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Entry version 110 (16 Jan 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

FAT atypical cadherin 1a

Gene

fat1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • pronephros development Source: ZFIN

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FAT atypical cadherin 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fat1aImported
Synonyms:fat1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050425-1 fat1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4188 – 4208HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500264272121 – 4611Sequence analysisAdd BLAST4591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3805 ↔ 3822PROSITE-ProRule annotation
Disulfide bondi4044 ↔ 4053PROSITE-ProRule annotation
Disulfide bondi4082 ↔ 4091PROSITE-ProRule annotation
Disulfide bondi4119 ↔ 4128PROSITE-ProRule annotation
Disulfide bondi4157 ↔ 4166PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2BGT8

PeptideAtlas

More...
PeptideAtlasi
A2BGT8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000017591 Expressed in 54 organ(s), highest expression level in tail bud paraxial mesoderm

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000112805

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2BGT8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3796 – 3833EGF-likeInterPro annotationAdd BLAST38
Domaini3835 – 4012LAM_G_DOMAINInterPro annotationAdd BLAST178
Domaini4017 – 4054EGF-likeInterPro annotationAdd BLAST38
Domaini4056 – 4092EGF-likeInterPro annotationAdd BLAST37
Domaini4093 – 4129EGF-likeInterPro annotationAdd BLAST37
Domaini4131 – 4167EGF-likeInterPro annotationAdd BLAST37

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157733

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046499

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005641

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2BGT8

KEGG Orthology (KO)

More...
KOi
K16506

Database of Orthologous Groups

More...
OrthoDBi
12779at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 29 hits
PF00008 EGF, 2 hits
PF07645 EGF_CA, 1 hit
PF02210 Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 34 hits
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00282 LamG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 34 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 14 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 1 hit
PS50025 LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2BGT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQNHMTSLLV VLLLLCGCTA NQSQDNAPIP LFTQSVYNAT IYENSAAKTY
60 70 80 90 100
VESPVKMGIY ITDPTWEIRY KIVSGDNENL FKAEDYHLGD FSFLRIRTKG
110 120 130 140 150
GSSAILNREV RDHYILTVKA MEKNSNAEAR TRVRIQVLDT NDLRPLFSPT
160 170 180 190 200
AYSISLPENT AIRTSVAKVM ATDADIGTNG EYYYSFREWT DMFSVHPTSG
210 220 230 240 250
VVTLTGKLDY SETKQYELEI LAVDRGMKLY GSSGFSSMAK LTVRVDQANE
260 270 280 290 300
HAPVITAVTL AASETDKDPT YAVVTVEDND QGANGEIASL SVVAGDPLQQ
310 320 330 340 350
FKAMRTSPGS KEYQIKAVKQ VDWDSQPFGY NLTLQAKDKG NPPQFSSAKV
360 370 380 390 400
IHVMSPHFKV GPPKFIQAIY RVNVSEFAPL HTPVVMVTAV PKYPQLKYAF
410 420 430 440 450
RHRLDKNHFA INPDSGLITT AAPLHADSVN KYELEVVTSD KKAVTKVIID
460 470 480 490 500
VIDVNNNGPE FKQTSYKASL DENMPTGTSV LTVKATDLDS GENGYVTYSI
510 520 530 540 550
ANVNSQPFVI DYFSGVISSS ETLDYELMPR IYTLKVRASD WGSPYRREVE
560 570 580 590 600
TQVTIMLNNL NDNKPLFENV DCDATVPRDH GVGDQITTVS AIDADELQLV
610 620 630 640 650
RYRIKAGNDL NVFEMNPSSG VLSLKQTLSE GEAAKVSYHS LQIIASDGEH
660 670 680 690 700
ETQPMFLNIT VVTAHKPVQV KCVDTGVASM LAEKLLQGSK VHTQSEPEDH
710 720 730 740 750
FQDFHSVNRV APQFADTFPS VIEVKEDLPV GARIVHLSAS DSDSGFNGKL
760 770 780 790 800
VYVISGGDAE SRFIIDMDSG WLKVFAPLDR ETTDHYTLNI TVYDLGIPQK
810 820 830 840 850
SSSRLLDVKI LDANDNSPQF LKETYSVEIS ESSTVGTEVI QVEAKDKDLG
860 870 880 890 900
DNGVVRYSIL ADTDQFAIDT ETGIVTVKKP LDREVQPVFV LKIAARDQAT
910 920 930 940 950
AEPQLVSTVL LKITLEDVND NPPKFIPPNY HVRVREDLPI GTVIMWLEAH
960 970 980 990 1000
DPDVGPSSQV RYSLIDSGDG KFEVDKLSGA VRIVQNLDYE KKQVYSLTAK
1010 1020 1030 1040 1050
AKDKGKPISL SSSCHIEVEV VDVNENLYRP LFPSFVDKGF IKEDVPIGTS
1060 1070 1080 1090 1100
VMKITAQDED KGRDGEIRYS IRDGSGLGIF TIDEDTGVIR TQELLDHETV
1110 1120 1130 1140 1150
PHYWLTVYAT DRGVVPLSSF VEVYIEVQDV NDNAPQTSEP VYYPSVMESS
1160 1170 1180 1190 1200
PKDVSIIQIE AFDPDTKSSE KLSYKITSGN PQGFFSINQK TGLVTTTSRK
1210 1220 1230 1240 1250
LDREQQDEHI LEITVSDQGV PAKSTTVRVI VKVLDENDNS PQFMEKVYKI
1260 1270 1280 1290 1300
KLPVREKPEK ERALKRDPVY RVIASDKDEG PNAEISYSIE EGDEQGKFFI
1310 1320 1330 1340 1350
EPKTGMVYSK KLSSAVDYDI LTIKAVDNGR PQKSATCRLH IEWIPKPEPS
1360 1370 1380 1390 1400
TVPLVFDEPF YTFSVMESDT VSHMLGVISL EPVDTPVWFE ITGGNSDSRF
1410 1420 1430 1440 1450
EVGKASGTMI VAQALDAEQK SHYNLTVNAT DGTRSVSTQV LIKVIDTNNH
1460 1470 1480 1490 1500
RPQFSKPKYE VDVSEDTPPE TEVLRITATD QDEKNKLTYT LLSSTDPFSL
1510 1520 1530 1540 1550
RKFRLDPGTG VLYTAERLDH ETMHQHTLTV MVRDQDIPVK RNLVRVIVNV
1560 1570 1580 1590 1600
QDTNDNAPWF SGAPYVGRVF ESAATGSAVL QVSALDKDKG QNAEIIYSIE
1610 1620 1630 1640 1650
SGNVANSFAI DPVLGTITVA KELDRNNKNR FELTVKASDK GTPPLSGTAA
1660 1670 1680 1690 1700
VDITVTISDN AIPKFAEKEF SAEVSETVLP GAFVSLVTAN SQSSVFYQIK
1710 1720 1730 1740 1750
DGNVNGAFDI NPNSGVVVTH SVLDYETIPS YKLTIQGTNM AGLASNTTLL
1760 1770 1780 1790 1800
IHLKDENDNA PVFIQDQFAG MVSESSPVNS VVLTKDNTPL VIRALDTDRD
1810 1820 1830 1840 1850
ANSRLVYQIV EPFAHNYFAI DSSTGAIRTI SELDYEQRSV FRFSVQVHDM
1860 1870 1880 1890 1900
GIPRHFAEKA ANVTIEILDV NDCPPQFSQD LYETTVLVPT YKGVEVITVN
1910 1920 1930 1940 1950
ASDADSGPNS RLFYSIVEGN IGEKFKMDPV TGVITIQNVT QLRSRYELRV
1960 1970 1980 1990 2000
RVSDGRFSKT SLVKINVREN KESTLRFTQE SYKAFVPENS SEKKTLAVIA
2010 2020 2030 2040 2050
AVGNQVNEPL FYTILNPDKR FTISRTSGVL SSTGTPFDRE EQGVFDIVVE
2060 2070 2080 2090 2100
VTRDDKSPDV AHVLVTVIIE DVNDNPPVFV NLPYQALVQV DADVDHIITK
2110 2120 2130 2140 2150
VTAVDADINE NAEINYHLQE LNEFVQISTD GEISLTKKLD KDSVNTEFII
2160 2170 2180 2190 2200
TVVARDGGEP ALSSSVEVPI LVVNKAMPVF EKAFYSLEIP ENIQLLTPIV
2210 2220 2230 2240 2250
HIQANDSEGP RIVYTITEGD PLNQFTINFN TGVIQVVKTL DFETHPAYKL
2260 2270 2280 2290 2300
SVRATDSLTG AKAEVFVDII LEDVNDNPPV FHTKLYNASL SEASVIGTSV
2310 2320 2330 2340 2350
LEVSATDADT GNNKVLFYQI VEDKDKSFDY FSIDRDTGTI WTTRMLDHEE
2360 2370 2380 2390 2400
KPSHRLLIRA VDGGVPALSS EVMVLIDVMD LNDNTPVFSQ NVYEATVSEL
2410 2420 2430 2440 2450
APRGHFVTQV QASDADISDS GKLEFSILSG NEGQNFAMDP NTGALVISNH
2460 2470 2480 2490 2500
RKPHMESLYN INVSVSDGVF RSSAIVKVNV ISANFHNPTF NQVDYVVELL
2510 2520 2530 2540 2550
ENSPVGTLVA EAQATDDDSG TYGRLTYHIV NDIAKDKFSI SENGEIFTLE
2560 2570 2580 2590 2600
SLDRENALEK VIPISLIAKD GGGKVGFCTV NVILTDINDN APQFRAADYR
2610 2620 2630 2640 2650
VNVASDVSRG TTILKIAASD MDEGSNADIT YSIETDADNV EENFEIHQFS
2660 2670 2680 2690 2700
GVIVTKESLI GLENQMYTFL VRAKDGGNPT KSSVVPVYVK ILAPEVPVPK
2710 2720 2730 2740 2750
FIESHYRFAI EEDLSLGSEI DVIQAESDQP VFYSLVKGNT PESNQDEVFV
2760 2770 2780 2790 2800
VDPSSGSLKL DKKLDHESTK WYQLTLQAQS EYEGSKVVSA VDISIQVKDV
2810 2820 2830 2840 2850
NDNRPLFESN PYEAFVVENL PGGTSVIQVK ATDLDSGTNG HVVYNLDPNQ
2860 2870 2880 2890 2900
ETRDIVELFA INSESGWITT LKELDRETRN KYTVSVLATD RGDKVQLMAS
2910 2920 2930 2940 2950
TRVDVTVVDV NDNPPKFTAE IYKGTVSEDD PPGGVIAILS TTDLDTEENN
2960 2970 2980 2990 3000
KQISYFITGG DPLGQFAIEH TQGEWKVSVR KPLDREEKDN YLLNITATDG
3010 3020 3030 3040 3050
TFTAKAVVEV KVLDANDNSP ICEKSFYMES VPEDSPAGRL ILQVSATDAD
3060 3070 3080 3090 3100
IRSNAQISYE LLGPGSEHFS IDSETGELKT LLPLDREEEE VHKMKVRALD
3110 3120 3130 3140 3150
GGGRFCEAEV EITVEDVNDN PPQFTTDPYT FTVFENTEIN TPVARLYASD
3160 3170 3180 3190 3200
LDTGANAEIL YSLLDSADGV FSIEEETGVV RLDRPLDREL QSLYTLRAQA
3210 3220 3230 3240 3250
TDRGSPRHLS SHTTVSVSIL DINDNPPVFE RREYTATVAE DIPVGTQVLR
3260 3270 3280 3290 3300
IHAASRDTEA GTEITYAIIN GNERGAFRVD PQTGGVFVIE PLDYETAHEF
3310 3320 3330 3340 3350
YLTVEATDGG TPSLSDLATV NINLTDVNDN SPVFNQDIYS AVISEDAELG
3360 3370 3380 3390 3400
KTVLTVMADD ADGPSSNQVR FSIIDGNQGS PFTIDPVRGE VKVARLLDRE
3410 3420 3430 3440 3450
KTSGYTLTVL ASDNGSPARS SSATINVDVS DINDNPPIFS QANYSIIIQE
3460 3470 3480 3490 3500
NQPIGASVLQ LTVSDRDASH NGPPFTFSII RGNEGDFFRI TPQGVLVSAA
3510 3520 3530 3540 3550
TLSRQTQEFY LLQAQVTDSG RPPLVSTAFV SVRLIEESIY PPSILPLDIF
3560 3570 3580 3590 3600
ITTATDEYSG GVLGKIHATD QDVYDTLTYS LAPDSSSTSE NSGLFSVSPA
3610 3620 3630 3640 3650
DGKLVARGNL DAGQYVLNIT VTDGRFTAAA RVNIHVRQAT AQALDNSIAV
3660 3670 3680 3690 3700
RFSAIAPEEF IGDYWRNFLR ALRNIAGVRR GDVQLVSLQP AADASGDLEV
3710 3720 3730 3740 3750
LLALERSGSP FQPQEVLYRK LNASVGVIEE MTGVRIVRVM KKLCAGLDCP
3760 3770 3780 3790 3800
LSFCQETIAL ETGAVSAYST ARISFVTPRH MRTAKCLCEG AECSILSKLC
3810 3820 3830 3840 3850
EGSPCPDGME CVEDPTHSKY RCICPEGKQE ECSERQSLTF SGNGYARYRL
3860 3870 3880 3890 3900
MENENKEEMK LSLRLRTFST HATVMYAKGT DYSILEIVNG RLQYKFDCGS
3910 3920 3930 3940 3950
GPGVVSVHST QVSDGQWHTV SLEVDGNYAR LVLDQVHAAS GTAPGTLRTL
3960 3970 3980 3990 4000
NLDTSMYFGG HVRPASGSGR LVMNGLRGCL EGIVFNGREL PLSQVRGAHS
4010 4020 4030 4040 4050
VLEELVEAAP GCSLAPPIQG CTSNPCTNGG TCLALPNGGY FCKCTAAFMG
4060 4070 4080 4090 4100
THCEVTISPC ASNPCLYGGT CIPRGGDFYC QCRGQYSGQR CQLGPYCTDN
4110 4120 4130 4140 4150
PCKNSGKCID SLDGPVCECE PGFQGERCLS DVDECLKNPC GNGGHCQNTY
4160 4170 4180 4190 4200
GSFSCNCSNG YSGQHCELRS EIRNEFVSTS WNIGLEEVIG IVVFVASIFF
4210 4220 4230 4240 4250
LVLLFVVVRK RICRRSKSKS DDDDKIGIST GTQNSFLHRP YFDAKLNRNI
4260 4270 4280 4290 4300
YSDIPPQVPV RPISYTPSIP SDSRNNLDRN SFEGSAIPEH PEFSTFNPDS
4310 4320 4330 4340 4350
VHGHRKTVAV CSVAPNLPPP PPSNSVSDSD SIQKPSWDYD YDAKVVDLDS
4360 4370 4380 4390 4400
CLSKKPVEDS ACHPYNTRGS MSEVHSLSSF QSESCDDNGY HWDTSDWMPS
4410 4420 4430 4440 4450
VQLPGIQEFP QYEVVEAPPT LYSDPALLDT DYYPGGYDIE SDFPPPPDDF
4460 4470 4480 4490 4500
PSHDDLPPPP PVPEYGDRYD TLQPASRGLN STPSSPGGSS IRHRPPLPQL
4510 4520 4530 4540 4550
YSLTQFLPHH HYSSDPEPQT NPTSTSTSSS TEGYRHGGFS LGYRRDFDPP
4560 4570 4580 4590 4600
AADNMSLSLY TSTASCSDMS ACCEESEVMM SDYESGGEEG AQFQRLIIPP
4610
LDSQHQQHTE V
Length:4,611
Mass (Da):506,720
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B36C5FD08DB4FA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QCG2E9QCG2_DANRE
FAT atypical cadherin 1a
fat1a fat1
4,614Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IRC6A0A0R4IRC6_DANRE
FAT atypical cadherin 1a
fat1a
4,608Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX511093 Genomic DNA No translation available.
BX537280 Genomic DNA No translation available.
BX908758 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_998132.2, NM_212967.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dr.87471

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSDART00000145068; ENSDARP00000112805; ENSDARG00000017591

Database of genes from NCBI RefSeq genomes

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GeneIDi
406172

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dre:406172

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511093 Genomic DNA No translation available.
BX537280 Genomic DNA No translation available.
BX908758 Genomic DNA No translation available.
RefSeqiNP_998132.2, NM_212967.2
UniGeneiDr.87471

3D structure databases

ProteinModelPortaliA2BGT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112805

Proteomic databases

PaxDbiA2BGT8
PeptideAtlasiA2BGT8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000145068; ENSDARP00000112805; ENSDARG00000017591
GeneIDi406172
KEGGidre:406172

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
406172
ZFINiZDB-GENE-050425-1 fat1a

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000157733
HOGENOMiHOG000046499
HOVERGENiHBG005641
InParanoidiA2BGT8
KOiK16506
OrthoDBi12779at2759
TreeFamiTF316403

Gene expression databases

BgeeiENSDARG00000017591 Expressed in 54 organ(s), highest expression level in tail bud paraxial mesoderm

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00028 Cadherin, 29 hits
PF00008 EGF, 2 hits
PF07645 EGF_CA, 1 hit
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 34 hits
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00282 LamG, 1 hit
SUPFAMiSSF49313 SSF49313, 34 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 14 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 1 hit
PS50025 LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2BGT8_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BGT8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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