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UniProtKB - A2BGQ4 (A2BGQ4_DANRE)
Protein
Submitted name:
MARVEL domain-containing 2b
Gene
marveld2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Biological processi
- cell-cell junction organization Source: InterPro
- sensory perception of sound Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: MARVEL domain-containing 2bImported |
Gene namesi | Name:marveld2bImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-050208-54, marveld2b |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- tight junction ARBA annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-UniRule
- tricellular tight junction Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 201 – 225 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 265 – 289 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 301 – 322 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 353 – 376 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, Tight junctionARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000061651, Expressed in mature ovarian follicle and 26 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 197 – 377 | MARVELInterPro annotationAdd BLAST | 181 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 67 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 105 – 150 | DisorderedSequence analysisAdd BLAST | 46 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 484 – 504 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 537 – 557 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 63 | Pro residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG4796, Eukaryota |
GeneTreei | ENSGT00940000155771 |
HOGENOMi | CLU_039176_1_0_1 |
OMAi | KYPSIHS |
OrthoDBi | 335949at2759 |
PhylomeDBi | A2BGQ4 |
TreeFami | TF326161 |
Family and domain databases
InterProi | View protein in InterPro IPR031176, ELL/occludin IPR008253, Marvel IPR031177, MARVELD2 IPR010844, Occludin_ELL |
PANTHERi | PTHR23288, PTHR23288, 1 hit PTHR23288:SF3, PTHR23288:SF3, 1 hit |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit PF07303, Occludin_ELL, 1 hit |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
i Sequence
Sequence statusi: Complete.
A2BGQ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFGNGSASR FDRVRDMPHY DQVPIGSMPW GQQPPYPLGG GVAASSFESL
60 70 80 90 100
PPPPLPENPP VGPEFYPSDV EDQVDDAMDI KPIRRFIPDS VKNFFRASVN
110 120 130 140 150
RGSKKLTFPL PPPPIDGNTT SQGVPCSPPH SRAPSPTAPS SYLDPYGGSG
160 170 180 190 200
GSYTSRKEQA MLLGEPLESV SGRSLQTAMT YSEKVEEYNQ RYAYMKSWAG
210 220 230 240 250
LLRILGCVEL LLGAAVFACV CAYVHKDNEW FNMYGYSMHQ VYGGASMGGM
260 270 280 290 300
YGGYGSSYSG PLTPFVLVVA GVAWIVTVII LILGITMYYR TILLDSSWWP
310 320 330 340 350
ITECVVNVAL GLLYLAAAIV YVRDTLRGGL CYYQQFTVGP NAGFCRTEAG
360 370 380 390 400
QNAAIIFLFV NMLLYLVGAI VCLKMWRHEA ARMRRERLEQ DMKSDGLPLN
410 420 430 440 450
MIGAGSSVSV PIQSAPVMTK LETFDGMPDH PAMMEPEILR GHIPAGHIPK
460 470 480 490 500
PLVIADYVAK YPTIRTDEER ERYKAVFNDQ YAEYKELHAE VQVLTQKFEE
510 520 530 540 550
MDNLMRNLPQ RPSSQMEQER ISSIVQEYNR KKADPTYQEK RERCEYLKNK
560 570
LAHIKQKIQE YDKIMDWNDG YS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX510923 Genomic DNA No translation available. |
RefSeqi | NP_001119878.1, NM_001126406.1 |
Genome annotation databases
Ensembli | ENSDART00000137178; ENSDARP00000122328; ENSDARG00000061651 |
GeneIDi | 563122 |
KEGGi | dre:563122 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX510923 Genomic DNA No translation available. |
RefSeqi | NP_001119878.1, NM_001126406.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000122328 |
Proteomic databases
PaxDbi | A2BGQ4 |
Genome annotation databases
Ensembli | ENSDART00000137178; ENSDARP00000122328; ENSDARG00000061651 |
GeneIDi | 563122 |
KEGGi | dre:563122 |
Organism-specific databases
CTDi | 563122 |
ZFINi | ZDB-GENE-050208-54, marveld2b |
Phylogenomic databases
eggNOGi | KOG4796, Eukaryota |
GeneTreei | ENSGT00940000155771 |
HOGENOMi | CLU_039176_1_0_1 |
OMAi | KYPSIHS |
OrthoDBi | 335949at2759 |
PhylomeDBi | A2BGQ4 |
TreeFami | TF326161 |
Gene expression databases
Bgeei | ENSDARG00000061651, Expressed in mature ovarian follicle and 26 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR031176, ELL/occludin IPR008253, Marvel IPR031177, MARVELD2 IPR010844, Occludin_ELL |
PANTHERi | PTHR23288, PTHR23288, 1 hit PTHR23288:SF3, PTHR23288:SF3, 1 hit |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit PF07303, Occludin_ELL, 1 hit |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2BGQ4_DANRE | |
Accessioni | A2BGQ4Primary (citable) accession number: A2BGQ4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |