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Entry version 104 (13 Feb 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b

Gene

grin2bb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • NMDA glutamate receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-3928662 EPHB-mediated forward signaling
R-DRE-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-8849932 Synaptic adhesion-like molecules

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:grin2bbImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-061207-27 grin2bb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei637 – 659HelicalSequence analysisAdd BLAST23
Transmembranei709 – 731HelicalSequence analysisAdd BLAST23
Transmembranei900 – 923HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2BH14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000030376 Expressed in 11 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000113415

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2BH14

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini510 – 878PBPeInterPro annotationAdd BLAST369
Domaini528 – 582Lig_chan-Glu_bdInterPro annotationAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1053 Eukaryota
ENOG410XNUR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155964

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113802

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052635

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2BH14

KEGG Orthology (KO)

More...
KOi
K05210

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKWERGS

Database of Orthologous Groups

More...
OrthoDBi
188544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2BH14

TreeFam database of animal gene trees

More...
TreeFami
TF314731

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR018884 NMDAR2_C
IPR028082 Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PF10565 NMDAR2_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00177 NMDARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2BH14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVGLAMFKG LYLHSSAMLV SLHLSSSPFS DCRVLSFVSL VSSFKLPLYI
60 70 80 90 100
SLLLLSLFFF PTCESRRGGG IGTPTGGMNS QSIISPPHYP PPGVSPVGPP
110 120 130 140 150
MSPKFAQGLS IAVILVGNSS EVSLSEGLEK EDFLHVPLPP KVELVTMNET
160 170 180 190 200
DPKSIINRIC ALMSRNWLQG VVFGDDTDQE AIAQILDFIS AQTHIPILGI
210 220 230 240 250
RGGSSMIMAA KDDHSMFFQF GPSIEQQASV MLNIMEEYDW YIFSIVTTYY
260 270 280 290 300
PGHQDFVNRI RSTVDNSFVG WELEEVLLLD MSVDDGDSKI QNQMKKLQSP
310 320 330 340 350
VILLYCTKEE ATTIFEVAHS VGLTGYGYTW IVPSLVAGDT DNVPNVFPTG
360 370 380 390 400
LISVSYDEWD YGLEARVRDA VAIIAMATST MMLDRGPHTL LKSGCHGAPD
410 420 430 440 450
KKGSKSGNPN EVLRYLMNVT FEGRNLSFSE DGFQMHPKLV IILLNKERQY
460 470 480 490 500
ERVGKWENGS LAMKYHVWPR FELYSDAEER EDDHLSIVTL EEAPFVIVED
510 520 530 540 550
VDPLSGTCMR NTVPCRKQLK LQNLTGDSGI YIKRCCKGFC IDILKKIAKS
560 570 580 590 600
VKFTYDLYLV TNGKHGKKIN GTWNGMVGEV VLKNAHMAVG SLTINEERSE
610 620 630 640 650
VIDFSVPFIE TGISVMVSRS NGTVSPSAFL EPFSADVWVM MFVMLLIVSA
660 670 680 690 700
VAVFVFEYFS PVGYNRCLAD GREPGGPSFT IGKAIWLLWG LVFNNSVPVQ
710 720 730 740 750
NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEYVD QVTGLSDKKF
760 770 780 790 800
QHPNDFSPPF RFGTVPNGST ERNIRNNYKE MHSYMTSFHQ KNVNEALHSL
810 820 830 840 850
KSGKLDAFIY DAAVLNYMAG RDEGCKLVTI GSGYIFATTG YGIAIQKDSG
860 870 880 890 900
WKRAVDLAIL QLFGDGEMEE LEALWLTGIC HNEKNEVMSS QLDVDNMAGV
910 920 930 940 950
FYMLGAAMAL SLITFIAEHL FYWQLRFCFM GVCSGKPGMT FSISRGIYSC
960 970 980 990 1000
IHGVQIEENK SALNSPSATM KMNMNNTHSN ILRLLRTAKN MTSVPGVNGS
1010 1020 1030 1040 1050
PHSALDYSHR ESAVYDISEH RRSLAGHSDC KPPPYLPEDN MFSDYVSEVE
1060 1070 1080 1090 1100
RTFGNLHLKD SNLYQDHYLH HHGGSELALG MSGPLPNRPR SLGSASSLEG
1110 1120 1130 1140 1150
GYDCDSLGGG VAPIFTTQPR QSLTHRNREK FDLIAGHPTQ SSFKSGLPDL
1160 1170 1180 1190 1200
YGKFSFKGGA SSSGFIAGHD RYCGGGGVGS GGDDGNIRSD VSDISTHTVT
1210 1220 1230 1240 1250
YGNLEGHSKR RKQYRDSLKK RPASAKSRRE QDEIELGFRR RPHHTIHHHH
1260 1270 1280 1290 1300
HHHPATQAHR SATPPVERKS QRGGNCTSYL FRDKENLRDF YVDQFRAKEG
1310 1320 1330 1340 1350
ASPWDLDLSD APGMGGGVGL GGGSCGGVVS SGGAGGACTS LVPMEDFLKG
1360 1370 1380 1390 1400
KSKKTECKGG MGGGSPGQQG HACWEKGIGG VGGLAGGDWE CRSCHSGGVG
1410 1420 1430 1440 1450
SGGSKPVCMH GGGGAGGYPA AGGVGGSSGG SGQISSRPSS ATCKRCDSCK
1460 1470 1480 1490 1500
KPGNLYDISE DNLLLDQIAG KHPLESGKGG GGTGAQTQVQ RRKFGPGGKV
1510 1520 1530 1540 1550
LRRQHSYDTF VELQKEGAGR MGGFGGGGGA SMLPPPRSVS LKDKDRYMEG
1560 1570 1580 1590 1600
ASPYAQMFEQ YAGGERETSY FGDRGKGGGS SFSLFRGGEG GLHRRSVGER
1610 1620 1630 1640 1650
DMRDRDRGMM GGGVGGTRGV GTYSLSKSLY PDKVNQNPFI PTFGDDQCLL
1660 1670 1680 1690 1700
HGAKSYYIKK QQAQPQQQQT PQQQQQQLLN NSRADFRGSM GVTSYLPASA
1710 1720 1730 1740 1750
TSGVLSNVAP RFPKELCLGG PLGNHHGGGP SNNKLLSARD GLGMGQGQRP
1760 1770
FNGSSNGHVY EKLSSIESDV
Length:1,770
Mass (Da):192,129
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE7F857CB0FD0D9E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX537268 Genomic DNA No translation available.
BX901927 Genomic DNA No translation available.
BX901961 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001121809.1, NM_001128337.2
XP_017210497.1, XM_017355008.1
XP_017210500.1, XM_017355011.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000143664; ENSDARP00000113415; ENSDARG00000030376

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
559976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:559976

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537268 Genomic DNA No translation available.
BX901927 Genomic DNA No translation available.
BX901961 Genomic DNA No translation available.
RefSeqiNP_001121809.1, NM_001128337.2
XP_017210497.1, XM_017355008.1
XP_017210500.1, XM_017355011.1

3D structure databases

ProteinModelPortaliA2BH14
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000113415

Proteomic databases

PaxDbiA2BH14

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000143664; ENSDARP00000113415; ENSDARG00000030376
GeneIDi559976
KEGGidre:559976

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
559976
ZFINiZDB-GENE-061207-27 grin2bb

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00940000155964
HOGENOMiHOG000113802
HOVERGENiHBG052635
InParanoidiA2BH14
KOiK05210
OMAiGKWERGS
OrthoDBi188544at2759
PhylomeDBiA2BH14
TreeFamiTF314731

Enzyme and pathway databases

ReactomeiR-DRE-3928662 EPHB-mediated forward signaling
R-DRE-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-8849932 Synaptic adhesion-like molecules

Gene expression databases

BgeeiENSDARG00000030376 Expressed in 11 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR018884 NMDAR2_C
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PF10565 NMDAR2_C, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2BH14_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BH14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: February 13, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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