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UniProtKB - A2BGS8 (A2BGS8_DANRE)

Entry version 85 (16 Jan 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Transient receptor potential cation channel, subfamily M, member 3

Gene

trpm3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-3295583 TRP channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transient receptor potential cation channel, subfamily M, member 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpm3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-060531-95 trpm3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei888 – 904HelicalSequence analysisAdd BLAST17
Transmembranei951 – 969HelicalSequence analysisAdd BLAST19
Transmembranei981 – 999HelicalSequence analysisAdd BLAST19
Transmembranei1020 – 1040HelicalSequence analysisAdd BLAST21
Transmembranei1098 – 1123HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2BGS8

PeptideAtlas

More...PeptideAtlasi		A2BGS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000039181 Expressed in 15 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2BGS8 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000123466

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini890 – 1132Ion_transInterPro annotationAdd BLAST243
Domaini1224 – 1278TRPM_tetraInterPro annotationAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1227 – 1247Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3614 Eukaryota
ENOG410XR5B LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157366

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG055663

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2BGS8

Identification of Orthologs from Complete Genome Data

More...OMAi		NEREHCM

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2BGS8

TreeFam database of animal gene trees

More...TreeFami		TF314204

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.1010, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005821 Ion_trans_dom
IPR029583 TRPM3
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf

The PANTHER Classification System

More...PANTHERi		PTHR13800:SF7 PTHR13800:SF7, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2BGS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AQKSWIERAF SKRECVHIIV STKDHHRCCC GRLIGQHVGL PPSISSNQNE 
        60         70         80         90        100
KSERVPKNDS LSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSY 
       110        120        130        140        150
DTKPDLLLHL MTKEWQLELP KLLISVHGGL QNFELQPKLK QVFGKGLIKA 
       160        170        180        190        200
AMTTGAWIFT GGVNTGVIRH VGDALKDHAS KSRGKICTIG IAPWGIVENQ 
       210        220        230        240        250
EDLVGKDVVR PYQTMSNPLS KLTVLNSLHS HFILADNGTT GKYGAEVKLR 
       260        270        280        290        300
RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 
       310        320        330        340        350
VCDGSGRASD ILAFGHKYSE EGGIINESLR DQLLVTIQKT FTYSRTQAQH 
       360        370        380        390        400
LFIILMECMK KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL 
       410        420        430        440        450
ALAWNRVDIA RSQIFIYGQQ WPVGSLEQSM LDALVLDRVD FVKLLIENGV 
       460        470        480        490        500
SMHRFLTLSR LEELYNTRHG PSNTLYHLVR DVKKGNLPPD YRISLIDIGL 
       510        520        530        540        550
VIEYLMGGAY RCNYTRKRFR TLYHNLFGPK RPKALKLLGM EDDMPIRRGR 
       560        570        580        590        600
QKTTRKREEE VDIDLDDPEI NHFPFPFHEL MVWAVLMKRQ KMALFFWQHG 
       610        620        630        640        650
EEAMAKALVA CKLCKAMAHE ASENDMVDDI SQELNQNSRE FGQLAVELLD 
       660        670        680        690        700
QSYKQDEQMA MKLLTYELKN WSNATCLQLA VAAKHRDFIA HTCSQMLLTD 
       710        720        730        740        750
MWMGRLRMRK NSGLKVILGL LLPPSILSLE FKNKDEMSYM PQDQDTYLQE 
       760        770        780        790        800
KDVDEPEKQA KEKEEEDMEF TVRSYCETQY NSVAMLGNVS SEASRKKQVE 
       810        820        830        840        850
EVQNRHRLIP LGRKIYEFYN APIVKFWFHT KVHDCHRLIP VGRKIKVQDR 
       860        870        880        890        900
NLLILVGHKM YEFYNNPFIK FWFCMVNSII YYTKTNCTLA YVGYLMLFNY 
       910        920        930        940        950
IVLVKMDLWP SPQEWIVIAY IFTNGIEKMR EILMSEPGKL LQKVKVWLQE 
       960        970        980        990       1000
YWNITDLMAI LIFSIGMVLR LQDPPLMSYG RVIYCVNIIY WYIRLLDIFG 
      1010       1020       1030       1040       1050
VNKYLGPYVM MIGKMMIDMM YFVIIMLVVL MSFGVARQAI LNPNEDPSWM 
      1060       1070       1080       1090       1100
LARNIFFMPY WMIYGEVFAD QIDPPCGQNI TTEEGVVMPL PPCKTGAWIV 
      1110       1120       1130       1140       1150
PAIMACYLLV ANILLVNLLI AVFNNTFFEV KSISNQVWKF QRYQLIMTFH 
      1160       1170       1180       1190       1200
ERPVLPPPLI IFSHITMVLK HLCCRWRKHD EDERDYGLKL FITEDELKKV 
      1210       1220       1230       1240       1250
HDFEEQCMEE YFREKDDRFN SSNDERIRVT SERVENMAMR LEEVNEREHF 
      1260       1270       1280       1290       1300
MKASLQTVDI RLAQMEEMIG RIAVALERVA GMDRGEVNKA RSRTSSDCTD 
      1310       1320       1330       1340       1350
TNYILRQSSF NSQEGNSYRL QESLEQGGDE SISPTSPTAL APRVRSHSFY 
      1360       1370       1380       1390       1400
VSHSSKDRSG ADRGEGFFKD KLFSLHRANS SQSVSSGAGP KESKPTPLNT 
      1410       1420       1430       1440       1450
LSVQQQLRPS SCIDIYVSAS EDVPPTESFL DSVRTVPTLA RDSSLHSEIM 
      1460       1470       1480       1490       1500
EAVLSGGRDC SGRAGGSERQ SDGTVLFEDS AAADLSLCSA HLLPDSLPPW 
      1510       1520       1530       1540       1550
DLDPSPPPSA GVLERSKSSR FLSTAGPLFL DEPHLVKSHS LMFTSRGYYG 
      1560       1570       1580       1590       1600
GMGVQVKAAE YTSITDCIDT RCVSTPYPVP ERSDSPGGSF TFDKPQDLGV 
      1610       1620       1630       1640       1650
SHPERDAELS HAESDLEEPA EGSGDTCKVG QSSSSGVIGA DLGLGLALGP 
      1660       1670       1680       1690       1700
FCSPISRLER ANSCSSSEES HSNIYSRKSF SISERMDKGR GSSRNPFQKA 
      1710       1720       1730 
RTGARLEGKT DSLSMRKMAK PSAFRSFDSR HNYT
Length:1,734
Mass (Da):196,524
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA8DF29741504CAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QYX6F1QYX6_DANRE
Transient receptor potential cation...
trpm3
1,583Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1734Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX323080 Genomic DNA No translation available.
BX511001 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000147188; ENSDARP00000123466; ENSDARG00000039181

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323080 Genomic DNA No translation available.
BX511001 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123466

Proteomic databases

PaxDbiA2BGS8
PeptideAtlasiA2BGS8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000147188; ENSDARP00000123466; ENSDARG00000039181

Organism-specific databases

ZFINiZDB-GENE-060531-95 trpm3

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00940000157366
HOVERGENiHBG055663
InParanoidiA2BGS8
OMAiNEREHCM
PhylomeDBiA2BGS8
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-DRE-3295583 TRP channels

Gene expression databases

BgeeiENSDARG00000039181 Expressed in 15 organ(s), highest expression level in brain
ExpressionAtlasiA2BGS8 baseline

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029583 TRPM3
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF7 PTHR13800:SF7, 2 hits
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2BGS8_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BGS8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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