Transient receptor potential cation channel, subfamily M, member 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium activated cation channel activity Source: InterPro

GO - Biological processⁱ

• detection of temperature stimulus Source: InterPro
• protein tetramerization Source: InterPro
• sensory perception of temperature stimulus Source: InterPro

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
AQKSWIERAF SKRECVHIIV STKDHHRCCC GRLIGQHVGL PPSISSNQNE 
        60         70         80         90        100
KSERVPKNDS LSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSY 
       110        120        130        140        150
DTKPDLLLHL MTKEWQLELP KLLISVHGGL QNFELQPKLK QVFGKGLIKA 
       160        170        180        190        200
AMTTGAWIFT GGVNTGVIRH VGDALKDHAS KSRGKICTIG IAPWGIVENQ 
       210        220        230        240        250
EDLVGKDVVR PYQTMSNPLS KLTVLNSLHS HFILADNGTT GKYGAEVKLR 
       260        270        280        290        300
RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 
       310        320        330        340        350
VCDGSGRASD ILAFGHKYSE EGGIINESLR DQLLVTIQKT FTYSRTQAQH 
       360        370        380        390        400
LFIILMECMK KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL 
       410        420        430        440        450
ALAWNRVDIA RSQIFIYGQQ WPVGSLEQSM LDALVLDRVD FVKLLIENGV 
       460        470        480        490        500
SMHRFLTLSR LEELYNTRHG PSNTLYHLVR DVKKGNLPPD YRISLIDIGL 
       510        520        530        540        550
VIEYLMGGAY RCNYTRKRFR TLYHNLFGPK RPKALKLLGM EDDMPIRRGR 
       560        570        580        590        600
QKTTRKREEE VDIDLDDPEI NHFPFPFHEL MVWAVLMKRQ KMALFFWQHG 
       610        620        630        640        650
EEAMAKALVA CKLCKAMAHE ASENDMVDDI SQELNQNSRE FGQLAVELLD 
       660        670        680        690        700
QSYKQDEQMA MKLLTYELKN WSNATCLQLA VAAKHRDFIA HTCSQMLLTD 
       710        720        730        740        750
MWMGRLRMRK NSGLKVILGL LLPPSILSLE FKNKDEMSYM PQDQDTYLQE 
       760        770        780        790        800
KDVDEPEKQA KEKEEEDMEF TVRSYCETQY NSVAMLGNVS SEASRKKQVE 
       810        820        830        840        850
EVQNRHRLIP LGRKIYEFYN APIVKFWFHT KVHDCHRLIP VGRKIKVQDR 
       860        870        880        890        900
NLLILVGHKM YEFYNNPFIK FWFCMVNSII YYTKTNCTLA YVGYLMLFNY 
       910        920        930        940        950
IVLVKMDLWP SPQEWIVIAY IFTNGIEKMR EILMSEPGKL LQKVKVWLQE 
       960        970        980        990       1000
YWNITDLMAI LIFSIGMVLR LQDPPLMSYG RVIYCVNIIY WYIRLLDIFG 
      1010       1020       1030       1040       1050
VNKYLGPYVM MIGKMMIDMM YFVIIMLVVL MSFGVARQAI LNPNEDPSWM 
      1060       1070       1080       1090       1100
LARNIFFMPY WMIYGEVFAD QIDPPCGQNI TTEEGVVMPL PPCKTGAWIV 
      1110       1120       1130       1140       1150
PAIMACYLLV ANILLVNLLI AVFNNTFFEV KSISNQVWKF QRYQLIMTFH 
      1160       1170       1180       1190       1200
ERPVLPPPLI IFSHITMVLK HLCCRWRKHD EDERDYGLKL FITEDELKKV 
      1210       1220       1230       1240       1250
HDFEEQCMEE YFREKDDRFN SSNDERIRVT SERVENMAMR LEEVNEREHF 
      1260       1270       1280       1290       1300
MKASLQTVDI RLAQMEEMIG RIAVALERVA GMDRGEVNKA RSRTSSDCTD 
      1310       1320       1330       1340       1350
TNYILRQSSF NSQEGNSYRL QESLEQGGDE SISPTSPTAL APRVRSHSFY 
      1360       1370       1380       1390       1400
VSHSSKDRSG ADRGEGFFKD KLFSLHRANS SQSVSSGAGP KESKPTPLNT 
      1410       1420       1430       1440       1450
LSVQQQLRPS SCIDIYVSAS EDVPPTESFL DSVRTVPTLA RDSSLHSEIM 
      1460       1470       1480       1490       1500
EAVLSGGRDC SGRAGGSERQ SDGTVLFEDS AAADLSLCSA HLLPDSLPPW 
      1510       1520       1530       1540       1550
DLDPSPPPSA GVLERSKSSR FLSTAGPLFL DEPHLVKSHS LMFTSRGYYG 
      1560       1570       1580       1590       1600
GMGVQVKAAE YTSITDCIDT RCVSTPYPVP ERSDSPGGSF TFDKPQDLGV 
      1610       1620       1630       1640       1650
SHPERDAELS HAESDLEEPA EGSGDTCKVG QSSSSGVIGA DLGLGLALGP 
      1660       1670       1680       1690       1700
FCSPISRLER ANSCSSSEES HSNIYSRKSF SISERMDKGR GSSRNPFQKA 
      1710       1720       1730 
RTGARLEGKT DSLSMRKMAK PSAFRSFDSR HNYT                  

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ