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Entry version 85 (16 Jan 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Transient receptor potential cation channel, subfamily M, member 3

Gene

trpm3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-3295583 TRP channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transient receptor potential cation channel, subfamily M, member 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpm3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060531-95 trpm3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei888 – 904HelicalSequence analysisAdd BLAST17
Transmembranei951 – 969HelicalSequence analysisAdd BLAST19
Transmembranei981 – 999HelicalSequence analysisAdd BLAST19
Transmembranei1020 – 1040HelicalSequence analysisAdd BLAST21
Transmembranei1098 – 1123HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2BGS8

PeptideAtlas

More...
PeptideAtlasi
A2BGS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000039181 Expressed in 15 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2BGS8 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000123466

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini890 – 1132Ion_transInterPro annotationAdd BLAST243
Domaini1224 – 1278TRPM_tetraInterPro annotationAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1227 – 1247Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3614 Eukaryota
ENOG410XR5B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157366

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055663

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2BGS8

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEREHCM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2BGS8

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1010, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR029583 TRPM3
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF7 PTHR13800:SF7, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2BGS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AQKSWIERAF SKRECVHIIV STKDHHRCCC GRLIGQHVGL PPSISSNQNE
60 70 80 90 100
KSERVPKNDS LSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSY
110 120 130 140 150
DTKPDLLLHL MTKEWQLELP KLLISVHGGL QNFELQPKLK QVFGKGLIKA
160 170 180 190 200
AMTTGAWIFT GGVNTGVIRH VGDALKDHAS KSRGKICTIG IAPWGIVENQ
210 220 230 240 250
EDLVGKDVVR PYQTMSNPLS KLTVLNSLHS HFILADNGTT GKYGAEVKLR
260 270 280 290 300
RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV
310 320 330 340 350
VCDGSGRASD ILAFGHKYSE EGGIINESLR DQLLVTIQKT FTYSRTQAQH
360 370 380 390 400
LFIILMECMK KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL
410 420 430 440 450
ALAWNRVDIA RSQIFIYGQQ WPVGSLEQSM LDALVLDRVD FVKLLIENGV
460 470 480 490 500
SMHRFLTLSR LEELYNTRHG PSNTLYHLVR DVKKGNLPPD YRISLIDIGL
510 520 530 540 550
VIEYLMGGAY RCNYTRKRFR TLYHNLFGPK RPKALKLLGM EDDMPIRRGR
560 570 580 590 600
QKTTRKREEE VDIDLDDPEI NHFPFPFHEL MVWAVLMKRQ KMALFFWQHG
610 620 630 640 650
EEAMAKALVA CKLCKAMAHE ASENDMVDDI SQELNQNSRE FGQLAVELLD
660 670 680 690 700
QSYKQDEQMA MKLLTYELKN WSNATCLQLA VAAKHRDFIA HTCSQMLLTD
710 720 730 740 750
MWMGRLRMRK NSGLKVILGL LLPPSILSLE FKNKDEMSYM PQDQDTYLQE
760 770 780 790 800
KDVDEPEKQA KEKEEEDMEF TVRSYCETQY NSVAMLGNVS SEASRKKQVE
810 820 830 840 850
EVQNRHRLIP LGRKIYEFYN APIVKFWFHT KVHDCHRLIP VGRKIKVQDR
860 870 880 890 900
NLLILVGHKM YEFYNNPFIK FWFCMVNSII YYTKTNCTLA YVGYLMLFNY
910 920 930 940 950
IVLVKMDLWP SPQEWIVIAY IFTNGIEKMR EILMSEPGKL LQKVKVWLQE
960 970 980 990 1000
YWNITDLMAI LIFSIGMVLR LQDPPLMSYG RVIYCVNIIY WYIRLLDIFG
1010 1020 1030 1040 1050
VNKYLGPYVM MIGKMMIDMM YFVIIMLVVL MSFGVARQAI LNPNEDPSWM
1060 1070 1080 1090 1100
LARNIFFMPY WMIYGEVFAD QIDPPCGQNI TTEEGVVMPL PPCKTGAWIV
1110 1120 1130 1140 1150
PAIMACYLLV ANILLVNLLI AVFNNTFFEV KSISNQVWKF QRYQLIMTFH
1160 1170 1180 1190 1200
ERPVLPPPLI IFSHITMVLK HLCCRWRKHD EDERDYGLKL FITEDELKKV
1210 1220 1230 1240 1250
HDFEEQCMEE YFREKDDRFN SSNDERIRVT SERVENMAMR LEEVNEREHF
1260 1270 1280 1290 1300
MKASLQTVDI RLAQMEEMIG RIAVALERVA GMDRGEVNKA RSRTSSDCTD
1310 1320 1330 1340 1350
TNYILRQSSF NSQEGNSYRL QESLEQGGDE SISPTSPTAL APRVRSHSFY
1360 1370 1380 1390 1400
VSHSSKDRSG ADRGEGFFKD KLFSLHRANS SQSVSSGAGP KESKPTPLNT
1410 1420 1430 1440 1450
LSVQQQLRPS SCIDIYVSAS EDVPPTESFL DSVRTVPTLA RDSSLHSEIM
1460 1470 1480 1490 1500
EAVLSGGRDC SGRAGGSERQ SDGTVLFEDS AAADLSLCSA HLLPDSLPPW
1510 1520 1530 1540 1550
DLDPSPPPSA GVLERSKSSR FLSTAGPLFL DEPHLVKSHS LMFTSRGYYG
1560 1570 1580 1590 1600
GMGVQVKAAE YTSITDCIDT RCVSTPYPVP ERSDSPGGSF TFDKPQDLGV
1610 1620 1630 1640 1650
SHPERDAELS HAESDLEEPA EGSGDTCKVG QSSSSGVIGA DLGLGLALGP
1660 1670 1680 1690 1700
FCSPISRLER ANSCSSSEES HSNIYSRKSF SISERMDKGR GSSRNPFQKA
1710 1720 1730
RTGARLEGKT DSLSMRKMAK PSAFRSFDSR HNYT
Length:1,734
Mass (Da):196,524
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA8DF29741504CAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QYX6F1QYX6_DANRE
Transient receptor potential cation...
trpm3
1,583Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1734Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX323080 Genomic DNA No translation available.
BX511001 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000147188; ENSDARP00000123466; ENSDARG00000039181

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323080 Genomic DNA No translation available.
BX511001 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123466

Proteomic databases

PaxDbiA2BGS8
PeptideAtlasiA2BGS8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000147188; ENSDARP00000123466; ENSDARG00000039181

Organism-specific databases

ZFINiZDB-GENE-060531-95 trpm3

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00940000157366
HOVERGENiHBG055663
InParanoidiA2BGS8
OMAiNEREHCM
PhylomeDBiA2BGS8
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-DRE-3295583 TRP channels

Gene expression databases

BgeeiENSDARG00000039181 Expressed in 15 organ(s), highest expression level in brain
ExpressionAtlasiA2BGS8 baseline

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029583 TRPM3
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF7 PTHR13800:SF7, 2 hits
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2BGS8_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BGS8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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