The MaxQuant DataBase

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MaxQBi
A2BH40

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A2BH40

PeptideAtlas

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PeptideAtlasi
A2BH40

PRoteomics IDEntifications database

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PRIDEi
A2BH40

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
A2BH40

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A2BH40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at high levels in the testis.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5. In the earlier stages at E9.5 and E10.5, is fairly ubiquitous though with clearly elevated expression in the progress zone and lateral mesoderm of limb buds, optic and otic vesicle, neural tube, and brain. Later on at E11.5 and E12.5, expression becomes more restricted and is confined to the interdigital area of limbs, dorsal mes/metencephalon, neocortex, and neural tube. Expression is seen in the eye lens from E10.5 until E12.5.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000007880 Expressed in 326 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2BH40 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A2BH40 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of a SWI/SNF-like EBAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Interacts with SMARCC1/BAF155 (By similarity).2 PublicationsBy similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
220298, 19 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1261 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1262 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant

Database of interacting proteins

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DIPi
DIP-58952N

Protein interaction database and analysis system

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IntActi
A2BH40, 22 interactors

Molecular INTeraction database

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MINTi
A2BH40

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000101517

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A2BH40

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2BH40

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1018 – 1109ARIDPROSITE-ProRule annotationAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi296 – 300LXXLL5
Motifi1369 – 1388Nuclear localization signalBy similarityAdd BLAST20
Motifi1710 – 1714LXXLL5
Motifi1965 – 1969LXXLL5
Motifi2083 – 2087LXXLL5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 20Poly-Pro5
Compositional biasi38 – 43Poly-Ala6
Compositional biasi53 – 425Gly-richAdd BLAST373
Compositional biasi331 – 350Ala-richAdd BLAST20
Compositional biasi405 – 612Gln-richAdd BLAST208
Compositional biasi999 – 1002Poly-Ser4
Compositional biasi1328 – 1500Gln-richAdd BLAST173
Compositional biasi1545 – 1644Pro-richAdd BLAST100
Compositional biasi1761 – 1766Poly-Glu6
Compositional biasi1773 – 1778Poly-Glu6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2510 Eukaryota
ENOG410Y034 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155194

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232161

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG058196

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2BH40

KEGG Orthology (KO)

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KOi
K11653

Identification of Orthologs from Complete Genome Data

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OMAi
MAFSGKD

Database for complete collections of gene phylogenies

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PhylomeDBi
A2BH40

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.60, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
IPR030094 BAF250a

The PANTHER Classification System

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PANTHERi
PTHR12656 PTHR12656, 1 hit
PTHR12656:SF12 PTHR12656:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2BH40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQVAPAAA SSLGNPPPPP SELKKAEQQQ REEAGGEAAA AAAERGEMKA
60 70 80 90 100
AAGQESEGPA VGPPQPLGKE LQDGAESNGG GGGGGAGSGG GPGAEPDLKN
110 120 130 140 150
SNGNAGPRPA LNNNLPEPPG GGGGGGSSSS DGVGAPPHSA AAALPPPAYG
160 170 180 190 200
FGQAYGRSPS AVAAAAAAVF HQQHGGQQSP GLAALQSGGG GGLEPYAGPQ
210 220 230 240 250
QNSHDHGFPN HQYNSYYPNR SAYPPPPQAY ALSSPRGGTP GSGAAAAAGS
260 270 280 290 300
KPPPSSSASA SSSSSSFAQQ RFGAMGGGGP SAAGGGTPQP TATPTLNQLL
310 320 330 340 350
TSPSSARGYQ GYPGGDYGGG PQDGGAGKGP ADMASQCWGA AAAAAAAAAA
360 370 380 390 400
VSGGAQQRSH HAPMSPGSSG GGGQPLARTP QSSSPMDQMG KMRPQPYGGT
410 420 430 440 450
NPYSQQQGPP SGPQQGHGYP GQPYGSQTPQ RYPMTMQGRA QSAMGSLSYA
460 470 480 490 500
QQIPPYGQQG PSAYGQQGQT PYYNQQSPHP QQQPPYAQQP PSQTPHAQPS
510 520 530 540 550
YQQQPQTQQP QLQSSQPPYS QQPSQPPHQQ SPTPYPSQQS TTQQHPQSQP
560 570 580 590 600
PYSQPQAQSP YQQQQPQQPA SSSLSQQAAY PQPQPQQSQQ TAYSQQRFPP
610 620 630 640 650
PQELSQDSFG SQASSAPSMT SSKGGQEDMN LSLQSRPSSL PDLSGSIDDL
660 670 680 690 700
PMGTEGALSP GVSTSGISSS QGEQSNPAQS PFSPHTSPHL PGIRGPSPSP
710 720 730 740 750
VGSPASVAQS RSGPLSPAAV PGNQMPPRPP SGQSDSIMHP SMNQSSIAQD
760 770 780 790 800
RGYMQRNPQM PQYTSPQPGS ALSPRQPSGG QMHSGVGSYQ QNSMGSYGPQ
810 820 830 840 850
GSQYGPQGGY PRQPNYNALP NANYPNAGMA GSMNPMGAGG QMHGQPGIPP
860 870 880 890 900
YGTLPPGRMA HASMGNRPYG PNMANMPPQV GSGMCPPPGG MNRKTQESAV
910 920 930 940 950
AMHVAANSIQ NRPPGYPNMN QGGMMGTGPP YGQGINSMAG MINPQGPPYP
960 970 980 990 1000
MGGTMANNSA GMAASPEMMG LGDVKLTPAT KMNNKADGTP KTESKSKKSS
1010 1020 1030 1040 1050
SSTTTNEKIT KLYELGGEPE RKMWVDRYLA FTEEKAMGMT NLPAVGRKPL
1060 1070 1080 1090 1100
DLYRLYVSVK EIGGLTQVNK NKKWRELATN LNVGTSSSAA SSLKKQYIQC
1110 1120 1130 1140 1150
LYAFECKIER GEDPPPDIFA AADSKKSQPK IQPPSPAGSG SMQGPQTPQS
1160 1170 1180 1190 1200
TSSSMAEGGD LKPPTPASTP HSQIPPLPGM SRSNSVGIQD AFPDGSDPTF
1210 1220 1230 1240 1250
QKRNSMTPNP GYQPSMNTSD MMGRMSYEPN KDPYGSMRKA PGSDPFMSSG
1260 1270 1280 1290 1300
QGPNGGMGDP YSRAAGPGLG SVAMGPRQHY PYGGPYDRVR TEPGIGPEGN
1310 1320 1330 1340 1350
MGTGAPQPNL MPSTPDSGMY SPSRYPPQQQ QQQQQQHDSY GNQFSTQGTP
1360 1370 1380 1390 1400
SSSPFPSQQT TMYQQQQQNY KRPMDGTYGP PAKRHEGEMY SVPYSAGQGQ
1410 1420 1430 1440 1450
PQQQQLPAAQ SQPASQPQAA QPSPQQDVYN QYSNAYPASA TAATDRRPAG
1460 1470 1480 1490 1500
GPQNQFPFQF GRDRVSAPPG SSAQQNMPPQ MMGGPIQASA EVAQQGTMWQ
1510 1520 1530 1540 1550
GRNDMTYNYA NRQNTGSATQ GPAYHGVNRT DEMLHTDQRA NHEGPWPSHG
1560 1570 1580 1590 1600
TRQPPYGPSA PVPPMTRPPP SNYQPPPSMP NHIPQVSSPA PLPRPMENRT
1610 1620 1630 1640 1650
SPSKSPFLHS GMKMQKAGPP VPASHIAPTP VQPPMIRRDI TFPPGSVEAT
1660 1670 1680 1690 1700
QPVLKQRRRL TMKDIGTPEA WRVMMSLKSG LLAESTWALD TINILLYDDN
1710 1720 1730 1740 1750
SIMTFNLSQL PGLLELLVEY FRRCLIEIFG ILKEYEVGDP GQRTLLDPGR
1760 1770 1780 1790 1800
FTKVYSPAHT EEEEEEHLDP KLEEEEEEGV GNDEEMAFLG KDKPSSENNE
1810 1820 1830 1840 1850
EKLVSKFDKL PVKIVQRNDP FVVDCSDKLG RVQEFDSGLL HWRIGGGDTT
1860 1870 1880 1890 1900
EHIQTHFESK IELLPSRPYV PCPTPPRKHL TTVEGTPGTT EQEGPPPDGL
1910 1920 1930 1940 1950
PEKRITATMD DMLSTRSSTL TDEGAKSAEA TKESSKFPFG ISPAQSHRNI
1960 1970 1980 1990 2000
KILEDEPHSK DETPLCTLLD WQDSLAKRCV CVSNTIRSLS FVPGNDFEMS
2010 2020 2030 2040 2050
KHPGLLLILG KLILLHHKHP ERKQAPLTYE KEEEQDQGVS CDKVEWWWDC
2060 2070 2080 2090 2100
LEMLRENTLV TLANISGQLD LSPYPESICL PVLDGLLHWA VCPSAEAQDP
2110 2120 2130 2140 2150
FSTLGPNAVL SPQRLVLETL SKLSIQDNNV DLILATPPFS RLEKLYSTMV
2160 2170 2180 2190 2200
RFLSDRKNPV CREMAVVLLA NLAQGDSLAA RAIAVQKGSI GNLLGFLEDS
2210 2220 2230 2240 2250
LAATQFQQSQ ASLLHMQNPP FEPTSVDMMR RAARALLALA KVDENHSEFT
2260 2270 2280
LYESRLLDIS VSPLMNSLVS QVICDVLFLI GQS
Length:2,283
Mass (Da):242,092
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F14BB1372CC4268
GO
Isoform 2 (identifier: A2BH40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-385: Missing.
     1336-1336: Q → QQQQQR

Show »
Length:1,903
Mass (Da):206,488
Checksum:i0080AA3C078CE09C
GO
Isoform 3 (identifier: A2BH40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1367-1583: Missing.

Show »
Length:2,066
Mass (Da):218,477
Checksum:i4532D4C3766E31D5
GO
Isoform 4 (identifier: A2BH40-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-385: Missing.
     1181-1181: Missing.
     1336-1336: Q → QQQQQR

Show »
Length:1,902
Mass (Da):206,400
Checksum:i2CEFFA889AE68DC2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAQ7E9QAQ7_MOUSE
AT-rich interactive domain-containi...
Arid1a
2,287Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q495E9Q495_MOUSE
AT-rich interactive domain-containi...
Arid1a
140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti697S → F in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti750D → E in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti758P → S in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti833M → I in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1011K → Q in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1148P → H in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1181 – 1182SR → G in AAK54504 (PubMed:11318604).Curated2
Sequence conflicti1635M → I in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1755Y → S in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1795S → P in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1799N → S in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1929E → D in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1956E → D in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti1974S → P in AAK54504 (PubMed:11318604).Curated1
Sequence conflicti2233A → P in AAK54504 (PubMed:11318604).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0387371 – 385Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST385
Alternative sequenceiVSP_0387381181Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_0387391336Q → QQQQQR in isoform 2 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0387401367 – 1583Missing in isoform 3. CuratedAdd BLAST217

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF268912 mRNA Translation: AAK54504.1
CR751606, BX537327, CR925752 Genomic DNA Translation: CAM20580.1
BX537327, CR751606, CR925752 Genomic DNA Translation: CAM25151.1
CR925752, BX537327, CR751606 Genomic DNA Translation: CAM27607.1
BC082554 mRNA Translation: AAH82554.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38908.1 [A2BH40-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074288.1, NM_001080819.1 [A2BH40-1]
XP_006539390.1, XM_006539327.3 [A2BH40-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.22478

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000008024; ENSMUSP00000008024; ENSMUSG00000007880 [A2BH40-4]
ENSMUST00000105897; ENSMUSP00000101517; ENSMUSG00000007880 [A2BH40-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
93760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:93760

UCSC genome browser

More...
UCSCi
uc008vdh.1 mouse [A2BH40-1]
uc008vdj.1 mouse [A2BH40-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268912 mRNA Translation: AAK54504.1
CR751606, BX537327, CR925752 Genomic DNA Translation: CAM20580.1
BX537327, CR751606, CR925752 Genomic DNA Translation: CAM25151.1
CR925752, BX537327, CR751606 Genomic DNA Translation: CAM27607.1
BC082554 mRNA Translation: AAH82554.1
CCDSiCCDS38908.1 [A2BH40-1]
RefSeqiNP_001074288.1, NM_001080819.1 [A2BH40-1]
XP_006539390.1, XM_006539327.3 [A2BH40-2]
UniGeneiMm.22478

3D structure databases

ProteinModelPortaliA2BH40
SMRiA2BH40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220298, 19 interactors
ComplexPortaliCPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1261 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1262 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
DIPiDIP-58952N
IntActiA2BH40, 22 interactors
MINTiA2BH40
STRINGi10090.ENSMUSP00000101517

PTM databases

iPTMnetiA2BH40
PhosphoSitePlusiA2BH40

Proteomic databases

EPDiA2BH40
MaxQBiA2BH40
PaxDbiA2BH40
PeptideAtlasiA2BH40
PRIDEiA2BH40

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008024; ENSMUSP00000008024; ENSMUSG00000007880 [A2BH40-4]
ENSMUST00000105897; ENSMUSP00000101517; ENSMUSG00000007880 [A2BH40-1]
GeneIDi93760
KEGGimmu:93760
UCSCiuc008vdh.1 mouse [A2BH40-1]
uc008vdj.1 mouse [A2BH40-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8289
MGIiMGI:1935147 Arid1a

Phylogenomic databases

eggNOGiKOG2510 Eukaryota
ENOG410Y034 LUCA
GeneTreeiENSGT00940000155194
HOGENOMiHOG000232161
HOVERGENiHBG058196
InParanoidiA2BH40
KOiK11653
OMAiMAFSGKD
PhylomeDBiA2BH40

Enzyme and pathway databases

ReactomeiR-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Arid1a mouse

Protein Ontology

More...
PROi
PR:A2BH40

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000007880 Expressed in 326 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiA2BH40 baseline and differential
GenevisibleiA2BH40 MM

Family and domain databases

Gene3Di1.10.150.60, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
IPR030094 BAF250a
PANTHERiPTHR12656 PTHR12656, 1 hit
PTHR12656:SF12 PTHR12656:SF12, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI1A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BH40
Secondary accession number(s): Q640Q1, Q925Q1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 20, 2007
Last modified: December 5, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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